118 research outputs found
Consensus guidelines for the use and interpretation of angiogenesis assays
- Author
- A Adini
- A Anisimov
- A Aspelund
- A Bikfalvi
- A Bouchet
- A Caporali
- A Fantin
- A Folch
- A Fraccaroli
- A Grutzkau
- A Haeger
- A Hayer
- A Helisch
- A Hruscha
- A Johns
- A Khademhosseini
- A Laude
- A Moldobaeva
- A Ny
- A Otani
- A Passaniti
- A Poltorak
- A Reade
- A Rossi
- A Sadanandam
- A Sakaue-Sawano
- A Scarpa
- A Scott
- A Stahl
- A Stahl
- A Stahl
- A Vargas
- A Vargas
- A Warth
- A Weiss
- A Weiss
- A Weiss
- A Zumsteg
- AA Hellingman
- AA Keskinov
- AA Nazarov
- AC Aplin
- AC Aplin
- AC Newman
- AC Tufan
- Adrian L. Harris
- AE Birsner
- AF Alghanem
- AF Orozco
- Agnes Noel
- AH Rizvi
- AJ Bastiaansen
- AJ Bastiaansen
- AJ Donato
- Alfred C. Aplin
- AM Cimpean
- AM Cimpean
- AM Ochsenbein
- Amber N. Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- AN Stratman
- Anca M. Cimpean
- Andreas Bikfalvi
- Andrew C. Dudley
- Andrey Anisimov
- Anna Dimberg
- Anna M. Randi
- Anna-Karin Olsson
- AO Dokun
- AO Dokun
- AO Smith
- AQ Reuwer
- Arjan W. Griffioen
- AS Harney
- AV Gore
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AW Griffioen
- AY Nossent
- B Blouw
- B Garmy-Susini
- B Huang
- B St Croix
- B Uzzan
- Bahar Yetkin-Arik
- Barbara C. Böck
- Bart Ghesquière
- Bertan Cakir
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- BL Roman
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- BM Weinstein
- BP Dranka
- Brant M. Weinstein
- Brenda R. Kwak
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- E Akbari
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- Judy R. van Beijnum
- Jussi Nurro
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- JW Baish
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- P Nowak-Sliwinska
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- R Xu
- R Zhang
- R. Hugh F. Bender
- Raghu Kalluri
- Rakesh K. Jain
- RE Conway
- RE Unger
- Reinier O. Schlingemann
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- V Torres-Estay
- V Vickerman
- V Weel van
- V Weel van
- V Weel van
- Valentin Djonov
- Victor W. M. van Hinsbergh
- VL Bridgeman
- VL Thijssen
- VN Pham
- VP Chauhan
- VP Chauhan
- VS Shirure
- VS Shirure
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- VV Tuchin
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- W Kim
- W Koh
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- W Lu
- W Pan
- W Song
- W Yi
- WS Kamoun
- WS Lee
- WW Kilarski
- WW Kilarski
- WW Kilarski
- WY Choi
- WY Hwang
- WY Hwang
- X Chen
- X Gu
- X Li
- X Meng
- X Wang
- X Wang
- X Wang
- XM Lopez
- XM Wijk van
- Y Adar
- Y Gazit
- Y Gazit
- Y Gong
- Y He
- Y Izumi
- Y Lei
- Y Li
- Y Lin
- Y Sato
- Y Tsuzuki
- Y Yang
- Y Yang
- Y Zhang
- Y Zhang
- Y Zheng
- Y Zheng
- Y Zhu
- Yan Gong
- YC Chen
- YH Hsu
- YK Young
- YR Cha
- Z Raval
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
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- AKI Research Group
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- Cheng CC
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- Chernyshuk S
- Chevret S
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- Chiou KR
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- Chiu LC
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- Chiurazzi C
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- Cho Y
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- Colombo A
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- FINNRESUSCI Study Group
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- GETGAG/SEMICYUC
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Juanas CA
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- PS-ICU Group
- Psarologakis C
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- Romeu JD
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- Rosario LE
- Rosario LE
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- Ruiz FC
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- Ruiz-Rodriguez JC
- Ruiz-Rodríguez JC
- Ruiz-Ruano RDEL
- Runge I
- Runge I
- Runge I
- Rutherford WB
- Rutten AM
- Rydingsward JE
- Saadat F
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- Sabeļņikovs O
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- Saito N
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- Sakieva FI
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- Salgado DR
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- Sandiumenge A
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- Santacruz C
- Santana JD
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- Santana MC
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- Santana PS
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- Santana SR
- Santiago AI
- Santiago AI
- Santos F
- Sanui M
- Sanz ER
- Sanz ER
- Sanz ER
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- Sanz ER
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- Sanz NM
- Sanz NM
- Sanz NM
- Sato K
- Savi C
- Savin I
- Savvidou S
- Sawamura A
- Sawamura A
- Sawamura A
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- Scala S
- Scales DC
- Scanziani E
- Scanziani E
- Schaller SJ
- Schlaepfer P
- Schleifer J
- Schmid RM
- Schmidt M
- Schneider AG
- Schoenenberger JA
- Schortgen F
- Schortgen F
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- Spronk PE
- Spronk PE
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- St George’s University of London
- Stamm J
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- Stubbs C
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- Suchomel P
- Suh GJ
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- Sánchez MJ
- Sánchez PC
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- Tokyo Womens Medical University
- Tomas E
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- Tsunano Y
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- Vaquerizo C
- Varas GM
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- Villarreal E
- Villarreal E
- Vincent B
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- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
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- Volta CA
- Volta CA
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- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
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- Vázquez CF
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- Wada T
- Wada T
- Wada T
- Wada T
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- Wang H
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- Wann SR
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- Wee S
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- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
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- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
ICAR: endoscopic skull‐base surgery
- Author
- Aaron G
- Aaron GP
- Abergel A
- Abouaf L
- Abrishamkar S
- Acioly MA
- Acioly MA
- Acuna RT
- Adams AS
- Adappa ND
- Aferzon M
- Agaimy A
- Agarwal A
- Aggarwal A
- Agrawal D
- Ahmed OH
- Aihara M
- Akagami R
- Alahmadi H
- Albu S
- Albu S
- Albu S
- Alexander A
- Alimohamadi M
- Almefty R
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almeida JR
- Almond MC
- Alobaid A
- Alobid I
- Alobid I
- Alos L
- AlQahtani A
- Altay T
- Alvarez FL
- Alves MV
- Al‐Mamgani A
- Al‐Mefty O
- Al‐Sheibani S
- Amano K
- Amdur RJ
- Amelot A
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management
- Amichetti M
- Amin SM
- Amit M
- Amit M
- Amit M
- Ammirati M
- Anari S
- Anderson D
- Anderson RL
- Andrade NA
- Andrews JC
- Anik I
- Ansa B
- Ansari M
- Antonelli AR
- Arafah BM
- Arafah BM
- Arafah BM.
- Arai A
- Arat YO
- Arbolay OL
- Ardehali MM
- Armengot M
- Arnautovic KI
- Arrer E
- Arslan HH
- Aryan HE
- Asano S
- Askoxylakis V
- Astrup J
- Awad AJ
- Awad M
- Azad TD
- Aziz KM
- Babin E
- Bachmann G
- Back L
- Backlund EO.
- Baijal V
- Balaker AE
- Ballah D
- Balzer JR
- Banks CA
- Banu MA
- Banu MA
- Banuchi VE
- Barnes L
- Baser B
- Baskin DS
- Battaglia P
- Battaglia P
- Becker AM
- Beckhardt RN
- Bedi AD
- Bedrosian JC
- Bedrosian JC
- Beer‐Furlan A
- Beer‐Furlan A
- Beham A
- Bejjani GK
- Bell D
- Bell RB
- Bell RB
- Berdahl JP
- Berhouma M
- Berker M
- Berker M
- Berkmann S
- Berkmann S
- Berkmann S
- Bernal‐Sprekelsen M
- Bernal‐Sprekelsen M
- Bernat AL
- Bertrand B
- Bhasker S
- Bhatti SN
- Bidot S
- Bills DC
- Bishop JA
- Biswas D
- Black PM
- Bleier BS
- Bleier BS
- Bleier BS
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- Yoshida E
- Yoshizaki T
- You R
- Youssef AS
- Youssef S
- Yunoue S
- Yu‐Wai‐Man P
- Zacharia BE
- Zada G
- Zaidi HA
- Zanation AM
- Zanation AM
- Zanation AM
- Zanation AM
- Zanation AM
- Zhan R
- Zhang C
- Zhang H
- Zhang HK
- Zhang L
- Zhang M
- Zhang Q
- Zhang Q
- Zhang Q
- Zhang Q
- Zhou Q
- Zhou Q
- Zimmer LA
- Zoli M
- Zoli M
- Zou X
- Zrebeet HA
- Zuccaro G.
- Zuniga MG
- Zwagerman NT
- Publication venue
- Publication date
- 01/07/2019
- Field of study
n/
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
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- Bakhai A
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- Baksi A
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- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
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- Banker D
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- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
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- Caballero-Valiente B
- Cabau Jr
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- Chamblee T
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- Chattin W
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- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
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- Cheng S
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- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
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- Cislowski D
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- Clocotan M
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- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
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- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
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- Da Silva D Jr
- Da Silva O Jr
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- Dalseg Am
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- De Krumbach L
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- Denecke C
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- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
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- Di Biase M
- Diago M
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- Dickstein K
- Diederich C
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- Dobilas V
- Dodds G
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- Doggett J
- Dognini Gp
- Doi M
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- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
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- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
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- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
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- Ebrahim I
- Eccleston D
- Echeverria L
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- Einhorn D
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- Ellenbroek D
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- Emil B
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- Facello A
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- Feitosa G
- Felario Junior Ga
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- Ferreira-Jardim A
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- Forgosh L
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- Frankenstein L
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- Goette A
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- Gordeev I
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- Goudev A
- Gould R
- Govindaraj D
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- Grigaraviciene I
- Grigorova V
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- Gyorgyova E
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- H Hansen
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- I Ivanov
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- Yupanqui H
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- Zadionchenko V
- Zadra R
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- Zdrenghea D
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- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L Barabási
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
- AE Finefrock
- AE Heazell
- AE Heazell
- AE Kartikasari
- AEC Ihekwaba
- AEC Ihekwaba
- AF Tramontano
- AH Berg
- AH Koeppen
- AH Koeppen
- AH Tong
- AI Bush
- AI Bush
- AI Bush
- AI Bush
- AI Faden
- AJ Ghio
- AJ Ghio
- AJ Ghio
- AJ Hulbert
- AJ Kowaltowski
- AJ Lusis
- AJ Matthews
- AJ Reyes
- AJ van Oostrom
- AJ Watson
- AJ White
- AJ Williams
- AK Junk
- AL Beal
- AL Hemdahl
- AL Hopkins
- AL Hopkins
- AL Lagan
- AL Mark
- AL Sirén
- AL Sirén
- AL Sirén
- AL Takeda
- AM Abeles
- AM Borzychowski
- AM Choi
- AM Dolga
- AM Elneihoum
- AM Elneihoum
- AM Feist
- AM Harvey
- AM Jenkinson
- AM Lin
- AM Samuni
- AM Snyder
- AN Crowson
- AN Tabah
- AP Bolger
- AP Breen
- AP Liappis
- AR Kallianpur
- AR Kallianpur
- AR Martin
- AR Ness
- AR Rechner
- AR Rumbold
- AS Baldwin Jr
- AS Binbrek
- AS Kaprelyants
- AS Wierzbicki
- AT McKie
- AV Lebedev
- AV Perkins
- AV Rao
- AW Maresso
- AY Andreyev
- AY Sun
- B Chakravarti
- B Chance
- B Cronin
- B de Valk
- B De Vries
- B Desoize
- B Drayer
- B Faller
- B Goodell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Huppertz
- B Jayawardhana
- B Kwak
- B Lachili
- B Lipinski
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
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- Aarup Petersen H
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- Zecchinelli AG
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- Zeuner WD
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- Zorbilmez C
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- Álvarez Fernández A
- Österberg K
- Özçelik Ö
- Široký J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Evidence for Top Quark Production in Nucleus-Nucleus Collisions
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Acharya H
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- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Peer reviewe
Observation of the B-s(0) -> X(3872)phi Decay
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmed A
- Ahuja S
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alvarez Gonzalez B
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Ambrogi F
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Ang L
- Antchev G
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Atakisi IO
- Atanasov I
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awan MIM
- Ayala E
- Aydogmus Sen F
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
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- Baechler J
- Bagaturia I
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Baldenegro Barrera C
- Ball AH
- Ban Y
- Band R
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrio Luna M
- Bartek R
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- Bartók M
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- Bastos D
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- Bauerdick LAT
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- Bayshev I
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- Becerril Gonzalez H
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- Bedoya CF
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- Belchior Batista Das Chagas E
- Belforte S
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- Benecke A
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- Benitez JF
- Benussi L
- Beretvas A
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- Berger T
- Beri SB
- Bermúdez Martínez A
- Bernardes CA
- Bernet C
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- Berryhill J
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- Bossini E
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
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- Abbaneo D
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- Abbrescia M
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
We describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in proton-proton collisions at an energy of s = 13 TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb - 1 . A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ¯
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