63 research outputs found
Scoping prediction of re-radiated ground-borne noise and vibration near high speed rail lines with variable soils
This paper outlines a vibration prediction tool, ScopeRail, capable of predicting in-door noise and vibration, within structures in close proximity to high speed railway lines. The tool is designed to rapidly predict vibration levels over large track distances, while using historical soil information to increase accuracy. Model results are compared to an alternative, commonly used, scoping model and it is found that ScopeRail offers higher accuracy predictions. This increased accuracy can potentially reduce the cost of vibration environmental impact assessments for new high speed rail lines.
To develop the tool, a three-dimensional finite element model is first outlined capable of simulating vibration generation and propagation from high speed rail lines. A vast array of model permutations are computed to assess the effect of each input parameter on absolute ground vibration levels. These relations are analysed using a machine learning approach, resulting in a model that can instantly predict ground vibration levels in the presence of different train speeds and soil profiles. Then a collection of empirical factors are coupled with the model to allow for the prediction of structural vibration and in-door noise in buildings located near high speed lines. Additional factors are also used to enable the prediction of vibrations in the presence of abatement measures (e.g. ballast mats and floating slab tracks) and additional excitation mechanisms (e.g. wheelflats and switches/crossings)
Cardiovascular and autonomic modulation by the central nervous system after aerobic exercise training
Ten simple rules for implementing open and reproducible research practices after attending a training course
Open, reproducible, and replicable research practices are a fundamental part of science. Training is often organized on a grassroots level, offered by early career researchers, for early career researchers. Buffet style courses that cover many topics can inspire participants to try new things; however, they can also be overwhelming. Participants who want to implement new practices may not know where to start once they return to their research team. We describe ten simple rules to guide participants of relevant training courses in implementing robust research practices in their own projects, once they return to their research group. This includes (1) prioritizing and planning which practices to implement, which involves obtaining support and convincing others involved in the research project of the added value of implementing new practices; (2) managing problems that arise during implementation; and (3) making reproducible research and open science practices an integral part of a future research career. We also outline strategies that course organizers can use to prepare participants for implementation and support them during this process
Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review
Measurement of event-shape observables in Zââ+ââ events in pp collisions at â s=7 TeV with the ATLAS detector at the LHC
Event-shape observables measured using charged particles in inclusive
-boson events are presented, using the electron and muon decay modes of the
bosons. The measurements are based on an integrated luminosity of of proton--proton collisions recorded by the ATLAS detector at the
LHC at a centre-of-mass energy TeV. Charged-particle
distributions, excluding the lepton--antilepton pair from the -boson decay,
are measured in different ranges of transverse momentum of the boson.
Distributions include multiplicity, scalar sum of transverse momenta, beam
thrust, transverse thrust, spherocity, and -parameter, which are
in particular sensitive to properties of the underlying event at small values
of the -boson transverse momentum. The Sherpa event generator shows larger
deviations from the measured observables than Pythia8 and Herwig7. Typically,
all three Monte Carlo generators provide predictions that are in better
agreement with the data at high -boson transverse momenta than at low
-boson transverse momenta and for the observables that are less sensitive to
the number of charged particles in the event.Comment: 36 pages plus author list + cover page (54 pages total), 14 figures,
4 tables, submitted to EPJC, All figures including auxiliary figures are
available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2014-0
Estratégias de implementação do processo de enfermagem para uma pessoa infectada pelo HIV
A exploração de gås natural em Mexilhão: anålise multicritério pelo método Todim
Follow up of GW170817 and its electromagnetic counterpart by Australian-led observing programmes
The discovery of the first electromagnetic counterpart to a gravitational wave signal has generated follow-up observations by over 50 facilities world-wide, ushering in the new era of multi-messenger astronomy. In this paper, we present follow-up observations of the gravitational wave event GW170817 and its electromagnetic counterpart SSS17a/DLT17ck (IAU label AT2017gfo) by 14 Australian telescopes and partner observatories as part of Australian-based and Australian-led research programs. We report early- to late-time multi-wavelength observations, including optical imaging and spectroscopy, mid-infrared imaging, radio imaging, and searches for fast radio bursts. Our optical spectra reveal that the transient source emission cooled from approximately 6 400 K to 2 100 K over a 7-d period and produced no significant optical emission lines. The spectral profiles, cooling rate, and photometric light curves are consistent with the expected outburst and subsequent processes of a binary neutron star merger. Star formation in the host galaxy probably ceased at least a Gyr ago, although there is evidence for a galaxy merger. Binary pulsars with short (100 Myr) decay times are therefore unlikely progenitors, but pulsars like PSR B1534+12 with its 2.7 Gyr coalescence time could produce such a merger. The displacement (~2.2 kpc) of the binary star system from the centre of the main galaxy is not unusual for stars in the host galaxy or stars originating in the merging galaxy, and therefore any constraints on the kick velocity imparted to the progenitor are poor
Recommended from our members
New high-capacity, calcium-based sorbents, calcium silicate sorbents. Final report, 1993--August 31, 1994
A search is being carried out for new calcium-based S0{sub 2} sorbents for induct injection. More specifically, a search is being carried out for induct injection calcium silicate sorbents that are highly cost effective. The objectives for the current year include the study of sorbents made from Ca(OH){sub 2}, from mixtures of Ca(OH){sub 2} and SiO{sub 2}, and from portland cement. They also include the study of sorbents made from model compounds. During this year, sorbents prepared from Ca(OH){sub 2} and from mixtures of Ca(OH){sub 2} and fumed SiO{sub 2} were investigated. The results show that very good SiO{sub 2}-modified Ca(OH){sub 2} sorbents in which the Si-to-Ca reactant ratio is low can be prepared from Ca(OH){sub 2} and fumed SiO{sub 2}. Sorbents prepared from Ca(OH){sub 2} and natural SiO{sub 2} or natural SiO{sub 2} sources were also studied. The results obtained show that very good SiO{sub 2}-modified Ca(OH){sub 2} sorbents and calcium silicate hydrate sorbents, C-S-H sorbents, can be prepared from Ca(OH){sub 2} and diatomite, pumice or perlite, minerals that are readily available. In addition. sorbents prepared from Ca{sub 3}SiO{sub 5} and {beta}-Ca{sub 2}SiO{sub 4} and from mixtures of these compounds and SiO{sub 2} were studied. The results secured demonstrate that very good C-S-H rich sorbents can be prepared from these compounds and from mixtures of them with SiO{sub 2}. They also provide information useful for interpreting the cement sorbent results. Sorbents prepared from cement and from mixtures of cement and natural SiO{sub 2} or SiO{sub 2} sources were investigated as well. The results secured show that cement and mixtures of it with diatomite, pumice or perlite rapidly yield excellent sorbents with the proper reaction conditions
Mitochondrial DNA polymorphisms and biogenesis genes in primary and metastatic uveal melanoma cell lines
Purpose: This study was designed to identify mitochondrial (mt) DNA variations in primary and metastatic uveal melanoma (UM) cell lines and their relation with cell metabolism to gain insight into metastatic progression.Method: The entire mtDNA genomes were sequenced using Sanger sequencing from two primary UM cell lines (92.1 and MEL270) and two cell lines (OMM2.3 and OMM2.5) derived from liver metastases of the MEL270 patient. The mtDNA copy numbers determined by the ratio of nDNA versus mtDNA. qRT-PCR was used to evaluate expression levels of mitochondrial biogenesis genes.Results: Sequencing showed that cell line MEL270 and metastases-derived OMM2.3 and OMM2.5 cell lines had homoplasmic single nucleotide polymorphisms (SNPs) representing J1c7a haplogroup, whereas 92.1 cells had mtDNA H31a haplogroup. mtDNA copy numbers were significantly higher in primary cell lines. The metastatic UM cells showed down-regulation of POLG, TFAM, NRF-1 and SIRT1 compared to their primary MEL270 cells. PGC-1 alpha was downregulated in 92.1 and upregulated in MEL270, OMM2.3 and OMM2.5.Conclusions: Our finding suggests that within metastatic cells, the heteroplasmic SNPs, copy numbers and mitochondrial biogenesis genes are modulated differentially compared to their primary UM cells. Therefore, investigating pathogenic mtDNA variants associated with cancer metabolic susceptibility may provide future therapeutic strategies in metastatic UM. (C) 2021 Published by Elsevier Inc.Ophthalmic researc
- âŠ