The impact of changes in corn prices on pesticides demand

Commodity prices have recently seen record grain prices with most growers generally improving their profitability. In 2007 the USA crop protection value experienced its biggest annual increase since 1984 with a US$30.5 billion increase compared to 2006. South African growers increased their gross margin even with lower historical yields, from US$480 per hectare in 2004, to an estimated US$1,133 per hectare in 2008. With the current global grain stock-touse ratios maintaining their lowest levels in 35 years, higher and more price volatility is expected to continue. Whilst growers have benefitted from these more favourable crop prices, agrochemical suppliers have battled to increase their chemical prices. In South Africa, other suppliers (seeds and fertiliser), managed to increase prices at least twofold the percentage agro-chemicals achieved from 2003 to 2008. The purpose of this research was therefore to try and understand how commodity prices influence corn growers’ pesticide demand, as well as to better understand their pesticide buying behaviour under fluctuating crop prices. A structured web-based questionnaire to collect primary data from corn growers within South Africa and Hungary was used. Besides the impact of commodity prices to business buying behaviour, the research also focused on the price elasticity of agro-chemicals, futures trading as a risk reduction mechanism and the value of agro-chemical sales representatives. From the findings the survey managed to highlight that even though commodity prices do impact agro-chemicals, it was not the biggest influencer towards agrochemical buying behaviour. The survey further indicated that similar to many other industrial goods, agro-chemicals represented fairly inelastic prices, most growers use hedging to reduce price uncertainty and the majority value the relationship with their agro-chemical representatives. The data also highlighted additional similarities that exist within the business buying behaviour of Hungarian and South African growers.Dissertation (MBA)--University of Pretoria, 2008.Gordon Institute of Business Science (GIBS)unrestricte

A circumnuclear disk of atomic hydrogen in Centaurus A

We present new observations, performed with the Australia Telescope Compact Array, of the HI absorption in the central regions of Centaurus A. For the first time, absorption is detected against the radio core at velocities blueshifted with respect to the systemic velocity. Moreover, the data show that the nuclear redshifted absorption component is broader than reported before. With these new results, the kinematics of the HI in the inner regions of Cen A appears very similar to that observed in emission for the molecular circumnuclear disk. This suggests that the central HI absorption is not, as was previously claimed, evidence of gas infall into the AGN, but instead is due to a cold, circumnuclear disk.Comment: Accepted for publication in A&A Letter, 4 pages, 2 figure

Probing radio source environments via HI and OH absorption

We present the results of HI and OH absorption measurements towards a sample of radio sources using the Arecibo 305-m telescope and the GMRT. In total, 27 radio sources were searched for associated 21-cm HI absorption. One totally new HI absorption system was detected against the radio galaxy 3C258, while five previously known HI absorption systems, and one galaxy detected in emission, were studied with improved frequency resolution and/or sensitivity. Our sample included 17 GPS and CSS objects, 4 of which exhibit HI absorption. This detection rate of ~25% compares with a value of ~40% by Vermeulen et al. for similar sources. We detected neither OH emission nor absorption towards any of the sources that were observed at Arecibo, and estimate a limit on the abundance ratio of N(HI)/N(OH)>4x10^6 for 3C258. We have combined our results with those from other available HI searches to compile a heterogeneous sample of 96 radio sources consisting of 27 GPS, 35 CSS, 13 flat spectrum and 21 large sources. The HI absorption detection rate is highest (~45%) for the GPS sources and least for the large sources. We find HI column density to be anticorrelated with source size, as reported earlier by Pihlstr\"om et al. The HI column density shows no significant dependence on either redshift or luminosity, which are themselves strongly correlated. These results suggest that the environments of radio sources on GPS/CSS scales are similar at different redshifts. Further, in accordance with the unification scheme, the GPS/CSS galaxies have an HI detection rate of ~40% which is significantly higher than the detection rate (~20%) towards the GPS/CSS quasars. Also, the principal (strongest) absorption component detected towards GPS sources appears blue-shifted in ~65% of the cases, in agreement with the growing evidence for jet-cloud interactions.Comment: Abridged abstract, 22 pages, 21 figures, moderately revised, accepted for publication in MNRA

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

The epigenetic mark indicative of DNA UV damage or double-strand breaks is achieved via a common pathway regardless of the cause of damage

Acid ceramidase regulates innate immune memory

Innate immune memory, also called “trained immunity,” is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions. We show that exogenously administered sphingolipids and inhibition of sphingolipid metabolizing enzymes modulate trained immunity. In particular, we reveal that acid ceramidase, an enzyme that converts ceramide to sphingosine, is a potent regulator of trained immunity. We show that acid ceramidase regulates the transcription of histone-modifying enzymes, resulting in profound changes in histone 3 lysine 27 acetylation and histone 3 lysine 4 trimethylation. We confirm our findings by identifying single-nucleotide polymorphisms in the region of ASAH1, the gene encoding acid ceramidase, that are associated with the trained immunity cytokine response. Our findings reveal an immunomodulatory effect of sphingolipids and identify acid ceramidase as a relevant therapeutic target to modulate trained immunity responses in innate immune-driven disorders.</p

Acid ceramidase regulates innate immune memory

Innate immune memory, also called “trained immunity,” is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions. We show that exogenously administered sphingolipids and inhibition of sphingolipid metabolizing enzymes modulate trained immunity. In particular, we reveal that acid ceramidase, an enzyme that converts ceramide to sphingosine, is a potent regulator of trained immunity. We show that acid ceramidase regulates the transcription of histone-modifying enzymes, resulting in profound changes in histone 3 lysine 27 acetylation and histone 3 lysine 4 trimethylation. We confirm our findings by identifying single-nucleotide polymorphisms in the region of ASAH1, the gene encoding acid ceramidase, that are associated with the trained immunity cytokine response. Our findings reveal an immunomodulatory effect of sphingolipids and identify acid ceramidase as a relevant therapeutic target to modulate trained immunity responses in innate immune-driven disorders.</p

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D-2 receptor occupancy of olanzapine in rats

A mechanism-based PK-PD model was developed to predict the time course of dopamine D-2 receptor occupancy (D2RO) in rat striatum following administration of olanzapine, an atypical antipsychotic drug. A population approach was utilized to quantify both the pharmacokinetics and pharmacodynamics of olanzapine in rats using the exposure (plasma and brain concentration) and D2RO profile obtained experimentally at various doses (0.01-40 mg/kg) administered by different routes. A two-compartment pharmacokinetic model was used to describe the plasma pharmacokinetic profile. A hybrid physiology- and mechanism-based model was developed to characterize the D-2 receptor binding in the striatum and was fitted sequentially to the data. The parameters were estimated using nonlinear mixed-effects modeling . Plasma, brain concentration profiles and time course of D2RO were well described by the model; validity of the proposed model is supported by good agreement between estimated association and dissociation rate constants and in vitro values from literature. This model includes both receptor binding kinetics and pharmacokinetics as the basis for the prediction of the D2RO in rats. Moreover, this modeling framework can be applied to scale the in vitro and preclinical information to clinical receptor occupancy