Personalized Posture and Fall Classification with Shallow Gated Recurrent Units

Link to final publication : https://ieeexplore.ieee.org/document/8787455International audienceActivities of Daily Living (ADL) classification is a key part of assisted living systems as it can be used to assess a person autonomy. We present in this paper an activity classification pipeline using Gated Recurrent Units (GRU) and inertial sequences. We aim to take advantage of the feature extraction properties of neural networks to free ourselves from defining rules or manually choosing features. We also investigate the advantages of resampling input sequences and personalizing GRU models to improve the performances. We evaluate our models on two datasets: a dataset containing five common postures: sitting, lying, standing, walking and transfer and a dataset named MobiAct V2 providing ADL and falls. Results show that the proposed approach could benefit eHealth services and particularly activity monitoring

Emotion Recognition with Pre-Trained Transformers Using Multimodal Signals

In this paper, we address the problem of multimodal emotion recognition from multiple physiological signals. We demonstrate that a Transformer-based approach is suitable for this task. In addition, we present how such models may be pretrained in a multimodal scenario to improve emotion recognition performances. We evaluate the benefits of using multimodal inputs and pre-training with our approach on a state-ofthe-art dataset

Evolution of Activities of Daily Living using Inertia Measurements: The Lunch and Dinner Activities

In the context of designing eHealth services for fragile people, we propose to monitor Activities of Daily Living (ADL) in order to anticipate the potential loss of autonomy by behaviour changes. Nowadays, the availability of non-stigmatising sensors such as inertial sensors embedded on Smartphones allows the estimation of people’s postures in real time in order to evaluate their autonomy in daily life. Our aim is to propose an unconstrained and non-intrusive method based on inertial sensors, which gives an indicator about a person’s autonomy. This method determines the correlation between people’s postures and activities over time in order to compute an index of ADL (IndexADL), specific to each person. The IndexADL variation over time is then a useful feature for positively or negatively evaluating people’s autonomy.  Our experiment, based on data collection of eight elderly people over a 3-month period, analyses the Lunch and Dinner activities with promising performances

PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signalling in cardiac myocytes

International audienceAims: β1- and β2-adrenergic receptors (β-ARs) produce different acute contractile effects on the heart partly because they impact on different cytosolic pools of cAMP-dependent protein kinase (PKA). They also exert different effects on gene expression but the underlying mechanisms remain unknown. The aim of this study was to understand the mechanisms by which β1- and β2-ARs regulate nuclear PKA activity in cardiomyocytes.Methods and results: We used cytoplasmic and nuclear targeted biosensors to examine cAMP signals and PKA activity in adult rat ventricular myocytes upon selective β1- or β2-ARs stimulation. Both β1- and β2-AR stimulation increased cAMP and activated PKA in the cytoplasm. Although the two receptors also increased cAMP in the nucleus, only β1-ARs increased nuclear PKA activity and up-regulated the PKA target gene and pro-apoptotic factor, inducible cAMP early repressor (ICER). Inhibition of phosphodiesterase (PDE)4, but not Gi, PDE3, GRK2 nor caveolae disruption disclosed nuclear PKA activation and ICER induction by β2-ARs. Both nuclear and cytoplasmic PKI prevented nuclear PKA activation and ICER induction by β1-ARs, indicating that PKA activation outside the nucleus is required for subsequent nuclear PKA activation and ICER mRNA expression. Cytoplasmic PKI also blocked ICER induction by β2-AR stimulation (with concomitant PDE4 inhibition). However, in this case nuclear PKI decreased ICER up-regulation by only 30%, indicating that other mechanisms are involved. Down-regulation of mAKAPβ partially inhibited nuclear PKA activation upon β1-AR stimulation, and drastically decreased nuclear PKA activation upon β2-AR stimulation in the presence of PDE4 inhibition.Conclusions: β1- and β2-ARs differentially regulate nuclear PKA activity and ICER expression in cardiomyocytes. PDE4 insulates a mAKAPβ-targeted PKA pool at the nuclear envelope that prevents nuclear PKA activation upon β2-AR stimulation

Inferring Availability for Communication in Smart Homes Using Context

International audienceThis paper presents a technique for inferring the availability of people to receive communications based on their current situation. This technique uses a context model that associates situations with learned preferences for communications. Situations are represented as a tuple composed of identity, time, place, activity, correspondent, and communication modality. A place-based activity recognition technique is used to recognize the current activity from sensor data. Availability for communications is learned from history of the occupant's preferences of availability for each situation. The system is demonstrated using a dataset of availability preferences recorded from the occupant of an instrumented apartment over a period of 4 weeks. Performance of the system is compared under various assumptions of independence of availability from some of the context elements. The paper is completed with a discussion of how such techniques can be used to construct an intelligent communications assistant for smart home services

Identification of R-Spondin Gene Signature Predictive of Metastatic Progression in BRAFV600E-Positive Papillary Thyroid Cancer

Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland and early stages are curable. However, a subset of PTCs shows an unusually aggressive phenotype with extensive lymph node metastasis and higher incidence of locoregional recurrence. In this study, we investigated a large cohort of PTC cases with an unusual aggressive phenotype using a high-throughput RNA sequencing (RNA-Seq) to identify differentially regulated genes associated with metastatic PTC. All metastatic PTC with mutated BRAF (V600E) but not BRAF wild-type expressed an up-regulation of R-Spondin Protein 4 (RSPO4) concomitant with an upregulation of genes involved in focal adhesion and cell-extracellular matrix signaling. Further immunohistochemistry validation confirmed the upregulation of these target genes in metastatic PTC cases. Preclinical studies using established PTC cell lines support that RSPO4 overexpression is associated with BRAF V600E mutation and is a critical upstream event that promote activation of kinases of focal adhesion signaling known to drive cancer cell locomotion and invasion. This finding opens up the potential of co-targeting B-Raf, RSPO and focal adhesion proteins as a pharmacological approach for aggressive BRAF V600E PTC

The GenTree Dendroecological Collection, tree-ring and wood density data from seven tree species across Europe

The dataset presented here was collected by the GenTree project (EU-Horizon 2020), which aims to improve the use of forest genetic resources across Europe by better understanding how trees adapt to their local environment. This dataset of individual tree-core characteristics including ring-width series and whole-core wood density was collected for seven ecologically and economically important European tree species: silver birch (Betula pendula), European beech (Fagus sylvatica), Norway spruce (Picea abies), European black poplar (Populus nigra), maritime pine (Pinus pinaster), Scots pine (Pinus sylvestris), and sessile oak (Quercus petraea). Tree-ring width measurements were obtained from 3600 trees in 142 populations and whole-core wood density was measured for 3098 trees in 125 populations. This dataset covers most of the geographical and climatic range occupied by the selected species. The potential use of it will be highly valuable for assessing ecological and evolutionary responses to environmental conditions as well as for model development and parameterization, to predict adaptability under climate change scenarios

Language endangerment and language documentation in Africa

Non peer reviewe