70 research outputs found
Examining the Antecedents of Repurchase Intention in Convenience Stores: A Perspective of Expectation-Disconfirmation Theory
- Publication venue
- AIS Electronic Library (AISeL)
- Publication date
- 04/12/2009
- Field of study
The density of convenience stores in Taiwan is the highest in the world. In a convenience store context, this study attempts to examine the relationship between service quality, customer satisfaction and repurchase intention, as well as the impact of customer familiarity with employees on customer satisfaction and repurchase intention. The result indicated that expectation had direct effect on service quality. The result also showed that service quality was positively related to disconfirmation. As expected, there were interrelationships among service quality, satisfaction, and repurchase intention. Moreover, customer familiarity with employees had positive, direct influence on both satisfaction and repurchase intentions
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
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- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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- Abdelfatah S
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
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- Carratalá A
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- Chhor V
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- Chiou KR
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- Chiumello D
- Chiurazzi C
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- Cho Y
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- Christopher KB
- Chrétien JM
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- Combes A
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- Dalhuisen A
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- De Backer A
- De Brito-Ashurst I
- De Cassai A
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- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
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- Eroles AA
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- Escalada SH
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- Escórcio S
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- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Ignacio ML
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- Ince C
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jean-Baptiste S
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- Jensen JU
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Juanas CA
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- Kolnikova I
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- Kumari BK
- Kumbamu A
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- Kurmukov IA
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- Kwon WY
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- Kyle UG
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- Lafuente E
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- Leitao AL
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- Lichtenstein D
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- Limuti R
- Lin KC
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- Lin KC
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- Lin KL
- Lin PH
- Lin SC
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- Lischinsky A
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- Lobo-Civico A
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- Loudet CI
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- Martín MC
- Martín-Loeches I
- Martín-Loeches I
- Martínez F
- Martínez L
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- Martínez MP
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- Mejías CR
- Mellis C
- Melnyk L
- Melo N
- Mendes A
- Mendez MC
- Mendonca AV
- Mendsaikhan N
- Menendez R
- Mengelle C
- Mercat A
- Mercat A
- Mercat A
- Mergulhão PJ
- Merino-Vega D
- Messenger D
- Mezidi M
- Mezidi M
- Michel L
- Midwinter MJ
- Mignot T
- Miguelena PR
- Mihara Y
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- Mimoz O
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
- Olavarria E
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- Olkkola KT
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- Onodera M
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- Pascual OA
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- PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre
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- Plug Working Group
- PLUG working group
- PLUG Working Group
- PLUG Working Group
- PLUG Working Group
- Plug working group
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- Podlepich V
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- Pozzi M
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- Preiser JC
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- PS-ICU Group
- Psarologakis C
- Puerto-Morlán A
- Pugliese F
- Pujol LM
- Pulham RA
- Pulitano' SM
- Pusapati R
- Puthucheary ZA
- Puthucheary ZA
- Putzu A
- Puybasset L
- Pérez A
- Pérez AG
- Pérez H
- Pérez HR
- Pérez HR
- Pérez LP
- Pérez LP
- Pérez LP
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- Quintana S
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- Quinza A
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- Radjou A
- Radu V
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- Ramirez P
- Ramirez V
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- Ramnarayan P
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- Ramos JV
- Ramos JV
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- Ramírez CS
- Ramírez CS
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- Ranzani OT
- Rapid Diagnosis of Infections in the Critically Ill Team
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- Renes-Carreño E
- Renuka S
- Repessé X
- Resche-Rigon M
- Restrepo MI
- Reusch S
- ReVA Research Network and the PROVE Network Investigators
- Revel N
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- Rey JR
- Reyes LF
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- Riad Z
- Rialp G
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- Richard JC
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- Ricksten SE
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- Riera J
- Riera J
- Riera SQ
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- Righy C
- Rigol M
- Rigon MR
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- Rios-Toro JJ
- Riozzi P
- Riozzi P
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- Ristagno G
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- Rivas RF
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- Rivera-Fernandez R
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- Rizoli S
- Rizos M
- Roasio A
- Robaglia D
- Robert R
- Robles CM
- Roca JM
- Rocha LL
- Rodrigues DP
- Rodrigues NJ
- Rodriguez A
- Rodriguez P
- Rodriguez-Biendicho A
- Rodriguez-Fernandez S
- Rodríguez FG
- Roesthuis L
- Rogero S
- Rolin N
- Rolla F
- Rolland-Debord C
- Romero DG
- Romero I
- Romero JC
- Romero JC
- Romero JC
- Romero JC
- Romeu JD
- Rood PJ
- Ros Martínez J
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rossetti AO
- Rossi S
- Rossini P
- Rosstalnaya A
- Rota L
- Roth GA
- Rottoli MR
- Rotzel HB
- Rousseau AF
- Routsi C
- Rouw N
- Rouzé A
- Rowlerson A
- Ruberto F
- Rubiera M
- Rubio RJ
- Rudiger A
- Ruffini C
- Ruffini C
- Ruijter A
- Ruiz A
- Ruiz BL
- Ruiz FC
- Ruiz J
- Ruiz-Ramos J
- Ruiz-Rodriguez JC
- Ruiz-Rodríguez JC
- Ruiz-Ruano RDEL
- Runge I
- Runge I
- Runge I
- Rutherford WB
- Rutten AM
- Rydingsward JE
- Saadat F
- Sabetian G
- Sabeļņikovs O
- Sabirov D
- Sadamoto Y
- Sadamoto Y
- Sadamoto Y
- Saeed S
- Saha T
- Saigal S
- Saito M
- Saito N
- Saitou N
- Sakai Y
- Sakieva FI
- Sakuma M
- Sakuraya M
- Sales G
- Salgado DR
- Salluh J
- Sampath S
- Sampath S
- Sampley S
- Sampson D
- Samuels T
- Samy W
- Sanchez A
- Sanchez JA
- Sanchez-Orézzoli MG
- Sandiumenge A
- Sandiumenge A
- Sandroni C
- Sani D
- Santacruz C
- Santana JD
- Santana JD
- Santana MC
- Santana MC
- Santana PS
- Santana PS
- Santana SR
- Santana SR
- Santiago AI
- Santiago AI
- Santos F
- Sanui M
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz NM
- Sanz NM
- Sanz NM
- Sato K
- Savi C
- Savin I
- Savvidou S
- Sawamura A
- Sawamura A
- Sawamura A
- Sawamura A
- Scala S
- Scales DC
- Scanziani E
- Scanziani E
- Schaller SJ
- Schlaepfer P
- Schleifer J
- Schmid RM
- Schmidt M
- Schneider AG
- Schoenenberger JA
- Schortgen F
- Schortgen F
- Schortgen F
- Schröder T
- Schuepbach R
- Schultz MJ
- Schultz MJ
- Schwarz C
- Schwarze S
- Schwerdtfeger K
- Sciurti R
- Scott SH
- Sedlák P
- Seemann R
- Seet E
- Sekhri K
- Seldon T
- Sellés MD
- Sendid B
- Senussi T
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- Serbource-Goguel J
- Sergey S
- Serpytis M
- Serra J
- Sesana G
- Shah A
- Shah H
- Shawaf S
- Shears J
- Sheils MA
- Shekerdemian LS
- Shekerdemian LS
- Sherif H
- Shi ZH
- Shimanskiy V
- Shimony JS
- Shin WJ
- Shin WJ
- Shinotsuka CR
- Shlyk I
- Shu CW
- Shuinotsuka C
- Shum HP
- Shum HP
- Sibley S
- Siddiqui SS
- Sidhu P
- Sigcha MS
- Sigera CS
- Signouret T
- Sigurta A
- Silva G
- Silva JC
- Silva JG
- Silva S
- Similowski T
- Simoes CM
- Simon G
- Simsir M
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- Simón IF
- Simón JM
- Simón JM
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- Singer M
- Singer M
- Singer M
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- Sipylaite J
- Sirisena N
- Sirvent JM
- Siu K
- Sjövall F
- Skinner L
- Skrak P
- Skrifvars M
- Skrifvars MB
- Smekal D
- Snelson C
- Snyder AZ
- Sobhanian S
- Soeffker G
- Soilemezi E
- Soilemezi E
- Soilemezi E
- Sokolova E
- Solanki S
- Soler EA
- Solligård E
- Solé-Violán J
- Somhorst P
- Son Y
- Song I
- Song JG
- Song JG
- Song JW
- Song YG
- Song YG
- Sonneville R
- Sosa M
- Sossou A
- Sousa SC
- Soussi S
- Souza VA
- Spadaro S
- Spadaro S
- Spahn DR
- Spatenkova V
- Spazzadeschi A
- Spijkstra JJ
- Spronk PE
- Spronk PE
- Sprung CL
- St George’s University of London
- Stamm J
- Stamouli M
- Stanić R
- Starczewska M
- Staszewsky L
- Stauffert N
- Stella A
- Stephens T
- Stiphout C
- Stocchetti N
- Stocchetti N
- Stougianni M
- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- Stümpfle R
- Stümpfle R
- Su F
- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
- Suh GY
- Suh JW
- Sullivan E
- Sun WZ
- Sun XM
- Sung D
- Suwanpasu S
- Suzuki S
- Suzuki T
- Swart M
- Sy O
- Sydow K
- Sylla P
- Sáez VC
- Sánchez B
- Sánchez B
- Sánchez EC
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez PC
- Sánchez PC
- Sánchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taggu A
- Taggu A
- Takahashi H
- Takaki S
- Takaki S
- Takeda M
- Takeda M
- Takei T
- Takei T
- Talan L
- Tamura T
- Tanaka H
- Tanaka S
- Tanaka S
- Tane N
- Tang KB
- Tang LK
- Tapia A
- Tapponnier R
- Tapponnier R
- Tapponnier R
- Tarabrin O
- Tarabrin P
- Tavazzi G
- Tavazzi G
- Teboul JL
- Telli S
- Temprano-Gómez I
- Tena SA
- Tencé N
- Terzi N
- Terzi N
- Terzi N
- Terzi N
- Thabut G
- Thabut G
- Theodorakopoulou M
- Thies P
- Thilakasiri MC
- Thomas B
- Thompson E
- Thévenin D
- Tiainen M
- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
- Tomic I
- Tominaga N
- Tomás MA
- Tonelotto BF
- Tonetti T
- Tonetti T
- Topcu L
- Tormos P
- Torner MM
- Torner MM
- Torrance HD
- Torrent RL
- Torrent RL
- Torres A
- Torres E
- Torres JC
- Torriglia F
- Torriglia F
- Torriglia F
- Torsvik M
- Tosi F
- Touratier S
- Touw HR
- Toval S
- Tran N
- Trapp O
- Travierso C
- Travieso PM
- Traynor T
- Trefler S
- Trenado J
- Trenado J
- Treso-Geira M
- Trifan B
- Triulzi F
- Troeltzsch M
- Troncoso I
- Trouiller P
- Tseng CJ
- Tsirigotis P
- Tsukahara K
- Tsunano Y
- Tsunoda M
- Tsunoda M
- Tsutui T
- Tucci MR
- Tudor BA
- Tuinman PR
- Tullo L
- Turel M
- Turon R
- Twisk JW
- Törnblom S
- Ugawa T
- Ujike Y
- Ulla DV
- Ullman A
- Unal M
- Urbanaviciute I
- Uriona S
- Urli T
- Usón MC
- Vaahersalo J
- Vaara S
- Vaid N
- Vakalos A
- Valbuena BL
- Valbuena BL
- Valeiras-Valero A
- Vallecoccia MS
- Vallejo-Báez J
- Vallverdu M
- Vallverdu M
- Vallverdú I
- Vallés J
- van den Boogaard M
- van der Heiden ES
- van der Hoeven JG
- van der Hoeven JG
- van der Voort PH
- van Galen T
- van Ieperen SN
- Van Logten T
- van Nes M
- van Putten MJ
- van Thiel RJ
- van Wijk A
- Vandijck D
- Vaneker I
- Vanhuyse F
- Vaporidi K
- Vaquerizo C
- Varas GM
- Varas JL
- Varea MM
- Vargiolu A
- Varma A
- Varpula T
- Vatsik MV
- Vazquez D
- Vedage D
- Vega LM
- Veigas P
- Vela JL
- Velasquez T
- Venkatesan K
- Venn R
- Venn R
- Venot M
- Venrdramin A
- Ventura-Rosado A
- Vergani G
- Verginella F
- Verhaeghe R
- Verhage R
- Vermeir P
- Veronesi M
- Vezzani A
- Vezzani A
- Vianna G
- Viciana R
- Vidal A
- Vidal MV
- Vidal MV
- Viegas E
- Vieillard-Baron A
- Vieira JE
- Viera MA
- Viera MA
- Vigne C
- Villa G
- Villa P
- Villalba D
- Villamizar PR
- Villamizar PR
- Villanova M
- Villard I
- Villarreal E
- Villarreal E
- Vincent B
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
- Vucic M
- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
- Wada T
- Wada T
- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- Author
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abdulle Abdishakur M.
- Abebo Teshome Abuka
- Abera Semaw Ferede
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- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Aiyar Sneha
- Akinyemi Rufus Olusola
- Akseer Nadia
- Al Lami Faris Hasan
- Al-Aly Ziyad
- Al-Maskari Fatma
- Al-Raddadi Rajaa
- Alahdab Fares
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- Alizadeh-Navaei Reza
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- Bhutta Zulfiqar A.
- Biadgilign Sibhatu
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- Bikbov Boris
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- Chisumpa Vesper Hichilombwe
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- Christopher Devasahayam Jesudas
- Ciobanu Liliana G.
- Cirillo Massimo
- Colombara Danny
- Cooper Cyrus
- Cortesi Paolo Angelo
- Criqui Michael H.
- Crump John A.
- Cárdenas Rosario
- Dadi Abel Fekadu
- Dalal Koustuv
- Dandona Lalit
- Dandona Rakhi
- Das Neves José
- Davitoiu Dragos V.
- De Courten Barbora
- De Leo Diego
- Degenhardt Louisa
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- Esteghamati Alireza
- Estep Kara
- Fanuel Fanuel Belayneh Bekele
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- Goodridge Amador
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- Goto Atsushi
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- Griswold Max
- Gugnani Harish Chander
- Gupta Rahul
- Gupta Rajeev
- Gupta Tanush
- Gupta Vipin
- Hafezi-Nejad Nima
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- Haro Josep Maria
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- Kasaeian Amir
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- Kassaw Nigussie Assefa
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- Kastor Anshul
- Katikireddi Srinivasa Vittal
- Kaul Anil
- Kawakami Norito
- Keiyoro Peter Njenga
- Kengne Andre Pascal
- Keren Andre
- Khader Yousef Saleh
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- Khan Ejaz Ahmad
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- Khosravi Ardeshir
- Khubchandani Jagdish
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- Kim Yun Jin
- Kimokoti Ruth W.
- Kinfu Yohannes
- Kisa Adnan
- Kissimova-Skarbek Katarzyna A.
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- Kucuk Bicer Burcu
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- Kumar Pushpendra
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- Lal Dharmesh Kumar
- Lalloo Ratilal
- Lambert Nkurunziza
- Lan Qing
- Larsson Anders
- Lavados Pablo M.
- Leasher Janet L.
- Lee Jong-Tae
- Lee Paul H.
- Leigh James
- Leshargie Cheru Tesema
- Leung Janni
- Leung Ricky
- Levi Miriam
- Li Kappe Darya
- Li Yichong
- Li Yongmei
- Liang Xiaofeng
- Liben Misgan Legesse
- Lim Stephen S.
- Linn Shai
- Liu Angela
- Liu Patrick Y.
- Liu Shiwei
- Liu Yang
- Lodha Rakesh
- Logroscino Giancarlo
- London Stephanie J.
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- Low Nicola
- Lozano Rafael
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- Macarayan Erlyn Rachelle King
- Magdy Abd El Razek Hassan
- Magdy Abd El Razek Mohammed
- Mahdavi Mahdi
- Majdan Marek
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- Majeed Azeem
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- Malhotra Rajesh
- Malta Deborah Carvalho
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- Rahimi-Movaghar Afarin
- Rahimi-Movaghar Vafa
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- Resnikoff Serge
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- Ruhago George Mugambage
- Saadat Soheil
- Sadat Nafis
- Safdarian Mahdi
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- Sagar Rajesh
- Sahathevan Ramesh
- Salama Joseph
- Salomon Joshua A.
- Salvi Sundeep Santosh
- Samy Abdallah M.
- Sanabria Juan R.
- Santomauro Damian
- Santos Itamar S.
- Santos João Vasco
- Santric Milicevic Milena M.
- Sartorius Benn
- Satpathy Maheswar
- Sawhney Monika
- Saxena Sonia
- Schmidt Maria Inês
- Schneider Ione J.C.
- Schwebel David C.
- Schwendicke Falk
- Schöttker Ben
- Seedat Soraya
- Sepanlou Sadaf G.
- Servan-Mori Edson E.
- Setegn Tesfaye
- Shackelford Katya Anne
- Shaheen Amira
- Shaikh Masood Ali
- Shamsipour Mansour
- Shariful Islam Sheikh Mohammed
- Sharma Jayendra
- Sharma Rajesh
- She Jun
- Shi Peilin
- Shields Chloe
- Shigematsu Mika
- Shinohara Yukito
- Shiri Rahman
- Shirkoohi Reza
- Shirude Shreya
- Shishani Kawkab
- Shrime Mark G.
- Sibai Abla Mehio
- Sigfusdottir Inga Dora
- Silva Diego Augusto Santos
- Silva João Pedro
- Silveira Dayane Gabriele Alves
- Singh Jasvinder A.
- Singh Narinder Pal
- Sinha Dhirendra Narain
- Skiadaresi Eirini
- Skirbekk Vegard
- Slepak Erica Leigh
- Sligar Amber
- Smith David L.
- Smith Mari
- Sobaih Badr H.A.
- Sobngwi Eugene
- Sorensen Reed J.D.
- Sousa Tatiane Cristina Moraes
- Sposato Luciano A.
- Sreeramareddy Chandrashekhar T.
- Srinivasan Vinay
- Stanaway Jeffrey D.
- Stathopoulou Vasiliki
- Steel Nicholas
- Stein Dan J.
- Stein Murray B.
- Steiner Caitlyn
- Steiner Timothy J.
- Steinke Sabine
- Stokes Mark Andrew
- Stovner Lars Jacob
- Strub Bryan
- Subart Michelle
- Sufiyan Muawiyyah Babale
- Suliankatchi Abdulkader Rizwan
- Sunguya Bruno F.
- Sur Patrick J.
- Swaminathan Soumya
- Sykes Bryan L.
- Sylte Dillon O.
- Tabarés-Seisdedos Rafael
- Taffere Getachew Redae
- Takala Jukka S.
- Tandon Nikhil
- Tavakkoli Mohammad
- Taveira Nuno
- Taylor Hugh R.
- Tehrani-Banihashemi Arash
- Tekelab Tesfalidet
- Temam Shifa Girma
- Terkawi Abdullah Sulieman
- Tesfaye Dawit Jember
- Tesssema Belay
- Thamsuwan Ornwipa
- Thomas Katie E.
- Thrift Amanda G.
- Tiruye Tenaw Yimer
- Tobe-Gai Ruoyan
- Tollanes Mette C.
- Tonelli Marcello
- Topor-Madry Roman
- Tortajada Miguel
- Touvier Mathilde
- Tran Bach Xuan
- Tripathi Suryakant
- Troeger Christopher
- Truelsen Thomas
- Tsoi Derrick
- Tuem Kald Beshir
- Tuzcu Emin Murat
- Tyrovolas Stefanos
- Ukwaja Kingsley N.
- Undurraga Eduardo A.
- Uneke Chigozie Jesse
- Updike Rachel
- Uthman Olalekan A.
- Uzochukwu Benjamin S. Chudi
- Van Boven Job F.M.
- Varughese Santosh
- Vasankari Tommi
- Venkatesh
- Venketasubramanian Narayanaswamy
- Vidavalur Ramesh
- Violante Francesco S.
- Vladimirov Sergey K.
- Vlassov Vasiliy Victorovich
- Vollset Stein Emil
- Vos Theo
- Wadilo Fiseha
- Wakayo Tolassa
- Wang Yuan-Pang
- Weaver Marcia
- Weichenthal Scott
- Weiderpass Elisabete
- Weintraub Robert G.
- Werdecker Andrea
- Westerman Ronny
- Whiteford Harvey A.
- Wijeratne Tissa
- Wiysonge Charles Shey
- Wolfe Charles D.A.
- Woodbrook Rachel
- Woolf Anthony D.
- Workicho Abdulhalik
- Wulf Hanson Sarah
- Xavier Denis
- Xu Gelin
- Yadgir Simon
- Yaghoubi Mohsen
- Yakob Bereket
- Yan Lijing L.
- Yano Yuichiro
- Ye Pengpeng
- Yimam Hassen Hamid
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z.
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zegeye Elias Asfaw
- Zenebe Zerihun Menlkalew
- Zhang Xueying
- Zhou Maigeng
- Zipkin Ben
- Zodpey Sanjay
- Zuhlke Liesl Joanna
- Ärnlöv Johan
- Publication venue
- Publication date
- 01/01/2017
- Field of study
As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016
Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- Author
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abdulkader Rizwan Suliankatchi
- Abdulle Abdishakur M.
- Abebo Teshome Abuka
- Abera Semaw Ferede
- Aboyans Victor
- Abu-Raddad Laith J.
- Ackerman Ilana N.
- Adedeji Isaac A.
- Adedji
- Adetokunboh Olatunji
- Afshin Ashkan
- Aggarwal Rakesh
- Agrawal Anurag
- Agrawal Sutapa
- Ahmed Muktar Beshir
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Aiyar Sneha
- Akinyemiju Tomi F.
- Akseer Nadia
- Al Lami Faris Hasan
- Al-Aly Ziyad
- Al-Maskari Fatma
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Tahiya
- Alasfoor Deena
- Alene Kefyalew Addis
- Ali Raghib
- Alizadeh-Navaei Reza
- Alkaabi Juma M.
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Allen Christine
- Almazroa Mohammad Abdulaziz
- Alsharif Ubai
- Alsowaidi Shirina
- Althouse Benjamin M.
- Altirkawi Khalid A.
- Alvis-Guzman Nelson
- Amare Azmeraw T.
- Amini Erfan
- Ammar Walid
- Amoako Yaw Ampem
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T.
- Anwari Palwasha
- Arora Megha
- Artaman Al
- Arthur Avokpaho Euripide Frinel G.
- Aryal Krishna Kumar
- Asgedom Solomon W.
- Atey Tesfay Mehari
- Atnafu Niguse Tadele
- Avila-Burgos Leticia
- Awasthi Ashish
- Awasthi Shally
- Azarpazhooh Mahmoud Reza
- Azzopardi Peter
- Babalola Tesleem Kayode
- Bacha Umar
- Badawi Alaa
- Balakrishnan Kalpana
- Bannick Marlena S.
- Barac Aleksandra
- Barker-Collo Suzanne L.
- Barquera Simon
- Barrero Lope H.
- Basu Sanjay
- Battista Robert
- Battle Katherine E.
- Baune Bernhard T.
- Bazargan-Hejazi Shahrzad
- Beardsley Justin
- Bedi Neeraj
- Bekele Bayu Begashaw
- Bell Michelle L.
- Bennett Derrick A.
- Bennett James R.
- Bensenor Isabela M.
- Benson Jennifer
- Berhane Adugnaw
- Berhe Derbew Fikadu
- Bernabé Eduardo
- Betsu Balem Demtsu
- Beuran Mircea
- Beyene Addisu Shunu
- Bhansali Anil
- Bhatt Samir
- Bhutta Zulfqar A.
- Biadgilign Sibhatu
- Bicer Burcu Kucuk
- Bienhof Kelly
- Bikbov Boris
- Birungi Charles
- Biryukov Stan
- Bisanzio Donal
- Bizuayehu Habtamu Mellie
- Blyth Fiona M.
- Boneya Dube Jara
- Bose Dipan
- Bou-Orm Ibrahim R.
- Bourne Rupert R. A.
- Brainin Michael
- Brayne Carol E. G.
- Brazinova Alexandra
- Breitborde Nicholas J. K.
- Briant Paul S.
- Britton Gabrielle
- Brugha Traolach S.
- Bryane
- Buchbinder Rachelle
- Bulto Lemma Negesa Bulto
- Bumgarner Blair
- Butt Zahid A.
- Bärnighausen Till
- Béjot Yannick
- Cahuana-Hurtado Lucero
- Cameron Ewan
- Campos-Nonato Ismael Ricardo
- Carabin Hélène
- Carpenter David O.
- Carrero Juan Jesus
- Carter Austin
- Carvalho Felix
- Casey Daniel
- Castañeda-Orjuela Carlos A.
- Castle Chris D.
- Catalá-López Ferrán
- Chang Jung-Chen
- Charlson Fiona J.
- Chaturvedi Pankaj
- Chen Honglei
- Chibalabala Mirriam
- Chibueze Chioma Ezinne
- Chisumpa Vesper Hichilombwe
- Chitheer Abdulaal A.
- Chowdhury Rajiv
- Christopher Devasahayam Jesudas
- Ciobanu Liliana G.
- Cirillo Massimo
- Colombara Danny
- Cooper Cyrus
- Cooper Leslie Trumbull
- Cortesi Paolo Angelo
- Cortinovis Monica
- Criqui Michael H.
- Cromwell Elizabeth A.
- Cross Marita
- Crump John A.
- Cárdenas Rosario
- Dadi Abel Fekadu
- Dalal Koustuv
- Damasceno Albertino
- Dandona Lalit
- Dandona Rakhi
- Das Jarlais Don C.
- Das Neves José
- Davitoiu Dragos V.
- Davletov Kairat
- De Courten Barbora
- De Leo Diego
- De Steur Hans
- Defo Barthelemy Kuate
- Degenhardt Louisa
- Deiparine Selina
- Dellavalle Robert P.
- Deribe Kebede
- Deribew Amare
- Dey Subhojit
- Dharmaratne Samath D.
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- Yadgir Simon
- Yaghoubi Mohsen
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- Yan Lijing L.
- Yano Yuichiro
- Ye Pengpeng
- Yihdego Mahari Gidey
- Yimam Hassen Hamid
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- Yonemoto Naohiro
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- Yotebieng Marcel
- Younis Mustafa Z.
- Yu Chuanhua
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zegeye Elias Asfaw
- Zenebe Zerihun Menlkalew
- Zhang Xueying
- Zheng Yingfeng
- Zhou Maigeng
- Zipkin Ben
- Zodpey Sanjay
- Zoeckler Leo
- Zuhlke Liesl Joanna
- Ärnlöv Johan
- Publication venue
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI).
METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE differed from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate.
FINDINGS: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and 1·96 years (1·69-2·13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2·3% [-5·9 to 0·9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the five lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16·1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally.
INTERPRETATION: At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs offset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention efforts, and development assistance for health, including financial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support.
FUNDING: Bill & Melinda Gates Foundation
Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
- Author
- Abate Degu
- Abay Solomon M
- Abbafati Cristiana
- Abbasi Nooshin
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdel-Rahman Omar
- Abdela Jemal
- Abdelalim Ahmed
- Abdi Alireza
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abebe Nebiyu Dereje
- Abebe Zegeye
- Abejie Ayenew Negesse
- Abera Semaw F
- Abil Olifan Zewdie
- Aboyans Victor
- Abraha Haftom Niguse
- Abrham Aklilu Roba
- Abu-Raddad Laith Jamal
- Abu-Rmeileh Niveen Me
- Abyu Gebre Y
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Acharya Pawan
- Adamu Abdu A
- Adebayo Oladimeji M
- Adedeji Isaac Akinkunmi
- Adedoyin Rufus Adesoji
- Adekanmbi Victor
- Adetokunboh Olatunji O
- Adhena Beyene Meressa
- Adhikari Tara Ballav
- Adib Mina G
- Adou Arsène Kouablan
- Adsuar Jose C
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agarwal Gina
- Aghayan Sargis Aghasi
- Agius Dominic
- Agrawal Anurag
- Agrawal Sutapa
- Ahmadi Alireza
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmed Muktar Beshir
- Ahmed Sayem
- Akalu Temesgen Yihunie
- Akanda Ali S
- Akbari Mohammad Esmaeil
- Akibu Mohammed
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akseer Nadia
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Maskari Fatma
- Al-Mekhlafi Hesham M
- Al-Raddadi Rajaa M
- Alahdab Fares
- Alam Khurshid
- Alam Tahiya
- Albujeer Ammar
- Alebel Animut
- Alene Kefyalew Addis
- Alhabib Samia
- Ali Raghib
- Alijanzadeh Mehran
- Alizadeh-Navaei Reza
- Aljunid Syed Mohamed
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Allen Christine A
- Almasi Ali
- Alonso Jordi
- Alsharif Ubai
- Altirkawi Khalid
- Alvis-Guzman Nelson
- Amare Azmeraw T
- Amenu Kebede
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- Andrei Catalina Liliana
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- Ansari Hossein
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- Antonio Carl Abelardo T
- Anwari Palwasha
- Appiah Lambert Tetteh
- Aremu Olatunde
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- Azzopardi-Muscat Natasha
- Babalola Tesleem Kayode
- Babazadeh Arefeh
- Badali Hamid
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- Troeger Christopher E
- Truelsen Thomas Clement
- Tsadik Afewerki Gebremeskel
- Tudor Car Lorainne
- Tuzcu E Murat
- Tymeson Hayley D
- Ukwaja Kingsley N
- Ullah Irfan
- Updike Rachel L
- Usman Muhammad Shariq
- Uthman Olalekan A
- Vaduganathan Muthiah
- Vaezi Afsane
- Vaidya Gaurang
- Valdez Pascual R
- van Donkelaar Aaron
- Varavikova Elena
- Vasankari Tommi Juhani
- Venketasubramanian Narayanaswamy
- Vidavalur Ramesh
- Villafaina Santos
- Violante Francesco S
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Vollmer Sebastian
- Vollset Stein Emil
- Vos Theo
- Vosoughi Kia
- Vujcic Isidora S
- Wagner Gregory R
- Wagnew Fasil Shiferaw
- Waheed Yasir
- Walson Judd L
- Wang Yanping
- Wang Yuan-Pang
- Wassie Molla Mesele
- Weiderpass Elisabete
- Weintraub Robert G
- Weiss Jordan
- Weldegebreal Fitsum
- Weldegwergs Kidu Gidey
- Werdecker Andrea
- Werkneh Adhena Ayaliew
- West T Eoin
- Westerman Ronny
- Whisnant Joanna L
- Whiteford Harvey A
- Widecka Justyna
- Widecka Katarzyna
- Wijeratne Tissa
- Wilner Lauren B
- Winkler Andrea Sylvia
- Wiyeh Alison B
- Wiysonge Charles Shey
- Wolde Haileab Fekadu
- Wolfe Charles D A
- Wu Shouling
- Xavier Denis
- Xu Gelin
- Xu Rixing
- Yadollahpour Ali
- Yahyazadeh Jabbari Seyed Hossein
- Yakob Bereket
- Yamada Tomohide
- Yan Lijing L
- Yano Yuichiro
- Yaseri Mehdi
- Yasin Yasin Jemal
- Ye Pengpeng
- Yearwood Jamal A
- Yeshaneh Alex
- Yimer Ebrahim M
- Yip Paul
- Yirsaw Biruck Desalegn
- Yisma Engida
- Yonemoto Naohiro
- Yonga Gerald
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z
- Yousefifard Mahmoud
- Yu Chuanhua
- Zaman Sojib Bin
- Zamani Mohammad
- Zare Zohreh
- Zavala-Arciniega Luis
- Zegeye Desalegn Tegabu
- Zegeye Elias Asfaw
- Zeleke Ayalew Jejaw
- Zendehdel Kazem
- Zerfu Taddese Alemu
- Zhang Anthony Lin
- Zhang Xueying
- Zhou Maigeng
- Zhu Jun
- Zimsen Stephanie R M
- Zodpey Sanjay
- Zoeckler Leo
- Zucker Inbar
- Zuhlke Liesel Joanna J
- Ärnlöv Johan
- Çavlin Alanur
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leaving no one behind”, it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990–2017, projected indicators to 2030, and analysed global attainment. Methods: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0–100, with 0 as the 2\ub75th percentile and 100 as the 97\ub75th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings: The global median health-related SDG index in 2017 was 59\ub74 (IQR 35\ub74–67\ub73), ranging from a low of 11\ub76 (95% uncertainty interval 9\ub76–14\ub70) to a high of 84\ub79 (83\ub71–86\ub77). SDG index values in countries assessed at the subnational level varied substantially, particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attainment by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation: The GBD study offers a unique, robust platform for monitoring the health-related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health-related SDG indicators, NCDs, NCD-related risks, and violence-related indicators will require a concerted shift away from what might have driven past gains—curative interventions in the case of NCDs—towards multisectoral, prevention-oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the SDGs. What is clear is that our actions—or inaction—today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017
- Author
- Abate Degu
- Abate Lkidan Hassen
- Abay Solomon M
- Abbafati Cristiana
- Abbasi Nooshin
- Abbastabar Hcdayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdel-Rahman Omar
- Abdela Jeinal
- Abdelalim Ahmed
- Abdi Alireza
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdurahman Ahmed Abdulahi
- Abebe Haftom Temesgen
- Abebe Molla
- Abebe Zegeye
- Abebo Teshome Abuka
- Aboyans Victor
- Abraha Haftom Niguse
- Abrham Aklilu Roba
- Abu-Raddad Laith Jamal
- Abu-Rmeileh Niveen Ml
- Acharya Pawan
- Adebayo Oladimeji M
- Adedeji Isaac Akinkimmi
- Adedoyin Rufus Adesoji
- Adekanmbi Victor
- Adetokunboh Olatunji O
- Adhena Beyene Meressa
- Adhikari Tara Banal
- Adib Mina G
- Adou Arsene Kouablan
- Adsuar Jose C
- Afaridern Mohsen
- Afshin Ashkan
- Agarwal Gina
- Aggarwal Rakesh
- Aghayan Sargis Agbasi
- Agrawal Anurag
- Agrawal Sutapa
- Ahmadi Alireza
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmed Mohamed Lemine Cheikh Brahim
- Ahmed Muktar Beshir
- Ahmed Sayem
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Akanda Ali S
- Akbari Mohammad Esmaeil
- Akibu Mohammed
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akseer Nadia
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Raddadi Rajaa M
- Alam Khurshid
- Alandab Fares
- Alebel Animut
- Aleman Alicia V
- Alene Kefyalew Addis
- Ali Raghib
- Alijanzadely Mehran
- Alizadeh-Navaei Reza
- Aljunid Syed Mohamed
- Alkerwi Ala'a
- Alla Francois
- Allebeck Peter
- Allen Christine A
- Alonso Jordi
- Alsharif Ubai
- Altirkawi Khalid
- Alvis-Cituman Nelson
- Amare Azmeraw T
- Amini Erfan
- Ammar Walid
- Amoako Yaw Ampem
- Anber Nahla Hamed
- Andrei Catalina Liliana
- Androudi Sofia
- Animut Megbani Debalkie
- Anjomshoa Mina
- Anlay Degefaye Zelalem
- Ansari Hossein
- Ansariadi Ansariadi
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T
- Appiah Seth Christopher Yaw
- Aremu Olatunde
- Areri Habtarnu Abera
- Arnlov Johan
- Aroma Megha
- Artaman Al
- Aryal Krishna K
- Asadi-Lari Mohsen
- Asayesh Hamid
- Asfaw Ephrem Tsegay
- Asgedom Solomon Weldegebreal
- Assadi Reza
- Ataro Zerihun
- Atey Tesfay Mehan Mehari
- Athari Seyyed Shamsadin
- Atique Suleman
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- Atteraya Madhu Sudhan
- Attia Engi F
- Ausloos Marcel
- Avila-Burgos Leticia
- Avokpaho Euripide FGA
- Awasthi Ash Ish
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- Ayele Henok Tadesse
- Ayele Yohanes
- Ayer Rakesh
- Ayuk Tam Be B
- Azzopardi Peter S
- Azzopardi-Muscat Natasha
- Badali Hamid
- Badawi Alaa
- Balakrishnan Kalpana
- Bali Ayele Geleto
- Banach Maciej
- Banstola Armit
- Barac Aleksandra
- Barboza Miguel A
- Barquera Simon
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- Basaleem Huda
- Basara Berrak Bora
- Bassat Quique
- Basu Arindam
- Basu Sanjay
- Baune Bernhard T
- Bazargan-Hejazi Shahrzad
- Bedi Neeraj
- Beghi Ettore
- Behzadifar Masoud
- Behzadifar Meysam
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- Bekele Bayu Begashaw
- Belachew Abate Bekele
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- Belay Ezra
- Belay Saba Abraham
- Belay Yihalem Abebe
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- Bennett Derrick A
- Bensenor Isabela M
- Berhane Adugnaw
- Berman Adam E
- Bernabe Eduardo
- Bernstein Robert S
- Bertolacci Gregory J
- Beuran Mircea
- Beyranvand Tina
- Bhala Neeraj
- Bhatia Eesh
- Bhatt Samir
- Bhattarai Suraj
- Bhaumik Soumyadeeep
- Bhutta Zulfiqar A
- Biadgo Belete
- Bicer Burcu Kucuk
- Bijani Ali
- Bikbov Boris
- Bililign Nigus
- Bin Sayeed Muhammad Shandaat
- Bin Zaman Sojib
- Birlik Sait Mentes
- Birungi Charles
- Bisanzio Donal
- Biswas Tuhin
- Bjorge Tone
- Bleyer Archie
- Bose Dipan
- Bosetti Cristina
- Boufous Soufiane
- Bourne Rupert
- Brady Oliver J
- Bragazzi Nicola Luigi
- Brant Luisa C
- Brazinova Alexandra
- Breitborde Nicholas JK
- Brenner Hermann
- Britton Gabrielle
- Brugha Traolach
- Burke Kristin E
- Busse Reinhard
- Butt Zahid A
- Cahuana-Hurtado Lucero
- Callender Charlton SKH
- Campos-Nonato Ismael R
- Caneras Giulia
- Canero Juan J
- Cano Jorge
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- Castro Franz
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- Cavlin Alanur
- Cerin Ester
- Chaiah Yazan
- Champs Ana Paula
- Chang Hsing-Yi
- Chang Jung-Chen
- Chattopadhyay Aparajita
- Chaturvedi Pankaj
- Chen Wanqing
- Chiang Peggy Pei-Chia
- Chimed-Ochir Odgerel
- Chin Ken Lee
- Chisumpa Vesper Hichilombwe
- Chitheer Abchilaal
- Choi Jee-Young J
- Christensen Hanne
- Christopher Devasahayam J
- Chung Sheng-Chia
- Cicuttini Flavia M
- Ciobanu Liliana G
- Cirillo Massimo
- Claro Rafael M
- Cohen Aaron J
- Coll Srinivas
- Collaborators GBD 2017 Mortality
- Collado-Mateo Daniel
- Constantin Maria-Magdalena
- Conti Sara
- Cooper Cyrus
- Cooper Leslie Trumbull
- Cortesi Paolo Angelo
- Cortinovis Monica
- Cousin Ewerton
- Criqui Michael H
- Cromwell Elizabeth A
- Crowe Christopher Stephen
- Crump John A
- Cucu Alexandra
- Cunningham Matthew
- Daba Alemneh Kabeta
- Dachew Berihun Assefa
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- Dang Anh Kim
- Dargan Paul I
- Daryani Ahmad
- Das Gupta Rajat
- das Neves Jose
- Das Siddharth K
- Dasa Tamirat Tesfaye
- Dash Aditya Prasad
- Davitoiu Dragos Virgil
- Davletov Kairat
- Dayama Anand
- de Courten Barbora
- De la Hoz Fernando Pio
- De Leo Diego
- De Neve Jan-Walter
- Defo Barthelemy Kuate
- Degefa Meaza Ginna
- Degenhardt Louisa
- Degfie Tizta T
- Deiparine Selina
- Dellavalle Robert P
- Demoz Gebre Teklemariam
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- Dessie Getenet Ayalew
- Dey Subhojit
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- Dhimal Meghnath
- Dicker Daniel
- Ding Eric L
- Djalalinia Shirin
- Doku David Teye
- Dolan Kate A
- Donnelly Christi A
- Dorsey E Ray
- Douwes-Schultz Dirk
- Doyle Kerrie E
- Drake Thomas M
- Driscoll Tim Robert
- Dubey Manisha
- Dubljanin Eleonora
- Duken Eyasu Ejeta
- Duncan Bruce B
- Duraes Andre R
- Ebrahimi Hedyeh
- Ebrahimpour Soheil
- Edessa Dumessa
- Edvardsson David
- Eggen Anne Elise
- El Bcheraoui Charbel
- El-Khatib Ziad
- Elfaramawi Mohammed
- Ellingsen Christian Lycke
- Elyazar Iqbal RF
- Enayati Ahmadali
- Endries Aman Yesuf Yesuf
- Er Benjamin
- Ermakov Sergey Petrovich
- Eshrati Babak
- Eskandarieff Sharareh
- Esmaeili Reza
- Esteghamati Alireza
- Esteghamati Sadaf
- Fakhar Matadi
- Fakhim Named
- Falavarjani Khalil Ghasemi
- Farag Tamer
- Faramarzi Mahbobelh
- Fareed Mohammad
- Farhadi Farzaneh
- Farid Talha A
- Farinha Carla Sofia E Sa
- Farioli Andrea
- Faro Andre
- Farvid Maryam S
- Farzadfar Farshad
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- Farzeli Mir Sohail
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- Feigl Andrea B
- Feizy Fariba
- Fentahum Netsanet
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Fernandes Joao C
- Feyissa Garumma Tolu
- Fijabi Daniel Obadare
- Filip Irina
- Finegold Samuel
- Fischer Florian
- Flor Luisa Sorio
- Foigt Nataliya A
- Ford John A
- Foreman Kyle J
- Frank Tahvi D
- Franklin Richard Charles
- Fukumoto Takeshi
- Fuller John E
- Fullman Nancy
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- Futran Neal D
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- Garcia-Gordillo Miguel A
- Gebre Abadi Kahsu
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- Gebregergs Gebremedhin Berne
- Gebrehiwot Tsegaye Tewelde
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- Geleijnse Johanna N
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- Gessner Bradford D
- Getachew Sefonias
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- Gezae Kebede Embaye
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- Ghaserni-Kasman Maryam
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- Gupta Tanush
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- Hachinski Vladimir
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- Hutfless Susan
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- Igumbor Elliman U
- Ikeda Chad Thomas
- Illesanmi Olayinka Stephen
- Iqbal Usman
- Irvani Seyed Sina Naghibi
- Isehunwa Oluwaseyi Oluwakemi
- Islam Farhad
- Islam Sheikh Mohammed Shariful
- Jahangiry Leila
- Jahanmehr Nader
- Jain Rajesh
- Jain Sudhir Kumar
- Jakovljevic Mihail
- James Spencer L
- Jayanbakht Mehdi
- Jayaraman Sudha
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- Jha Ravi Prakash
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- Ji John S
- Johnson Sarah Charlotte
- Jonas Jost B
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- Jozwiak Jacek Jerzy
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- Kawakami Norito
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- Kemp Grant Rodgers
- Kengne Andre Pascal
- Keren Andre
- Keresellidze Maia
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- Khajavi Alireza
- Khalid Nauman
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- Latifi Arman
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- Leigh James
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- Levi Miriam
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- Li Xiaohong
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- Liang Xiaofeng
- Liben Misgan Legesse
- Lim Lee-Ling
- Lim Stephen S
- Limenih Miteku Andualem
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- Lodha Rakesh
- Logroscino Giancarlo
- Lonsdale Chris
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- Lotufo Paulo A
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- Lucas Tim CD
- Lunevicius Raimundas
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- Malta Deborah Carvaho
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- Manamo Wondimu Ayele
- Manda Ana-Laura
- Mansoumia Mohammad Ali
- Mantovani Lorenzo Giovanni
- Mapoma Chabila Christopher
- Marami Dadi
- Marayilla Joemer C
- Marcenes Wagner
- Marina Shakhnazarova
- Martinez-Raga Jose
- Martins Sheila CO
- Martins-Melo Francisco Rogerlandio
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- Masiye Felix
- Massenburg Benjamin Ballard
- Matin Behzad Karami
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- Mazidi Mohsen
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- McKee Martin
- Mehata Suresh
- Mehendale Sanjay Madhav
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- Rahman Muhammad Aziz
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- Sawhney Monika
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- Singam Narayana Sarma Venkata
- Singh Jasvinder A
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- Tekalign Tigist Gashaw
- Tekle Merhawi Gebremedhin
- Temesgen Habtamu
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- Tripathi Suryakant
- Tripathy Srikanth Prasad
- Truelsen Thomas Clement
- Truong Nu Thi
- Tsadik Afewerki Gehremeskel
- Tsilimparis Nikolaos
- Tuzcu E Murat
- Tyrovolas Stefanos
- Ukwaja Kingsley Nnanna
- Ullah Irfan
- Usman Muhammad Shaniq
- Uthman Olalekan A
- Uzun Selen Begun
- Vaduganathan Muthiah
- Vaezi Afsane
- Vaidya Gaurang
- Valdez Pascual R
- Varavikova Elena
- Varughese Santosh
- Vasankari Tommi Juhani
- Vasconcelos Ana Maria Nogales
- Velasquez This Moreno
- Venketasubramanian Narayanaswamy
- Vidavalur Ramesh
- Villafaina Santos
- Violante Francesco S
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Vollset Stein Emil
- Vos Theo
- Vosoughi Kia
- Vujcic Isidora S
- Wagner Gregory R
- Wagnew Fasil Shiferaw Wagnew
- Waheed Yasir
- Wang Yanping
- Wang Yuan-Pang
- Wassie Molla Mesele
- Weaver Nicole Davis
- Weiderpass Elisabete
- Weintraub Robert G
- Weiss Daniel J
- Weiss Jordan
- Weldegebreal Fitsum
- Weldegwergs Kidu Gidey
- Werdecker Andrea
- Westerman Ronny
- Whiteford Harvey A
- Widecka Justyna
- Widecka Katarzyna
- Wijeratne Tissa
- Winkler Andrea Sylvia
- Wiysonge Charles Shey
- Wolfe Charles DA
- Wondemagegn Sintayehu Ambachew
- Wu Shouling
- Wyper Grant MA
- Xu Gelin
- Yadav Rajaram
- Yakob Bereket
- Yamada Tomohide
- Yan Lijing L
- Yano Yuichiro
- Yaseri Mehdi
- Yasin Jemal Yasin
- Ye Pengpeng
- Yearwood Jamal A
- Yentur Gokalp Kadri
- Yeshaneh Alex
- Yimer Ebrahim M
- Yip Paul
- Yisma Engida
- Yonemoto Naohiro
- Yoon Seok-Jun
- York Hunter W
- Yotebieng Marcel
- Younis Mustafa Z
- Yousefifard Mahmoud
- Yu Chuanhua
- Zachariah Geevar
- Zadnik Vesna
- Zafar Shamsa
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zamani Mohammad
- Zare Zohreh
- Zeeb Hajo
- Zeleke Mulugeta Molla
- Zenebe Zerihun Menlkalew
- Zerfu Taddese Alemu
- Zhang Kai
- Zhang Xueying
- Zhu Jun
- Zodpey Sanjay
- Zucker Inbar
- Zuhlke Liesl Joanna J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1-4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0-8·4) while the total sum of global YLDs increased from 562 million (421-723) to 853 million (642-1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6-9·2) for males and 6·5% (5·4-7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782-3252] per 100 000 in males vs 1400 [1279-1524] per 100 000 in females), transport injuries (3322 [3082-3583] vs 2336 [2154-2535]), and self-harm and interpersonal violence (3265 [2943-3630] vs 5643 [5057-6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury
Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017.
- Author
- Abate Degu
- Abay Solomon M
- Abbafati Cristiana
- Abbasi Nooshin
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdel-Rahman Omar
- Abdela Jemal
- Abdelalim Ahmed
- Abdi Alireza
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abebe Nebiyu Dereje
- Abebe Zegeye
- Abejie Ayenew Negesse
- Abera Semaw F
- Abil Olifan Zewdie
- Aboyans Victor
- Abraha Haftom Niguse
- Abrham Aklilu Roba
- Abu-Raddad Laith Jamal
- Abu-Rmeileh Niveen Me
- Abyu Gebre Y
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Acharya Pawan
- Adamu Abdu A
- Adebayo Oladimeji M
- Adedeji Isaac Akinkunmi
- Adedoyin Rufus Adesoji
- Adekanmbi Victor
- Adetokunboh Olatunji O
- Adhena Beyene Meressa
- Adhikari Tara Ballav
- Adib Mina G
- Adou Arsène Kouablan
- Adsuar Jose C
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agarwal Gina
- Aghayan Sargis Aghasi
- Agius Dominic
- Agrawal Anurag
- Agrawal Sutapa
- Ahmadi Alireza
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmed Muktar Beshir
- Ahmed Sayem
- Akalu Temesgen Yihunie
- Akanda Ali S
- Akbari Mohammad Esmaeil
- Akibu Mohammed
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akseer Nadia
- Al-Aly Ziyad
- Al-Eyadhy Ayman
- Al-Maskari Fatma
- Al-Mekhlafi Hesham M
- Al-Raddadi Rajaa M
- Alahdab Fares
- Alam Khurshid
- Alam Tahiya
- Albujeer Ammar
- Alebel Animut
- Alene Kefyalew Addis
- Alhabib Samia
- Ali Raghib
- Alijanzadeh Mehran
- Alizadeh-Navaei Reza
- Aljunid Syed Mohamed
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Allen Christine A
- Almasi Ali
- Alonso Jordi
- Alsharif Ubai
- Altirkawi Khalid
- Alvis-Guzman Nelson
- Amare Azmeraw T
- Amenu Kebede
- Amini Erfan
- Ammar Walid
- Anber Nahla Hamed
- Anderson Jason A
- Andrei Catalina Liliana
- Androudi Sofia
- Animut Megbaru Debalkie
- Anjomshoa Mina
- Ansari Hossein
- Ansariadi Ansariadi
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T
- Anwari Palwasha
- Appiah Lambert Tetteh
- Aremu Olatunde
- Areri Habtamu Abera
- Arora Monika
- Aryal Krishna K
- Asayesh Hamid
- Asfaw Ephrem Tsegay
- Asgedom Solomon Weldegebreal
- Asghar Rana Jawad
- Assadi Reza
- Ataro Zerihun
- Atique Suleman
- Atre Sachin R
- Atteraya Madhu Sudhan
- Ausloos Marcel
- Avila-Burgos Leticia
- Avokpaho Euripide F G A
- Awasthi Ashish
- Ayala Quintanilla Beatriz Paulina
- Ayele Henok Tadesse
- Ayele Yohanes
- Ayer Rakesh
- Azarpazhooh Mahmoud Reza
- Azzopardi Peter S
- Azzopardi-Muscat Natasha
- Babalola Tesleem Kayode
- Babazadeh Arefeh
- Badali Hamid
- Badawi Alaa
- Balakrishnan Kalpana
- Bali Ayele Geleto
- Banach Maciej
- Banerjee Amitava
- Banoub Joseph Adel Mattar
- Banstola Amrit
- Barac Aleksandra
- Barboza Miguel A
- Barker-Collo Suzanne Lyn
- Barrero Lope H
- Barthelemy Celine M
- Bassat Quique
- Basu Arindam
- Basu Sanjay
- Battista Robert J
- Baune Bernhard T
- Baynes Habtamu Wondifraw
- Bazargan-Hejazi Shahrzad
- Bedi Neeraj
- Beghi Ettore
- Behzadifar Masoud
- Behzadifar Meysam
- Bekele Bayu Begashaw
- Belachew Abate Bekele
- Belay Aregawi Gebreyesus
- Belay Saba Abraham
- Belay Yihalem Abebe
- Bell Michelle L
- Bello Aminu K
- Bennett Derrick A
- Bensenor Isabela M
- Benzian Habib
- Berhane Adugnaw
- Berhe Abadi Kidanemariam
- Berman Adam E
- Bernabe Eduardo
- Bernstein Robert S
- Bertolacci Gregory J
- Beuran Mircea
- Beyranvand Tina
- Bhala Neeraj
- Bhalla Ashish
- Bhansali Anil
- Bhattarai Suraj
- Bhaumik Soumyadeep
- Bhutta Zulfiqar A
- Biadgo Belete
- Biehl Molly H
- Bijani Ali
- Bikbov Boris
- Bililign Nigus
- Bin Sayeed Muhammad Shahdaat
- Birlik Sait Mentes
- Birungi Charles
- Bisanzio Donal
- Biswas Tuhin
- Bitew Helen
- Bizuneh Hailemichael
- Bjertness Espen
- Bobasa Eshetu Mulisa
- Boufous Soufiane
- Bourne Rupert
- Bozorgmehr Kayvan
- Bragazzi Nicola Luigi
- Brainin Michael
- Brant Luisa C
- Brauer Michael
- Brazinova Alexandra
- Breitborde Nicholas J K
- Briant Paul Svitil
- Britton Gabrielle
- Brugha Traolach
- Bukhman Gene
- Busse Reinhard
- Butt Zahid A
- Bärnighausen Till Winfried
- Béjot Yannick
- Cahuana-Hurtado Lucero
- Callender Charlton SKH
- Campos-Nonato Ismael R
- Campuzano Rincon Julio Cesar
- Cano Jorge
- Car Josip
- Car Mate
- Carrero Juan J
- Carter Austin
- Carvalho Félix
- Castañeda-Orjuela Carlos A
- Castillo Rivas Jacqueline
- Castro Franz
- Causey Kate
- Cercy Kelly M
- Cerin Ester
- Chaiah Yazan
- Chalek Julian
- Chang Hsing-Yi
- Chang Jung-Chen
- Chattopadhyay Aparajita
- Chattu Vijay Kumar
- Chaturvedi Pankaj
- Chiang Peggy Pei-Chia
- Chin Ken Lee
- Chisumpa Vesper Hichilombwe
- Chitheer Abdulaal
- Choi Jee-Young J
- Chowdhury Rajiv
- Christensen Hanne
- Christopher Devasahayam J
- Chung Sheng-Chia
- Cicuttini Flavia M
- Ciobanu Liliana G
- Cirillo Massimo
- Claro Rafael M
- Claßen Thomas Khaled Dwayne
- Cohen Aaron J
- Collado-Mateo Daniel
- Cooper Cyrus
- Cooper Leslie Trumbull
- Cornaby Leslie
- Cortinovis Monica
- Costa Megan
- Cousin Ewerton
- Cromwell Elizabeth A
- Crowe Christopher Stephen
- Cunningham Matthew
- Cárdenas Rosario
- Daba Alemneh Kabeta
- Dadi Abel Fekadu
- Dandona Lalit
- Dandona Rakhi
- Dang Anh Kim
- Dargan Paul I
- Daryani Ahmad
- Das Gupta Rajat
- das Neves José
- Das Siddharth K
- Dasa Tamirat Tesfaye
- Dash Aditya Prasad
- Davis Adrian C
- Davitoiu Dragos Virgil
- Davletov Kairat
- Dayama Anand
- de Courten Barbora
- De Leo Diego
- De Neve Jan-Walter
- De Steur Hans
- Degefa Meaza Girma
- Degenhardt Louisa
- Degfie Tizta Tilahun
- Deiparine Selina
- Dellavalle Robert P
- Demoz Gebre Teklemariam
- Demtsu Balem
- Denova-Gutiérrez Edgar
- Deribe Kebede
- Dervenis Nikolaos
- Dessie Getenet Ayalew
- Dey Subhojit
- Dharmaratne Samath D
- Dhimal Meghnath
- Dicker Daniel
- Dinberu Mesfin Tadese
- Ding Eric L
- Djalalinia Shirin
- Do Huyen Phuc
- Dokova Klara
- Doku David Teye
- Douwes-Schultz Dirk
- Driscoll Tim Robert
- Duan Leilei
- Dubey Manisha
- Dubljanin Eleonora
- Duken Eyasu Ejeta
- Duncan Bruce B
- Duraes Andre R
- Ebrahimpour Soheil
- Edvardsson David
- El Bcheraoui Charbel
- El-Khatib Ziad
- Eldrenkamp Erika
- Elyazar Iqbal RF
- Enayati Ahmadali
- Endries Aman Yesuf
- Eshrati Babak
- Eskandarieh Sharareh
- Esteghamati Alireza
- Esteghamati Sadaf
- Estep Kara
- Fakhar Mahdi
- Fakhim Hamed
- Fanzo Jessica
- Faramarzi Mahbobeh
- Fareed Mohammad
- Farhadi Farzaneh
- Farid Talha A
- Farinha Carla Sofia e Sá
- Farioli Andrea
- Faro Andre
- Farvid Maryam S
- Farzadfar Farshad
- Farzaei Mohammad Hosein
- Farzam Hossein
- Fazaeli Ali Akbar
- Fazeli Mir Sohail
- Feigin Valery L
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- Feldman Rachel
- Fentahun Netsanet
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
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- Fuller John E
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- Gebregergs Gebremedhin Berhe
- Gebrehiwot Tsegaye Tewelde
- Gebremedhin Amanuel Tesfay
- Gebremichael Bereket
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- Kemmer Laura
- Kemp Grant Rodgers
- Kengne Andre Pascal
- Keren Andre
- Kesavachandran Chandrasekharan Nair
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- Khafaei Behzad
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- Lebedev Georgy
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- Leigh James
- Leinsalu Mall
- Leshargie Cheru Tesema
- Leung Janni
- Lewycka Sonia
- Li Shanshan
- Li Xiaohong
- Li Yichong
- Liang Juan
- Liang Xiaofeng
- Liben Misgan Legesse
- Lim Lee-Ling
- Lim Stephen S
- Limenih Miteku Andualem
- Linn Shai
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- Lorkowski Stefan
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- Martins-Melo Francisco Rogerlândio
- Martopullo Ira
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- Moghadamnia Ali Akbar
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- Mohammadi Moslem
- Mohammadifard Noushin
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- Mohammed Mohammed A
- Mohammed Shafiu
- Mohan Murali B V
- Mohan Viswanathan
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- Moitra Modhurima
- Mokdad Ali H
- Molokhia Mariam
- Monasta Lorenzo
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- Mountjoy-Venning W Cliff
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- Muche Achenef Asmamaw
- Muchie Kindie Fentahun
- Mueller Ulrich Otto
- Muhammed Oumer Sada S
- Mukhopadhyay Satinath
- Mullany Erin C
- Muller Kate
- Mumford John Everett
- Murhekar Manoj
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- Murthy G V S
- Murthy Srinivas
- Musa Jonah
- Musa Kamarul Imran
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- Muthupandian Saravanan
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- Nagarajan Ahamarshan Jayaraman
- Nagel Gabriele
- Naghavi Mohsen
- Naheed Aliya
- Nahvijou Azin
- Naidoo Kovin
- Naik Gurudatta
- Naik Nitish
- Najafi Farid
- Naldi Luigi
- Nam Hae Sung
- Nangia Vinay
- Nansseu Jobert Richie
- Nascimento Bruno Ramos
- Nawaz Haseeb
- Neamati Nahid
- Negoi Ionut
- Negoi Ruxandra Irina
- Neupane Subas
- Newton Charles Richard James
- Ngalesoni Frida N
- Ngunjiri Josephine W
- Nguyen Anh
- Nguyen Grant
- Nguyen Ha
- Nguyen Huong Lan Thi
- Nguyen Huong Thanh
- Nguyen Minh
- Nichols Emma
- Nigatu Solomon Gedlu
- Ningrum Dina Nur Anggraini
- Nirayo Yirga Legesse
- Nisar Muhammad Imran
- Nixon Molly R
- Nolutshungu Nomonde
- Nomura Marika
- Norheim Ole F
- Noroozi Mehdi
- Norrving Bo
- Noubiap Jean Jacques
- Nouri Hamid Reza
- Nourollahpour Shiadeh Malihe
- Nowroozi Mohammad Reza
- Nyasulu Peter S
- Obermeyer Carla Makhlouf
- Ofori-Asenso Richard
- Ogah Okechukwu Samuel
- Ogbo Felix Akpojene
- Oh In-Hwan
- Okoro Anselm
- Oladimeji Kelechi E
- Oladimeji Olanrewaju
- Olagunju Andrew T
- Olagunju Tinuke O
- Olivares Pedro R
- Olsen Helen Elizabeth
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Ong Kanyin L
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- Oommen Anu Mary
- Opio John Nelson
- Oren Eyal
- Oros Andrei
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- Ortiz Alberto
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- Ortiz-Panozo Eduardo
- Ota Erika
- Otstavnov Stanislav S
- Owolabi Mayowa Ojo
- P A Mahesh
- Pakhale Smita
- Pakhare Abhijit P
- Pan Wen-Harn
- Pana Adrian
- Panda Basant Kumar
- Panda-Jonas Songhomitra
- Pandian Jeyaraj Durai
- Papantoniou Nikolaos
- Park Eun-Kee
- Parry Charles D H
- Parsian Hadi
- Patel Shanti
- Pati Sanghamitra
- Patle Ajay
- Patton George C
- Paturi Vishnupriya Rao
- Paudel Deepak
- Paulson Katherine R
- Pearce Neil
- Peprah Emmanuel K
- Pereira David M
- Perico Norberto
- Pervaiz Aslam
- Pesudovs Konrad
- Petri William A
- Petzold Max
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- Pigott David M
- Pillay Julian David
- Pirsaheb Meghdad
- Pletcher Martin
- Pond Constance Dimity
- Postma Maarten J
- Pourshams Akram
- Poustchi Hossein
- Prabhakaran Dorairaj
- Prakash Swayam
- Prasad Narayan
- Purcell Caroline A
- Pyakurel Manita
- Qorbani Mostafa
- Quansah Reginald
- Radfar Amir
- Rafay Anwar
- Rafiei Alireza
- Rahim Fakher
- Rahimi Kazem
- Rahimi-Movaghar Afarin
- Rahimi-Movaghar Vafa
- Rahman Mahfuzar
- Rahman Md Shafiur
- Rahman Mohammad Hifz Ur
- Rahman Muhammad Aziz
- Rahman Sajjad ur
- Rai Rajesh Kumar
- Rajati Fatemeh
- Rajsic Sasa
- Ram Usha
- Rana Saleem M
- Ranabhat Chhabi Lal
- Ranjan Prabhat
- Rasella Davide
- Rawaf David Laith
- Rawaf Salman
- Razo-García Christian
- Reddy K Srinath
- Reiner Robert C
- Reis Cesar
- Reitsma Marissa B
- Remuzzi Giuseppe
- Renzaho Andre M N
- Resnikoff Serge
- Reynales-Shigematsu Luz Myriam
- Rezaei Satar
- Rezaeian Shahab
- Rezai Mohammad Sadegh
- Riahi Seyed Mohammad
- Ribeiro Antonio Luiz P
- Rios-Blancas Maria Jesus
- Roba Kedir Teji
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- Roever Leonardo
- Ronfani Luca
- Roshandel Gholamreza
- Rostami Ali
- Roth Gregory A
- Roy Ambuj
- Rubagotti Enrico
- Ruhago George Mugambage
- Sabde Yogesh Damodar
- Sachdev Perminder S
- Saddik Basema
- Sadeghi Ehsan
- Safari Hosein
- Safari Yahya
- Safari-Faramani Roya
- Safdarian Mahdi
- Safi Sare
- Safiri Saeid
- Sagar Rajesh
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sajadi Haniye Sadat
- Salam Nasir
- Salama Joseph S
- Salamati Payman
- Saldanha Raphael de Freitas
- Saleem Zikria
- Salimi Yahya
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- Seedat Soraya
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- Seyedmousavi Seyedmojtaba
- Shabaninejad Hosein
- Shackelford Katya Anne
- Shafieesabet Azadeh
- Shaheen Amira A
- Shaikh Masood Ali
- Shams-Beyranvand Mehran
- Shamsi Mohammad Bagher
- Shamsizadeh Morteza
- Sharafi Heidar
- Sharafi Kiomars
- Sharif Mehdi
- Sharif-Alhoseini Mahdi
- Sharma Jayendra
- Sharma Rajesh
- Sharma Sharad Kumar
- She Jun
- Sheikh Aziz
- Shey Muki Shehu
- Shi Peilin
- Shibuya Kenji
- Shields Chloe
- Shifa Girma Temam
- Shiferaw Mekonnen Sisay
- Shigematsu Mika
- Shiri Rahman
- Shirkoohi Reza
- Shirude Shreya
- Shishani Kawkab
- Shiue Ivy
- Shokraneh Farhad
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- Shukla Sharvari Rahul
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- Siabani Soraya
- Sibai Abla Mehio
- Siddiqi Tariq J
- Sigfusdottir Inga Dora
- Silpakit Naris
- Silva Diego Augusto Santos
- Silva João Pedro
- Silva Natacha Torres da
- Silveira Dayane Gabriele Alves
- Singh Jasvinder A
- Singh Narinder Pal
- Singh Om Prakash
- Singh Prashant Kumar
- Singh Virendra
- Sinha Dhirendra Narain
- Skiadaresi Eirini
- Sliwa Karen
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- Smith Mari
- Soares Filho Adauto Martins
- Sobaih Badr Hasan
- Sobhani Soheila
- Soljak Michael
- Soofi Moslem
- Soosaraei Masoud
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- Soriano Joan B
- Soshnikov Sergey
- Soyiri Ireneous N
- Spinelli Angela
- Sposato Luciano A
- Sreeramareddy Chandrashekhar T
- Srinivasan Raghavendra Guru
- Srinivasan Vinay
- Stanaway Jeffrey D
- Starodubov Vladimir I
- Stathopoulou Vasiliki
- Steckling Nadine
- Stein Dan J
- Stewart Leo G
- Stockfelt Leo
- Stokes Mark A
- Straif Kurt
- Sudaryanto Agus
- Sufiyan Mu'awiyyah Babale
- Sunguya Bruno F
- Sur Patrick John
- Sutradhar Ipsita
- Sykes Bryan L
- Sylaja P N
- Sylte Dillon O
- Szoeke Cassandra E I
- Tabarés-Seisdedos Rafael
- Tabuchi Takahiro
- Tadakamadla Santosh Kumar
- Tamirat Koku Sisay
- Tandon Nikhil
- Tanser Frank C
- Tassew Aberash Abay
- Tassew Segen Gebremeskel
- Tavakkoli Mohammad
- Taveira Nuno
- Tawye Nega Yimer
- Tehrani-Banihashemi Arash
- Tekalign Tigist Gashaw
- Tekle Merhawi Gebremedhin
- Temesgen Habtamu
- Temsah Mohamad-Hani
- Temsah Omar
- Terkawi Abdullah Sulieman
- Teshale Manaye Yihune
- Teshome Destaw Fetene
- Tessema Belay
- Teweldemedhin Mebrahtu
- Thakur Jarnail Singh
- Thankappan Kavumpurathu Raman
- Theis Andrew
- Thirunavukkarasu Sathish
- Thomas Laura Anne
- Thomas Nihal
- Thomson Alan J
- Thrift Amanda G
- Tilahun Binyam
- To Quyen G
- Tobe-Gai Ruoyan
- Tonelli Marcello
- Topor-Madry Roman
- Torre Anna E
- Tortajada-Girbés Miguel
- Tovani-Palone Marcos Roberto
- Towbin Jeffrey A
- Tran Bach Xuan
- Tran Khanh Bao
- Tran Tung Thanh
- Tripathy Srikanth Prasad
- Troeger Christopher E
- Truelsen Thomas Clement
- Tsadik Afewerki Gebremeskel
- Tudor Car Lorainne
- Tuzcu E Murat
- Tymeson Hayley D
- Ukwaja Kingsley N
- Ullah Irfan
- Updike Rachel L
- Usman Muhammad Shariq
- Uthman Olalekan A
- Vaduganathan Muthiah
- Vaezi Afsane
- Vaidya Gaurang
- Valdez Pascual R
- van Donkelaar Aaron
- Varavikova Elena
- Vasankari Tommi Juhani
- Venketasubramanian Narayanaswamy
- Vidavalur Ramesh
- Villafaina Santos
- Violante Francesco S
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Vollmer Sebastian
- Vollset Stein Emil
- Vos Theo
- Vosoughi Kia
- Vujcic Isidora S
- Wagner Gregory R
- Wagnew Fasil Shiferaw
- Waheed Yasir
- Walson Judd L
- Wang Yanping
- Wang Yuan-Pang
- Wassie Molla Mesele
- Weiderpass Elisabete
- Weintraub Robert G
- Weiss Jordan
- Weldegebreal Fitsum
- Weldegwergs Kidu Gidey
- Werdecker Andrea
- Werkneh Adhena Ayaliew
- West T Eoin
- Westerman Ronny
- Whisnant Joanna L
- Whiteford Harvey A
- Widecka Justyna
- Widecka Katarzyna
- Wijeratne Tissa
- Wilner Lauren B
- Winkler Andrea Sylvia
- Wiyeh Alison B
- Wiysonge Charles Shey
- Wolde Haileab Fekadu
- Wolfe Charles D A
- Wu Shouling
- Xavier Denis
- Xu Gelin
- Xu Rixing
- Yadollahpour Ali
- Yahyazadeh Jabbari Seyed Hossein
- Yakob Bereket
- Yamada Tomohide
- Yan Lijing L
- Yano Yuichiro
- Yaseri Mehdi
- Yasin Yasin Jemal
- Ye Pengpeng
- Yearwood Jamal A
- Yeshaneh Alex
- Yimer Ebrahim M
- Yip Paul
- Yirsaw Biruck Desalegn
- Yisma Engida
- Yonemoto Naohiro
- Yonga Gerald
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z
- Yousefifard Mahmoud
- Yu Chuanhua
- Zaman Sojib Bin
- Zamani Mohammad
- Zare Zohreh
- Zavala-Arciniega Luis
- Zegeye Desalegn Tegabu
- Zegeye Elias Asfaw
- Zeleke Ayalew Jejaw
- Zendehdel Kazem
- Zerfu Taddese Alemu
- Zhang Anthony Lin
- Zhang Xueying
- Zhou Maigeng
- Zhu Jun
- Zimsen Stephanie R M
- Zodpey Sanjay
- Zoeckler Leo
- Zucker Inbar
- Zuhlke Liesel Joanna J
- Ärnlöv Johan
- Çavlin Alanur
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of 'leaving no one behind', it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health-related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990-2017, projected indicators to 2030, and analysed global attainment. METHODS: We measured progress on 41 health-related SDG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health-related SDG index, we transformed the value for each indicator on a scale of 0-100, with 0 as the 2·5th percentile and 100 as the 97·5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
- Carvalho Rui
- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
- Cieslik Grazyna
- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
- Conway James
- Coronel Julian
- Cortes-Maisonet Gregorio
- Cortes-Maisonet Gregorio
- Cournoyer Serge
- Crawford Veronica
- Cristina Gregorini Maria
- Cruz Humberto
- Cruzado Garrit Josep
- Cure Carlos
- Curiac Dan
- Cutfield Rick
- Dandillaya Ramprasad
- Dang Cuong
- Danos Peter
- Darawsha Mahmud
- de \uc1lvaro Fernando
- de Paula Rogerio
- Deerochanawong Chaicharn
- Degenhardt Stefan
- Demko Arkadiy
- Derwahl Karl
- Dhanireddy Soni
- Din Zia
- Distiller Larry
- Dixon Bradley
- Dolores Mart\uednez Esteban M\uaa
- Donath Marc
- Donets Oleksandra
- Dong Junwu
- Dong Youping
- Doshi Ankur
- Doubel Peter
- Dreval Alexander
- Drexel Heinz
- Du Yuming
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- Dumitrescu Adriana
- Dunn Peter
- Dur\ue1n Carlos
- Duyck Francis
- Dzupina Andrej
- E Costa Fernando Teixeira
- Ebenbichler Christoph
- Ebisui Osamu
- Edelsberger Tomas
- Edin Anton
- Eduardo Figueiredo Carlos
- Eduardo Salles Joao
- Efrati Shai
- Ekinci Elif
- El Shahawy Mahfouz
- El-Shahawy Mohammed
- Elbert Alicia
- Elias Mazen
- Eliaschewitz Freddy
- Eliasson Ken
- Emdin Michele
- Engelen Wendy
- Eren Necmi
- Eriksen Erik
- Ermakova Polina
- Escalada San Mart\uedn Javier
- Escobedo de la Pe\uf1a Jorge
- Esteves Cesar
- Eugenia Canziani Maria
- Eustace Joe
- Evans John
- Faber Jens
- Fadda George
- Fang Sum Chee
- Fang Yi
- Fangh\ue4nel Salm\uf3n Guillermo
- Farah Ghassan
- Farber Evgeny
- Farooq Umar
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- Fernando Roland
- Fiaccadori Enrico
- Fikry Sameh
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- Fitz-Patrick David
- Flack John
- Fliesser-G\uf6rzer Evelyn
- Fluck Patrick
- Fogelfeld Leon
- Fonseca Vivian
- Forti Adriana
- Franek Edward
- Frank Malin
- Frias Juan
- Fujita Naruhiro
- Furuya Ryuichi
- Fushtey Ivan
- G Lieverse A
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- Gallouj Karim
- Galphin Claude
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- Garcia-Mayol Luis
- Gaysina Leyla
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- George L Bakris
- Georgiev Dimitar
- Gerasimos Filippatos
- Giebel Thomas
- Gillard Pieter
- Giorgio Battaglia Giovanni
- Gislason Gunnar
- Glandt Mariela
- Goldstein Gary
- Goluch Richard
- Gonz\ue1lez Albarr\ue1n Olga
- Gonz\ue1lez G\ue1lvez Guillermo
- Gonz\ue1lez Gonz\ue1lez Jos\ue9
- Gonz\ue1lez Fernando
- Gonzalez Edgar
- Gonzalez-Abreu Francisco
- Gordeev Ivan
- Gore Ashwini
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- Grossman Ehud
- Guan Tianjun
- Guerci Bruno
- Guerrot Dominique
- Guia Jose
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- Guo Weiying
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- Guti\ue9rrez Ochoa Ramiro
- Guzm\ue1n Gustavo
- H Boonstra A
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- Habwe Violet
- Hagemeier Robert
- Hagenow Andreas
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- Hamasaki Akihiro
- Hamet Pavel
- Hamilton Maxine
- Hammoud Jamal
- Handelsman Stuart
- Hangaard J\uf8rgen
- Hanna Fahmy
- Hanusch Ursula
- Hao Chuanming
- Harcsa Eleonora
- Hart Randolph
- Hartman Israel
- Hasalova Zapletalova Jitka
- Hasnul Halimi Bin Wan Hasan Wan
- Hasslacher Christoph
- Hatazaki Masahiro
- Hatunic Mensud
- Hatziagelaki Erifili
- Hayashi Terumasa
- Heigerick Glenn
- Heitor Susana
- Hellberg Olof
- Hellgren Margareta
- Henein Sam
- Hern\ue1ndez Jaras Julio
- Hern\ue1ndez Eric
- Hernandez German
- Hernandez-Cassis Carlos
- Herrera Carlos
- Higashi Takayuki
- Hirohata Yoshihide
- Hissa Miguel
- Hoffmann Michal
- Hola Olga
- Holian John
- Honkasalo Mikko
- Honkasalo Mikko
- Horacek Thomas
- Horinouchi Shuji
- Hornova Lucie
- Houdova Jana
- Hougardy Jean-Michel
- Hrmova Helena
- Humaloja Kari
- Hung Cheng-Chieh
- Hwang YouCheol
- Ibarra Jaime
- Ibern\uf3n Meritxell
- Imoto Hirofumi
- Inagaki Akemi
- Inagaki Masayuki
- Ioannidis Ioannis
- Ipatko Irina
- Iranmanesh Ali
- Irizar Santana Sa\ufal
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- Ishii Masao
- Ishiko Tamayo
- Jackson Timothy
- Jain Mahendra
- Jamerson Kenneth
- Jansen van Rensburg Dirkie
- Jaramillo Carlos
- Jaramillo Nicol\ue1s
- Jaroslaw Pacyk Grzegorz
- Jiang Fangfang
- Jiang Ju-Ying
- Jiang Sheng
- Jinnouchi Hideaki
- Johnson Karen
- Joshi Mukesh
- Joshi Shaifali
- Juhl Claus
- Juli\ue1n Segura de la Morena Jos\ue9
- Jungmair Wolfgang
- Kahal Hassan
- Kalashnikova Marina
- Kalathil Dhanya
- Kalina Akos
- Kanai Hidetoshi
- Kananen Kristiina
- Kanda Daisuke
- Kanehara Hideo
- Kang JunGoo
- Kantola Ilkka
- Karasek David
- Karlsson Thomas
- Kashima Masayuki
- Kato Kiyoe
- Katsuki Takeshi
- Kattah William
- Kawamitsu Katsunori
- Kawasaki Satsuki
- Kayali Zeid
- Kaye William
- Kazup Szilvia
- Kelly Allan
- Keltai Katalin
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- Khan Bobby
- Khan Muhammad
- Khanh Tran
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- Kikuchi Fumi
- Kikuchi Hidetoshi
- Kilvert Anne
- Kim HyeSoon
- Kim InJoo
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- Kirschner Robert
- Kiss Julianna
- Klein Alexandre
- Klimontov Vadim
- Kloos Christof
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- Kobalava Zhanna
- Kobayashi Kunihisa
- Koch Stanley
- Koch Thorsten
- Kocyigit Ismail
- Kogut Dmytro
- Koide Junko
- Koistinen Arvo
- Komisarenko Julia
- Kooy Adriaan
- Kopecka Sarka
- Kopyt Nelson
- Korff Gary
- Korsoff Pirkko
- Kosachunhanan Natapong
- Kosmacheva Elena
- Kotzker Wayne
- Kounadi Theodora
- Kovacs Laszlo
- Kovar Richard
- Kovesdy Csaba
- Koziolova Natalya
- Kr\ufcger Thilo
- Krarup Thure
- Kravchun Nonna
- Krcova Eva
- Krebs Jeremy
- Kreit Camil
- Krekels Marielle
- Kriauciuniene Dovile
- Krishna Arvind
- Kronfli Saeed
- Krzykowska Jolanta
- Kuang Jian
- Kubota Miyuki
- Kuchar Jiri
- Kumbasar Abdulbaki
- Kurnatowska Ilona
- Kusano Yoshiro
- Kutejova Vlasta
- Kvitkova Lyudmila
- Kyriakidou Christina
- L Penne E
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- La Manna Gaetano
- Lahtela Jorma
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- Lee Chien-Te
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- Lee Paul
- Lee WooJe
- Lei Minxiang
- Leite Jr Maurilo
- LeJeune Derek
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- Lerman Sam
- Levashov Sergey
- Li Dongmei
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- Li Ling
- Li Yan
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- Li Zhonghe
- Li\ue9vano Manuel
- Liberman Alberto
- Liberty Idit
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- Lim Soo
- Lindhardt Morten
- Lindholm Carl-Johan
- Linfert Douglas
- Literati-Nagy Botond
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- Liutkus Joanne
- Long Gang
- Loong Loh Chek
- Lora Henry
- Lu Guoyuan
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- Lucheva Mariya
- Ludvik Bernhard
- Luigi Cavalot Franco
- Luis M Ruilope
- Lurie Alexander
- M Barendregt J N
- M van Leendert Ruud J
- M\ue9ndez Machado Gustavo
- M\ufcller Joachim
- Ma Jianhua
- MacIsaac Richard
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- Madero Rovalo Magdalena
- Madore Francois
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- Mareev Vyacheslav
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- Mileder Margit
- Min Cho Young
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- Minh Nui Nguyen
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- Minton Stephen
- Mirasol Roberto
- Mistodie Cristina
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- Miyaoka Hiroaki
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- Mo Zhaohui
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- Nischik Ruth
- Niu Jianying
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- Nomiyama Takashi
- Nonchev Boyan
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- Noritake Masayuki
- Noronha Irene
- Norwood Paul
- Nowicki Michal
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- Nyirati Gabor
- O Donovan Richard
- O Keefe Dennis
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- Odugbesan A
- Ogiwara Takayuki
- Oguz Aytekin
- Ohashi Hiroshi
- Okamoto Hideki
- Okenka Libor
- Oliver David
- Onaca Adriana
- Oparil Suzanne
- Osonoi Takeshi
- Ozdogan Oner
- P\ue9rez Manghi Federico
- Packham David
- Palyutin Shamil
- Pamugas Glenda
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- Pani Antonello
- Paoli-Bruno Jorge
- Paolino Bruno
- Papadopoulou Dorothea
- Papagianni Aikaterini
- Pape Alexia
- Paschoalin Nathalia
- Paschoalin Raphael
- Pascual Santos Julio
- Passadakis Ploumis
- Patel Rajesh
- Patel Rakesh
- Paulweber Bernhard
- Paveliu Silvia
- Pech\ue8re-Bertschi Antoinette
- Pecoits Filho Roberto
- Pedersen-Bjergaard Pedersen-Bjergaard Ulrik
- Peixoto Aldo
- Peng Ai
- Pereira Amalia
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- Peter Kolkhof
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- Pintilei Ella
- Pisani Antonio
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- R Winkelmann Bernhard
- Radulian Gabriela
- Radzeviciene Lina
- Raina Rupesh
- Rajiv Agarwal
- Ramanathan Kodangudi
- Ramos L\uf3pez Gabriel
- Ramos-Gonez Luis
- Rangelov Rangel
- Ranjith Naresh
- Rashkov Rosen
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- Rastogi Anjay
- Ratnasingam Jeyakantha
- Rayner Brian
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- Ruhullah Yusuf
- Rump Lars
- Ruoff Gary
- Rusicka Teresa
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- Ryu Jeffrey
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- Sarvan Mohamed
- Sasaki Nobuhiro
- Satirapoj Bancha
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- Saxena Sanjeev
- Sch\uf6ll Norbert
- Sch\uf6nherr Hans-Robert
- Sch\ufcrholz Thomas
- Scheen Andr\ue9
- Schernthaner Gerit-Holger
- Schettler Volker
- Schiefke Ingolf
- Schlichthaar Heike
- Schneider Karoly
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- Schr\uf6ppel Bernd
- Schwartz Daniel
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- Scott Russell
- Seco Gilberto
- Seeber Mary
- Sekigami Taiji
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- Serhiyenko Oleksandr
- Seron Daniel
- Serota Harvey
- Serusclat Pierre
- Shafi Tariq
- Shahid Nauman
- Shanik Michael
- Sharma Santosh
- Shen Feixia
- Shen Jiansong
- Sherenkov Alexander
- Shi Bingyin
- Shibasaki Taro
- Shibata Hirotaka
- Shinoda Junji
- Shu Daniel
- Siebert Heidi
- Sigal Helena
- Silva Ana
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- Simon Judit
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- Skokowska Ewa
- Smelser James
- Smirnov Ivan
- Smith Mark
- Smolyarchuk Elena
- Smuts Nine
- Sobajima Hiroshi
- Soe Kyaw
- Sokolova Liubov
- Solache Ortiz Gustavo
- Soln\uf8r Leidulv
- Solomon Richard
- Solovev Oleg
- Soroka Eugene
- Sosovec Dalibor
- Soto Alfonso
- Soufer Joseph
- Sourij Harald
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- Spaak Jonas
- Speeckaert Marijn
- Spodniakova Denisa
- Sritara Piyamitr
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- Stankiewicz Andrzej
- Stas Koen
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- Stefan D Anker
- Stefanidis Ioannis
- Stemler Lutz
- Stephenson Hugo
- Stompor Tomasz
- Stoyanovska-Elencheva Bilyana
- Strack Georg
- Strand Jorma
- Strey Christopher
- Strongin Leonid
- Stryzhak Vasyl
- Su Qing
- Suarez Rosa
- Subramanian Bala
- Sue Kirkman M
- Sugitatsu Kazuya
- Sugiura Toshiyuki
- Sugiyama Toru
- Sulosaari Sakari
- Sun Zhuxing
- Suranyi Michael
- Suzuki Daisuke
- Suzuki Masaaki
- Swift Pauline
- Szerlip Harold
- Szilagyi Iosif
- Szocs Albert
- T Luik P
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- Tagarev Zhivko
- Tamirisa Aparna
- Tanaka Asami
- Tanaka Seiichi
- Tang Shuifu
- Tanque Maribel
- Tarng Der-Cherng
- Tavli Talat
- Tayob Mohammed
- Teitelbaum Ivor
- Tellier Guy
- Temelkova-Kurktschieva Theodora
- Temizhan Ahmet
- Tengmark Bengt-Olov
- Tennankore Karthik
- Terront M\uf3nica
- Thomson Stephen
- Thorup Frode
- Tigen Mustafa
- Tirador Louie
- Tiuryn-Petrulewicz Agnieszka
- Tobe Sheldon
- Tomanek Pavel
- Tong Nanwei
- Tonolo Giancarlo
- Topliss Duncan
- Toursarkissian Nicole
- Tran Tuan-Huy
- Treger Richard
- Trevisan Roberto
- Trokis J
- Troya Maribel
- Trujillo Freddy
- Trullenque Gretel
- Tsch\uf6pe Diethelm
- Tsoukas George
- Tsunematsu Izumi
- Tu Shih-Te
- Turcu Liana
- Turk Thomas
- Tytus Richard
- Ujihara Makoto
- Ukhanova Olga
- Ulmer Achim
- Umpierrez Guillermo
- Urbach Daniel
- Urbach Dorothea
- Urbanaviciene Egle
- Urbonas Gediminas
- Urina Miguel
- Ustundag Sedat
- Vacaru Georgeta
- Valdes Martin
- Valdez Ortiz Rafael
- Valika Shujauddin
- Vallejos Augusto
- van Buren M
- van den Born Bert-Jan
- van der Giet Markus
- VAN Gaal Luc
- VAN Hoang Lam
- van Zyl Louis
- Vanbelleghem Hilde
- Vandeleur James
- Varleta Paola
- Vasas Szilard
- Vasconcellos Eduardo
- Vasileva Svetla
- Vega Damaris
- Velaviciene Audrone
- Vencio Sergio
- Verges Bruno
- Verlan Nadezhda
- Vi\uf1es Gloria
- Vijayaraman Arutchelvam
- Vila Lobos Ana
- Villagordoa Mesa Juan
- Villegas Iv\ue1n
- Vitou Louise
- Vlad Adrian
- Vlasenko Maryna
- Vorokhobina Natalya
- Wainstein Julio
- Wainstein Julio
- Walsh Michael
- Wan Ronald Ma Ching
- Wang Hao
- Wang Jianqin
- Wang Li
- Wang Lihua
- Wang Xinjun
- Wanner Christoph
- Wasilewska Katarzyna
- Wassermann Alfredo
- Wei Jiali
- Weisnagel Stanley
- Weissman Peter
- Whaley-Connell Adam
- Wierusz-Wysocka Bogna
- Wilderman Igor
- Winston Jonathan
- Wise Jonathan
- Wittert Gary
- Wnetrzak-Michalska Renata
- Wong Yuk-Ki
- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
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