Contributo para a melhoria do desempenho térmico das paredes de taipa

O uso da construção em terra remonta ao início da nossa civilização. Nas regiões do Alentejo e do Algarve existe ainda um grande número de edifícios com paredes em taipa, mas esta tecnologia tem vindo a cair em desuso desde meados do século passado. A construção em terra é altamente sustentável, já que a terra per si é um material 100% reutilizável e pode ser facilmente encontrado em quase todos os lugares do mundo. Os edifícios com paredes em taipa apresentam uma elevada inércia térmica o que, dadas as características climáticas de Portugal, beneficia o seu comportamento térmico. No entanto, seria desejável que a condutibilidade térmica da taipa fosse menor. As preocupações ambientais relativas ao consumo energético, associado ao conforto na habitação, e ao fabrico, transporte e aplicação dos materiais utilizados na construção, levou-nos a procurar novas soluções de tipologias construtivas em terra. Atendendo a estes aspetos e à melhoria da eficiência energética das habitações, neste trabalho são apresentados os resultados dos ensaios realizados em laboratório sobre novas soluções de construção em terra. O local selecionado para a recolha de amostras de terra foi Serpa. Foi feita a caracterização geotécnica do material terra e preparadas diversas composições com a incorporação de argila expandida e de regranulado de cortiça expandida. A argila expandida e o regranulado de cortiça expandida também foram escolhidos por serem isolantes térmicos produzidos a partir de matérias primas disponíveis nas regiões do Alentejo e do Algarve, regiões do nosso país com maior aptência para o uso da taipa. De maneira a caracterizar as diferentes composições sob o ponto de vista mecânico e do desempenho térmico, foram fabricados cubos com 10 cm de aresta e ensaiados de modo a se calcular a sua resistência à compressão e a sua condutibilidade térmica. Os resultados obtidos mostraram que a utilização deste tipo de tipologias construtivas em terra com a incorporação de argila expandida e de regranulado de cortiça expandida permite aumentar o seu desempenho, fazendo que seja possível adaptar esta tipologia às necessidades dos dias de hoje, nomeadamente às exigências estabelecidas pelo Regulamento das Características de Comportamento Térmico dos Edifícios (RCCTE). Os resultados desta investigação têm aplicabilidade, com as devidas adaptações, tanto em construções em taipa como em construções em adobe

The effect of the inclusion of trunk-strengthening exercises to a multimodal exercise program on physical activity levels and psychological functioning in older adults: Secondary data analysis of a randomized controlled trial

Background Engaging in multimodal exercise program helps mitigate age-related decrements by improving muscle size, muscle strength, balance, and physical function. The addition of trunk-strengthening within the exercise program has been shown to significantly improve physical functioning outcomes. Whether these improvements result in improved psychological outcomes associated with increased physical activity levels requires further investigation. We sought to explore whether the inclusion of trunk-strengthening exercises to a multimodal exercise program improves objectively measured physical activity levels and self-reported psychological functioning in older adults. Method We conducted a secondary analysis within a single-blinded parallel-group randomized controlled trial. Sixty-four healthy older (≥ 60 years) adults were randomly allocated to a 12-week walking and balance exercise program with (n = 32) or without (n = 32) inclusion of trunk strengthening exercises. Each program involved 12 weeks of exercise training, followed by a 6-week walking-only program (identified as detraining). Primary outcome measures for this secondary analysis were physical activity (accelerometry), perceived fear-of-falling, and symptoms of anxiety and depression. Results Following the 12-week exercise program, no significant between-group differences were observed for physical activity, sedentary behaviour, fear-of-falling, or symptoms of anxiety or depression. Significant within-group improvements (adjusted mean difference [95%CI]; percentage) were observed in moderate-intensity physical activity (6.29 [1.58, 11.00] min/day; + 26.3%) and total number of steps per min/day (0.81 [0.29 to 1.33] numbers or + 16.3%) in trunk-strengthening exercise group by week 12. With respect to within-group changes, participants in the walking-balance exercise group increased their moderate-to-vigorous physical activity (MVPA) (4.81 [0.06 to 9.56] min/day; + 23.5%) and reported reduction in symptoms of depression (-0.26 [-0.49 to -0.04] points or -49%) after 12 weeks of the exercise program. The exercise-induced increases in physical activity levels in the trunk-strengthening exercise group were abolished 6-weeks post-program completion. While improvements in physical activity levels were sustained in the walking-balance exercise group after detraining phase (walking only). Conclusions The inclusion of trunk strengthening to a walking-balance exercise program did not lead to statistically significant between-group improvements in physical activity levels or psychological outcomes in this cohort following completion of the 12-week exercise program

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy. Further, a number of different intracellular and microenvironmental factors have been correlated with the emergence of drug resistance. With the goal of better understanding drug resistance and its connection with the tumor microenvironment, we have developed a hybrid discrete-continuous mathematical model. In this model, cancer cells described through a particle-spring approach respond to dynamically changing oxygen and DNA damaging drug concentrations described through partial differential equations. We thoroughly explored the behavior of our self-calibrated model under the following common conditions: a fixed layout of the vasculature, an identical initial configuration of cancer cells, the same mechanism of drug action, and one mechanism of cellular response to the drug. We considered one set of simulations in which drug resistance existed prior to the start of treatment, and another set in which drug resistance is acquired in response to treatment. This allows us to compare how both kinds of resistance influence the spatial and temporal dynamics of the developing tumor, and its clonal diversity. We show that both pre-existing and acquired resistance can give rise to three biologically distinct parameter regimes: successful tumor eradication, reduced effectiveness of drug during the course of treatment (resistance), and complete treatment failure

Rede De Apoio Social, Saúde Mental E Qualidade De Vida: Um Estudo Transversal Na Atenção Primária

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)The objective of this study was to identify the association between emotional distress and social support networks with quality of life in primary care patients. This was a cross-sectional study involving 1,466 patients in the cities of São Paulo and Rio de Janeiro, Brazil, in 2009/2010. The General Health Questionnaire, the Hospital Anxiety and Depression Scale and the brief version of the World Health Organization Quality of Life Instrument were used. The Social Support Network Index classified patients with the highest and lowest index as socially integrated or isolated. A bivariate analysis and four multiple linear regressions were conducted for each quality of life outcome. The means scores for the physical, psychological, social relations, and environment domains were, respectively, 64.7; 64.2; 68.5 and 49.1. In the multivariate analysis, the psychological domain was negatively associated with isolation, whereas the social relations and environment domains were positively associated with integration. Integration and isolation proved to be important factors for those in emotional distress as they minimize or maximize negative effects on quality of life. © 2016, Fundacao Oswaldo Cruz. All rights reserved.3212CNPq, Conselho Nacional de Desenvolvimento Científico e TecnológicoConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Orbital structure of the GJ876 extrasolar planetary system, based on the latest Keck and HARPS radial velocity data

We use full available array of radial velocity data, including recently published HARPS and Keck observatory sets, to characterize the orbital configuration of the planetary system orbiting GJ876. First, we propose and describe in detail a fast method to fit perturbed orbital configuration, based on the integration of the sensitivity equations inferred by the equations of the original $N$-body problem. Further, we find that it is unsatisfactory to treat the available radial velocity data for GJ876 in the traditional white noise model, because the actual noise appears autocorrelated (and demonstrates non-white frequency spectrum). The time scale of this correlation is about a few days, and the contribution of the correlated noise is about 2 m/s (i.e., similar to the level of internal errors in the Keck data). We propose a variation of the maximum-likelihood algorithm to estimate the orbital configuration of the system, taking into account the red noise effects. We show, in particular, that the non-zero orbital eccentricity of the innermost planet \emph{d}, obtained in previous studies, is likely a result of misinterpreted red noise in the data. In addition to offsets in some orbital parameters, the red noise also makes the fit uncertainties systematically underestimated (while they are treated in the traditional white noise model). Also, we show that the orbital eccentricity of the outermost planet is actually ill-determined, although bounded by $\sim 0.2$. Finally, we investigate possible orbital non-coplanarity of the system, and limit the mutual inclination between the planets \emph{b} and \emph{c} orbits by $5^\circ-15^\circ$, depending on the angular position of the mutual orbital nodes.Comment: 36 pages, 11 figures, 3 tables; Accepted to Celestial Mechanics and Dynamical Astronom

Survival, Mortality, Causes and Places of Death in a European Huntington's Disease Prospective Cohort

Neurological Motor Disorder

Against all odds? Forming the planet of the HD196885 binary

HD196885Ab is the most "extreme" planet-in-a-binary discovered to date, whose orbit places it at the limit for orbital stability. The presence of a planet in such a highly perturbed region poses a clear challenge to planet-formation scenarios. We investigate this issue by focusing on the planet-formation stage that is arguably the most sensitive to binary perturbations: the mutual accretion of kilometre-sized planetesimals. To this effect we numerically estimate the impact velocities $dv$ amongst a population of circumprimary planetesimals. We find that most of the circumprimary disc is strongly hostile to planetesimal accretion, especially the region around 2.6AU (the planet's location) where binary perturbations induce planetesimal-shattering $dv$ of more than 1km/s. Possible solutions to the paradox of having a planet in such accretion-hostile regions are 1) that initial planetesimals were very big, at least 250km, 2) that the binary had an initial orbit at least twice the present one, and was later compacted due to early stellar encounters, 3) that planetesimals did not grow by mutual impacts but by sweeping of dust (the "snowball" growth mode identified by Xie et al., 2010b), or 4) that HD196885Ab was formed not by core-accretion but by the concurent disc instability mechanism. All of these 4 scenarios remain however highly conjectural.Comment: accepted for publication by Celestial Mechanics and Dynamical Astronomy (Special issue on EXOPLANETS

Density functional method for nonequilibrium electron transport

We describe an ab initio method for calculating the electronic structure, electronic transport, and forces acting on the atoms, for atomic scale systems connected to semi-infinite electrodes and with an applied voltage bias. Our method is based on the density functional theory (DFT) as implemented in the well tested Siesta approach (which uses non-local norm-conserving pseudopotentials to describe the effect of the core electrons, and linear combination of finite-range numerical atomic orbitals to describe the valence states). We fully deal with the atomistic structure of the whole system, treating both the contact and the electrodes on the same footing. The effect of the finite bias (including selfconsistency and the solution of the electrostatic problem) is taken into account using nonequilibrium Green's functions. We relate the nonequilibrium Green's function expressions to the more transparent scheme involving the scattering states. As an illustration, the method is applied to three systems where we are able to compare our results to earlier ab initio DFT calculations or experiments, and we point out differences between this method and existing schemes. The systems considered are: (1) single atom carbon wires connected to aluminum electrodes with extended or finite cross section, (2) single atom gold wires, and finally (3) large carbon nanotube systems with point defects.Comment: 18 pages, 23 figure

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02