High bat (Chiroptera) diversity in the Early Eocene of India

The geographic origin of bats is still unknown, and fossils of earliest bats are rare and poorly diversified, with, maybe, the exception of Europe. The earliest bats are recorded from the Early Eocene of North America, Europe, North Africa and Australia where they seem to appear suddenly and simultaneously. Until now, the oldest record in Asia was from the Middle Eocene. In this paper, we report the discovery of the oldest bat fauna of Asia dating from the Early Eocene of the Cambay Formation at Vastan Lignite Mine in Western India. The fossil taxa are described on the basis of well-preserved fragments of dentaries and lower teeth. The fauna is highly diversified and is represented by seven species belonging to seven genera and at least four families. Two genera and five species are new. Three species exhibit very primitive dental characters, whereas four others indicate more advanced states. Unexpectedly, this fauna presents strong affinities with the European faunas from the French Paris Basin and the German Messel locality. This could result from the limited fossil record of bats in Asia, but could also suggest new palaeobiogeographic scenarios involving the relative position of India during the Early Eocene

Vegan diets : practical advice for athletes and exercisers.

With the growth of social media as a platform to share information, veganism is becoming more visible, and could be becoming more accepted in sports and in the health and fitness industry. However, to date, there appears to be a lack of literature that discusses how to manage vegan diets for athletic purposes. This article attempted to review literature in order to provide recommendations for how to construct a vegan diet for athletes and exercisers. While little data could be found in the sports nutrition literature specifically, it was revealed elsewhere that veganism creates challenges that need to be accounted for when designing a nutritious diet. This included the sufficiency of energy and protein; the adequacy of vitamin B12, iron, zinc, calcium, iodine and vitamin D; and the lack of the long-chain n-3 fatty acids EPA and DHA in most plant-based sources. However, via the strategic management of food and appropriate supplementation, it is the contention of this article that a nutritive vegan diet can be designed to achieve the dietary needs of most athletes satisfactorily. Further, it was suggested here that creatine and β-alanine supplementation might be of particular use to vegan athletes, owing to vegetarian diets promoting lower muscle creatine and lower muscle carnosine levels in consumers. Empirical research is needed to examine the effects of vegan diets in athletic populations however, especially if this movement grows in popularity, to ensure that the health and performance of athletic vegans is optimised in accordance with developments in sports nutrition knowledge

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Caracterización Clínica e Histopatológica del Carcinoma Baso celular

Introduction: The basaloma also known as basal cell carcinoma is the most frequent case of skin cancer. It can be seen mostly in face, nose and forehead.Objective: To identify the clinical and histopathological characteristics of basal cell carcinoma in patients who underwent surgery at the Maxillo Facial Service of the Celia Sánchez Manduley University Hospital in Manzanillo, during the period from September to December 2016.Methodological Design: It was carried out a descriptive and observant study to identify the clinical and histopathological characteristics of the basal cell carcinoma in patients that were treated in the Maxillofacial Service of the Clinical-Surgical Hospital ´´ Celia Sánchez Manduley´´, between the months of September and December of 2016. The sample had 60 patients.Results: The basal cell carcinoma predominated in males (55%) mostly between the ages of 60 and 80 years (68,67%). This disease was most frequently presented in white people (75%); located mainly in the cheeks (43%), with a size between one and two centimeters. These lesions presented a low diagnosis error with only a two percentage.Conclusions: The research reveal a high frequency of this disease in elderly people mostly men, with a bigger tendency to be located in the facial regions sun exposed. It was also confirmed that these lesions were detected and treated in early stages. Their diagnosis and treatment are performed with a small margin of error.Introducción: el basaloma, también llamado carcinoma de células basales y carcinoma basocelular, es la forma más frecuente de cáncer de piel y se puede encontrar principalmente en cara, nariz y frente.Objetivo: identificar las características clínicas e histopatológicas del carcinoma basocelular en pacientes que fueron operados en el Servicio de Máxilo Facial del Hospital Universitario Celia Sánchez Manduley de Manzanillo, en el período comprendido entre los meses de septiembre a diciembre de 2016.Material y Métodos: se realizó un estudio observacional, descriptivo y de corte transversal para identificar las características clínicas e histopatológicas del carcinoma basocelular en pacientes que fueron operados en el Servicio de Máxilo Facial del Hospital Clínico-quirúrgico Celia Sánchez Manduley de Manzanillo, en el período comprendido entre los meses de septiembre a diciembre de 2016. La muestra estuvo constituida por 60 pacientes.Resultados:  el carcinoma basocelular predominó en el sexo masculino (55%) sobre todo en las edades de 60 a 80 años (68,67%). Esta lesión se presentó con mayor frecuencia en personas de piel blanca (75%); localizándose principalmente en las mejillas (43%) con un tamaño predominante de 1 a 2 cm. Esta lesión presentó bajo error diagnóstico con solo el 2%. Conclusiones: la investigación reveló una alta frecuencia de la enfermedad en personas de edad avanzada sobre todo en hombres, con mayor tendencia a presentarse en regiones faciales expuestas al sol. También se constató que las lesiones son detectadas y tratadas en un estado incipiente. Su diagnóstico y tratamiento se realzan con un margen de error muy pequeño

Evaluation of chemiluminescence, toluidine blue and histopathology for detection of high risk oral precancerous lesions: A cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Early detection holds the key to an effective control of cancers in general and of oral cancers in particular. However, screening procedures for oral cancer are not straightforward due to procedural requirements as well as feasibility issues, especially in resource-limited countries.</p> <p>Methods</p> <p>We conducted a cross-sectional study to compare the performance of chemiluminescence, toluidine blue and histopathology for detection of high-risk precancerous oral lesions. We evaluated 99 lesions from 55 patients who underwent chemiluminescence and toluidine blue tests along with biopsy and histopathological examination. We studied inter-as well as intra-rater agreement in the histopathological evaluation and then using latent class modeling, we estimated the operating characteristics of these tests in the absence of a reference standard test.</p> <p>Results</p> <p>There was a weak inter-rater agreement (kappa < 0.15) as well as a weak intra-rater reproducibility (Pearson's r = 0.28, intra-class correlation rho = 0.03) in the histopathological evaluation of potentially high-risk precancerous lesions. When compared to histopathology, chemiluminescence and toluidine blue retention had a sensitivity of 1.00 and 0.59, respectively and a specificity of 0.01 and 0.79, respectively. However, latent class analysis indicated a low sensitivity (0.37) and high specificity (0.90) of histopathological evaluation. Toluidine blue had a near perfect high sensitivity and specificity for detection of high-risk lesions.</p> <p>Conclusion</p> <p>In our study, there was variability in the histopathological evaluation of oral precancerous lesions. Our results indicate that toluidine blue retention test may be better suited than chemiluminescence to detect high-risk oral precancerous lesions in a high-prevalence and low-resource setting like India.</p

The effects of hip muscle strengthening on knee load, pain, and function in people with knee osteoarthritis: a protocol for a randomised, single-blind controlled trial

BACKGROUND: Lower limb strengthening exercises are an important component of the treatment for knee osteoarthritis (OA). Strengthening the hip abductor and adductor muscles may influence joint loading and/or OA-related symptoms, but no study has evaluated these hypotheses directly. The aim of this randomised, single-blind controlled trial is to determine whether hip abductor and adductor muscle strengthening can reduce knee load and improve pain and physical function in people with medial compartment knee OA. METHODS/DESIGN: 88 participants with painful, radiographically confirmed medial compartment knee OA and varus alignment will be recruited from the community and randomly allocated to a hip strengthening or control group using concealed allocation stratified by disease severity. The hip strengthening group will perform 6 exercises to strengthen the hip abductor and adductor muscles at home 5 times per week for 12 weeks. They will consult with a physiotherapist on 7 occasions to be taught the exercises and progress exercise resistance. The control group will be requested to continue with their usual care. Blinded follow up assessment will be conducted at 12 weeks after randomisation. The primary outcome measure is the change in the peak external knee adduction moment measured during walking. Questionnaires will assess changes in pain and physical function as well as overall perceived rating of change. An intention-to-treat analysis will be performed using linear regression modelling and adjusting for baseline outcome values and other demographic characteristics. DISCUSSION: Results from this trial will contribute to the evidence regarding the effect of hip strengthening on knee loads and symptoms in people with medial compartment knee OA. If shown to reduce the knee adduction moment, hip strengthening has the potential to slow disease progression. TRIAL REGISTRATION: Australia New Zealand Clinical Trials Registry ACTR12607000001493

Vineyard microclimate and yield under different plastic covers.

The use of plastic cover in vineyards minimizes effects of adverse weather conditions. The northwest of São Paulo State is one of the largest grape producing regions in Brazil; however, few studies investigate the effects of different plastic covers on vineyards in this region. This study compared the effect of black shading screen (BSS) and braided polypropylene film (BPF) on BRS Morena vineyard microclimate, grown on an overhead trellis system in the northwestern São Paulo. The experiments were carried out during three growing seasons (2012 ? 2014). BSS allowed superior incoming solar radiation (SR) transmissivity, resulting in higher net radiation (Rn), and higher ratio between photosynthetically active (PAR) and SR. No differences were observed between the average air temperatures (T) and relative humidity (RH) of covered environments (BPF and BSS) and outside condition (automatic weather station ? AWS), due to high air circulation, despite wind speed (WS) reduction caused by plastic covers. BPF provided better conditions for vineyard growth with higher fruit yield than vineyard under BSS regarding the number of shoots with bunches per plant, bunch and stem weights, longitudinal diameter of berries, quantity of fertile buds per shoot, and yield per shoot and per plant. BPF covers also influenced leaf size and growth speed of plants in vineyards. Keywords Black shading screen . Braided polypropylene film . BRS Morena . Leaf wetness duration . Yiel