200 research outputs found

    Transcutaneous Electrical Nerve Stimulation In Dysphonic Women

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    Background: Studies indicate correlation between dysphonia and muscle tension. Aim: To evaluate bilaterally the electrical activity of the suprahyoid muscles (SH), sternocleidomastoid (SCM), and trapezius (T), the presence of pain and the voice, after applying transcutaneous electrical nerve stimulation (TENS). Method: Ten (10) women with nodules or bilateral mucus thickening, and phonation fissure. Volunteers were submitted to 10 TENS sessions (200μs and 10Hz) for 30 minutes. Pain was evaluated using an analogical visual scale; the voice was evaluated through laryngoscopy and through a perceptive-auditory and acoustic analysis; and the myoelectric signal was converted using the Root Media Square (RMS). Voice and EMG data gathering was performed during the production of the E/vowel and during spontaneous speech (SS). Statistical analysis: Shapiro-Wilk Test followed by the Wilcoxon Test, or t Student, or Friedman Test (p<0.05). Results: It was observed that the TENS decreased the RMS readings, pre and pos treatment, for the Right T (RT) (2.80 ± 1.36 to 1.77 ± 0.93), the Left T (LT) (3.62 ± 2.10 to 2.10 ± 1.06), the Left SCM (LSCM) (2.64 ± 0.69 to 1.94 ± 0.95), and the SH (11.59 ± 7.72 to 7.82 ± 5.95) during the production of the E/vowel; and for the RT (3.56 ± 2.77 to 1.93 ± 1.13), the LT (4.68 ± 2.56 to 3.09 ± 2.31), the Right SCM (RSCM) (3.94 ± 2.04 to 2.51 ± 1.87), and the LSCM (3.54 ± 1.04 to .12 ± 3.00) during SS. A relieve in pain was also observed. Regarding the voice analysis, there was a decrease in level of laryngeal injuries; no difference was observed during the production of the E/vowel in the perceptive-auditory analysis; there was a decrease in the level of dysphonia and hoarseness during SS. Conclusion: TENS is effective in improving the clinical and functional signs of dysphonic women.203189194Behrman, A., Common practices of voice therapists in the evaluation of patients (2005) J Voice, 19 (3), pp. 454-469Dromey, C., Nissen, S.L., Roy, N., Merrill, R.M., Articulatory changes following treatment of muscle tension dysphonia: Preliminary acoustic evidence (2008) J Speech Lang Hear Res, 51 (1), pp. 196-208Gillivan-Murphy, P., Drinnan, M.J., O'Dwyer, T.P., Ridha, H., Carding, P., The effectiveness of a voice treatment approach for teachers with self-reported voice problems (2006) J Voice, 20 (3), pp. 423-431Schneider, S.L., Sataloff, R.T., Voice therapy for the professional voice (2007) Otolaryngol Clin North Am, 40 (5), pp. 1133-1149Rubin, J.S., Blake, E., Mathieson, L., Musculoskeletal patterns in patients with voice disorders (2007) J Voice, 21 (4), pp. 477-484Sluka, K.A., Walsh, D.M., Transcutaneous electrical nerve stimulation: Basic science mechanisms and clinical effectiveness (2003) Pain, 4, pp. 109-121Penkner, K., Janda, M., Lorenzoni, M.A., A comparison of the muscular relaxation effect of TENS and EMG-biofeedback in patients with bruxism (2001) J Oral Rehabil, 28 (9), pp. 849-853Guimarães, B.T.L., A eletroestimulação nervosa transcutânea no relaxamento laríngeo (1992) Revista Lugar em FonoaudiologiaGuirro, R.R.J., Forti, F., Rodrigues-Bigaton, D., Proposal for electrical insulation of the electromyographic signal acquisition module (2006) Electromyogr Clin Neurophysiol, 46 (6), pp. 355-363Cram, J.R., Kasman, G.S., Haltz, J., (1998) Introduction to surface electromyography, , Aspen PubleshersBehlau, M., Azevedo, R., Pontes, P., Gonçalves, M.I.R., Constrição anteroposterior do vestíbulo laríngeo em indivíduos normais durante a fonação sustentada. (1998) Revista da Sociedade Brasileira de Fonoaudiologia, 2 (4), pp. 56-60Voz, B.M., (2001) O Livro do Especialista, , Rio de Janeiro: RevinterRodrigues, D., Oliveira, A.S., Bérzin, F., Effect of conventional TENS on pain and electromyographic activity of masticatory muscles in TDM patients (2004) Braz Oral Res, 18 (4), pp. 290-295Rodrigues, D., Oliveira, A.S., Bérzin, F., Effect of TENS on the activation pattern of the masticatory muscles in TMD patients (2004) Braz J Oral Sci, 13 (10), pp. 510-514Kamyszek G, Ketcham R, Garcia RJr, Radke J. Electromyographic evidence of reduce muscle activity when ULF-TENS is applied to the Vth and VIIth cranial nerves Cranio. 2001;19(3):162-8Guimaraes, B.T.L., Relaxamento laringeo com o uso da eletroestimulação nervosa transcutânea (Tens): Um estudo comparativo (2000) Revista Lugar em FonoaudiologiaChesterton, L.S., Barlas, P., Foster, N.E., Lundeberg, T., Wright, C.C., Caxter, G.D., Sensory stimulation (TENS): Effects of parameter manipulation on mechanical pain thresholds in healthy human subjects (2002) Pain, 99 (1-2), pp. 253-262Milne, S., Welch, V., Brosseau, L., Saginu, R.M., Shea, B., Tugwell, S., (2003) Transcutaneous electrical nerve stimulation (TENS) for chronic low back pain, , Oxford: The Cochrane LibraryCarrol, D., Moore, R.A., McQuay, H.J., Fairman, F., Trame'r, M., Leijon, G., (2003) Trancutaneous electrical nerve stimulation (TENS) for chronic pain, , Oxford: The Cochrane LibraryKöke, A.J.A., Schoutend, J.S.A.G., Lamerichs-Geelenc, M.J.H., Lipschc, J.S.M., Waltjec, E.M.H., Kleefa, M., Pain reducing effect of three types of transcutaneous electrical nerve stimulation in patients with chronic pain: A randomized crossover trial (2004) Pain, 108 (1-2), pp. 36-42Kalra, A., Urban, M.O., Sluka, K.A., Blockade of Opioid Receptors in Rostral Venral Medulla. Prevents Antihyperalgesia Produced by Transcutaneous Electrical Nerve Stimulation (TENS) (2001) J. Pharmacol Exp. Ther, 298 (1), pp. 257-263Kofler, M., Functional organization of exteroceptive inhibition following nociceptiva electrical fingertip stimulation in humans (2003) Clin Neurophysiol, 114 (6), pp. 973-980Kofler, M., Influence of trancutaneous electrical nerve stimulation on cutaneous silent periods in humans (2004) Neuroscience Letters, 360 (1-2), pp. 69-72Gonçalves, R.N., Ordenes, I.E.U., Rodrigues-Bigaton, D., Efeito indireto da TENS sobre os músculos cervicais em portadores de DTM. (2007) Fisioterapia em Movimento, 20 (2), pp. 83-90Ido, C., Rothenbuhler, R., Janz, L., Eletroestimulação nervosa trancutânea de baixa freqüência nos "tender points" dos pacientes fibromioálgicos juvenis. (2003) Rev Fisioter Univ. São Paulo, 10 (1), pp. 1-

    Neurolysin knockout mice generation and initial phenotype characterization

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    The oligopeptidase neurolysin (EC 3.4.24.16; Nln) was first identified in rat brain synaptic membranes and shown to ubiquitously participate in the catabolism of bioactive peptides such as neurotensin and bradykinin. Recently, it was suggested that Nln reduction could improve insulin sensitivity. Here, we have shown that Nln knockout mice (KO) have increased glucose tolerance, insulin sensitivity and gluconeogenesis. KO mice have increased liver mRNA for several genes related to gluconeogenesis. Isotopic label semi-quantitative peptidomic analysis suggests increase in specific intracellular peptides in gastrocnemius and epididymal adipose tissue, which likely is involved with the increased glucose tolerance and insulin sensitivity in the KO mice. These results suggest the exciting new possibility that Nln is a key enzyme for energy metabolism and could be a novel therapeutic target to improve glucose uptake and insulin sensitivity

    The performance of the jet trigger for the ATLAS detector during 2011 data taking

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    The performance of the jet trigger for the ATLAS detector at the LHC during the 2011 data taking period is described. During 2011 the LHC provided proton–proton collisions with a centre-of-mass energy of 7 TeV and heavy ion collisions with a 2.76 TeV per nucleon–nucleon collision energy. The ATLAS trigger is a three level system designed to reduce the rate of events from the 40 MHz nominal maximum bunch crossing rate to the approximate 400 Hz which can be written to offline storage. The ATLAS jet trigger is the primary means for the online selection of events containing jets. Events are accepted by the trigger if they contain one or more jets above some transverse energy threshold. During 2011 data taking the jet trigger was fully efficient for jets with transverse energy above 25 GeV for triggers seeded randomly at Level 1. For triggers which require a jet to be identified at each of the three trigger levels, full efficiency is reached for offline jets with transverse energy above 60 GeV. Jets reconstructed in the final trigger level and corresponding to offline jets with transverse energy greater than 60 GeV, are reconstructed with a resolution in transverse energy with respect to offline jets, of better than 4 % in the central region and better than 2.5 % in the forward direction

    Combination of searches for Higgs boson pairs in pp collisions at \sqrts = 13 TeV with the ATLAS detector

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    This letter presents a combination of searches for Higgs boson pair production using up to 36.1 fb(-1) of proton-proton collision data at a centre-of-mass energy root s = 13 TeV recorded with the ATLAS detector at the LHC. The combination is performed using six analyses searching for Higgs boson pairs decaying into the b (b) over barb (b) over bar, b (b) over barW(+)W(-), b (b) over bar tau(+)tau(-), W+W-W+W-, b (b) over bar gamma gamma and W+W-gamma gamma final states. Results are presented for non-resonant and resonant Higgs boson pair production modes. No statistically significant excess in data above the Standard Model predictions is found. The combined observed (expected) limit at 95% confidence level on the non-resonant Higgs boson pair production cross-section is 6.9 (10) times the predicted Standard Model cross-section. Limits are also set on the ratio (kappa(lambda)) of the Higgs boson self-coupling to its Standard Model value. This ratio is constrained at 95% confidence level in observation (expectation) to -5.0 &lt; kappa(lambda) &lt; 12.0 (-5.8 &lt; kappa(lambda) &lt; 12.0). In addition, limits are set on the production of narrow scalar resonances and spin-2 Kaluza-Klein Randall-Sundrum gravitons. Exclusion regions are also provided in the parameter space of the habemus Minimal Supersymmetric Standard Model and the Electroweak Singlet Model. For complete list of authors see http://dx.doi.org/10.1016/j.physletb.2019.135103</p

    Searches for lepton-flavour-violating decays of the Higgs boson in s=13\sqrt{s}=13 TeV pp\mathit{pp} collisions with the ATLAS detector

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    This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H → eτ and H → μτ , performed with the ATLAS detector at the LHC. The searches are based on a data sample of proton–proton collisions at a centre-of-mass energy √s = 13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. No significant excess is observed above the expected background from Standard Model processes. The observed (median expected) 95% confidence-level upper limits on the leptonflavour-violating branching ratios are 0.47% (0.34+0.13−0.10%) and 0.28% (0.37+0.14−0.10%) for H → eτ and H → μτ , respectively.publishedVersio

    Search for flavour-changing neutral currents in processes with one top quark and a photon using 81 fb⁻¹ of pp collisions at \sqrts = 13 TeV with the ATLAS experiment

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    A search for flavour-changing neutral current (FCNC) events via the coupling of a top quark, a photon, and an up or charm quark is presented using 81 fb−1 of proton–proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Events with a photon, an electron or muon, a b-tagged jet, and missing transverse momentum are selected. A neural network based on kinematic variables differentiates between events from signal and background processes. The data are consistent with the background-only hypothesis, and limits are set on the strength of the tqγ coupling in an effective field theory. These are also interpreted as 95% CL upper limits on the cross section for FCNC tγ production via a left-handed (right-handed) tuγ coupling of 36 fb (78 fb) and on the branching ratio for t→γu of 2.8×10−5 (6.1×10−5). In addition, they are interpreted as 95% CL upper limits on the cross section for FCNC tγ production via a left-handed (right-handed) tcγ coupling of 40 fb (33 fb) and on the branching ratio for t→γc of 22×10−5 (18×10−5). © 2019 The Author(s

    Search for long-lived neutral particles in pp collisions at s√=13 TeV that decay into displaced hadronic jets in the ATLAS calorimeter

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    This paper describes a search for pairs of neutral, long-lived particles decaying in the ATLAS calorimeter. Long-lived particles occur in many extensions to the Standard Model and may elude searches for new promptly decaying particles. The analysis considers neutral, long-lived scalars with masses between 5 and 400 GeV, produced from decays of heavy bosons with masses between 125 and 1000 GeV, where the long-lived scalars decay into Standard Model fermions. The analysis uses either 10.8 fb−1 or 33.0 fb−1 of data (depending on the trigger) recorded in 2016 at the LHC with the ATLAS detector in proton–proton collisions at a centre-of-mass energy of 13 TeV. No significant excess is observed, and limits are reported on the production cross section times branching ratio as a function of the proper decay length of the long-lived particles

    Search for single vector-like B quark production and decay via B → bH(b¯b) in pp collisions at √s = 13 TeV with the ATLAS detector

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    A search is presented for single production of a vector-like B quark decaying into a Standard Model b-quark and a Standard Model Higgs boson, which decays into a b¯b pair. The search is carried out in 139 fb−1 of √s = 13 TeV proton-proton collision data collected by the ATLAS detector at the LHC between 2015 and 2018. No significant deviation from the Standard Model background prediction is observed, and mass-dependent exclusion limits at the 95% confidence level are set on the resonance production cross-section in several theoretical scenarios determined by the couplings cW, cZ and cH between the B quark and the Standard Model W, Z and Higgs bosons, respectively. For a vector-like B occurring as an isospin singlet, the search excludes values of cW greater than 0.45 for a B resonance mass (mB) between 1.0 and 1.2 TeV. For 1.2 TeV < mB < 2.0 TeV, cW values larger than 0.50–0.65 are excluded. If the B occurs as part of a (B, Y) doublet, the smallest excluded cZ coupling values range between 0.3 and 0.5 across the investigated resonance mass range 1.0 TeV < mB < 2.0 TeV

    Search for boosted diphoton resonances in the 10 to 70 GeV mass range using 138 fb−1 of 13 TeV pp collisions with the ATLAS detector

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    A search for diphoton resonances in the mass range between 10 and 70 GeV with the ATLAS experiment at the Large Hadron Collider (LHC) is presented. The analysis is based on pp collision data corresponding to an integrated luminosity of 138 fb−1 at a centre-of-mass energy of 13 TeV recorded from 2015 to 2018. Previous searches for diphoton resonances at the LHC have explored masses down to 65 GeV, finding no evidence of new particles. This search exploits the particular kinematics of events with pairs of closely spaced photons reconstructed in the detector, allowing examination of invariant masses down to 10 GeV. The presented strategy covers a region previously unexplored at hadron colliders because of the experimental challenges of recording low-energy photons and estimating the backgrounds. No significant excess is observed and the reported limits provide the strongest bound on promptly decaying axion-like particles coupling to gluons and photons for masses between 10 and 70 GeV

    Evidence for the charge asymmetry in pp → tt¯ production at s√ = 13 TeV with the ATLAS detector

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    Inclusive and differential measurements of the top–antitop (tt¯) charge asymmetry Att¯C and the leptonic asymmetry Aℓℓ¯C are presented in proton–proton collisions at s√ = 13 TeV recorded by the ATLAS experiment at the CERN Large Hadron Collider. The measurement uses the complete Run 2 dataset, corresponding to an integrated luminosity of 139 fb−1, combines data in the single-lepton and dilepton channels, and employs reconstruction techniques adapted to both the resolved and boosted topologies. A Bayesian unfolding procedure is performed to correct for detector resolution and acceptance effects. The combined inclusive tt¯ charge asymmetry is measured to be Att¯C = 0.0068 ± 0.0015, which differs from zero by 4.7 standard deviations. Differential measurements are performed as a function of the invariant mass, transverse momentum and longitudinal boost of the tt¯ system. Both the inclusive and differential measurements are found to be compatible with the Standard Model predictions, at next-to-next-to-leading order in quantum chromodynamics perturbation theory with next-to-leading-order electroweak corrections. The measurements are interpreted in the framework of the Standard Model effective field theory, placing competitive bounds on several Wilson coefficients
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