20 research outputs found
Percutaneous Management of a Long Saphenous Vein Graft Aneurysm: A Case Report and Review of Literature
Aneurysms of saphenous vein grafts are rare but can result in complications such as myocardial infarction or death. Percutaneous treatment has included a variety of approaches, including covered stents. Long aneurysms in saphenous vein grafts pose an additional challenge due to the lack of coronary covered stents with sufficient length. We present successful treatment of a long saphenous vein graft aneurysm with use of peripheral covered stents over two coronary guidewires, a 55-centimeter 8-French sheath and no guide catheter
The first gamma-ray outburst of a Narrow-Line Seyfert 1 Galaxy: the case of PMN J0948+0022 in July 2010
We report on a multiwavelength campaign on the radio-loud Narrow-Line Seyfert
1 (NLS1) Galaxy PMN J0948+0022 (z=0.5846) performed in 2010 July-September and
triggered by a high-energy gamma-ray outburst observed by the Large Area
Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope. The peak flux in
the 0.1-100 GeV energy band exceeded, for the first time in this type of
source, the value of 10^-6 ph cm^-2 s^-1, corresponding to an observed
luminosity of 10^48 erg s^-1. Although the source was too close to the Sun
position to organize a densely sampled follow-up, it was possible to gather
some multiwavelength data that confirmed the state of high activity across the
sampled electromagnetic spectrum. The comparison of the spectral energy
distribution of the NLS1 PMN J0948+0022 with that of a typical blazar - like 3C
273 - shows that the power emitted at gamma rays is extreme.Comment: 8 pages, 7 figures, 2 tables. Accepted for the publication on MNRAS
Main Journal. Typo in bibliography correcte
Unprecedented study of the broadband emission of Mrk 421 during flaring activity in March 2010
A flare from the TeV blazar Mrk 421, occurring in March 2010, was observed
for 13 consecutive days from radio to very high energy (VHE, E > 100 GeV)
gamma-rays with MAGIC, VERITAS, Whipple, FermiLAT, MAXI, RXTE, Swift,
GASP-WEBT, and several optical and radio telescopes. We model the day-scale
SEDs with one-zone and two-zone synchrotron self-Compton (SSC) models,
investigate the physical parameters, and evaluate whether the observed
broadband SED variability can be associated to variations in the relativistic
particle population.
Flux variability was remarkable in the X-ray and VHE bands while it was minor
or not significant in the other bands. The one-zone SSC model can describe
reasonably well the SED of each day for the 13 consecutive days. This flaring
activity is also very well described by a two-zone SSC model, where one zone is
responsible for the quiescent emission while the other smaller zone, which is
spatially separated from the first one, contributes to the daily-variable
emission occurring in X-rays and VHE gamma-rays.
Both the one-zone SSC and the two-zone SSC models can describe the daily SEDs
via the variation of only four or five model parameters, under the hypothesis
that the variability is associated mostly to the underlying particle
population. This shows that the particle acceleration and cooling mechanism
producing the radiating particles could be the main one responsible for the
broadband SED variations during the flaring episodes in blazars. The two-zone
SSC model provides a better agreement to the observed SED at the narrow peaks
of the low- and high-energy bumps during the highest activity, although the
reported one-zone SSC model could be further improved by the variation of the
parameters related to the emitting region itself (, and ), in
addition to the parameters related to the particle population.Comment: Published in A&A, 30 pages, 15 figures, 6 tables. Online-data:
multi-wavelength light curves (data in Fig. 1) and broadband spectral energy
distributions (the data in Figs. 6, and B1-B4) are available at the CDS via
anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via
http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/578/A22. Corresponding authors:
David Paneque ([email protected]), Shangyu Sun ([email protected]), Hajime
Takami ([email protected]
Multi-system neurological disease is common in patients with OPA1 mutations
Additional neurological features have recently been described in seven families transmitting pathogenic mutations in OPA1, the most common cause of autosomal dominant optic atrophy. However, the frequency of these syndromal 'dominant optic atrophy plus' variants and the extent of neurological involvement have not been established. In this large multi-centre study of 104 patients from 45 independent families, including 60 new cases, we show that extra-ocular neurological complications are common in OPA1 disease, and affect up to 20% of all mutational carriers. Bilateral sensorineural deafness beginning in late childhood and early adulthood was a prominent manifestation, followed by a combination of ataxia, myopathy, peripheral neuropathy and progressive external ophthalmoplegia from the third decade of life onwards. We also identified novel clinical presentations with spastic paraparesis mimicking hereditary spastic paraplegia, and a multiple sclerosis-like illness. In contrast to initial reports, multi-system neurological disease was associated with all mutational subtypes, although there was an increased risk with missense mutations [odds ratio = 3.06, 95% confidence interval = 1.44-6.49; P = 0.0027], and mutations located within the guanosine triphosphate-ase region (odds ratio = 2.29, 95% confidence interval = 1.08-4.82; P = 0.0271). Histochemical and molecular characterization of skeletal muscle biopsies revealed the presence of cytochrome c oxidase-deficient fibres and multiple mitochondrial DNA deletions in the majority of patients harbouring OPA1 mutations, even in those with isolated optic nerve involvement. However, the cytochrome c oxidase-deficient load was over four times higher in the dominant optic atrophy + group compared to the pure optic neuropathy group, implicating a causal role for these secondary mitochondrial DNA defects in disease pathophysiology. Individuals with dominant optic atrophy plus phenotypes also had significantly worse visual outcomes, and careful surveillance is therefore mandatory to optimize the detection and management of neurological disability in a group of patients who already have significant visual impairment
A global experiment on motivating social distancing during the COVID-19 pandemic
Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on oneâs core values) or behavioral intentions. Results supported hypothesized associations between peopleâs existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges
Insights into the high-energy Îł-ray emission of Markarian 501 from extensive multifrequency observations in the Fermi era
We report on the Îł-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) Îł-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 ± 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 ± 0.14, and the softest one is 2.51 ± 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size âČ0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (â1044 erg s-1) constitutes only a small fraction (âŒ10-3) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude. © 2011. The American Astronomical Society
The simultaneous low state spectral energy distribution of 1ES 2344+514 from radio to very high energies
Context. BL Lacertae objects are variable at all energy bands on time scales down to minutes. To construct and interpret their spectral energy distribution (SED), simultaneous broad-band observations are mandatory. Up to now, the number of objects studied during such campaigns is very limited and biased towards high flux states. Aims. We present the results of a dedicated multi-wavelength study of the high-frequency peaked BL Lacertae (HBL) object and known TeV emitter 1ES 2344+514 by means of a pre-organised campaign. Methods. The observations were conducted during simultaneous visibility windows of MAGIC and AGILE in late 2008. The measurements were complemented by Mets hovi, RATAN-600, KVA+Tuorla, Swift and VLBA pointings. Additional coverage was provided by the ongoing long-term F-GAMMA and MOJAVE programs, the OVRO 40-m and CrAO telescopes as well as the Fermi satellite. The obtained SEDs are modelled using a one-zone as well as a self-consistent two-zone synchrotron self-Compton model. Results. 1ES 2344+514 was found at very low flux states in both X-rays and very high energy gamma rays. Variability was detected in the low frequency radio and X-ray bands only, where for the latter a small flare was observed. The X-ray flare was possibly caused by shock acceleration characterised by similar cooling and acceleration time scales. MOJAVE VLBA monitoring reveals a static jet whose components are stable over time scales of eleven years, contrary to previous findings. There appears to be no significant correlation between the 15 GHz and R-band monitoring light curves. The observations presented here constitute the first multi-wavelength campaign on 1ES 2344+514 from radio to VHE energies and one of the few simultaneous SEDs during low activity states. The quasi-simultaneous Fermi-LAT data poses some challenges for SED modelling, but in general the SEDs are described well by both applied models. The resulting parameters are typical for TeV emitting HBLs. Consequently it remains unclear whether a so-called quiescent state was found in this campaign