245 research outputs found
Development and AFM study of porous scaffolds for wound healing applications
An engineering approach to the development of biomaterials for promotion of wound healing emphasises the importance
of a well-controlled architecture and concentrates on optimisation of morphology and surface chemistry to stimulate
guidance of the cells within the wound environment. A series of three-dimensional porous scaffolds with 80–90% bulk porosity
and fully interconnected macropores were prepared from two biodegradable materials – cellulose acetate (CA) and poly (lacticco-glycolic
acid) (PLGA) through the phase inversion mechanism of formation. Surface morphology of obtained scaffolds
was determined using atomic force microscopy (AFM) in conjunction with optical microscopy. Scanning Electron Microscopy
(SEM) was applied to characterise scaffolds bulk morphology. Biocompatibility and biofunctionality of the prepared materials
were assessed through a systematic study of cell/material interactions using atomic force microscopy (AFM) methodologies together
with in vitro cellular assays. Preliminary data with human fibroblasts demonstrated a positive influence of both scaffolds
on cellular attachment and growth. The adhesion of cells on both biomaterials were quantified by AFM force measurements in
conjunction with a cell probe technique since, for the first time, a fibroblast probe has been successfully developed and optimal
conditions of immobilisation of the cells on the AFM cantilever have been experimentally determined
Adsorption of Superplasticizers on Model Powders: Temperature dependance, effect on Zeta Potential and Role of Chemical Structure
A mean-field kinetic lattice gas model of electrochemical cells
We develop Electrochemical Mean-Field Kinetic Equations (EMFKE) to simulate
electrochemical cells. We start from a microscopic lattice-gas model with
charged particles, and build mean-field kinetic equations following the lines
of earlier work for neutral particles. We include the Poisson equation to
account for the influence of the electric field on ion migration, and
oxido-reduction processes on the electrode surfaces to allow for growth and
dissolution. We confirm the viability of our approach by simulating (i) the
electrochemical equilibrium at flat electrodes, which displays the correct
charged double-layer, (ii) the growth kinetics of one-dimensional
electrochemical cells during growth and dissolution, and (iii) electrochemical
dendrites in two dimensions.Comment: 14 pages twocolumn, 17 figure
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy
We review HB stars in a broad astrophysical context, including both variable
and non-variable stars. A reassessment of the Oosterhoff dichotomy is
presented, which provides unprecedented detail regarding its origin and
systematics. We show that the Oosterhoff dichotomy and the distribution of
globular clusters (GCs) in the HB morphology-metallicity plane both exclude,
with high statistical significance, the possibility that the Galactic halo may
have formed from the accretion of dwarf galaxies resembling present-day Milky
Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the
second-parameter problem is presented. A technique is proposed to estimate the
HB types of extragalactic GCs on the basis of integrated far-UV photometry. The
relationship between the absolute V magnitude of the HB at the RR Lyrae level
and metallicity, as obtained on the basis of trigonometric parallax
measurements for the star RR Lyrae, is also revisited, giving a distance
modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are
studied. Finally, the conductive opacities used in evolutionary calculations of
low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and
Space Scienc
Terrestrial habitat requirements of nesting freshwater turtles
Because particular life history traits affect species vulnerability to development pressures, cross-species summaries of life history traits are useful for generating management guidelines. Conservation of aquatic turtles, many members of which are regionally or globally imperiled, requires knowing the extent of upland habitat used for nesting. Therefore, we compiled distances that nests and gravid females had been observed from wetlands. Based on records of \u3e 8000 nests and gravid female records compiled for 31 species in the United States and Canada, the distances that encompass 95% of nests vary dramatically among genera and populations, from just 8 m for Malaclemys to nearly 1400 m for Trachemys. Widths of core areas to encompass varying fractions of nesting populations (based on mean maxima across all genera) were estimated as: 50% coverage = 93 m, 75% = 154 m, 90% = 198 m, 95% = 232 m, 100% = 942 m. Approximately 6–98 m is required to encompass each consecutive 10% segment of a nesting population up to 90% coverage; thereafter, ca. 424 m is required to encompass the remaining 10%. Many genera require modest terrestrial areas (\u3c200 m zones) for 95% nest coverage (Actinemys, Apalone, Chelydra, Chrysemys, Clemmys, Glyptemys, Graptemys, Macrochelys, Malaclemys, Pseudemys, Sternotherus), whereas other genera require larger zones (Deirochelys, Emydoidea, Kinosternon, Trachemys). Our results represent planning targets for conserving sufficient areas of uplands around wetlands to ensure protection of turtle nesting sites, migrating adult female turtles, and dispersing turtle hatchlings
Bimanual Coordination and Corpus Callosum Microstructure in Young Adults with Traumatic Brain Injury: A Diffusion Tensor Imaging Study
Measurement of CP observables in B± → D(⁎)K± and B± → D(⁎)π± decays
Measurements of CP observables in B ± →D (⁎) K ± and B ± →D (⁎) π ± decays are presented, where D (⁎) indicates a neutral D or D ⁎ meson that is an admixture of D (⁎)0 and D¯ (⁎)0 states. Decays of the D ⁎ meson to the Dπ 0 and Dγ final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± π ∓ , K + K − and π + π − final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb −1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± →D ⁎ K ± and B ± →D ⁎ π ± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± →DK ± and B ± →Dπ ± decays is an update of previous LHCb measurements. The B ± →DK ± results are the most precise to date
Search for leptophobic Z ' bosons decaying into four-lepton final states in proton-proton collisions at root s=8 TeV
Peer reviewe
Search for black holes and other new phenomena in high-multiplicity final states in proton-proton collisions at root s=13 TeV
Peer reviewe
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