794 research outputs found
Recording Lifetime Behavior and Movement in an Invertebrate Model
- Author
- A Gabadinho
- A Maye
- AA Robie
- Amy Morice
- CB Nielson
- D Grover
- D Grover
- D Grover
- D Valente
- Donald K. Ingram
- FW Wolf
- J-R Martin
- James R. Carey
- Janeth Cruz-Enriquez
- JE Zimmerman
- JR Carey
- K Branson
- K Koh
- Kevin Kaub
- KG Iliadi
- Leopoldo Altamirano-Robles
- Nikos Papadopoulos
- OT Inan
- P Sharma
- Pablo Liedo
- S Zou
- Sige Zou
- Simon Melov
- TG Bross
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Characterization of lifetime behavioral changes is essential for understanding aging and aging-related diseases. However, such studies are scarce partly due to the lack of efficient tools. Here we describe and provide proof of concept for a stereo vision system that classifies and sequentially records at an extremely fine scale six different behaviors (resting, micro-movement, walking, flying, feeding and drinking) and the within-cage (3D) location of individual tephritid fruit flies by time-of-day throughout their lives. Using flies fed on two different diets, full sugar-yeast and sugar-only diets, we report for the first time their behavioral changes throughout their lives at a high resolution. We have found that the daily activity peaks at the age of 15–20 days and then gradually declines with age for flies on both diets. However, the overall daily activity is higher for flies on sugar-only diet than those on the full diet. Flies on sugar-only diet show a stronger diurnal localization pattern with higher preference to staying on the top of the cage during the period of light-off when compared to flies on the full diet. Clustering analyses of age-specific behavior patterns reveal three distinct young, middle-aged and old clusters for flies on each of the two diets. The middle-aged groups for flies on sugar-only diet consist of much younger age groups when compared to flies on full diet. This technology provides research opportunities for using a behavioral informatics approach for understanding different ways in which behavior, movement, and aging in model organisms are mutually affecting
A linkage study of candidate loci in familial Parkinson's Disease
- Author
- AA Hicks
- AJ Hughes
- Catherine E Burgess
- CB Lucking
- D Schindelhauer
- DJ Vandenbergh
- DL Choi-Lundberg
- DM Frim
- DR Love
- E Leroy
- E Sobel
- EM Valente
- H Ichinose
- H Payami
- Haydeh Payami
- HH Goring
- HH Goring
- HH Goring
- HW Mages
- JJ Treanor
- JR Gulcher
- K Wakabayashi
- Karin Wirdefeldt
- L Kruglyak
- Lisa Westerberg
- M Boehnke
- M Farrer
- M Funayama
- M Hutton
- M Saarma
- Martin Schalling
- MG Murer
- MH Polymeropoulos
- N Pankratz
- N Risch
- PC Maisonpierre
- RH Zetterstrom
- RW Cottingham Jr
- S Engelender
- S Zareparsi
- S Zareparsi
- SG Amara
- T Gasser
- T Kitada
- V Bonifati
- WD Le
- Y Ishizaka
- Publication venue
- BioMed Central
- Publication date
- 01/01/2003
- Field of study
BACKGROUND: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease. Most cases are sporadic, however familial cases do exist. We examined 12 families with familial Parkinson's disease ascertained at the Movement Disorder clinic at the Oregon Health Sciences University for genetic linkage to a number of candidate loci. These loci have been implicated in familial Parkinson's disease or in syndromes with a clinical presentation that overlaps with parkinsonism, as well as potentially in the pathogenesis of the disease. METHODS: The examined loci were PARK3, Parkin, DRD (dopa-responsive dystonia), FET1 (familial essential tremor), BDNF (brain-derived neurotrophic factor), GDNF (glial cell line-derived neurotrophic factor), Ret, DAT1 (the dopamine transporter), Nurr1 and Synphilin-1. Linkage to the α-synuclein gene and the Frontotemporal dementia with parkinsonism locus on chromosome 17 had previously been excluded in the families included in this study. Using Fastlink, Genehunter and Simwalk both parametric and model-free non-parametric linkage analyses were performed. RESULTS: In the multipoint parametric linkage analysis lod scores were below -2 for all loci except FET1 and Synphilin-1 under an autosomal dominant model with incomplete penetrance. Using non-parametric linkage analysis there was no evidence for linkage, although linkage could not be excluded. A few families showed positive parametric and non-parametric lod scores indicating possible genetic heterogeneity between families, although these scores did not reach any degree of statistical significance. CONCLUSIONS: We conclude that in these families there was no evidence for linkage to any of the loci tested, although we were unable to exclude linkage with both parametric and non-parametric methods
Fluctuation-Driven Neural Dynamics Reproduce Drosophila Locomotor Patterns.
- Author
- A Büschges
- A Censi
- A Destexhe
- A Destexhe
- A Eldar
- A Keller
- A Longtin
- A Sorribes
- AA Faisal
- AA Koulakov
- AA Prinz
- AL Nelson
- Aldo A Faisal
- Andrea Maesani
- BJ Cole
- C Montell
- CR Reyn von
- CS Mendes
- D Sussillo
- D Sussillo
- D Valente
- Dario Floreano
- E Doi
- E Marder
- E Marder
- EJ Izquierdo
- EJ Izquierdo
- F Bartumeus
- FW Wolf
- G Benettin
- GJ Stephens
- GJ Székely
- GL Collingridge
- I Tsuda
- J Schneider
- JL Kaplan
- JR Martin
- JR Martin
- JS Anderson
- JS Kain
- K Ahnert
- K Branson
- K Wiesenfeld
- K-I Funahashi
- KJ Mann
- KM Stiefel
- Kyle Gustafson
- M Ai
- M Clerc
- MD McDonnell
- MM Churchland
- NA Dunn
- NN Schraudolph
- P Coen
- P Fatt
- P Ramdya
- P Ramdya
- Pavan Ramdya
- PJ Choi
- PR Montague
- R Cossart
- R Poli
- RD Beer
- RD Beer
- RD Beer
- RD Beer
- RE Ritzmann
- Richard Benton
- S Grillner
- S Grillner
- S Hanai
- S Strogatz
- S Yorozu
- SQ Lima
- SS Bidaye
- Steeve Cruchet
- SW Flavell
- T Ohyama
- TA Markow
- TFC Mackay
- TI Toth
- TJ Prescott
- V Mante
- VR Cane
- X Jin
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
The neural mechanisms determining the timing of even simple actions, such as when to walk or rest, are largely mysterious. One intriguing, but untested, hypothesis posits a role for ongoing activity fluctuations in neurons of central action selection circuits that drive animal behavior from moment to moment. To examine how fluctuating activity can contribute to action timing, we paired high-resolution measurements of freely walking Drosophila melanogaster with data-driven neural network modeling and dynamical systems analysis. We generated fluctuation-driven network models whose outputs-locomotor bouts-matched those measured from sensory-deprived Drosophila. From these models, we identified those that could also reproduce a second, unrelated dataset: the complex time-course of odor-evoked walking for genetically diverse Drosophila strains. Dynamical models that best reproduced both Drosophila basal and odor-evoked locomotor patterns exhibited specific characteristics. First, ongoing fluctuations were required. In a stochastic resonance-like manner, these fluctuations allowed neural activity to escape stable equilibria and to exceed a threshold for locomotion. Second, odor-induced shifts of equilibria in these models caused a depression in locomotor frequency following olfactory stimulation. Our models predict that activity fluctuations in action selection circuits cause behavioral output to more closely match sensory drive and may therefore enhance navigation in complex sensory environments. Together these data reveal how simple neural dynamics, when coupled with activity fluctuations, can give rise to complex patterns of animal behavior
Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury
- Author
- AA Aravin
- AA Camargo
- Andrew JG Simpson
- B Ewing
- B Ewing
- B Lemaitre
- C Castillejo-López
- C Scherfer
- Daniela D Araujo
- E De Gregorio
- E De Gregorio
- E Dias Neto
- EM Reis
- Emmanuel Dias-Neto
- Enilza M Espreafico
- H Jiang
- H Tang
- I-H Jang
- J Ross
- J Sambrook
- JJ Perona
- Josane F Sousa
- JR Manak
- L Kalfayan
- M Hild
- M Stapleton
- M Stapleton
- M Yandell
- Marco A Zago
- Marco AV Cunha
- Maria L Paçó-Larson
- MC Sogayar
- MD Adams
- Nadia Monesi
- ND Rawlings
- Rafaela M Maia
- Ricardo GP Ramos
- S Misra
- Sandro J Souza
- SE Celniker
- SF Altschul
- SJ de Souza
- V Stolc
- Valeria Valente
- Wilson A Silva
- WR Pearson
- X Huang
- Z Kambris
- Publication venue
- BioMed Central
- Publication date
- 01/01/2007
- Field of study
<p>Abstract</p> <p>Background</p> <p>The sequencing of the <it>D.melanogaster </it>genome revealed an unexpected small number of genes (~ 14,000) indicating that mechanisms acting on generation of transcript diversity must have played a major role in the evolution of complex metazoans. Among the most extensively used mechanisms that accounts for this diversity is alternative splicing. It is estimated that over 40% of <it>Drosophila </it>protein-coding genes contain one or more alternative exons. A recent transcription map of the <it>Drosophila </it>embryogenesis indicates that 30% of the transcribed regions are unannotated, and that 1/3 of this is estimated as missed or alternative exons of previously characterized protein-coding genes. Therefore, the identification of the variety of expressed transcripts depends on experimental data for its final validation and is continuously being performed using different approaches. We applied the Open Reading Frame Expressed Sequence Tags (ORESTES) methodology, which is capable of generating cDNA data from the central portion of rare transcripts, in order to investigate the presence of hitherto unnanotated regions of <it>Drosophila </it>transcriptome.</p> <p>Results</p> <p>Bioinformatic analysis of 1,303 <it>Drosophila </it>ORESTES clusters identified 68 sequences derived from unannotated regions in the current <it>Drosophila </it>genome version (4.3). Of these, a set of 38 was analysed by polyA<sup>+ </sup>northern blot hybridization, validating 17 (50%) new exons of low abundance transcripts. For one of these ESTs, we obtained the cDNA encompassing the complete coding sequence of a new serine protease, named SP212. The <it>SP212 </it>gene is part of a serine protease gene cluster located in the chromosome region 88A12-B1. This cluster includes the predicted genes CG9631, CG9649 and CG31326, which were previously identified as up-regulated after immune challenges in genomic-scale microarray analysis. In agreement with the proposal that this <it>locus </it>is co-regulated in response to microorganisms infection, we show here that SP212 is also up-regulated upon injury.</p> <p>Conclusion</p> <p>Using the ORESTES methodology we identified 17 novel exons from low abundance <it>Drosophila </it>transcripts, and through a PCR approach the complete CDS of one of these transcripts was defined. Our results show that the computational identification and manual inspection are not sufficient to annotate a genome in the absence of experimentally derived data.</p
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arcangeletti C
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Artoni G
- Artz S
- Asai S
- Asawatavonvanich T
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Ayoub MK
- Azuelos G
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Balaji S
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnea R
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barsov S
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bassalat A
- Basso MJ
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beisiegel F
- Bell AS
- Bella G
- Bella LA
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Berlingen JM
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertram IA
- Besson N
- Bethani A
- Bethke S
- Betti A
- Bevan AJ
- Beyer J
- Bhattacharya DS
- Bhattarai P
- Bi R
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz N
- Biglietti M
- Billoud TR
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Birman M
- Bisanz T
- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- Bjorke K
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boeriu OEV
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bolz AE
- Bomben M
- Bona M
- Bonilla JS
- Boonekamp M
- Booth CD
- Borecka-Bielska HM
- Borgna LS
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Boscherini D
- Bosman M
- Bostanabad MG
- Bouaouda K
- Boudreau J
- Bouhova-Thacker E
- Boumediene D
- Bourdarios CA
- Boutle SK
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt G
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- Brau B
- Brau JE
- Brendlinger K
- Brenner L
- Brenner R
- Bressler S
- Bret MC
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks WK
- Brost E
- Broughton JH
- Bruncko D
- Bruni A
- Bruni G
- Bruni LS
- Bruno S
- Bruschi M
- Bruscino N
- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Buehrer F
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- Bugge MK
- Bulekov O
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Buschmann E
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- Bylund OB
- Cabras G
- Cabrera Urban S
- Caforio D
- Cai H
- Cairo VMM
- Cakir IT
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camarda S
- Camarero Munoz D
- Camarri P
- Camelia EA
- Cameron D
- Camincher C
- Campana S
- Campanelli M
- Camplani A
- Campoverde A
- Canale V
- Canesse A
- Cantero J
- Cao T
- Cao Y
- Capua M
- Cardarelli R
- Cardillo F
- Carducci G
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carra S
- Carter JWS
- Casado MP
- Casha AF
- Casper DW
- Castelijn R
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
- Castillo LRF
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
- Cavallaro E
- Cavalli-Sforza M
- Cavasinni V
- Celebi E
- Cerda Alberich L
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chan J
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chau CC
- Che S
- Chekanov S
- Chekulaev S
- Chelkov GA
- Chen B
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- Chen CH
- Chen H
- Chen J
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- Chen SJ
- Chen X
- Chen Y-H
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cheu E
- Cheung K
- Chevalerias TJA
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov M
- Choi K
- Chomont AR
- Chouridou S
- Chow YS
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Chytka L
- Cieri D
- Ciesla KM
- Cinca D
- Cindro V
- Cioara IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
- Clark A
- Clark MR
- Clark PJ
- Clement C
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Cohen H
- Coimbra AEC
- Cole B
- Colijn AP
- Collot J
- Conde Muino P
- Connell SH
- Connelly IA
- Constantinescu S
- Conventi F
- Cooper-Sarkar AM
- Corga KDV
- Cormier F
- Cormier KJR
- Cornell SD
- Corpe LD
- Corradi M
- Correia AMH
- Corrigan EE
- Corriveau F
- Costa MJ
- Costanza F
- Costanzo D
- Cowan G
- Cowley JW
- Crane J
- Cranmer K
- Crawley SJ
- Creager RA
- Crepe-Renaudin S
- Crescioli F
- Cristinziani M
- Croft V
- Crosetti G
- Cueto A
- Cukierman AR
- Cunningham WR
- Czekierda S
- Czodrowski P
- D'amen G
- D'Amico V
- D'Auria S
- D'Eramo L
- da Costa JBG
- Da Fonseca Pinto J
- Da Via C
- Dabrowski W
- Dachs F
- Dado T
- Dahbi S
- Dai T
- Dallapiccola C
- Dam M
- Damazio DO
- Damp J
- Dandoy JR
- Daneri MF
- Dann NS
- Danninger M
- Dao V
- Darbo G
- Dartsi O
- Dattagupta A
- Daubney T
- David C
- Davidek T
- Davis DR
- Dawson I
- De Asmundis R
- De Beurs M
- De Castro S
- De Cecco S
- De Groot N
- de Jong P
- De la Torre H
- de Lima DEF
- De Lima RT
- De Maria A
- De Pedis D
- De Regie JBDV
- de Renstrom PAB
- De Sa RCL
- De Salvo A
- De Sanctis U
- De Santis M
- De Santo A
- De Sousa MJDCS
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- Debenedetti C
- Dedovich D
- Deiana AM
- Del Peso J
- Delgove D
- Deliot F
- Delitzsch CM
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- Della Volpe D
- Delmastro M
- Delporte C
- Delsart PA
- DeMarco DA
- Demers S
- Demichev M
- Demontigny G
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Deterre C
- Dette K
- Deutsch C
- Devesa MR
- Deviveiros PO
- Di Bello FA
- Di Ciaccio A
- Di Ciaccio L
- Di Clemente WK
- Di Donato C
- Di Girolamo A
- Di Gregorio G
- Di Micco B
- Di Nardo R
- Di Petrillo KF
- Di Sipio R
- Diaconu C
- Dias FA
- Diaz LP
- Diaz MA
- Diaz YD
- Dickinson J
- Diehl EB
- Dietrich J
- Dimitrievska A
- Ding W
- Dingfelder J
- Dittus F
- Djama F
- Djobava T
- Djuvsland J
- Do Vale TD
- Dobre M
- Dodsworth D
- Doglioni C
- Dolejsi J
- Dolezal Z
- Dominguez LP
- Don MMR
- Donadelli M
- Dong B
- Donini J
- Donszelmann TC
- Dopke J
- Doria A
- Dova MT
- Doyle AT
- Drechsler E
- Dreyer E
- Dreyer T
- Drobac AS
- Du D
- Duan Y
- Dubinin F
- Dubovsky M
- Dubreuil A
- Duchovni E
- Duckeck G
- Ducourthial A
- Ducu OA
- Duda D
- Dudarev A
- Dudder AC
- Duelsen C
- Dueren M
- Duffeld EM
- DuflOt L
- Duhrssen M
- Dumancic M
- Dumitriu AE
- Duncan AK
- Dunford M
- Duperrin A
- Durglishvili A
- Duschinger D
- Dutta B
- Duvnjak D
- Dyckes G
- Dyndal M
- Dysch S
- Dziedzic BS
- Ecker KM
- Eggleston MG
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Jarrari H
- El Kossei R
- El Moursli RC
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Elliot AA
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Emerman A
- Enari Y
- Epland MB
- Erdmann J
- Ereditato A
- Erland PA
- Errenst M
- Escalier M
- Escobar C
- Estrada Pastor O
- Etzion E
- Evans H
- Ezhilov A
- Fabbri F
- Fabbri L
- Fabiani V
- Facini G
- Fakhrutdinov RM
- Falciano S
- Falke PJ
- Falke S
- Faltova J
- Fang Y
- Fanourakis G
- Fanti M
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
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- Abdesselam A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
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- Yildizb HD
- Yilmaz M
- Yoosootiniya R
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- Zajacova Z
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- Zanello L
- Zarzhitsky P
- Zaytsev A
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- Zenin O
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
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- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
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- Zhu CG
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- Zhuravlov V
- Zieminska D
- Zimmermann R
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- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
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- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro
- Author
- A Kujumgiev
- A Pereira
- A Russo
- A Russo
- AA Dihal
- AC Pagliarone
- AH Banskota
- Ana Margarida Ferreira
- C Ekmekcioglu
- C Pinheiro
- CB Colen
- CK Shim
- Cristina Almeida-Aguiar
- D Xiang
- E Szliszka
- F Hu
- F Li
- F Scazzocchio
- Filipa Morais-Santos
- Fátima Baltazar
- G Basini
- H Pratsinis
- Isabel Valença
- J Fang
- KW Seo
- L Moreira
- M Amoros
- M Ishihara
- M Turktekin
- MC Marcucci
- MG Miguel
- MJ Valente
- N Oršolić
- OK Mirzoeva
- P Goncalves
- Q Wang
- RA Coss
- RA Gatenby
- RG Woisky
- S Kuntz
- S Ramos
- S Ramos
- S Silici
- SI Falcao
- V Bankova
- Vera Miranda-Gonçalves
- VL Singleton
- VS Bankova
- VS Bankova
- W Greenaway
- W Wang
- WG Kaelin Jr
- WK Kim
- WL Lin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Propolis is a resin collected by bees from plant buds and exudates, which is further processed through the activity of bee enzymes. Propolis has been shown to possess many biological and pharmacological properties, such as antimicrobial, antioxidant, immunostimulant and antitumor activities. Due to this bioactivity profile, this resin can become an alternative, economic and safe source of natural bioactive compounds.Antitumor action has been reported in vitro and in vivo for propolis extracts or its isolated compounds; however, Portuguese propolis has been little explored. The aim of this work was to evaluate the in vitro antitumor activity of Portuguese propolis on the human colon carcinoma cell line HCT-15, assessing the effect of different fractions (hexane, chloroform and ethanol residual) of a propolis ethanol extract on cell viability, proliferation, metabolism and death.
METHODS:
Propolis from Angra do Heroísmo (Azores) was extracted with ethanol and sequentially fractionated in solvents with increasing polarity, n-hexane and chloroform. To assess cell viability, cell proliferation and cell death, Sulforhodamine B, BrDU incorporation assay and Anexin V/Propidium iodide were used, respectively. Glycolytic metabolism was estimated using specific kits.
RESULTS:
All propolis samples exhibited a cytotoxic effect against tumor cells, in a dose- and time-dependent way. Chloroform fraction, the most enriched in phenolic compounds, appears to be the most active, both in terms of inhibition of viability and cell death. Data also show that this cytotoxicity involves disturbance in tumor cell glycolytic metabolism, seen by a decrease in glucose consumption and lactate production.
CONCLUSION:
Our results show that Portuguese propolis from Angra do Heroísmo (Azores) can be a potential therapeutic agent against human colorectal cancer.We thank the Portuguese Science and Technology Foundation (FCT) for VMG fellowship (ref. SFRH/BI/33503/2008). The authors thank Mr. Antonio Marques from Frutercoop - Azores, who kindly collected and provided the propolis sample for the study
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- Tsur E
- Tuchming B
- Tully C
- Tung KL
- Turluer ML
- Turner-Watson MF
- Tyapkin IA
- Tyapkin P
- Tzamarias S
- Uchida Y
- Ueda I
- Ujvari B
- Ulbricht J
- Uvarov V
- Vachon B
- Valassi A
- Valente E
- Valenti G
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- van Dalen JA
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- van Dierendonck D
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- van Remortel N
- Van Vulpen I
- Vannerem P
- Vayaki A
- Vegni G
- Veillet JJ
- Veloso F
- Venturi A
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- Vetlitsky I
- Vicinanza D
- Videau H
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- Viertel G
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- Vitale L
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- Vogel H
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- von Krogh J
- von Wimmersperg-Toeller JH
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- Waananen A
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- Wadhwa M
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- Waller D
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- Wang ZM
- Ward CP
- Ward DR
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- Washbrook AJ
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- Watkins PM
- Watson AT
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- Weber M
- Weiser C
- Well PS
- Wengler T
- Wermes N
- Werner S
- Wetterling D
- White R
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- Wiedenmann W
- Wienemann P
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- Witek M
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- Wu J
- Wu SL
- Wu SX
- Wu X
- Wunsch M
- Wyatt TR
- Wynhoff S
- Xia L
- Xie Y
- Xu R
- Xu ZZ
- Xue S
- Yamamoto J
- Yamashita S
- Yang BZ
- Yang CG
- Yang HJ
- Yang M
- Yeh SC
- Yuan C
- Yushchenko O
- Zachariadou K
- Zalewska A
- Zalewski P
- Zalite A
- Zalite Y
- Zavrtanik D
- Zeitnitz C
- Zer-Zion D
- Zhang J
- Zhang L
- Zhang ZP
- Zhao J
- Zhao W
- Zhu GY
- Zhu RY
- Zhuang HL
- Zhuravlov V
- Zichichi A
- Ziegler T
- Zilizi G
- Zimin NI
- Zimmermann B
- Zintchenko A
- Zito G
- Zivkovic L
- Zobernig G
- Zoller M
- Zupan M
- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 17/07/2003
- Field of study
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
- Antipov P
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- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
- Arora S
- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
- Avetisyan A
- Avila C
- Awan MIM
- Ayan AS
- Ayhan A
- Azhgirey I
- Aziz T
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- Azzurri P
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- Babucci E
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- Calderon A
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- Chang YH
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- Cheung HWK
- Chien CY
- Chierici R
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- Chiorboli M
- Chipaux R
- Chiumarulo F
- Chlebana F
- Choi M
- Choi S
- Choi Y
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- Choudhury RK
- Christian G
- Christiansen T
- Chtchipounov L
- Chuang SH
- Chung J
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- Churin I
- Chwalek T
- Cihangir S
- Cimmino A
- Cirino G
- Cittolin S
- Ciulli V
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- Claes DR
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- Cockerill DJA
- Codispoti G
- Colafranceschi S
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- Colino N
- Colling D
- Colonna D
- Conetti S
- Contardo D
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- Conti E
- Conway J
- Cooper SI
- Cordonnier AM
- Cortabitarte RV
- Cossutti F
- Costa M
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- Coughlan JA
- Cousins R
- Covarelli R
- Cox B
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- Creanza D
- Cremaldi LM
- Cripps N
- Crotty I
- Cuevas J
- Cuffiani M
- Cumalat JP
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- Cure B
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- Cutts D
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- D'Angelo P
- D'Antone I
- D'Enterria D
- D'Hondt J
- Dabrowski R
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- Dagenhart W
- Dahmes B
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- Dallavalle GM
- Dambach S
- Damgov J
- Damiao DD
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- Daniel M
- Danielson T
- Darmenov N
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- Daskalakis G
- Dasu S
- Dattola D
- Daubie E
- David A
- Davids M
- Davies G
- de Abril IM
- de Abril MM
- de Barbaro P
- De Benedetti A
- De Boer W
- de Cassagnac RG
- de Fatis TT
- De Filippis N
- De Gruttola M
- De Guio F
- De La Cruz B
- De Lentdecker G
- De Mattia M
- de Monchenault GH
- De Palma M
- De Robertis G
- De Roeck A
- De Souza SF
- de Troconiz JF
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- De Weirdt S
- De Wolf EA
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- Debreczeni G
- Deiters K
- Dejardin M
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- del Arbol PMR
- Del Re D
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- Deliomeroglu M
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- Dellacasa G
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- Di Giovanni GP
- Di Marco E
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- Dias MAF
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- Dimitrov A
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
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