Management reference for nature reserve networks based on MaxEnt modeling and gap analysis: a case study of the brown–eared pheasant in China

Referencia para la gestión de las redes de reservas naturales basada en la creación de modelos MaxEnt y el análisis de deficiencias: un estudio del faisán orejudo pardo en China La planificación de reservas naturales y la creación de redes son importantes para la conservación de los hábitats y la fauna silvestre. Los análisis de las deficiencias son instrumentos eficientes y fiables para establecer un orden de prioridad entre las iniciativas de conservación de hábitats, en especial por lo que respecta a las especies en peligro de extinción. Proponemos un plan de conservación para el faisán orejudo pardo, Crossoptilon mantchuricum, mediante la determinación de las zonas con una protección insuficiente en las 14  reservas naturales existentes. En total, se seleccionaron 45  localidades y 11  variables ambientales en función de las características del uso del hábitat del faisán orejudo pardo, y se utilizó un modelo de máxima entropía (MaxEnt) para obtener la distribución de la especie. Los resultados del modelo MaxEnt mostraron una elevada precisión de predicción. Los resultados del análisis de las deficiencias revelaron que en las montañas Luliang, en Shanxi, y las montañasXiaowutai, en Hebei, la protección era insuficiente. Encontramos 458  km2 de hábitat óptimo y 1.390  km2 de hábitat moderadamente adecuado dentro de los límites de la reserva natural nacional. No obstante, casi 1.861  km2 del hábitat óptimo y 17.035  km2 del hábitat moderadamente adecuado no estaban protegidos, lo que equivale al 9,0% y el 82,1%, respectivamente, del hábitat adecuado total. La mayor parte de la superficie sin protección estaba formada por hábitat moderadamente adecuado para el faisán orejudo pardo y debería considerarse prioritaria en las iniciativas futuras de conservación. Hay nueve reservas naturales a lo largo de un eje norte–sur en las montañas Luliang que forma un pasillo ecológico. Para mantener la integridad, originalidad y continuidad de estos hábitats y, por tanto, proteger el faisán orejudo pardo, deberían reforzarse los departamentos locales de conservación con miras a mejorar la gestión de la reserva natural a escala provincial y poner en práctica eficazmente las iniciativas de conservación.Referencia para la gestión de las redes de reservas naturales basada en la creación de modelos MaxEnt y el análisis de deficiencias: un estudio del faisán orejudo pardo en China La planificación de reservas naturales y la creación de redes son importantes para la conservación de los hábitats y la fauna silvestre. Los análisis de las deficiencias son instrumentos eficientes y fiables para establecer un orden de prioridad entre las iniciativas de conservación de hábitats, en especial por lo que respecta a las especies en peligro de extinción. Proponemos un plan de conservación para el faisán orejudo pardo, Crossoptilon mantchuricum, mediante la determinación de las zonas con una protección insuficiente en las 14  reservas naturales existentes. En total, se seleccionaron 45  localidades y 11  variables ambientales en función de las características del uso del hábitat del faisán orejudo pardo, y se utilizó un modelo de máxima entropía (MaxEnt) para obtener la distribución de la especie. Los resultados del modelo MaxEnt mostraron una elevada precisión de predicción. Los resultados del análisis de las deficiencias revelaron que en las montañas Luliang, en Shanxi, y las montañasXiaowutai, en Hebei, la protección era insuficiente. Encontramos 458  km2 de hábitat óptimo y 1.390  km2 de hábitat moderadamente adecuado dentro de los límites de la reserva natural nacional. No obstante, casi 1.861  km2 del hábitat óptimo y 17.035  km2 del hábitat moderadamente adecuado no estaban protegidos, lo que equivale al 9,0% y el 82,1%, respectivamente, del hábitat adecuado total. La mayor parte de la superficie sin protección estaba formada por hábitat moderadamente adecuado para el faisán orejudo pardo y debería considerarse prioritaria en las iniciativas futuras de conservación. Hay nueve reservas naturales a lo largo de un eje norte–sur en las montañas Luliang que forma un pasillo ecológico. Para mantener la integridad, originalidad y continuidad de estos hábitats y, por tanto, proteger el faisán orejudo pardo, deberían reforzarse los departamentos locales de conservación con miras a mejorar la gestión de la reserva natural a escala provincial y poner en práctica eficazmente las iniciativas de conservación.Nature reserve designs and networks are important for wildlife and habitat conservation. Gap analyses are efficient and reliable tools for prioritizing habitat conservation efforts, especially when considering endangered species. We propose a conservation plan for the brown–eared pheasant, Crossoptilon mantchuricum, by identifying protection gap areas based on 14 existing nature reserves. A total of 45 locality sites and 11 environmental variables were selected according to the characteristics of habitat use of the brown–eared pheasant and applied to a maximum entropy (MaxEnt) model to obtain the species distribution. The MaxEnt model results showed a high prediction accuracy. The gap analysis results revealed that the Luliang Mountains in Shanxi and the Xiaowutai Mountains in Hebei had protection gaps. We found 458 km2 of optimum habitat and 1,390 km2 of moderately suitable habitat within the national nature reserve range. However, almost 1,861 km2 of the optimum habitat and 17,035 km2 of the moderately suitable habitat were unprotected, equivalent to 9.0% and 82.1%, respectively, of the total suitable habitat. Most of the unprotected area comprised moderately suitable habitat for brown–eared pheasant and should be prioritized in future conservation efforts. There are nine nature reserves along a north–to–south range in the Luliang Mountains that form a wildlife habitat corridor. To maintain the integrity, originality, and continuity of these habitats and thus protect brown–eared pheasants, local conservation departments should be strengthened to improve provincial nature reserve management and successfully carry out conservation efforts

AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer

The receptor tyrosine kinase AXL promotes migration, invasion, and metastasis. Here, we evaluated the role of AXL in endometrial cancer. High immunohistochemical expression of AXL was found in 76% (63/83) of advanced-stage, and 77% (82/107) of high-grade specimens and correlated with worse survival in uterine serous cancer patients. In vitro, genetic silencing of AXL inhibited migration and invasion but had no effect on proliferation of ARK1 endometrial cancer cells. AXL-deficient cells showed significantly decreased expression of phospho-AKT as well as uPA, MMP-1, MMP-2, MMP-3, and MMP-9. In a xenograft model of human uterine serous carcinoma with AXL-deficient ARK1 cells, there was significantly less tumor burden than xenografts with control ARK1 cells. Together, these findings underscore the therapeutic potentials of AXL as a candidate target for treatment of metastatic endometrial cancer

Dissecting Sources of Quantitative Gene Expression Pattern Divergence Between Drosophila Species

The function of a transcriptional circuit is compared in three closely related species of Drosophila. Using quantitative imaging of gene expression, targeted transgenic reporter fly lines, and a computational framework, the sources of their differing expression outputs are identified

Continuous Processing and Efficient in Situ\textit{in Situ} Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy

Real-time NMR spectroscopy has proven to be a rapid and an effective monitoring tool to study the hypervalent iodine(III) mediated cyclopropanation. With the ever increasing number of new synthetic methods for carbon−carbon bond formation, the NMR $\textit{in situ}$ monitoring of reactions is becoming a highly desirable enabling method. In this study, we have demonstrated the versatility of benchtop NMR using inline and online real-time monitoring methods to access mutually complementary information for process understanding, and we developed new approaches for real-time monitoring addressing challenges associated with better integration into continuous processes.University of Cambridge (Daphne Jackson Fellowship), iCON through CMAC (Grant ID: RG74817), Engineering and Physical Sciences Research Council (Critical Mass grant (Grant ID: EP/K009494K/1), Core Capability grant (Grant ID: EP/K039520/1

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Search for direct stau production in events with two hadronic tau-leptons in root s=13 TeV pp collisions with the ATLAS detector

A search for the direct production of the supersymmetric partners ofτ-leptons (staus) in final stateswith two hadronically decayingτ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of139fb−1, recorded with the ATLAS detector at the LargeHadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected StandardModel background is observed. Limits are derived in scenarios of direct production of stau pairs with eachstau decaying into the stable lightest neutralino and oneτ-lepton in simplified models where the two staumass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidencelevel for a massless lightest neutralino

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Women's leadership in the Asian Century: does expansion mean inclusion?

This paper draws on British Council commissioned research in response to concerns about women's absence from senior leadership positions in higher education in South Asia. The study sought existing knowledge from literature, policies, and available statistics and collected original interview data from 30 academics in Afghanistan, Bangladesh, India, Nepal, Pakistan, and Sri Lanka. A central finding was that gender is not a category of analysis in higher education policy, research or statistical data in the region. Our interview data suggest that leadership was frequently not an object of desire for women. Being associated with particular types of masculinities, leadership often carried a heavy affective load for those women who transgressed patriarchal socio-cultural norms and disrupted the symbolic order of women being led by men. Leadership was frequently perceived and experienced by women in terms of navigating a range of ugly feelings and toxicities that depleted aspirations, well-being and opportunities

Epidemiosurveillance of Brucella infection in humans, non-ruminants and wildlife from Pakistan perspective (2000-2020)

ΔΕΝ ΔΙΑΤΙΘΕΤΑΙ ΠΕΡΙΛΗΨΗThis review aimed at providing an overview of the prevalence and epidemiosurveillance of brucellosis in non-ruminants and humans in Pakistan during 2000-2020. Sero-prevalence of brucellosis has been reported in non-ruminants such as camels, equines, dogs and humans with the range of 0.5-21%, 16.23-62.6%, 9.2-63.8% and 2.0-70% respectively. Non-target species like Avian, reptiles and amphibians were also reported with the prevalence of 2.5%, 24.9% and 25% respectively. Ignorance and indifference make it endemic in ruminants and much-neglected disease in non-ruminants with less or no studies reported in canines. Vaccines are available and being used for ruminants while none is available for non-ruminants, which may serve as an important source of spreading disease in animals and humans. In Pakistan, it is considered as ignored disease in non-ruminants lacking effective policies for control and eradication. This review guides policymakers to draw guidelines regarding brucellosis control and eradication using one health approach