313 research outputs found
Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development
- Author
- A Seiler
- AM Wobus
- Andrew Devitt
- CE Turner
- CJ Phiel
- D Huangfu
- David A. Nagel
- DJ Newport
- DM Juriloff
- E Robert
- EJ Hill
- EJ Hill
- Elizabeth K. Woehrling
- Elizabeth Torr
- Eric J. Hill
- G Bug
- G Johnson
- G Scholz
- GA Jung
- GP Daston
- H Nau
- HF Teng
- HT Hogberg
- HT Nguyen
- J Hsieh
- JM Breier
- John D. O’Neil
- K Kultima
- LH Price
- M Gottlicher
- M Hammerschmidt
- M Hirano
- M Kapushesky
- Michael D. Coleman
- MJ Brodie
- MK Rowe
- MR Fielden
- Partha Mukhopadhyay
- PS Klein
- PS Walmod
- PW Andrews
- RA Currie
- RM Niles
- S Kumar
- T Lee
- U Werling
- XN Li
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 19/03/2013
- Field of study
Mood stabilising drugs such as lithium (LiCl) and valproic acid (VPA) are the first line agents for treating conditions such as Bipolar disorder and Epilepsy. However, these drugs have potential developmental effects that are not fully understood. This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. Treatment with VPA and LiCl resulted in the differential expression of 331 and 164 genes respectively. In the subset of VPA targeted genes, 114 were downregulated whilst 217 genes were upregulated. In the subset of LiCl targeted genes, 73 were downregulated and 91 were upregulated. Gene ontology (GO) term enrichment analysis was used to highlight the most relevant GO terms associated with a given gene list following toxin exposure. In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. Whilst LiCl exposure did not significantly alter the proportion of cells expressing markers for stem cells/undifferentiated cells (Oct4, SSEA4), neurons (Neurofilament M), astrocytes (GFAP) or cell cycle phase, the drug caused a 1.4-fold increase in total cell number. In contrast, exposure to VPA resulted in significant upregulation of Oct4, SSEA, Neurofilament M and GFAP with significant decreases in both G2/M phase cells and cell number. This neurosphere model might provide the basis of a human-based cellular approach for the regulatory exploration of developmental impact of potential toxic chemicals
Imaging metabolic heterogeneity in cancer
- Author
- A Hirayama
- A Marusyk
- A Schulze
- A Shakya
- A Sottoriva
- A Viale
- AF Shields
- AJ Walsh
- AR Howlett
- AT Shah
- AW Glaudemans
- B Altenberg
- B Chance
- B Huang
- B Quistorff
- B Scher
- BP Lieberman
- C Denkert
- C Jose
- C-L Ho
- Debanti Sengupta
- E Dijkers
- E Elhami
- ECY Chan
- F Guillaumond
- F Hu
- F Ishikawa
- F López-Ríos
- FA Gallagher
- FU Nielsen
- G Di Chiro
- G Migneco
- G Pratx
- G Pöpperl
- GI Bell
- Guillem Pratx
- H Jadvar
- H Minn
- H Schirrmeister
- H Zhuang
- HA Wieder
- HF Wehrl
- HF Wehrl
- HN Xu
- HN Xu
- HN Xu
- HN Xu
- J Fan
- J Kurhanewicz
- J-K Chung
- JA Bertout
- JD Gordan
- JH Sung
- JN Thupari
- JS Modica-Napolitano
- JV Frangioni
- K Cai
- K Garber
- K Golman
- K Golman
- K Smolková
- KA Krohn
- KH Vousden
- KJ Hope
- KJ Yagle
- KR Keshari
- KW Chan
- KW Cheng
- LZ Li
- LZ Li
- M Findlay
- M Gerlinger
- M Guppy
- M Guppy
- M Jain
- M Li
- M Muruganandham
- M Phelps
- M Picchio
- M van Kruchten
- MC Louzao
- MG Vander Heiden
- MG Vander Heiden
- MJ Albers
- MJ Bissell
- ML Macheda
- MS Judenhofer
- MS May
- N Jagannathan
- N Oyama
- N Ramanujam
- NT Vu
- O Warburg
- PD Shreve
- PL Pedersen
- PP Hsu
- Q Chen
- R Bar-Shalom
- R Bonavia
- R Bos
- R Rossignol
- R Sarkar
- RA Cairns
- RA Gatenby
- RG O’Neil
- RJ Gillies
- RJ Gillies
- RL Elstrom
- RL Wahl
- RP Hill
- S Baek
- S Walenta
- S Walker-Samuel
- S-M Eschmann
- SN Krylov
- SS Gambhir
- T Fan
- T Reya
- T Simsek
- T Ziebart
- TB Rodrigues
- TH Witney
- TH Witney
- TW-M Fan
- W Mueller-Klieser
- WW Moses
- XL Zu
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Operation and performance of the ATLAS Tile Calorimeter in Run 1
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouelfadl 
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez 
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor 
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Arce ATH
- Ardell RE
- Arduh FA
- Argos FC
- Arguin J-
- Argyropoulos S
- Armadans R
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME
- Atkin RJ
- Atkinson M
- Atlay NB
- Auerbach B
- Augsten K
- Avolio G
- Avramidou R
- Axen B
- Ayoub MK
- Azuelos G
- Álvarez Piqueras D
- Åkesson TPA
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahilo JJL
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Baines JT
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- Baldin EM
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- Barreiro Guimarães da Costa J
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- Zou R
- Zur 
- Zwalinski L
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The Tile Calorimeter is the hadron calorimeter covering the central region of the ATLAS experiment at the Large Hadron Collider. Approximately 10,000 photomultipliers collect light from scintillating tiles acting as the active material sandwiched between slabs of steel absorber. This paper gives an overview of the calorimeter’s performance during the years 2008–2012 using cosmic-ray muon events and proton–proton collision data at centre-of-mass energies of 7 and 8TeV with a total integrated luminosity of nearly 30 fb−1. The signal reconstruction methods, calibration systems as well as the detector operation status are presented. The energy and time calibration methods performed excellently, resulting in good stability of the calorimeter response under varying conditions during the LHC Run 1. Finally, the Tile Calorimeter response to isolated muons and hadrons as well as to jets from proton–proton collisions is presented. The results demonstrate excellent performance in accord with specifications mentioned in the Technical Design Report
Search for supersymmetry in events with four or more leptons in √s =13 TeV pp collisions with ATLAS
- Author
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- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
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- Yamanaka T
- Yamane F
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang Y
- Yang Z
- Yao W
- Yap YC
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- Yau Wong KH
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- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yorita K
- Yoshihara K
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- Young CJS
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- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemaityte G
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
- Zerwas D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
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- Zhang M
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- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
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- Zhou M
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- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb −1 of proton-proton collisions delivered by the Large Hadron Collider at s √ =13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95% confidence level in simplified models of General Gauge Mediated supersymmetry, where higgsino masses are excluded up to 295 GeV. In R -parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46 TeV, 1.06 TeV, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively
Measurement of the t¯tZ and t¯tW cross sections in proton-proton collisions at √s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
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- Adamek L
- Adelman J
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- Aguilar-Saavedra JA
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- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
A measurement of the associated production of a top-quark pair (t¯t) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb−1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The t¯tZ and t¯tW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σt¯tZ=0.95±0.08stat±0.10syst pb and σt¯tW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the t¯tZ cross section is used to set constraints on effective field theory operators which modify the t¯tZ vertex
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
- Author
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- Zemaityte G
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- Zhemchugov A
- Zheng Z
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- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √=13TeV
- Author
- Aad G
- Abbott B
- Abbott DC
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- Abraham NL
- Abramowicz H
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- Bobbink GJ
- Bobrovnikov VS
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- Bryngemark L
- Brüers B
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- Budagov IA
- Buddenbrock SEV
- Bugge MK
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- Bullard BA
- Burch TJ
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- Burgard CD
- Burger AM
- Burghgrave B
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- Burton CD
- Burzynski JC
- Buschmann E
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buzykaev AR
- Bylund OB
- Büscher V
- Cabras G
- Caforio D
- Cai H
- Cairo VMM
- Cakir IT
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- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvet D
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- Camarda S
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- Camerlingo MT
- Cameron D
- Camincher C
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- Camplani A
- Canale V
- Canesse A
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- Cao Y
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- Capua M
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- Castillo FL
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- Cavaliere V
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- Cheng HC
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- Cheplakov A
- Cheremushkina E
- Cheu E
- Cheung K
- Chevalier L
- Chevalérias TJA
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
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- Choi K
- Chomont AR
- Chou Y
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- Christopher LD
- Chu MC
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- Ciaccio AD
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- Cieri D
- Ciesla KM
- Cindro V
- Cioară IA
- Ciocio A
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- Da Costa AMMJ
- da Costa JBG
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Daalen TRV
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- Donszelmann TC
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- Dova MT
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- Dreyer E
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- Dumitriu AE
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- Dutta B
- Duvnjak D
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb−1 of s√=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38−0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
Monitoring and data quality assessment of the ATLAS liquid argon calorimeter
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
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- AbouZeid OS
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- Acharya BS
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- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
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- Albrand S
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- Aleksandrov IN
- Alessandria F
- Alexa C
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- Allbrooke BMM
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
The liquid argon calorimeter is a key component of the ATLAS detector installed at the CERN Large Hadron Collider. The primary purpose of this calorimeter is the measurement of electron and photon kinematic properties. It also provides a crucial input for measuring jets and missing transverse momentum. An advanced data monitoring procedure was designed to quickly identify issues that would affect detector performance and ensure that only the best quality data are used for physics analysis. This article presents the validation procedure developed during the 2011 and 2012 LHC data-taking periods, in which more than 98% of the proton-proton luminosity recorded by ATLAS at a centre-of-mass energy of 7-8 TeV had calorimeter data quality suitable for physics analysis
Erratum: Search for Resonant and Nonresonant Higgs Boson Pair Production in the bb[over ¯]τ^{+}τ^{-} Decay Channel in pp Collisions at sqrt[s]=13 TeV with the ATLAS Detector [Phys. Rev. Lett. 121, 191801 (2018)]
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- Aad G
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- Yamaguchi Y
- Yamamoto A
- Yamanaka T
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- Yamatani M
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- Yao W
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- Yigitbasi E
- Yildirim E
- Yorita K
- Yoshihara K
- Young C
- Young C
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- Yu J
- Yue X
- Yuen S
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zaidan R
- Zaitsev A
- Zakareishvili T
- Zakharchuk N
- Zalieckas J
- Zambito S
- Zanzi D
- Zaripovas D
- Zeitnitz C
- Zeißner S
- Zemaityte G
- Zeng J
- Zeng Q
- Zenin O
- Zerwas D
- Zgubič M
- Zhang D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhou Y
- Zhu C
- Zhu H
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas T
- Zou R
- Zur Nedden M
- Zwalinski L
- Ženiš T
- Živković L
- Publication venue
- American Physical Society
- Publication date
- 01/03/2019
- Field of study
Search for flavour-changing neutral current top-quark decays t → qZ in proton-proton collisions at \sqrt{s} = 13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam ER
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
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- Bahrasemani H
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- Chafaq A
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- Chapman JD
- Charlton DG
- Chau CC
- Chavez Barajas CA
- Che S
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- Chegwidden A
- Chekanov S
- Chekulaev SV
- Chelkov GA
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- Cheu E
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- Chevalier L
- Chiarella V
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- Chisholm AS
- Chitan A
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- Cowan G
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- Crawley SJ
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- Cueto A
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- Cukierman AR
- Cummings J
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- Czodrowski P
- Cúth J
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
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- Del Peso J
- Delgove D
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- Delitzsch CM
- Della Pietra M
- della Volpe D
- Dell’Acqua A
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- Delmastro M
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- Demers S
- Demichev M
- Demilly A
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- Deviveiros PO
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- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/07/2018
- Field of study
A search for flavour-changing neutral-current processes in top-quark decays is presented. Data collected with the ATLAS detector from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of s√=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1, are analysed. The search is performed using top-quark pair events, with one top quark decaying through the t → qZ (q = u, c) flavour-changing neutral-current channel, and the other through the dominant Standard Model mode t → bW. Only Z boson decays into charged leptons and leptonic W boson decays are considered as signal. Consequently, the final-state topology is characterized by the presence of three isolated charged leptons (electrons or muons), at least two jets, one of the jets originating from a b-quark, and missing transverse momentum from the undetected neutrino. The data are consistent with Standard Model background contributions, and at 95% confidence level the search sets observed (expected) upper limits of 1.7 × 10−4 (2.4 × 10−4) on the t → uZ branching ratio and 2.4 × 10−4 (3.2 × 10−4) on the t → cZ branching ratio, constituting the most stringent limits to date.
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