Caracterización molecular y diseño de marcadores moleculares CAPS para el gen de la S-RNasa en Prunus serotina subsp. capuli

Prunus serotina subsp. capuli is a species of economic, commercial, nutritional and ethnobotanical interest in Ecuador; however, it is yet to be domesticated in the country. P. serotina displays the mechanism of gametophytic self-incompatibility (SI), which favors the genetic diversity and biological fitness of the species...En el Ecuador, Prunus serotina subsp. capuli es una especie de interés económico, commercial, nutricional y etnobotánico; sin embargo, esta aún no ha sido domesticada en el país. P. serotina presenta el mecanismo de auto-incompatibilidad gametofítica (AI) el cual favorece la diversidad genética y eficacia biológica de la especie..

Language as a cue for social categorization in bilingual communities

This registered report article investigates the role of language as a dimension of social categorization. Our critical aim was to investigate whether categorization based on language occurs even when the languages coexist within the same sociolinguistic context, as is the case in bilingual communities. Bilingual individuals of two bilingual communities, the Basque Country (Spain) and Veneto (Italy), were tested using the memory confusion paradigm in a 'Who said what?' task. In the encoding part of the task, participants were presented with different faces together with auditory sentences. Two different languages of the sentences were presented in each study, with half of the faces always associated with one language and the other half with the other language. Spanish and Basque languages were used in Study 1, and Italian and Venetian dialect in Study 2. In the test phase, the auditory sentences were presented again and participants were required to decide which face uttered each sentence. As expected, participants error rates were high. Critically, participants were more likely to confuse faces from the same language category than from the other (different) language category. The results indicate that bilinguals categorize individuals belonging to the same sociolinguistic community based on the language these individuals speak, suggesting that social categorization based on language is an automatic process.AL is supported by a PhD grant for the research theme "Bilinguismo e scelte ambientali. Comprendere l’impatto della lingua sulle decisioni utilizzando il bilinguismo italiano-veneto" from the Dipartimento di Psicologia dello Sviluppo e della Socializzazione,University of Padova. MS is supported by grants PGC2018-097970-B-I00 and RED2018-102615-T funded by NCIN/AEI (Spanish Government) and by the Basque Government (IT1169-19). CB is supported by the Ramón y Cajal research program (RYC2018-026174). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study

When the “Tabula” is Anything but “Rasa:” What Determines Performance in the Auditory Statistical Learning Task?

First published: 05 February 2022How does prior linguistic knowledge modulate learning in verbal auditory statistical learning (SL) tasks? Here, we address this question by assessing to what extent the frequency of syllabic co-occurrences in the learners’ native language determines SL performance. We computed the frequency of co-occurrences of syllables in spoken Spanish through a transliterated corpus, and used this measure to construct two artificial familiarization streams. One stream was constructed by embedding pseudowords with high co-occurrence frequency in Spanish (“Spanish-like” condition), the other by embedding pseudowords with low co-occurrence frequency (“Spanish-unlike” condition). Native Spanish-speaking participants listened to one of the two streams, and were tested in an old/new identification task to examine their ability to discriminate the embedded pseudowords from foils. Our results show that performance in the verbal auditory SL (ASL) task was significantly influenced by the frequency of syllabic co-occurrences in Spanish: When the embedded pseudowords were more “Spanish-like,” participants were better able to identify them as part of the stream. These findings demonstrate that learners’ task performance in verbal ASL tasks changes as a function of the artificial language's similarity to their native language, and highlight how linguistic prior knowledge biases the learning of regularities.This paper was supported by the ERC Advanced Grant (project 692502, L2STAT), awarded to Ram Frost under the Horizon 2020 research and innovation program

Foreigner talk through word reduction in native/non-native spoken interactions

We explore the properties of foreigner talk through word reduction. Word reduction signals that the speaker is referring to the same entity as previously and should be preserved for foreigner talk. However, it leads to intelligibility loss, which works against foreigner talk. Pairs of speakers engaged in a task where native speakers talked either to a native or non-native listener. Natives talking to non-natives performed foreigner talk for duration and intensity. Duration and intensity were reduced for native and non-native listeners equally. These results suggest that word reduction is insensitive to communicative adjustments in the context of foreign talk.This work was supported by grants from the Spanish Government (PSI2011-23033, Consolider Ingenio 2010 CSD2007-00012) and the Catalan government (Consolidat SGR 2009-1521). Sara RodríguezCuadrado was supported by a predoctoral fellowship from the Spanish Government (FPU 2008–2012). Cristina Baus was supported by the People Program (Marie Curie Actions, FP7- PEOPLE 2014–2016) under REA agreement n° 623845.We would like to thank Sumeer Chadha, Joanna Corey and Carlos Romero-Rivas for their assistance during data recruitment and manuscript elaboration

The Multilingual Picture Database

Publisher Copyright: © 2022, The Author(s).The growing interdisciplinary research field of psycholinguistics is in constant need of new and up-to-date tools which will allow researchers to answer complex questions, but also expand on languages other than English, which dominates the field. One type of such tools are picture datasets which provide naming norms for everyday objects. However, existing databases tend to be small in terms of the number of items they include, and have also been normed in a limited number of languages, despite the recent boom in multilingualism research. In this paper we present the Multilingual Picture (Multipic) database, containing naming norms and familiarity scores for 500 coloured pictures, in thirty-two languages or language varieties from around the world. The data was validated with standard methods that have been used for existing picture datasets. This is the first dataset to provide naming norms, and translation equivalents, for such a variety of languages; as such, it will be of particular value to psycholinguists and other interested researchers. The dataset has been made freely available.Peer reviewe

p21WAF1/CIP1 Upregulation through the Stress Granule-Associated Protein CUGBP1 Confers Resistance to Bortezomib-Mediated Apoptosis

p21(WAF1/CIP1) is a well known cyclin-dependent kinase inhibitor induced by various stress stimuli. Depending on the stress applied, p21 upregulation can either promote apoptosis or prevent against apoptotic injury. The stress-mediated induction of p21 involves not only its transcriptional activation but also its posttranscriptional regulation, mainly through stabilization of p21 mRNA levels. We have previously reported that the proteasome inhibitor MG132 induces the stabilization of p21 mRNA, which correlates with the formation of cytoplasmic RNA stress granules. The mechanism underlying p21 mRNA stabilization, however, remains unknown.We identified the stress granules component CUGBP1 as a factor required for p21 mRNA stabilization following treatment with bortezomib ( =  PS-341/Velcade). This peptide boronate inhibitor of the 26S proteasome is very efficient for the treatment of myelomas and other hematological tumors. However, solid tumors are sometimes refractory to bortezomib treatment. We found that depleting CUGBP1 in cancer cells prevents bortezomib-mediated p21 upregulation. FISH experiments combined to mRNA stability assays show that this effect is largely due to a mistargeting of p21 mRNA in stress granules leading to its degradation. Altering the expression of p21 itself, either by depleting CUGBP1 or p21, promotes bortezomib-mediated apoptosis.We propose that one key mechanism by which apoptosis is inhibited upon treatment with chemotherapeutic drugs might involve upregulation of the p21 protein through CUGBP1

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI