Evolución postquirúrgica del cierre de la herida quirúrgica por segunda intención en terceros molares

Introduction: third molar surgery is a treatment often performed during the dentistry practice work. Nowadays it is the most used conventional surgical technique.Objective: to evaluate the postoperative results in patients with non-semi-retained mandibular molars, with closure of the wound by secondary intention, regarding aspects such as the presence of pain, edema, bleeding, sepsis and mandibular trismus.Methods: an analytical, longitudinal, prospective case-control study was conducted at Abel Santamaria Cuadrado General Teaching Hospital in Pinar del Río, in the period from September 2010 to July 2013. The sample consisted of 120 patients attending the maxillofacial surgery office because of semi-retained mandibular third molars. For statistical analysis we used the Kolmogorov-Smirnov statistic methods and the Fisher exact probability variant.Results: for the 60 patients operated by conventional surgical suture with vestibular flap, after 72 hours pain appeared, and it was moderate in 48-80%, and at 12 hours, it was intense for the 20%. For the 60 patients operated by surgical technique with wound closure by secondary intention, after 72 hours only 15 patients (25%) had mild pain.Conclusions: There was a better postoperative result in patients with surgical wound closure by secondary intention, with 45% of the patients with no pain and 90% with slight edema after 72 hours of surgery; the study showed no symptoms such as bleeding, sepsis, or mandibular trismus.Introducción: la cirugía del tercer molar constituye uno de los tratamientos que con frecuencia se realiza en la práctica estomatológica. Actualmente es la técnica quirúrgica convencional más empleada. Objetivo: evaluar la evolución postoperatoria en los pacientes con terceros molares inferiores semiretenidos, con cierre de la herida quirúrgica por segunda intención, según la presencia de dolor, edema, sangramiento, sepsis y trismo mandibular.Material y método: se realizó un estudio analítico, longitudinal, prospectivo de casos y controles en el Hospital General Docente "Abel Santamaría Cuadrado" de Pinar del Río en el período comprendido desde septiembre de 2010 hasta julio de 2013. La muestra estuvo compuesta por 120 pacientes que asistieron a la consulta de cirugía maxilofacial por presentar los terceros molares mandibulares semiretenidos. Para el análisis estadístico se emplearon las técnicas de estadística comparativas de Kolmogorov-Smirnov y la de probabilidad exacta de Fisher.Resultados: en los 60 pacientes operados mediante la técnica quirúrgica convencional con sutura del colgajo vestibular, a las 72 horas presentaban dolor, en 48 era moderado para un 80%, y en 12, era intenso para un 20%. De los 60 que fueron operados mediante la técnica quirúrgica con cierre de la herida por segunda intención, a las 72 horas solo 15 pacientes para un 25% tenían dolor ligero.Conclusiones: hubo una mejor evolución postoperatoria en los pacientes con cierre de la herida quirúrgica por segunda intención, con un 45% de los casos sin dolor y un 90% con edema ligero a las 72 horas de operados; no presentaron síntomas como sangramiento, sepsis, ni trismo mandibular

Evolución postquirúrgica del cierre de la herida quirúrgica por segunda intención en terceros molares

Introduction: third molar surgery is a treatment often performed during the dentistry practice work. Nowadays it is the most used conventional surgical technique.Objective: to evaluate the postoperative results in patients with non-semi-retained mandibular molars, with closure of the wound by secondary intention, regarding aspects such as the presence of pain, edema, bleeding, sepsis and mandibular trismus.Methods: an analytical, longitudinal, prospective case-control study was conducted at Abel Santamaria Cuadrado General Teaching Hospital in Pinar del Río, in the period from September 2010 to July 2013. The sample consisted of 120 patients attending the maxillofacial surgery office because of semi-retained mandibular third molars. For statistical analysis we used the Kolmogorov-Smirnov statistic methods and the Fisher exact probability variant.Results: for the 60 patients operated by conventional surgical suture with vestibular flap, after 72 hours pain appeared, and it was moderate in 48-80%, and at 12 hours, it was intense for the 20%. For the 60 patients operated by surgical technique with wound closure by secondary intention, after 72 hours only 15 patients (25%) had mild pain.Conclusions: There was a better postoperative result in patients with surgical wound closure by secondary intention, with 45% of the patients with no pain and 90% with slight edema after 72 hours of surgery; the study showed no symptoms such as bleeding, sepsis, or mandibular trismus.Introducción: la cirugía del tercer molar constituye uno de los tratamientos que con frecuencia se realiza en la práctica estomatológica. Actualmente es la técnica quirúrgica convencional más empleada. Objetivo: evaluar la evolución postoperatoria en los pacientes con terceros molares inferiores semiretenidos, con cierre de la herida quirúrgica por segunda intención, según la presencia de dolor, edema, sangramiento, sepsis y trismo mandibular.Material y método: se realizó un estudio analítico, longitudinal, prospectivo de casos y controles en el Hospital General Docente "Abel Santamaría Cuadrado" de Pinar del Río en el período comprendido desde septiembre de 2010 hasta julio de 2013. La muestra estuvo compuesta por 120 pacientes que asistieron a la consulta de cirugía maxilofacial por presentar los terceros molares mandibulares semiretenidos. Para el análisis estadístico se emplearon las técnicas de estadística comparativas de Kolmogorov-Smirnov y la de probabilidad exacta de Fisher.Resultados: en los 60 pacientes operados mediante la técnica quirúrgica convencional con sutura del colgajo vestibular, a las 72 horas presentaban dolor, en 48 era moderado para un 80%, y en 12, era intenso para un 20%. De los 60 que fueron operados mediante la técnica quirúrgica con cierre de la herida por segunda intención, a las 72 horas solo 15 pacientes para un 25% tenían dolor ligero.Conclusiones: hubo una mejor evolución postoperatoria en los pacientes con cierre de la herida quirúrgica por segunda intención, con un 45% de los casos sin dolor y un 90% con edema ligero a las 72 horas de operados; no presentaron síntomas como sangramiento, sepsis, ni trismo mandibular

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

In mitosis, the Greatwall kinase (called microtubule-associated serine/threonine kinase like [Mastl] in mammals) is essential for prometaphase entry or progression by suppressing protein phosphatase 2A (PP2A) activity. PP2A suppression in turn leads to high levels of Cdk1 substrate phosphorylation. We have used a mouse model with an oocyte-specific deletion of Mastl to show that Mastl-null oocytes resume meiosis I and reach metaphase I normally but that the onset and completion of anaphase I are delayed. Moreover, after the completion of meiosis I, Mastl-null oocytes failed to enter meiosis II (MII) because they reassembled a nuclear structure containing decondensed chromatin. Our results show that Mastl is required for the timely activation of anaphase-promoting complex/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 activity that is needed for the entry into MII in mouse oocytes

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Empirical investigation to explore potential gains from the amalgamation of Phase Changing Materials (PCMs) and wood shavings

The reduction of gained heat, heat peak shifting and the mitigation of air temperature fluctuations are some desirable properties that are sought after in any thermal insulation system. It cannot be overstated that these factors, in addition to others, govern the performance of such systems thus their effect on indoor ambient conditions. The effect of such systems extends also to Heating, Ventilation and Air-conditioning (HVAC) systems that are set up to operate optimally in certain conditions. Where literature shows that PCMs and natural materials such as wood-shavings can provide efficient passive insulation for buildings, it is evident that such approaches utilise methods that are of a degree of intricacy which requires specialist knowledge and complex techniques, such as micro-encapsulation for instance. With technical and economic aspects in mind, an amalgam of PCM and wood-shavings has been created for the purpose of being utilised as a feasible thermal insulation. The amalgamation was performed in the simplest of methods, through submerging the wood shavings in PCM. An experimental procedure was devised to test the thermal performance of the amalgam and compare this to the performance of the same un-amalgamated materials. Comparative analysis revealed that no significant thermal gains would be expected from such amalgamation. However, significant reduction in the total weight of the insulation system would be achieved that, in this case, shown to be up to 20.94%. Thus, further reducing possible strains on structural elements due to the application of insulation on buildings. This can be especially beneficial in vernacular architectural approaches where considerably large amounts and thicknesses of insulations are used. In addition, cost reduction could be attained as wood shavings are significantly cheaper compared to the cost of PCMs

The CARMENES search for exoplanets around M dwarfs

Context. The CARMENES instrument, installed at the 3.5 m telescope of the Calar Alto Observatory in Almería, Spain, was conceived to deliver high-accuracy radial velocity (RV) measurements with long-term stability to search for temperate rocky planets around a sample of nearby cool stars. Moreover, the broad wavelength coverage was designed to provide a range of stellar activity indicators to assess the nature of potential RV signals and to provide valuable spectral information to help characterise the stellar targets. Aims: We describe the CARMENES guaranteed time observations (GTO), spanning from 2016 to 2020, during which 19 633 spectra for a sample of 362 targets were collected. We present the CARMENES Data Release 1 (DR1), which makes public all observations obtained during the GTO of the CARMENES survey. Methods: The CARMENES survey target selection was aimed at minimising biases, and about 70% of all known M dwarfs within 10 pc and accessible from Calar Alto were included. The data were pipeline-processed, and high-level data products, including 18 642 precise RVs for 345 targets, were derived. Time series data of spectroscopic activity indicators were also obtained. Results: We discuss the characteristics of the CARMENES data, the statistical properties of the stellar sample, and the spectroscopic measurements. We show examples of the use of CARMENES data and provide a contextual view of the exoplanet population revealed by the survey, including 33 new planets, 17 re-analysed planets, and 26 confirmed planets from transiting candidate follow-up. A subsample of 238 targets was used to derive updated planet occurrence rates, yielding an overall average of 1.44 ± 0.20 planets with 1 M⊕ < Mpl sin i < 1000 M⊕ and 1 day < Porb < 1000 days per star, and indicating that nearly every M dwarf hosts at least one planet. All the DR1 raw data, pipeline-processed data, and high-level data products are publicly available online. Conclusions: CARMENES data have proven very useful for identifying and measuring planetary companions. They are also suitable for a variety of additional applications, such as the determination of stellar fundamental and atmospheric properties, the characterisation of stellar activity, and the study of exoplanet atmospheres

The CARMENES search for exoplanets around M dwarfs. Two temperate Earth-mass planet candidates around Teegarden’s Star

Context.Teegarden’s Star is the brightest and one of the nearest ultra-cool dwarfs in the solar neighbourhood. For its late spectral type (M7.0 V),the star shows relatively little activity and is a prime target for near-infrared radial velocity surveys such as CARMENES.Aims.As part of the CARMENES search for exoplanets around M dwarfs, we obtained more than 200 radial-velocity measurements of Teegarden’sStar and analysed them for planetary signals.Methods.We find periodic variability in the radial velocities of Teegarden’s Star. We also studied photometric measurements to rule out stellarbrightness variations mimicking planetary signals.Results.We find evidence for two planet candidates, each with 1.1M⊕minimum mass, orbiting at periods of 4.91 and 11.4 d, respectively. Noevidence for planetary transits could be found in archival and follow-up photometry. Small photometric variability is suggestive of slow rotationand old age.Conclusions.The two planets are among the lowest-mass planets discovered so far, and they are the first Earth-mass planets around an ultra-cooldwarf for which the masses have been determined using radial velocities.We thank the referee Rodrigo Díaz for a careful review andhelpful comments. M.Z. acknowledges support from the Deutsche Forschungs-gemeinschaft under DFG RE 1664/12-1 and Research Unit FOR2544 “BluePlanets around Red Stars”, project no. RE 1664/14-1. CARMENES isan instrument for the Centro Astronómico Hispano-Alemán de Calar Alto(CAHA, Almería, Spain). CARMENES is funded by the German Max-Planck-Gesellschaft (MPG), the Spanish Consejo Superior de InvestigacionesCientíficas (CSIC), the European Union through FEDER/ERF FICTS-2011-02 funds, and the members of the CARMENES Consortium (Max-Planck-Institut für Astronomie, Instituto de Astrofísica de Andalucía, LandessternwarteKönigstuhl, Institut de Ciències de l’Espai, Institut für Astrophysik Göttingen,Universidad Complutense de Madrid, Thüringer Landessternwarte Tautenburg,Instituto de Astrofísica de Canarias, Hamburger Sternwarte, Centro de Astro-biología and Centro Astronómico Hispano-Alemán), with additional contribu-tions by the Spanish Ministry of Economy, the German Science Foundationthrough the Major Research Instrumentation Programme and DFG ResearchUnit FOR2544 “Blue Planets around Red Stars”, the Klaus Tschira Stiftung, thestates of Baden-Württemberg and Niedersachsen, and by the Junta de Andalucía.Based on data from the CARMENES data archive at CAB (INTA-CSIC). Thisarticle is based on observations made with the MuSCAT2 instrument, devel-oped by ABC, at Telescopio Carlos Sánchez operated on the island of Tener-ife by the IAC in the Spanish Observatorio del Teide. Data were partly col-lected with the 150-cm and 90-cm telescopes at the Sierra Nevada Observa-tory (SNO) operated by the Instituto de Astrofísica de Andalucía (IAA-CSIC).Data were partly obtained with the MONET/South telescope of the MOnitoringNEtwork of Telescopes, funded by the Alfried Krupp von Bohlen und HalbachFoundation, Essen, and operated by the Georg-August-Universität Göttingen,the McDonald Observatory of the University of Texas at Austin, and the SouthAfrican Astronomical Observatory. We acknowledge financial support from theSpanish Agencia Estatal de Investigación of the Ministerio de Ciencia, Inno-vación y Universidades and the European FEDER/ERF funds through projectsAYA2015-69350-C3-2-P, AYA2016-79425-C3-1/2/3-P, AYA2018-84089, BES-2017-080769, BES-2017-082610, ESP2015-65712-C5-5-R, ESP2016-80435-C2-1/2-R, ESP2017-87143-R, ESP2017-87676-2-2, ESP2017-87676-C5-1/2/5-R, FPU15/01476, RYC-2012-09913, the Centre of Excellence ”Severo Ochoa”and ”María de Maeztu” awards to the Instituto de Astrofísica de Canarias (SEV-2015-0548), Instituto de Astrofísica de Andalucía (SEV-2017-0709), and Cen-tro de Astrobiología (MDM-2017-0737), the Generalitat de Catalunya throughCERCA programme”, the Deutsches Zentrum für Luft- und Raumfahrt throughgrants 50OW0204 and 50OO1501, the European Research Council through grant694513, the Italian Ministero dell’instruzione, dell’università de della ricerca andUniversità degli Studi di Roma Tor Vergata through FFABR 2017 and “Mis-sion: Sustainability 2016”, the UK Science and Technology Facilities Council through grant ST/P000592/1, the Israel Science Foundation through grant848/16, the Chilean CONICYT-FONDECYT through grant 3180405, the Mexi-can CONACYT through grant CVU 448248, the JSPS KAKENHI through grantsJP18H01265 and 18H05439, and the JST PRESTO through grant JPMJPR1775

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe