101 research outputs found
Prediction of Associations between microRNAs and Gene Expression in Glioma Biology
- Author
- A Krek
- A Legesse-Miller
- A Li
- A Subramanian
- Aiguo Li
- AJ Enright
- Alice Zhang
- B Kefas
- B Kefas
- BP Lewis
- C Li
- CF Schaefer
- CM Croce
- CZ Chen
- D Arjona
- Dolores Arjona
- DP Bartel
- Dragan Maric
- E Iorns
- E van Rooij
- EC Lai
- EE Schmidt
- GA Calin
- H Ohgaki
- HB Houbaviy
- Howard A. Fine
- J Godlewski
- J Godlewski
- J Lee
- J Pierson
- J Qi
- J Silber
- J Zhang
- JA Chan
- Jean Claude Zenklusen
- Jennifer Walling
- JR Lytle
- L Breiman
- L He
- LF Sempere
- LL Parker
- M Lagos-Quintana
- M Lagos-Quintana
- M Lu
- N Rajewsky
- NJ Martinez
- P Gonzalez-Gomez
- P Kleihues
- Rachel Anolik
- RS Pillai
- S Griffiths-Jones
- S Sengupta
- SA Ciafre
- SE Mir
- Simon Rogers
- Stefan Wuchty
- Susie Ahn
- T Du
- TC Chang
- Y Benjamini
- Y Kotliarov
- Y Li
- Y Zhang
- Yuri Kotliarov
- Z Li
- Publication venue
- Public Library of Science
- Publication date
- 16/02/2011
- Field of study
Despite progress in the determination of miR interactions, their regulatory role in cancer is only beginning to be unraveled. Utilizing gene expression data from 27 glioblastoma samples we found that the mere knowledge of physical interactions between specific mRNAs and miRs can be used to determine associated regulatory interactions, allowing us to identify 626 associated interactions, involving 128 miRs that putatively modulate the expression of 246 mRNAs. Experimentally determining the expression of miRs, we found an over-representation of over(under)-expressed miRs with various predicted mRNA target sequences. Such significantly associated miRs that putatively bind over-expressed genes strongly tend to have binding sites nearby the 3′UTR of the corresponding mRNAs, suggesting that the presence of the miRs near the translation stop site may be a factor in their regulatory ability. Our analysis predicted a significant association between miR-128 and the protein kinase WEE1, which we subsequently validated experimentally by showing that the over-expression of the naturally under-expressed miR-128 in glioma cells resulted in the inhibition of WEE1 in glioblastoma cells
Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS
- Author
- A Abulencia
- A. A. Carter
- A. A. Grillo
- A. A. Komar
- A. A. Korol
- A. A. Minaenko
- A. A. Nepomuceno
- A. A. Snesarev
- A. A. Solodkov
- A. A. Talyshev
- A. Ahmad
- A. Aloisio
- A. Alonso
- A. Altheimer
- A. Amorim
- A. Andreazza
- A. Angerami
- A. Annovi
- A. Antonaki
- A. Antonov
- A. Artamonov
- A. Astbury
- A. B. Fenyuk
- A. Bangert
- A. Baroncelli
- A. Bassalat
- A. Basye
- A. Beddall
- A. Bellerive
- A. Belloni
- A. Bingul
- A. Bocci
- A. Bogouch
- A. Borisov
- A. Boveia
- A. Brandt
- A. Bruni
- A. Buzatu
- A. C. Bundock
- A. C. Daniells
- A. C. Florez Bustos
- A. C. König
- A. C. Martyniuk
- A. C. Schaffer
- A. Canepa
- A. Castelli
- A. Catinaccio
- A. Cattai
- A. Cerri
- A. Cervelli
- A. Chafaq
- A. Cheplakov
- A. Chilingarov
- A. Chitan
- A. Ciocio
- A. Clark
- A. Coccaro
- A. Corso-Radu
- A. Cortes-Gonzalez
- A. D. Hawkins
- A. D. Pilkington
- A. Dafinca
- A. De Salvo
- A. De Santo
- A. Dell’Acqua
- A. Demilly
- A. Dewhurst
- A. Di Ciaccio
- A. Di Domenico
- A. Di Girolamo
- A. Di Mattia
- A. Di Simone
- A. Do Valle Wemans
- A. Doria
- A. Dos Anjos
- A. Dotti
- A. Dudarev
- A. D’Orazio
- A. E. Barton
- A. E. Kiryunin
- A. E. Loevschall-Jensen
- A. Ereditato
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- A. Huettmann
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- Y. Ming
- Y. Munwes
- Y. Nagai
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Okumura
- Y. Oren
- Y. Pylypchenko
- Y. Rozen
- Y. S. Gao
- Y. Sakurai
- Y. Sasaki
- Y. Silver
- Y. Smirnov
- Y. Sugaya
- Y. Suzuki
- Y. Takahashi
- Y. Takubo
- Y. Tayalati
- Y. Unno
- Y. V. Grishkevich
- Y. Wu
- Y. Yamaguchi
- Y. Yamazaki
- Y. Yang
- Y. Yasu
- Y. Zhu
- Yu. A. Tikhonov
- Z. Czyczula
- Z. D. Greenwood
- Z. Dolezal
- Z. Gecse
- Z. H. Citron
- Z. Hajduk
- Z. Hubacek
- Z. J. Grout
- Z. Kohout
- Z. L. Ren
- Z. Liang
- Z. Marshall
- Z. Rurikova
- Z. V. Krumshteyn
- Z. Vykydal
- Z. Weng
- Z. Yan
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured
Measuring depression with CES-D in Chinese patients with type 2 diabetes: the validity and its comparison to PHQ-9
- Author
- A Demirchyan
- Alice P S Kong
- Andrea O Y Luk
- B Waitzfelder
- BH Hidaka
- CD Williams
- CK Cheung
- D Stahl
- DV Sheehan
- G Kim
- GT Ko
- Hairong Nan
- HJ Yang
- I Molosankwe
- JC Chan
- JC Chan
- Juliana C N Chan
- JW Chan
- K Kroenke
- K Milette
- KH Makambi
- L Manea
- LE Egede
- M Pompili
- Marco H B Lam
- MC Edwards
- ME Khamseh
- MJ Cho
- N Hermanns
- N Iwata
- Norman Sartorius
- PJ Lustman
- PM Lewinsohn
- Risa Ozaki
- Rose Z W Ting
- Roseanne O. Yeung
- Siu-Ping Lam
- ST Cheng
- TM Chen
- WY So
- X Yu
- Y Jang
- Y Zhang
- YL Wong
- Yun-Kwok Wing
- Yuying Zhang
- Z Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A.
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R.
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O.
- Ademuyiwa Adesoji O.
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O.
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
- Ahmed Lopna Ahmed Mohamed
- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
- Ajah Jonathan
- Ajai Olalekan
- Ajao Akinlabi
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- Akoto Elliot
- Akpenyi Onyinye
- Al Amin Shadid
- Al Attar Samaa Mahmoud
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- Al Bastawis Fatema
- Al Meligy Amgad
- Al Rafati Ahmad Abdel Razaq
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- Al Saied Ghiath
- Al Subaie Norah
- Al-Bahrani Ahmed
- Al-Buhaisi Alaa
- Al-Dakka Emad
- Al-faqawi Maha
- Al-farram Hadeel
- Al-khatib Ahmed
- Al-Marakby Dina
- Al-saqqa Sara
- Al-Saqqa Sara W.
- Al-Slaibi Ibrahim
- Al-taher Taher
- AlaaelDein Shahinaz
- Alada Muslimat
- Alakaloko Felix
- Alaloul Enas
- Alamin Shadid
- Alamoudi Mohammed
- Albiety Adel
- Alcca Ticona Willy
- Alejos Bermudez Ysabel Esthefany
- Alexander Philip
- Alexander Philip
- Alexandre Challine
- Alghamdi Ahmed
- Alghamdi Mohammed Saleh A.
- Alhady Khaled
- Alhammali Tariq
- Alhassan Basmah
- Alhazmi Wedyan
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- Ali Ahmed
- Ali Citra Dewi Mohd
- Ali Elsayed
- Ali Safia
- Ali Syed Abdul Wahhab Eusoffee Wan
- Ali Tebian Hassanein Ahmed
- Ali Wadah
- Alihonou Thierry
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- Amole Isaac
- Amreia Mahmoud
- Anderson Frank
- Andika Ferry Fitriya Ayu
- Andreotti Dario
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- Ang Yun Lin
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- Anis Echaieb
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- Anthoulakis Christos
- Antoniozzi Angelo
- Anwar Nourhan
- Anyanwu Lofty-John
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- Arslan Ekin
- Arsyad Hasbi Maulana
- Arthur Tom
- Aruldas Neerav
- Asar Yomna Hosny
- Asare-Bediako Kwasi
- Ashour Ahmad
- Ashour Ahmad
- Ashour Khlood
- Ashtari Morvarid
- Asi Fatema
- Asilah Siti Mohd Desa
- Assal Abdelrahman
- Asturias Sabrina
- Asumah Hamza
- Ata Ahmed
- Ata Aya Yehia
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- Augestad Knut Magne
- Aviles Susan
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- Aziz Dayang Nita Abdul
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- Azizeldine Mohammed G.
- Azzie Georges
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- Baba Suleiman
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- Bahar Suraya
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- Baquero Suarez Alibeth Andres
- Baraka Heba
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- Drake Thomas M.
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- Violi Paola
- Visinskas Petras
- Voulgaris Evangelos
- Wael Noha
- Wakefield Rebecca
- Waledziak Maciej
- Walker Michael
- Walker Nathan
- Walls Luke
- Walsh Michael
- Waqar Muhammad
- Warren Oliver
- Waterman Ade
- Werder Gabriela
- Whitaker John
- White Rebecca
- Whitehurst Katharine
- Wiborg Joachim
- Widiastini T. Ariani
- Widmer Lukas Werner
- Wijayarathna L. S.
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Wilson Michael
- Wimalge P. M. S. N.
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- Elsevier
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
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- A Allan
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- A Aspinwall
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- N Harris
- N Jacques
- N Keenan
- N Lancaster
- N Love
- N MacCallum
- N Michalak-Glinska
- N Motherwell
- N Muchenje
- N Nikitas
- N Pathan
- N Pattison
- N Proudfoot
- N Rea
- N Richardson
- N Rodden
- N Roe
- N Rogers
- N Runciman
- N Schumacher
- N Schunki
- N Slawson
- N Staines
- N Thomson
- N Truman
- N White
- Nichol Alistair
- Nicholas Parkinson
- Nicholas Price
- Nicky Day
- Nicola Picchiotti
- O Adanini
- O Akinkugbe
- O Ezeobu
- O Jones
- O Kelsall
- O Mercer
- O Mitchelmore
- O Olufuwa
- O Prysyazhna
- O Zongo
- Oosthuyzen Wilna
- Openshaw Peter J M
- P Alexander
- P Anderson
- P Bamford
- P Barry
- P Boyle
- P Clark
- P Coghlan
- P Doble
- P Donnison
- P Ebano
- P Gondo
- P Grant
- P Harding
- P Henderson
- P Hutton
- P Jackson
- P MacGoey
- P May
- P McConnell
- P Mercer
- P O'Brien
- P O'Neil
- P Parkinson
- P Parsons
- P Paul
- P Polgarova
- P Ranga
- P Rice
- P Rogers
- P Saunderson
- P Shanmugasundaram
- P Springle
- P Szedlak
- P Turner
- P Williams
- Pairo-Castineira Erola
- Pamela Raggi
- Paola Magro
- Paolo Cameli
- Paolo Piacentini
- Parkinson Nick
- Pasko Dorota
- Patrick Sulem
- Patrizia Zucchi
- Paul Finernan
- Paul Klenerman
- Pereira Alexandre C
- Peter W Horby
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pietro Pinoli
- Ponting Chris P
- Porteous David J
- R Astin-Chamberlain
- R Barber
- R Baruah
- R Bi
- R Bolton
- R Bowles
- R Boyle
- R Bradley
- R Campbell
- R Campbell
- R Chan
- R Charlesworth
- R Clark
- R Crawley
- R Crowe
- R Cusack
- R Davies
- R Doonan
- R Flanagan
- R Gascoyne
- R Girach
- R Gomez
- R Griffiths
- R Hall
- R Hamill
- R Haq
- R Harford
- R Harper
- R Herdman-Grant
- R Howle
- R Jacob
- R Jha
- R Johnson
- R Jones
- R Joy
- R Kanu
- R Kapoor
- R Kausar
- R Khade
- R Kitson
- R Kumar
- R Lean
- R Lim
- R Loosley
- R Lorusso
- R M Genetu
- R Marshall
- R O'Leary
- R Paramsothy
- R Parker
- R Partridge
- R Penn
- R Pepermans Saluzzio
- R Pollard
- R Price
- R Prout
- R Pugh
- R Raobaikady
- R Reece-Anthony
- R Rikunenko
- R Rojo
- R Saha
- R Sandhu
- R Shaw
- R Shokkar
- R Simms
- R Stead
- R Stewart
- R Sundaram
- R Tully
- R Tutton
- R Vincent
- R Walker
- R Wilcox
- R Wolf-Roberts
- R Worner
- R Wulandari
- Rachel Law
- Raffaele Scala
- Rawlik Konrad
- Renieri
- Renzo Scaggiante
- Richard Clark
- Richard S Tedder
- Richmond Anne
- Riinu Pius
- Rita Perna
- Roberta Russo
- Ross Hendry
- Rossella Tita
- Rowan Kathy
- Russell Clark D
- Ruth Armstrong
- Ruth Lyons
- Ryan S Thwaites
- S Agrawal
- S Allen
- S Allibone
- S Anderson
- S Archer
- S Bano
- S Bean
- S Beavis
- S Bell
- S Bennett
- S Benyon
- S Bird
- S Blowes
- S Board
- S Bonner
- S Brett
- S Buckley
- S Campos
- S Cathcart
- S Chapman
- S Charlton
- S Cherian
- S Chukkambotla
- S Clamp
- S Clark
- S Clements
- S Coetzee
- S Cole
- S Cornell
- S Cutler
- S Dale
- S Donlon
- S Farnell-Ward
- S Fowler
- S Garrioch
- S Gibson
- S Gopal
- S Greer
- S Gurung Rai
- S Henderson
- S Hierons
- S Hope
- S Humphreys
- S Hussain
- S Jenkins
- S Jhanji
- S Jones
- S Jose
- S Joseph
- S Kaul
- S Keenan
- S Keith
- S Kennedy-Hay
- S Kimber
- S Kumar
- S Laha
- S Latham
- S Leaver
- S Lee
- S Leggett
- S MacFadyen
- S Manna
- S Marriott
- S Masuko
- S McIvor
- S McKechnie
- S Melling
- S Mellor
- S Mepham
- S Metherell
- S Mitchard
- S Mohamed Ally
- S Monnery
- S Moore
- S Morrison
- S Moultrie
- S Mtuwa
- S Mulla
- S Munt
- S Murdoch
- S O'Sullivan
- S Packham
- S Patch
- S Pearson
- S Pitts
- S Preston
- S Purvis
- S Quaid
- S Ray
- S Roche
- S Rose
- S Rundell
- S Salmi
- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
- S Sousa Arias
- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma
- Author
- A Jemal
- A Li
- A Subramanian
- AD Panani
- Alice Yingting Wu
- AR Cachia
- AS Yustein
- B Lee
- B Vogelstein
- D Nijhawan
- DA Solomon
- G Tamura
- GH Zhao
- H Bengtsson
- H Bengtsson
- HH Hartgrink
- IB Tan
- Ioana Cutcutache
- J Barretina
- J Ferlay
- JC Lang
- John Richard McPherson
- JU Kang
- K Takahashi
- Khee Chee Soo
- KJ Purdie
- London Lucien Ooi
- M Baudis
- M Giefing
- M Rasmussen
- M Tada
- MG Rhyu
- MS Wu
- N Deng
- N Deng
- Niantao Deng
- NL Solimini
- P Loo Van
- P Muscarella
- P Nair
- PA Futreal
- Patrick Tan
- R Beroukhim
- R Beroukhim
- Roy Welsch
- S Tang
- S Uchino
- S Veeriah
- Shenli Zhang
- Steven G. Rozen
- T Kohno
- T Noguchi
- T Popova
- T Sano
- Wai Keong Wong
- WD Foulkes
- WE Johnson
- Weng Hoong Chan
- Y Nannya
- Y Wu
- Yuka Suzuki
- Z Lei
- Zhengdeng Lei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Virus genomes reveal factors that spread and sustained the Ebola epidemic.
- Author
- A Arias
- A Goba
- Adrianne Gladden-Young
- AJ Drummond
- AJ Drummond
- AK Rowe
- Amadou Sall
- Andreas Gnirke
- Andrew J. Tatem
- Andrew Rambaut
- Antonino Di Caro
- Armando Arias
- Augustine Goba
- B Abdoulaye
- B Diallo
- Bart L. Haagmans
- Bernice Dahn
- BL Bass
- Boubacar Diallo
- Brima Kargbo
- C Viboud
- Chantal B. Reusken
- Christian B. Matranga
- Christian T. Happi
- Christine M. Malboeuf
- Christophe Fraser
- CJ Edwards
- Daniel J. Park
- Danny Asogun
- David A. Matthews
- DG Bausch
- Dhamari Naidoo
- Di Liu
- DJ Blackley
- DJ Park
- Donald S. Grant
- E Simon-Loriere
- Edward C. Holmes
- Ekaete Alice Tobin
- Etienne Simon-Loriere
- F Bielejec
- Fatorma Bolay
- Filip Bielejec
- George F. Gao
- Georgios Pollakis
- Gustavo Palacios
- Guy Baele
- Gytis Dudas
- I Goodfellow
- Ian Goodfellow
- Isatta Wurie
- J Gardy
- J Quick
- J Truscott
- J-F Gélinas
- JA Carpenter
- James Qu
- Jason T. Ladner
- Jeffrey R. Kugelman
- Jens H. Kuhn
- JH Kuhn
- Jia Lu
- John S. Schieffelin
- Jonathan D’Ambrozio
- Joseph W. Diclaro
- Joshua Quick
- JR Kugelman
- JT Ladner
- Julian A. Hiscox
- K Katoh
- Kendra West
- Kilian Stoecker
- Kristian G. Andersen
- Lawrence S. Fakoli
- Lucy Thorne
- Luiz Max Carvalho
- Luke W. Meredith
- M Chan
- M Hasegawa
- MAR Ferreira
- Marc A. Suchard
- Mariano Sanchez-Lockhart
- Marion P. G. Koopmans
- Matthew Cotten
- MEJ Woolhouse
- Merle L. Gilbert
- Michael J. Elmore
- Michael R. Wiley
- Miles W. Carroll
- MJ Ferrari
- Mohamed A. Vandi
- MS Gill
- MW Carroll
- My V. T. Phan
- Nathan L. Yozwiak
- Nicholas J. Loman
- NL Yozwiak
- Nuno R. Faria
- N’Faly Magassouba
- OA Folarin
- Oliver G. Pybus
- Ousmane Faye
- P Lemey
- P Lemey
- P Rueda
- Pardis C. Sabeti
- Paul Kellam
- Philippe Lemey
- Pierre Formenty
- R Cattaneo
- R Fischer
- Rachel S. Sealfon
- Robert F. Garry
- Roman Wölfel
- S Baize
- Sahr M. Gevao
- Sakoba Keïta
- Sarah L. Caddy
- Sarah M. Winnicki
- Saskia L. Smits
- SE Mate
- Shannon Whitmer
- Shirlee Wohl
- Simon Dellicour
- Simon J. Watson
- SK Gire
- SL Smits
- SLM Whitmer
- Sophie Duraffour
- Stephan Günther
- Stephen F. Schaffner
- Stephen Gire
- Stuart T. Nichol
- Suzan D. Pas
- Suzanne Mate
- Sylvia O. Blyden
- Tolbert Nyenswah
- Trevor Bedford
- Umaru Jah
- Ute Ströher
- VN Minin
- W Yang
- Y Xia
- Y-G Tong
- Z Yang
- Publication venue
- Nature
- Publication date
- 01/01/2017
- Field of study
The 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
- Barrett Fiona
- Basire Donna
- Basu N.
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes Hannah
- Beadsworth M.
- Beckett P
- Beggs Mark
- Begum M
- Beirne Paul
- Bell Murdina
- Bell R
- Bennett Kaytie
- Beranova Eva
- Bermperi Areti
- Berridge Anthony
- Berry C.
- Betts Sarah
- Bevan Emily
- Bhui K
- Bingham Michelle
- Birchall K
- Bishop L.
- Bisnauthsing Karen
- Blaikely J.
- Bloss Angela
- Bolger A.
- Bolton Charlotte E.
- Bonnington J.
- Botkai A
- Bourne Charlotte
- Bourne Michelle
- Bramham K.
- Brear Lucy
- Breen G
- Breeze Jonathon
- Briggs A.
- Bright E
- Brightling Christopher E
- Brill Simon
- Brindle K
- Broad Lauren
- Broadley A
- Brookes C
- Broome M
- Brown Ammani
- Brown Angela
- Brown J.
- Brown Jeremy S
- Brown Jo
- Brown M.
- Brown M.
- Brown V.
- Brugha Terry
- Brunskill Nigel
- Buch M.
- Buckley Phil
- Bularga A.
- Bullmore E
- Bunker Jenny
- Burden L.
- Burdett Tracy
- Burn D.
- Burns A.
- Burns G.
- Busby J.
- Butcher Robyn
- Butt Al-Tahoor
- Byrne S.
- Cairns P
- Calder P C
- Calvelo Ellen
- Carborn H
- Card Bethany
- Carr Caitlin
- Carr Liesel
- Carson G
- Carter Penny
- Casey A
- Cassar Mark P.
- Cavanagh J
- Chablani Manish
- Chalder Trudie
- Chalmers James D.
- Chambers R C
- Chan Flora
- Channon K M
- Chapman Kerry
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen Jin
- Cheng Yutung
- Chetham Luke
- Childs C
- Chilvers Edwin R
- Chinoy H
- Chiribiri Amedeo
- Chong-James K.
- Choudhury Gourab
- Choudhury N.
- Chowienczyk P
- Christie C
- Chrystal Melanie
- Clark Cameron
- Clark D
- Clarke Jude
- Clohisey S.
- Coakley G.
- Coburn Zach
- Coetzee S.
- Cole Joby
- Coleman C
- Conneh Florence
- Connell David
- Connolly B.
- Connor Lynda
- Cook Amanda
- Cooper B
- Cooper J
- Cooper Shirley
- Copeland D.
- Cosier Tracey
- Coulding Martina
- Coupland C.
- Cox Eleanor
- Craig T.
- Crisp P
- Cristiano Daniele
- Crooks M.G.
- Cross Andy
- Cruz Isabel
- Cullinan P.
- Cuthbertson Dan J
- Daines L
- Dalton Matthhew
- Daly Patrick
- Daniels Alison
- Dark P
- Dasgin J
- David A
- David C.
- Davies Ellie
- Davies Ffyon
- Davies Gareth
- Davies Gwyneth A
- Davies Kim
- Davies Melanie J
- Dawson Joy
- Daynes E
- De Soyza Anthony
- Deakin B
- Deans Andrew
- Deas C.
- Deery Joanne
- Defres S.
- Dell Amanda
- Dempsey K.
- Denneny E
- Dennis J
- Dewar A.
- Dharmagunawardena R
- Diar Bakerly Nawar
- Dickens C
- Dipper A.
- Diver Sarah
- Diwanji Shalin N
- Dixon Myles
- Djukanovic R
- Dobson H.
- Dobson S.L.
- Docherty Annemarie B.
- Donaldson A.
- Dong T.
- Dormand N.
- Dougherty Andrew
- Dowling R
- Drain S.
- Draxlbauer K
- Drury Katie
- Dulawan Pearl
- Dunleavy A
- Dunn Sarah
- Dupont Catherine
- Earley Joanne
- Easom Nicholas
- Echevarria Carlos
- Edwards Sarah
- Edwardson C
- El-Taweel Hosni
- Elliott Anne
- Elliott K
- Ellis Y.
- Elmer Anne
- Elneima Omer
- Evans D
- Evans H
- Evans J
- Evans R
- Evans Rachael A
- Evans Ranuromanana I.
- Evans Teriann
- Evenden Cerys
- Evison Lynsey
- Fabbri L
- Fairbairn Sara
- Fairman Alexandra
- Fallon K.
- Faluyi David
- Favager Clair
- Fayzan Tamanah
- Featherstone James
- Felton T.
- Ferreira Vanessa M.
- Finch J
- Finney Selina
- Finnigan J
- Finnigan Lucy
- Fisher Helen
- Fletcher S
- Flockton Rachel
- Flynn Margaret
- Foot H
- Foote David
- Ford Amber
- Forton D
- Fraile Eva
- Francis C.
- Francis R
- Francis Susan
- Frankel A.
- Fraser Emily
- Free Rob
- French N.
- Fu X
- Fuld Jonathan
- Furniss J.
- Garner Lucie
- Gautam N
- Geddes John R.
- George J.
- George P.
- Gibbons M
- Gill Mandy
- Gill Rhyan
- Gilmour L.
- Gleeson Fergus
- Glossop Jodie
- Glover Sarah
- Goodman N
- Goodwin Camelia
- Gooptu Bibek
- Gordon Hussain
- Gorsuch T.
- Greatorex M
- Greenhaff P.L.
- Greenhalf William
- Greenhalgh Alan
- Greening Neil J
- Greenwood John P
- Gregory Heidi
- Gregory Rebecca
- Grieve D.
- Griffin Denise
- Griffiths L
- Guerdette Anne-Marie
- Guillen Guio Beatriz
- Gummadi Mahitha
- Gupta Ayushman
- Gurram Sambasivarao
- Guthrie E
- Guy Z
- Hadley K
- Haggar Ahmed
- Hainey Kera
- Hairsine Brigid
- Haldar Pranab
- Hall I
- Hall Lucy
- Halling-Brown Mark
- Hamil R.
- Hancock Alyson
- Hancock Kia
- Hanley N.A.
- Haq Sulaimaan
- Hardwick H.E.
- Hardy E
- Hardy Tim
- Hargadon Beverley
- Harrington Kate
- Harris Edward
- Harris Victoria C
- Harrison Ewen M.
- Harrison P.
- Hart Nicholas
- Harvey Alice
- Harvey M
- Harvie M
- Haslam L
- Hastie Claire
- Havinden-Williams May
- Hawkes Jenny
- Hawkings Nancy
- Haworth Jill
- Hayday A.
- Haynes Matthew
- Hazeldine J
- Hazelton Tracy
- Heaney Liam G.
- Heeley Cheryl
- Heeney J L
- Heightman M
- Heller S.
- Henderson M
- Henson Helen
- Hesselden L
- Hewitt Melanie
- Highett Victoria
- Hillman T
- Hiwot T
- Ho Ling-Pei
- Hoare Amy
- Hoare Michaela
- Hockridge J
- Hogarth Philip
- Holbourn Ailsa
- Holden S
- Holdsworth L.
- Holgate D
- Holland Maureen
- Holloway Leah
- Holmes Katie
- Holmes Megan
- Holroyd-Hind B
- Holt L
- Hormis Anil
- Horsley Alexander
- Hosseini A.
- Hotopf M
- Houchen-Wolloff Linzy
- Howard K
- Howard Luke S.
- Howell Alice
- Hufton E
- Hughes A D
- Hughes Joan
- Hughes Paul J C
- Hughes Rachel Ann
- Humphries Amy
- Huneke N
- Hurditch E
- Hurst John R
- Husain M
- Hussell T.
- Hutchinson John
- Ibrahim W
- Ilyas F
- Ingham Julie
- Ingram L
- Ionita D
- Isaacs K
- Ismail K.
- Jackson T
- Jacob Joseph
- James W.Y.
- Jang W.
- Jarman Claire
- Jarrold I.
- Jarvis Hannah
- Jastrub Roman
- Jayaraman Bhagy
- Jenkins R Gisli
- Jezzard Peter
- Jiwa Kasim
- Johnson C
- Johnson S
- Johnston D.
- Jolley Caroline J.
- Jones Don
- Jones G.
- Jones H.
- Jones Heather
- Jones I.
- Jones L.
- Jones Mark G
- Jones S.
- Jose Sherly
- Kabir T.
- Kaltsakas G.
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- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
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- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
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- Barve Minal
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- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
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- Bell Bryan
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- Beltran Pedro
- Bender Lewis H
- Bender Steven
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- Benz Steven
- Bera Tapan
- Berglund Peter
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- Bommareddy Praveen K
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- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
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- Bullock Kim
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- Butterfield Lisa H
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- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
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- Chen Xiaomu
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- Chen Xiufen
- Chen Yu
- Chen Yu
- Chenchik Alex
- Chheda Zinal
- Chiang Eugene
- Chikina Maria
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- Coussens Lisa M
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- Craggs Graham
- Craig Andrew
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- Cruickshank Scott
- Csuka Orsolya
- Curbishley Stuart
- Curiel Tyler
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- Curran Michael
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- Da Costa Andre
- Dai Fu
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- Daud Adil
- David Justin M
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- de Gruijl Tanja
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- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
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- DeBenedette Mark
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- Decock Julie
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- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
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- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
- Demaria Sandra
- Deng Liang
- Deng Weiwen
- Deng Wentao
- Denies Sofie
- Denis Caroline
- Desbien Anthony L
- deVries Michele
- Dhupkar Pooja
- Diab Adi
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- Dobkin Julie
- Doener Fatma
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- Doman Thompson
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- Duvvuri Uma
- Dyson Mike
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- Eickhoff Jens
- Eisenhower Mary
- El Alaoui Meddy
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- English Jessie
- Enstrom Amanda
- Eremeev Artem
- Eriksson Emma
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- Eriksson Emma
- Ertelt Kathleen
- Eswarappa Rajesh
- Evans Elizabeth
- Evans Kathy
- Facciabene Andrea
- Facciabene Andrea
- Facciabene Andrea
- Facciponte John
- Facciponte John
- Falchook Gerald
- Fantini Massimo
- Fantini Massimo
- Fantini Massimo
- Farkas Emil
- Farren Matthew
- Faustman Denise
- Fa’ak Faisal
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- Femel Julia
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- Weinstein Gregory
- Weiss Christian
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- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
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- Xu Yitong
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- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Ylösmäki Erkko
- Young Gregory
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W
- Young Steve W
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
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- Carmen Gomez
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- Edward W Rowe
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- Electron Kebebew
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- Fred Sweep
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- Fruzsina Molnár-Gábor
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- W Kimryn Rathmell
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- Xiao Xiao
- Xiaobo Li
- Xiaoping Su
- Xiaotong Li
- Xiaotong Yao
- Xing Hua
- Xingmin Liu
- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
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