Creating and curating an archive: Bury St Edmunds and its Anglo-Saxon past

This contribution explores the mechanisms by which the Benedictine foundation of Bury St Edmunds sought to legitimise and preserve their spurious pre-Conquest privileges and holdings throughout the Middle Ages. The archive is extraordinary in terms of the large number of surviving registers and cartularies which contain copies of Anglo-Saxon charters, many of which are wholly or partly in Old English. The essay charts the changing use to which these ancient documents were put in response to threats to the foundation's continued enjoyment of its liberties. The focus throughout the essay is to demonstrate how pragmatic considerations at every stage affects the development of the archive and the ways in which these linguistically challenging texts were presented, re-presented, and represented during the Abbey’s history

Mississippi River low-flows: context, causes, and future projections

The Mississippi River represents a major commercial waterway, and periods of anomalously low river levels disrupt riverine transport. These low-flow events occur periodically, with a recent event in the fall of 2022 slowing barge traffic and generating sharp increases in riverine transportation costs. Here we combine instrumental river gage observations from the lower Mississippi River with output from the Community Earth System Model v2 Large Ensemble (LENS2) to evaluate historical trends and future projections of Mississippi River low streamflow extremes, place the 2022 low-flow event in a broader temporal context, and assess the hydroclimatic mechanisms that mediate the occurrence of low-flows. We show that the severity and duration of low-flow events gradually decreased between 1950 and 1980 coincident with the establishment of artificial reservoirs. In the context of the last ∼70 years, the 2022 low-flow event was less severe in terms of stage or discharge minima than other low-flow events of the mid- and late-20th century. Model simulations from the LENS2 dataset show that, under a moderate-high emissions scenario (SSP3-7.0), the severity and duration of low-flow events is projected to decrease through to the end of the 21st century. Finally, we use the large sample size afforded by the LENS2 dataset to show that low-flow events on the Mississippi River are associated with cold tropical Pacific forcing (i.e. La Niña conditions), providing support for the hypothesis that the El Niño-Southern Oscillation plays a critical role in mediating Mississippi River discharge extremes. We anticipate that our findings describing the trends in and hydroclimatic mechanisms of Mississippi River low-flow occurrence will aid water resource managers to reduce the negative impacts of low water levels on riverine transport

Experimental Infection of Domestic Pigs with an African Swine Fever Virus Field Strain Isolated in 2021 from the Dominican Republic

African swine fever virus (ASFV) is the etiological agent of African swine fever (ASF), a disease of domestic and wild swine that has spread throughout a large geographical area including Central Europe, East and Southeast Asia, and Southern Africa. Typically, the clinical presentation of the disease in affected swine heavily depends on the virulence of the ASFV strain. Very recently, ASFV was detected in the Dominican Republic (DR) and Haiti, constituting the first diagnosis of ASFV in more than 40 years in the Western hemisphere. In this report, the clinical presentation of the disease in domestic pigs inoculated with an ASFV field strain isolated from samples collected in the DR (ASFV-DR21) was observed. Two groups of domestic pigs were inoculated either intramuscularly (IM) or oronasally (ON) with ASFV-DR21 (104 hemadsorbing dose-50% (HAD50)). A group of naïve pigs (designated as the contact group) was co-housed with the ASFV-DR21 IM-inoculated animals to evaluate ASFV transmission and disease manifestation. Animals inoculated IM with ASFV-DR21 developed an acute disease leading to humane euthanasia at approximately day 7 post-inoculation (pi). Interestingly, animals inoculated via the ON route with ASFV-DR21 developed a heterogeneous pattern of disease kinetics. One animal developed an acute form of the disease and was euthanized on day 7 pi, another animal experienced a protracted presentation of the disease with euthanasia by day 16 pi, and the remaining two animals presented a milder form of the disease, surviving through the 28-day observational period. The contact animals also presented with a heterogenous presentation of the disease. Three of the animals presented protracted but severe forms of the disease being euthanized at days 14, 15 and 21 pi. The other two animals presented with a milder form of the disease, surviving the entire observational period. In general, virus titers in the blood of animals in all study groups closely followed the clinical presentation of the disease, both in length and extent. Importantly, all animals presenting with a prolonged form of the disease, as well as those surviving throughout the observational period, developed a strong ASFV-specific antibody response. These results suggest that ASFV-DR21, unless inoculated parenterally, produces a spectrum of clinical disease, with some animals experiencing an acute fatal form while others presented with a mild transient disease accompanied by the induction of a strong antibody response. At the time of publication, this is the first report characterizing the virulent phenotype of an ASFV field strain isolated from samples collected in the DR during the 2021 outbreak and provides information that may be used in developing epidemiological management measures to control ASF on the island of Hispaniola

Varicocele

Varicocele is clinically defined as an abnormal dilatation of the veins of the pampiniform plexus with continuous or intermittent reflux of the venous blood. It is actually considered the most common correctable cause of male infertility, even though the mechanisms responsible for infertility are still unclear. The prevalence of this disorder in the general population is approximately 15\u201320 % [1], and it is involved in up to 40 % of cases of men infertility [2\u20134]