Epidermal Inclusion Cyst Presenting as a Palpable Scrotal Mass

We report a scrotal epidermal inclusion cyst located outside the median raphe which a rare entity in the absence of trauma and few cases have been reported. 47 year old male presents with a complaint of right sided testicular swelling and discomfort. On examination a 3 cm mass was palpated between the scrotum and the medial thigh on the subcutaneous tissue with a positive slip sign. Complete surgical excision of the cyst was performed. Histopathology confirmed epidermal inclusion cyst with no evidence of malignancy

On Exploring Proactive Cloud Elasticity for Internet of Things Demands

Today, Internet of Things (IoT) is an emergent concept in which billions of devices are connected to Internet capable of producing and exchanging data. One of the most used technologies in this area regards to the Radio Frequency Identification (RFID). It can produce large amount of data from many things like objects, persons and assets. Thus, it is needed middlewares which must support processing in large scales. However, the state-of-the-art does not present satisfactory solutions in which this kind of middlewares are capable of adapt themselves according to processing demands. In this context, this article presents a proactive cloud elasticity model called Proliot aiming at providing scalability to IoT middlewares. Proliot is capable of predicting load behavior combining time series techniques. In addition, it adapts cloud resources beforehand an overload or underload situation occurs. We evaluated our model comparing results with a reactive elasticity model. In our experiments, Proliot achieved best performance up to 76% when compared to Eliot.Sociedad Argentina de Informática e Investigación Operativa (SADIO

On Exploring Proactive Cloud Elasticity for Internet of Things Demands

Today, Internet of Things (IoT) is an emergent concept in which billions of devices are connected to Internet capable of producing and exchanging data. One of the most used technologies in this area regards to the Radio Frequency Identification (RFID). It can produce large amount of data from many things like objects, persons and assets. Thus, it is needed middlewares which must support processing in large scales. However, the state-of-the-art does not present satisfactory solutions in which this kind of middlewares are capable of adapt themselves according to processing demands. In this context, this article presents a proactive cloud elasticity model called Proliot aiming at providing scalability to IoT middlewares. Proliot is capable of predicting load behavior combining time series techniques. In addition, it adapts cloud resources beforehand an overload or underload situation occurs. We evaluated our model comparing results with a reactive elasticity model. In our experiments, Proliot achieved best performance up to 76% when compared to Eliot.Sociedad Argentina de Informática e Investigación Operativa (SADIO

On Exploring Proactive Cloud Elasticity for Internet of Things Demands

Today, Internet of Things (IoT) is an emergent concept in which billions of devices are connected to Internet capable of producing and exchanging data. One of the most used technologies in this area regards to the Radio Frequency Identification (RFID). It can produce large amount of data from many things like objects, persons and assets. Thus, it is needed middlewares which must support processing in large scales. However, the state-of-the-art does not present satisfactory solutions in which this kind of middlewares are capable of adapt themselves according to processing demands. In this context, this article presents a proactive cloud elasticity model called Proliot aiming at providing scalability to IoT middlewares. Proliot is capable of predicting load behavior combining time series techniques. In addition, it adapts cloud resources beforehand an overload or underload situation occurs. We evaluated our model comparing results with a reactive elasticity model. In our experiments, Proliot achieved best performance up to 76% when compared to Eliot.Sociedad Argentina de Informática e Investigación Operativa (SADIO

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss

Hearing loss is one of the top contributors to years lived with disability and is a risk factor for dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported hearing impairment on 723,266 individuals and identified 48 significant loci, 10 of which are novel. A large proportion of associations comprised missense variants, half of which lie within known familial hearing loss loci. We used single-cell RNA-sequencing data from mouse cochlea and brain and mapped common-variant genomic results to spindle, root, and basal cells from the stria vascularis, a structure in the cochlea necessary for normal hearing. Our findings indicate the importance of the stria vascularis in the mechanism of hearing impairment, providing future paths for developing targets for therapeutic intervention in hearing loss

Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota

Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk

Measurement of vector boson scattering and constraints on anomalous quartic couplings from events with four leptons and two jets in proton-proton collisions at root s=13 TeV

Peer reviewe

Search for pair-produced resonances decaying to jet pairs in proton-proton collisions at √s=8 TeV

Results are reported of a general search for pair production of heavy resonances decaying to pairs of hadronic jets in events with at least four jets. The study is based on up to 19.4 fb(-1) of integrated luminosity from proton-proton collisions at a center-of-mass energy of 8 TeV, recorded with the CMS detector at the LHC. Limits are determined on the production of scalar top quarks (top squarks) in the framework of R-parity violating supersymmetry and on the production of color-octet vector bosons (colorons). First limits at the LHC are placed on top squark production for two scenarios. The first assumes decay to a bottom quark and a light-flavor quark and is excluded for masses between 200 and 385 GeV, and the second assumes decay to a pair of light-flavor quarks and is excluded for masses between 200 and 350 GeV at 95% confidence level. Previous limits on colorons decaying to light-flavor quarks are extended to exclude masses from 200 to 835 GeV

Search for a light pseudoscalar Higgs boson produced in association with bottom quarks in pp collisions at root s=8 TeV

Peer reviewe