615 research outputs found
Short Telomeres in Hatchling Snakes: Erythrocyte Telomere Dynamics and Longevity in Tropical Pythons
- Author
- A Benetos
- A Pauliny
- AM Bronikowski
- Beata Ujvari
- CB Harley
- CB Harley
- CE Finch
- CM Martin-Ruiz
- CW Greider
- EH Blackburn
- H Cogger
- J Karlseder
- J Meyne
- J Sambrook
- K Matsubara
- K Okuda
- ME Hall
- MF Hausmann
- MF Hausmann
- MF Hausmann
- RA Miller
- RH Cawthon
- Robert C. Fleischer
- S Jemielity
- S Kyo
- T Madsen
- T Madsen
- TBL Kirkwood
- Thomas Madsen
- TS Nawrot
- W Klapper
- Y Michikawa
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
Telomere length (TL) has been found to be associated with life span in birds and humans. However, other studies have demonstrated that TL does not affect survival among old humans. Furthermore, replicative senescence has been shown to be induced by changes in the protected status of the telomeres rather than the loss of TL. In the present study we explore whether age- and sex-specific telomere dynamics affect life span in a long-lived snake, the water python (Liasis fuscus)
Finland
- Author
- Publication venue
- Springer International Publishing AG
- Publication date
- 01/01/2020
- Field of study
Peer reviewe
A Prospective Assessment of Psychosocial Factors Among Bariatric Versus Non-bariatric Surgery Candidates
- Author
- AN Fabricatore
- AN Fabricatore
- AU Bauchowitz
- B MĂŒhlhans
- B Thonney
- CB Pull
- DB Sarwer
- GC Hout van
- GE Simon
- GL Blackburn
- HP Santry
- I Greenberg
- JF Kinzl
- LE Bocchieri
- LE Bocchieri-Ricciardi
- MA Kalarchian
- MP Dymek
- MS Kaplan
- PJ Teixeira
- PJ Teixeira
- PR Sackett
- Raquel Friedman
- RR Wing
- S Herpertz
- S Walfish
- Sarah Adler
- SH Niego
- TA Wadden
- Thomas Rutledge
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
A human breast cancer model for the study of telomerase inhibitors based on a new biotinylated-primer extension assay
- Author
- AK Bednarek
- AM Burger
- B Fisher
- B Thompson
- B Windle
- C Chadeneau
- CB Harley
- CB Harley
- CB Harley
- CM Price
- CW Greider
- CW Greider
- D D Von Hoff
- D Gilley
- D Sun
- D Sun
- D Sun
- E Hiyama
- E Izbicka
- E Izbicka
- E Raymond
- E Raymond
- E Silvas
- EH Blackburn
- G Mangold
- H Soda
- I Faraoni
- J Plowman
- J-I Tsao
- JW Shay
- JW Shay
- JW Shay
- JW Shay
- JW Shay
- K Davidson
- KC Healy
- KR Prowse
- KR Prowse
- L Harrington
- M Piccart
- MZ Levy
- NW Kim
- PJ Vojta
- R Laurence
- RC Allsopp
- RT Wheelhouse
- S Marcand
- S Sharma
- S Sharma
- SE Holt
- T Ishibashi
- TM Bryan
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
How Humans Differ from Other Animals in Their Levels of Morphological Variation
- Author
- A Raychaudhuri
- A Schumacher
- AB Migliano
- AE Pusey
- Andrew P. Hendry
- Ann E. McKellar
- AR Templeton
- B Pawlowski
- BA Swinburn
- C Darwin
- CB Ruff
- CGN Mascie-Taylor
- CM Carmichael
- CN Stephan
- D Houle
- D Nettle
- D Nettle
- DN Nettle
- DS Falconer
- GH Perry
- H Lange
- I Dasgupta
- J Polivy
- J Sobal
- JA Endler
- JG Kingsolver
- JN Spuhler
- JW Peirce
- JZ Li
- K Ball
- K Donohue
- MD Shriver
- NA Rosenberg
- O Pascalis
- PT Katzmarzyk
- R Lande
- R Sear
- RA Fisher
- Rebecca Sear
- SJ Arnold
- T Bielicki
- TM Blackburn
- V Polo
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
Animal species come in many shapes and sizes, as do the individuals and populations that make up each species. To us, humans might seem to show particularly high levels of morphological variation, but perhaps this perception is simply based on enhanced recognition of individual conspecifics relative to individual heterospecifics. We here more objectively ask how humans compare to other animals in terms of body size variation. We quantitatively compare levels of variation in body length (height) and mass within and among 99 human populations and 848 animal populations (210 species). We find that humans show low levels of within-population body height variation in comparison to body length variation in other animals. Humans do not, however, show distinctive levels of within-population body mass variation, nor of among-population body height or mass variation. These results are consistent with the idea that natural and sexual selection have reduced human height variation within populations, while maintaining it among populations. We therefore hypothesize that humans have evolved on a rugged adaptive landscape with strong selection for body height optima that differ among locations
RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells
- Author
- A De Cian
- AJ Zaug
- AM Burger
- AM Zahler
- C Leonetti
- C Leonetti
- CB Harley
- CB Harley
- Chris OâCallaghan
- CL Grand
- CM Incles
- CO Marian
- D Gomez
- D Gomez
- D Hanahan
- E Salvati
- EH Blackburn
- EY Snyder
- G Pennarun
- H Tahara
- HE Williams
- I Horikawa
- I-Li Tan
- J Hu
- J Husby
- J Kim
- J Reed
- J-P Liu
- JC Cookson
- Jennifer H. Ward
- Joseph Najbauer
- JW Shay
- K Dorovinizis
- KJ Wu
- KP Patel
- M Ruden
- MA Blasco
- Malcolm F. G. Stevens
- MS Bobola
- P Castelo-Branco
- P Phatak
- Priya Radhakrishnan
- R Rahman
- RA Heald
- RA Hirst
- Richard G. Grundy
- Robert A. Hirst
- Ruman Rahman
- S Miller
- S Neidle
- SM Gowan
- SM Gowan
- Stuart J. Smith
- Sunil Lagah
- T Lemarteleur
- T Miyazaki
- T Shalaby
- T-M Ou
- TA Brooks
- V Gonzalez
- WC Hahn
- X Wu
- Y Pei
- ZG Dikmen
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 15/01/2014
- Field of study
Background
Telomeric 3â overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 ligands have been designed to directly disrupt telomeric structure.
Methods
We exposed brain tumor cells to the G4 ligand 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) and investigated proliferation, cell cycle dynamics, telomere length, telomerase activity and activated c-Myc levels.
Results
Although all cell lines tested were sensitive to RHPS4, PFSK-1 central nervous system primitive neuroectodermal cells, DAOY medulloblastoma cells and U87 glioblastoma cells exhibited up to 30-fold increased sensitivity compared to KNS42 glioblastoma, C6 glioma and Res196 ependymoma cells. An increased proportion of S-phase cells were observed in medulloblastoma and high grade glioma cells whilst CNS PNET cells showed an increased proportion of G1-phase cells. RHPS4-induced phenotypes were concomitant with telomerase inhibition, manifested in a telomere length-independent manner and not associated with activated c-Myc levels. However, anti-proliferative effects were also observed in normal neural/endothelial cells in vitro and ex vivo.
Conclusion
This study warrants in vivo validation of RHPS4 and alternative G4 ligands as potential anti-cancer agents for brain tumors but highlights the consideration of dose-limiting tissue toxicities
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at âs = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov AV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Arguin J-F
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Arslan O
- Artamonov A
- Artoni G
- Asai S
- Asbah N
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- Atlay NB
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Azuelos G
- Azuma Y
- Baak MA
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Badescua E
- Bagiacchi P
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
- Balli F
- Banas E
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- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
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- Bartsch V
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- Batley JR
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- Beauchemin PH
- Beccherle R
- Bechtle P
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- Beddall AJ
- Bedikian S
- Bednyakov VA
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- Beemster LJ
- Beermann TA
- Begel M
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- Belanger-Champagne C
- Belenguer MJ
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- Biglietti M
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- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
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- Boeriu OEV
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- Bogdanchikov AG
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- Chernyatin V
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- Childers JT
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- della Porta GZ
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- Etzion E
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- Favareto A
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- Fehling-Kaschek M
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- Filipcic A
- Filipcic A
- Filipuzzi M
- Filipuzzi M
- Filthaut F
- Filthaut F
- Fincke-Keeler M
- Fincke-Keeler M
- Finelli KD
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- Fiolhais MCN
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- Fiorini L
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- Firan A
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- Fischer J
- Fischer J
- Fisher MJ
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- Fitzgerald EA
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- Flechl M
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- Fleck I
- Fleck I
- Fleischmann P
- Fleischmann P
- Fleischmann S
- Fleischmann S
- Fletcher G
- Fletcher G
- Fletcher GT
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- Flick T
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- Floderus A
- Floderus A
- Florez Bustos AC
- Flowerdew MJ
- Flowerdew MJ
- Formica A
- Formica A
- Forti A
- Forti A
- Fortin D
- Fortin D
- Fournier D
- Fournier D
- Fox H
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- Francavilla P
- Francavilla P
- Franchini M
- Franchini M
- Franchino S
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- Francis D
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- Franklin M
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- Franz S
- Franz S
- Fraternali M
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- Fratin S
- Fratina S
- French ST
- French ST
- Friedrich C
- Friedrich C
- Friedrich F
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- Froidevaux D
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- Frost JA
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- Fukunaga C
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- Fulsom BG
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- Fuster J
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- Gabaldon C
- Gabizon O
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- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gabrielli A
- Gadatsch S
- Gadatsch S
- Gadomski S
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- Gagliardi G
- Gagliardi G
- Gagnon P
- Gagnon P
- Galea C
- Galea C
- Galhardo B
- Galhardo B
- Gallas EJ
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- Gallo V
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- Gallop BJ
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- Gallus P
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- Gandrajula RP
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- Gao J
- Gao YS
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- Gaob J
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- Garcia Navarro JE
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- Garcia C
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- Garcia JAB
- Garcia-Sciveres M
- Garcia-Sciveres M
- Gardner RW
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- Garelli N
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- Garonne V
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- Garrido MDMC
- Gatti C
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- Gaudio G
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- Gaur B
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- Gauthier L
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- Gauzzi P
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- Gavrilenko IL
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- Gay C
- Gay C
- Gaycken G
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- Gazis EN
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- Ge P
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- Gecse Z
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- Gee CNP
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- Geerts DAA
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- Geich-Gimbel C
- Geich-Gimbel C
- Gellerstedt K
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- Gemme C
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- Gemmell A
- Gemmell A
- Genest MH
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- Gentile S
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- George M
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- George S
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- Gerbaudo D
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- Gershon A
- Gershon A
- Ghazlane H
- Ghazlane H
- Ghodbane N
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- Giacobbe B
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- Giagu S
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- Giangiobbe V
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- Giannetti P
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- Gianotti F
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- Gibbard B
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- Gilchriese M
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- Gillberg D
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- Gillman AR
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- Gingrich DM
- Gingrich M
- Giokaris N
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- Giordani MP
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- Giordano R
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- Giorgi FM
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- Giugni D
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- Giuliani C
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- Giunta M
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- Gjelsten BK
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- Gorini B
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- Gorini E
- Gorini E
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- Gornicki E
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- Goshaw AT
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- Gostkin MI
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- Zeitnitz C
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- Zhemchugov A
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- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
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- Zimmermann S
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- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of âs = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentreâofâmassframeisusedtosuppressthelargemultiâjetbackground.ThecrossâsectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at sâ=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
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- Altheimer A
- Alviggi MG
- Amako K
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
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- Anduaga XS
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- Angelozzi I
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- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov AV
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- Arabidze G
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- Zurzolo G
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fbâ1 of protonâproton collision data at âs = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via tËâtÏË01 or tËâ bÏ˱1 âbW(â)ÏË01 , where ÏË01 (Ï˱1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of tË â tÏË01 . For a branching fraction of 100%, top squark masses in the range 270â645 GeV are excluded for ÏË01 masses below 30 GeV. For a branching fraction of 50% to either tË â tÏË01 or tË â bÏ˱1 , and assuming the Ï˱1 mass to be twice the ÏË01 mass, top squark masses in the range 250â550 GeV are excluded for ÏË01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at âs=8TeV
- Author
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- Zimmermann R
- Zimmermann S
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- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fbâ1of data collected in protonâproton collisions at âs=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis
- Author
- A Benetos
- A Smogorzewska
- Alison M. Dunning
- AM Joshua
- AM Valdes
- Amanda Ewart Toland
- BM Unryn
- CB Harley
- CM Raynaud
- EH Blackburn
- EH Blackburn
- ES Epel
- Göran Roos
- H der-Sarkissian
- H. Dean Hosgood
- HD Hosgood 3rd
- HJ Sommerfeld
- Hongxia Ma
- HR Kim
- HX An
- I De Vivo
- IK Moon
- IM Lee
- J Barwell
- J Han
- J Lau
- J Prescott
- J Shen
- J Shen
- J Xing
- JA Van Ziffle
- JP Higgins
- JS Jang
- K Broberg
- K Nordfjall
- KA Pooley
- Karen A. Pooley
- KK Wong
- L Fern
- L Hou
- L Mirabello
- L Mirabello
- L Shao
- LA Panossian
- M Baudis
- M Egger
- M Kammori
- M McGrath
- MA Blasco
- MA Blasco
- Min Shen
- MM Gramatges
- MT Hemann
- N Mantel
- NF Mathon
- PE Slagboom
- Q Lan
- Qingyi Wei
- R Capper
- R DerSimonian
- RA Risques
- RC Allsopp
- RY Zee
- S Brouilette
- SA Stewart
- SE Artandi
- SE Artandi
- Sheng Wei
- SM Gadalla
- SU Wiemann
- T Idei
- T von Zglinicki
- T von Zglinicki
- T von Zglinicki
- U Friedrich
- U Svenson
- Ulrika Svenson
- VG Gorgoulis
- X Liu
- X Wu
- Y Kinouchi
- YL Zheng
- Zhensheng Liu
- Ziyuan Zhou
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
BACKGROUND: Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting. METHODS: A dataset composed of 11,255 cases and 13,101 controls from 21 publications was included in a meta-analysis to evaluate the association between overall cancer risk or cancer-specific risk and the relative telomere length. Heterogeneity among studies and their publication bias were further assessed by the Ï(2)-based Q statistic test and Egger's test, respectively. RESULTS: The results showed that shorter telomeres were significantly associated with cancer risk (ORâ=â1.35, 95% CIâ=â1.14-1.60), compared with longer telomeres. In the stratified analysis by tumor type, the association remained significant in subgroups of bladder cancer (ORâ=â1.84, 95% CIâ=â1.38-2.44), lung cancer (ORâ=â2.39, 95% CIâ=â1.18-4.88), smoking-related cancers (ORâ=â2.25, 95% CIâ=â1.83-2.78), cancers in the digestive system (ORâ=â1.69, 95% CIâ=â1.53-1.87) and the urogenital system (ORâ=â1.73, 95% CIâ=â1.12-2.67). Furthermore, the results also indicated that the association between the relative telomere length and overall cancer risk was statistically significant in studies of Caucasian subjects, Asian subjects, retrospective designs, hospital-based controls and smaller sample sizes. Funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis (Pâ=â0.532). CONCLUSIONS: The results of this meta-analysis suggest that the presence of shortened telomeres may be a marker for susceptibility to human cancer, but single larger, well-design prospective studies are warranted to confirm these findings
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