The Brazilian Drug Information System - SISMED

This paper describes the professional profile of pharmacists as specialists in drug information. Drug Information (DI) and Drug Information Centers (DIC) are defined. The fundamental activity of a DIC should be that of providing passive information or answering questions. The advantage of a DIC network is discussed, and strategies to implement the Brazilian Drug Information System (SISMED) are presented: investment in professional specialization and regular meetings of DIC coordinators to exchange experiences. The different DICs work within a cooperative protocol. Four training courses have been held, resulting in the rapid development of Brazil's national DIC network. Two national meetings of DIC professionals have helped strengthen the Brazilian Drug Information System.Foram descritas as atividades do farmacêutico especialista em informação sobre medicamentos (IM) e caracterizados os Centros de Informação sobre Medicamentos (CIMs), deixando claro o que não são e o que são - mitos e fatos. Foram apresentadas as definições de IM e de CIMs e apresentadas as atividades usuais dos Centros, destacando a informação passiva como atividade fundamental. Foi apresentado o Sistema Brasileiro de Informação sobre Medicamentos (SISMED), uma rede de CIMs integrados através de um Protocolo de Cooperação que estabelece os requisitos mínimos para o funcionamento dos CIMs e os mecanismos de cooperação entre os Centros participantes. As estratégias para a formação do SISMED foram a capacitação de recursos humanos e encontros dos responsáveis pelos CIMs. O treinamento de recursos humanos através de quatro cursos, deu suporte à implantação rápida de CIMs pelo Brasil, preenchendo importante lacuna, e consolidando definitivamente esta atividade no país, dentro dos preceitos adotados mundialmente. Os encontros periódicos dos que trabalham nos CIMs fortaleceram os Centros, e consequentemente, o SISMED.1121112

Phylogeny of Diving Beetles Reveals a Coevolutionary Arms Race between the Sexes

BACKGROUND: Darwin illustrated his sexual selection theory with male and female morphology of diving beetles, but maintained a cooperative view of their interaction. Present theory suggests that instead sexual conflict should be a widespread evolutionary force driving both intersexual coevolutionary arms races and speciation. METHODOLOGY/PRINCIPAL FINDINGS: We combined Bayesian phylogenetics, complete taxon sampling and a multi-gene approach to test the arms race scenario on a robust diving beetle phylogeny. As predicted, suction cups in males and modified dorsal surfaces in females showed a pronounced coevolutionary pattern. The female dorsal modifications impair the attachment ability of male suction cups, but each antagonistic novelty in females corresponds to counter-differentiation of suction cups in males. CONCLUSIONS: A recently diverged sibling species pair in Japan is possibly one consequence of this arms race and we suggest that future studies on hypoxia might reveal the key to the extraordinary selection for female counter-adaptations in diving beetles

Avaliação e perspectivas da abordagem à conservação do patrimônio organístico no Brasil

Órgãos de tubos são construídos no Brasil, ou importados do exterior, desde as primeiras décadas do período colonial. Estes instrumentos, apesar de constituírem um conjunto relativamente exíguo, representam um testemunho histórico e musical de valor inestimável. No entanto, de um modo geral, encontram-se em condições precárias de funcionamento e, em parte, mais ou menos descaracterizados profundamente, quanto à sua estrutura e configuração original, às vezes em estado de abandono e, por incrível que pareça, ainda sujeitos ao risco de intervenções arbitrárias e desprovidas de bases técnicas e de preocupação histórica e musicológica. Neste artigo, busca-se percorrer o caminho que levou à atual situação e discutem-se os princípios e os critérios de processos de recuperação, manutenção e conservação preventiva desse patrimônio, partindo dos pressupostos do respeito à sua originalidade e do direito a restauros segundo os rigorosos cânones já definidos para objetos com plena condição de bem cultural, cujo reconhecimento para os órgãos de qualquer época deve ser urgentemente garantido.Pipe organs have been built in Brazil or imported from elsewhere since the very first decades of the colonial period. Albeit relatively small in number, such instruments have inestimable historical and musical value. Notwithstanding, they are generally in very poor working condition and some have lost much of their original structure and configuration; they are often found in a state of abandonment and, incredible as it may seem, still under the threat of arbitrary interventions performed with no technical expertise or any concern for their historical and musicological significance. This article is an effort to understand how this state of affairs came to be, and discusses principles and criteria for the restoration, maintenance and preventive conservation of this legacy, based on assumptions regarding its original conditions and entitlement to restoration in accordance with the stringent standards already set for artifacts that enjoy the full status of cultural assets, which should also be urgently granted to pipe organs of any time and age

Photoswitchable diacylglycerols enable optical control of protein kinase C.

Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs, which feature a photoswitchable acyl chain. The PhoDAGs are inactive in the dark and promote the translocation of proteins that feature C1 domains toward the plasma membrane upon a flash of UV-A light. This effect is quickly reversed after the termination of photostimulation or by irradiation with blue light, permitting the generation of oscillation patterns. Both protein kinase C and Munc13 can thus be put under optical control. PhoDAGs control vesicle release in excitable cells, such as mouse pancreatic islets and hippocampal neurons, and modulate synaptic transmission in Caenorhabditis elegans. As such, the PhoDAGs afford an unprecedented degree of spatiotemporal control and are broadly applicable tools to study DAG signaling

The human diabetes proteome project (HDPP): The 2014 update

Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.</p

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente