Spectroscopic versus Photometric Metallicities: Milky Way Dwarf Spheroidal Companions as a Test Case

Aims. The method of deriving photometric metallicities using red giant branch stars is applied to resolved stellar populations under the common assumption that they mainly consist of single-age old stellar populations. We explore the effect of the presence of mixed-age stellar populations on deriving photometric metallicities. Methods. We use photometric data sets for the five Galactic dwarf spheroidals Sculptor, Sextans, Carina, Fornax, and Leo II in order to derive their photometric metallicity distribution functions from their resolved red giant branches using isochrones of the Dartmouth Stellar Evolutionary Database. We compare the photometric metallicities with published spectroscopic metallicities based on the analysis of the near-infrared Ca triplet (Ca T), both on the metallicity scale of Carretta & Gratton and on the scale defined by the Dartmouth isochrones. In addition, we compare the photometric metallicities with published spectroscopic metallicities based on spectral synthesis and medium-resolution spectroscopy, and on high resolution spectra where available. Results. The mean properties of the spectroscopic and photometric metallicity samples are comparable within the intrinsic scatter of each method although the mean metallicities of dSphs with pronounced intermediate-age population fractions may be underestimated by the photometric method by up to a few tenths of dex in [Fe/H]. The star-by-star differences of the spectroscopic minus the photometric metallicities show a wide range of values along the fiducial spectroscopic metallicity range, with the tendency to have systematically lower photometric metallicities for those dwarf spheroidals with a higher fraction of intermediate-age populations. Such discrepancies persist even in the case of the purely old Sculptor dSph, where one would na\"ively expect a very good match when comparing with medium or low resolution metallicity measurements. Overall, the agreement between Ca T metallicities and photometric metallicities is very good in the metallicity range from ~ -2 dex to ~ -1.5 dex. We find that the photometric method is reliable in galaxies that contain small (less than 15%) intermediate-age stellar fractions. Therefore, in the presence of mixed-age stellar populations, one needs to quantify the fraction of the intermediate-age stars in order to assess their effect on determining metallicities from photometry alone. Finally, we note that the comparison of spectroscopic metallicities of the same stars obtained with different methods reveals similarly large discrepancies as the comparison with photometric metallicities.Comment: 17 pages, 12 figures; A&A accepte

In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids.

Malaria is a parasitic tropical disease that kills around 600,000 patients every year. The emergence of resistant Plasmodium falciparum parasites to artemisinin-based combination therapies (ACTs) represents a significant public health threat, indicating the urgent need for new effective compounds to reverse ACT resistance and cure the disease. For this, extensive curation and homogenization of experimental anti-Plasmodium screening data from both in-house and ChEMBL sources were conducted. As a result, a coherent strategy was established that allowed compiling coherent training sets that associate compound structures to the respective antimalarial activity measurements. Seventeen of these training sets led to the successful generation of classification models discriminating whether a compound has a significant probability to be active under the specific conditions of the antimalarial test associated with each set. These models were used in consensus prediction of the most likely active from a series of curcuminoids available in-house. Positive predictions together with a few predicted as inactive were then submitted to experimental in vitro antimalarial testing. A large majority from predicted compounds showed antimalarial activity, but not those predicted as inactive, thus experimentally validating the in silico screening approach. The herein proposed consensus machine learning approach showed its potential to reduce the cost and duration of antimalarial drug discovery

Chemical evolution of the Small Magellanic Cloud based on planetary nebulae

We investigate the chemical evolution of the Small Magellanic Cloud (SMC) based on abundance data of planetary nebulae (PNe). The main goal is to investigate the time evolution of the oxygen abundance in this galaxy by deriving an age-metallicity relation. Such a relation is of fundamental importance as an observational constraint of chemical evolution models of the SMC. We have used high quality PNe data in order to derive the properties of the progenitor stars, so that the stellar ages could be estimated. We collected a large number of measured spectral fluxes for each nebula, and derived accurate physical parameters and nebular abundances. New spectral data for a sample of SMC PNe obtained between 1999 and 2002 are also presented. These data are used together with data available in the literature to improve the accuracy of the fluxes for each spectral line. We obtained accurate chemical abundances for PNe in the Small Magellanic Cloud, which can be useful as tools in the study of the chemical evolution of this galaxy and of Local Group galaxies. We present the resulting oxygen versus age diagram and a similar relation involving the [Fe/H] metallicity based on a correlation with stellar data. We discuss the implications of the derived age-metallicity relation for the SMC formation, in particular by suggesting a star formation burst in the last 2-3 Gyr.Comment: 11 pages, 6 figures, accepted for publication in Astronomy and Astrophysic

A close look at the Centaurus A group of galaxies: I. Metallicity distribution functions and population gradients in early-type dwarfs

We study dwarf galaxies in the Centaurus A group to investigate their metallicity and possible environmental effects. The Centaurus A group (at ~4 Mpc from the Milky Way) contains about 50 known dwarf companions of different morphologies and stellar contents, thus making it a very interesting target to study how these galaxies evolve. Here we present results for the early-type dwarf galaxy population in this group. We use archival HST/ACS data to study the resolved stellar content of 6 galaxies, together with isochrones from the Dartmouth stellar evolutionary models. We derive photometric metallicity distribution functions of stars on the upper red giant branch via isochrone interpolation. The 6 galaxies are moderately metal-poor (=-1.56 to -1.08), and metallicity spreads are observed (internal dispersions of sigma_[Fe/H]=0.10 to 0.41 dex). We also investigate the possible presence of intermediate-age stars, and discuss how these affect our results. The dwarfs exhibit flat to weak radial metallicity gradients. For the two most luminous, most metal-rich galaxies, we find statistically significant evidence for at least two stellar subpopulations: the more metal-rich stars are found in the center of the galaxies, while the metal-poor ones are more broadly distributed within the galaxies. We find no clear trend of the derived physical properties as a function of (present-day) galaxy position in the group, which may be due to the small sample we investigate. We compare our results to the early-type dwarf population of the Local Group, and find no outstanding differences, despite the fact that the Centaurus A group is a denser environment that is possibly in a more advanced dynamical stage.Comment: 21 pages, 12 figures, accepted for publication in Astronomy and Astrophysic

Carbon enrichment of the evolved stars in the Sagittarius dwarf spheroidal

We present spectra of 1142 colour-selected stars in the direction of the Sagittarius Dwarf Spheroidal (Sgr dSph) galaxy, of which 1058 were taken with VLT/FLAMES multi-object spectrograph and 84 were taken with the SAAO Radcliffe 1.9-m telescope grating spectrograph. Spectroscopic membership is confirmed (at >99% confidence) for 592 stars on the basis of their radial velocity, and spectral types are given. Very slow rotation is marginally detected around the galaxy's major axis. We identify five S stars and 23 carbon stars, of which all but four carbon stars are newly-determined and all but one (PQ Sgr) are likely Sgr dSph members. We examine the onset of carbon-richness in this metal-poor galaxy in the context of stellar models. We compare the stellar death rate (one star per 1000-1700 years) to known planetary nebula dynamical ages and find that the bulk population produce the observed (carbon-rich) planetary nebulae. We compute average lifetimes of S and carbon stars as 60-250 and 130-500 kyr, compared to a total thermal-pulsing asymptotic giant branch lifetime of 530-1330 kyr. We conclude by discussing the return of carbon-rich material to the ISM.Comment: 14 pages, 10 figures, accepted MNRA

Characterization of volatile compounds of Daucus crinitus Desf. Headspace Solid Phase Microextraction as alternative technique to Hydrodistillation

<p>Abstract</p> <p>Background</p> <p>Traditionally, the essential oil of aromatic herbs is obtained using hydrodistillation (HD). Because the emitted volatile fraction plays a fundamental role in a plant's life, various novel techniques have been developed for its extraction from plants. Among these, headspace solid phase microextraction (HS-SPME) can be used to obtain a rapid fingerprint of a plant's headspace. <it>Daucus crinitus </it>Desf. is a wild plant that grows along the west coast of Algeria. Only a single study has dealt with the chemical composition of the aerial part oils of Algerian <it>D. crinitus</it>, in which isochavicol isobutyrate (39.0%), octyl acetate (12.3%), and β-caryophyllene (5.4%) were identified. Using GC-RI and GC-MS analysis, the essential oils and the volatiles extracted from separated organs of <it>D. crinitus </it>Desf. were studied using HS-SPME.</p> <p>Results</p> <p>GC-RI and GC-MS analysis identified 72 and 79 components in oils extracted using HD and in the volatile fractions extracted using SPME, respectively. Two types of essential oils were produced by the plant: the root oils had aliphatic compounds as the main component (87.0%-90.1%), and the aerial part oils had phenylpropanoids as the main component (43.1%-88.6%). HS-SPME analysis showed a more precise distribution of compounds in the organs studied: oxygenated aliphatic compounds were well represented in the roots (44.3%-84.0%), hydrocarbon aliphatic compounds were in the leaves and stems (22.2%-87.9%), and phenylpropanoids were in the flowers and umbels (47.9%-64.2%). Moreover, HS-SPME allowed the occurrence of isochavicol (29.6 - 34.7%) as main component in <it>D. crinitus </it>leaves, but it was not detected in the oils, probably because of its solubility in water.</p> <p>Conclusions</p> <p>This study demonstrates that HD and HS-SPME modes could be complimentary extraction techniques in order to obtain the complete characterization of plant volatiles.</p

Search for CP violation in D+→ϕπ+ and D+s→K0Sπ+ decays

A search for CP violation in D + → ϕπ + decays is performed using data collected in 2011 by the LHCb experiment corresponding to an integrated luminosity of 1.0 fb−1 at a centre of mass energy of 7 TeV. The CP -violating asymmetry is measured to be (−0.04 ± 0.14 ± 0.14)% for candidates with K − K + mass within 20 MeV/c 2 of the ϕ meson mass. A search for a CP -violating asymmetry that varies across the ϕ mass region of the D + → K − K + π + Dalitz plot is also performed, and no evidence for CP violation is found. In addition, the CP asymmetry in the D+s→K0Sπ+ decay is measured to be (0.61 ± 0.83 ± 0.14)%

Study of Bc+B_c^+ decays to the K+K−π+K^+K^-\pi^+ final state and evidence for the decay Bc+→χc0π+B_c^+\to\chi_{c0}\pi^+

A study of $B_c^+\to K^+K^-\pi^+$ decays is performed for the first time using data corresponding to an integrated luminosity of 3.0 $\mathrm{fb}^{-1}$ collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of $7$ and $8$ TeV. Evidence for the decay $B_c^+\to\chi_{c0}(\to K^+K^-)\pi^+$ is reported with a significance of 4.0 standard deviations, resulting in the measurement of $\frac{\sigma(B_c^+)}{\sigma(B^+)}\times\mathcal{B}(B_c^+\to\chi_{c0}\pi^+)$ to be $(9.8^{+3.4}_{-3.0}(\mathrm{stat})\pm 0.8(\mathrm{syst}))\times 10^{-6}$. Here $\mathcal{B}$ denotes a branching fraction while $\sigma(B_c^+)$ and $\sigma(B^+)$ are the production cross-sections for $B_c^+$ and $B^+$ mesons. An indication of $\bar b c$ weak annihilation is found for the region $m(K^-\pi^+)<1.834\mathrm{\,Ge\kern -0.1em V\!/}c^2$, with a significance of 2.4 standard deviations.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-022.html, link to supplemental material inserted in the reference

Observation of an Excited Bc+ State

Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+π+π- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bc∗(2S31)+ state reconstructed without the low-energy photon from the Bc∗(1S31)+→Bc+γ decay following Bc∗(2S31)+→Bc∗(1S31)+π+π-. A second state is seen with a global (local) statistical significance of 2.2σ (3.2σ) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date