Impact of an occupancy and activity based window use model on the prediction of the residential energy use and thermal comfort

The opening of windows can lead to high energy losses in wintertime, especially in nearly zero-energy buildings. But can reduce overheating significantly in summertime. Therefore, window use models have been created in the past to assess the energy use and thermal comfort in residential buildings. The models are mostly based on weather-variables. However, a recent study (Verbruggen, Janssens, et al. 2018) indicated that these models were not able to accurately predict the window use in wintertime. For that reason, an occupancy and activity based model was developed. In this article, the impact of the application of the new window opening model on the residential energy use and thermal comfort was assessed. The object-oriented modelling language Modelica was used to simulate the energy use and temperatures in a nearly-zero energy house, which is a representation of an existing house in a nearly zero-energy neighbourhood in Kortrijk. From this neighbourhood, measured energy use data was available as well as window sensor data for some of the houses. These measured data were compared to the simulated data of the new window use model, a weather-based model and the Belgian EPBD-calculation method. The occupancy and activity based model could predict more accurately the average opening durations in wintertime and could better account for the large variation in window use compared to weather-based models. An optimal window opening strategy could limit the overheating significantly, even prevent it in the bedrooms and bathroom. However, opening the windows also implies an increase in energy use for heating. Some combinations of different window opening habits can limit the overheating, while limiting the increase in energy use at the same time

Inclusion of window opening habits in a window model based on activity and occupancy patterns

The occupants’ window opening behaviour can have a substantial influence on the indoor climate and the energy use in low energy dwellings. In literature, most window opening models are based on outdoor and/or indoor climate variables. However a study of Verbruggen et al. [1] revealed that these models are not able to predict the window opening behaviour accurately in wintertime, which may be attributed to the presence of window opening habits. The occupants perform the habits not according to a fixed time step but rather to the performance of a reoccurring activity or an occupancy change. Therefore, a window opening model is generated based on the occupancy and activity patterns of the inhabitants. The model links certain behaviours to specific activities or moments in an occupant’s day without relating it to an exact time-step or specific weather conditions. Data on these habits and the links with occupancy are acquired from a survey conducted in a NZEB case-study project in Belgium. This paper includes the results of the habit-survey and explains how the window use model based on habits is generated. Based on the answers from the survey the window use in bedrooms and bathrooms could be fully defined for 93% of the households, only in the living room no complete window use profile could be defined. The developed model is able to predict the window use in a more realistic way compared to weather-models, with window opening actions linked to specific moments in the occupant’s day

The influence of window opening habits on the residential energy use in nearly zero energy buildings

In this paper, we discuss the presence of habits in the window opening behaviour of social housing tenants in a nearly zero-energy development in Belgium. A window opening habit can be defined as an action with a window that is repeated daily around the same time independently of the prevailing weather conditions. A carbon neutral social housing estate (106 apartments and 90 single family dwellings) was used as a test case. Questionnaires, window opening logging with a building monitoring system and cross-sectional surveys were used to collect window opening data. A method to identify window opening habits is determined. Up to 45% of the occupants act on some sort of habit in wintertime, predominantly in the bedrooms and in the morning. In summer these habits dissipate due to very long window openings. Weather variables and indoor climate parameters, traditionally used as the basis for window opening behaviour models, are rather poor predictors of opening behaviour in winter. The incorporation of habits in window opening models can lead to more reliable predictions of window opening behaviour

Utilization of heat recovery ventilation: steady-state two-zone heat loss analysis and field studies

In new houses in Europe the share of mechanical ventilation with heat recovery is increasing as a result of more severe energy performance requirements and of energy labelling for residential ventilation units. The methods used to assess the influence of heat recovery ventilation on the heating energy use in energy labelling and certification are typically based on single zone energy balance equations, although heating behaviour and set-points differ in different rooms of a dwelling. As a result of this the energy savings of heat recovery ventilation as assessed with single zone methods may be larger than when the spatial variations in dwellings are taken into account. This is related to the fact that the recovered heat supplied to the dwelling through the ventilation system is not ‘useful’ to reduce space heating and cooling demand at all time and in every room. A two-zone steady-state heat loss analysis was conducted to investigate the relation between spatial variations in a dwelling and the utilization of heat recovery. One zone represents the rooms in a house which are regularly heated and are typically equipped with heat emitters and local controls. The other zone represents the rooms which are rarely heated or have no individual heat emitters or controls. The results show the differences between a single zone and two-zone approach in terms of the effects of heat recovery ventilation on building heat loss, and define the main influencing parameters for the utilization of heat recovery in residential ventilation systems. The analysis is supported by results of a field study where energy use in 114 low-energy houses was monitored. Half of the houses had mechanical ventilation systems with heat recovery, while the other half had demand-controlled mechanical extract ventilation. Apart from the differences in ventilation systems, the houses were largely identical

Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19.

OBJECTIVES: The pandemic spread of the coronavirus SARS-CoV-2 is due, in part, to the immunological properties of the host-virus interaction. The clinical presentation varies from individual to individual, with asymptomatic carriers, mild-to-moderate-presenting patients and severely affected patients. Variation in immune response to SARS-CoV-2 may underlie this clinical variation. METHODS: Using a high-dimensional systems immunology platform, we have analysed the peripheral blood compartment of 6 healthy individuals, 23 mild-to-moderate and 20 severe COVID-19 patients. RESULTS: We identify distinct immunological signatures in the peripheral blood of the mild-to-moderate and severe COVID-19 patients, including T-cell lymphopenia, more consistent with peripheral hypo- than hyper-immune activation. Unique to the severe COVID-19 cases was a large increase in the proportion of IL-10-secreting regulatory T cells, a lineage known to possess anti-inflammatory properties in the lung. CONCLUSION: As IL-10-secreting regulatory T cells are known to possess anti-inflammatory properties in the lung, their proportional increase could contribute to a more severe COVID-19 phenotype. We openly provide annotated data (https://flowrepository.org/experiments/2713) with clinical correlates as a systems immunology resource for the COVID-19 research community

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

Variation in Structure and Process of Care in Traumatic Brain Injury: Provider Profiles of European Neurotrauma Centers Participating in the CENTER-TBI Study.

INTRODUCTION: The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for optimal care for TBI patients. The first step in CER is to map the existing variation. The aim of current study is to quantify variation in general structural and process characteristics among centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. METHODS: We designed a set of 11 provider profiling questionnaires with 321 questions about various aspects of TBI care, chosen based on literature and expert opinion. After pilot testing, questionnaires were disseminated to 71 centers from 20 countries participating in the CENTER-TBI study. Reliability of questionnaires was estimated by calculating a concordance rate among 5% duplicate questions. RESULTS: All 71 centers completed the questionnaires. Median concordance rate among duplicate questions was 0.85. The majority of centers were academic hospitals (n = 65, 92%), designated as a level I trauma center (n = 48, 68%) and situated in an urban location (n = 70, 99%). The availability of facilities for neuro-trauma care varied across centers; e.g. 40 (57%) had a dedicated neuro-intensive care unit (ICU), 36 (51%) had an in-hospital rehabilitation unit and the organization of the ICU was closed in 64% (n = 45) of the centers. In addition, we found wide variation in processes of care, such as the ICU admission policy and intracranial pressure monitoring policy among centers. CONCLUSION: Even among high-volume, specialized neurotrauma centers there is substantial variation in structures and processes of TBI care. This variation provides an opportunity to study effectiveness of specific aspects of TBI care and to identify best practices with CER approaches

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study

Abstract Background General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess and quantify variation in perceptions on intensive care unit (ICU) management of patients with TBI in European neurotrauma centers. Methods We performed a survey as part of the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. We analyzed 23 questions focused on: 1) circulatory and respiratory management; 2) fever control; 3) use of corticosteroids; 4) nutrition and glucose management; and 5) seizure prophylaxis and treatment. Results The survey was completed predominantly by intensivists (n = 33, 50%) and neurosurgeons (n = 23, 35%) from 66 centers (97% response rate). The most common cerebral perfusion pressure (CPP) target was > 60 mmHg (n = 39, 60%) and/or an individualized target (n = 25, 38%). To support CPP, crystalloid fluid loading (n = 60, 91%) was generally preferred over albumin (n = 15, 23%), and vasopressors (n = 63, 96%) over inotropes (n = 29, 44%). The most commonly reported target of partial pressure of carbon dioxide in arterial blood (PaCO2) was 36–40 mmHg (4.8–5.3 kPa) in case of controlled intracranial pressure (ICP) < 20 mmHg (n = 45, 69%) and PaCO2 target of 30–35 mmHg (4–4.7 kPa) in case of raised ICP (n = 40, 62%). Almost all respondents indicated to generally treat fever (n = 65, 98%) with paracetamol (n = 61, 92%) and/or external cooling (n = 49, 74%). Conventional glucose management (n = 43, 66%) was preferred over tight glycemic control (n = 18, 28%). More than half of the respondents indicated to aim for full caloric replacement within 7 days (n = 43, 66%) using enteral nutrition (n = 60, 92%). Indications for and duration of seizure prophylaxis varied, and levetiracetam was mostly reported as the agent of choice for both seizure prophylaxis (n = 32, 49%) and treatment (n = 40, 61%). Conclusions Practice preferences vary substantially regarding general supportive and preventive measures in TBI patients at ICUs of European neurotrauma centers. These results provide an opportunity for future comparative effectiveness research, since a more evidence-based uniformity in good practices in general ICU management could have a major impact on TBI outcome