10 research outputs found
The attenuating effects of 1,2,3,4,6 penta-O-galloyl-β- d -glucose on inflammatory cytokines release from activated BV-2 microglial cells
No full textBeta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis
No full textAnti-inflammatory effects of thymoquinone and its protective effects against several diseases
No full textDissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
No full textAlleviation of prilocaine-induced epileptiform activity and cardiotoxicity by thymoquinone
No full text
Alzheimer’s disease: Natural products as inhibitors of neuroinflammation
No full textAlzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD
