Inside pass predicts ball possession effectiveness in NBA basketball

The aims of this study were to analyse the effects of using inside pass on ball possession effectiveness and to identify game performance indicators to predict inside pass success in the National Basketball Association (NBA), considering situational variables. A total of 4207 closed ball possessions (± 10 points difference) where recorded from 25 matches of the 2010 NBA Playoffs series. Ball possessions were classified whether including inside pass (n=808) or not (n=3399). Predictive analysis of use and effectiveness was made through a series of binomial logistic regressions and Classification tree analysis (CHAID). Results indicate that ball possessions including inside pass were more effective and longer in duration, finding a greater use in top-4 NBA teams regardless the game period. Additionally, inside pass effectiveness was influenced by: the receiver attitude, reception distance, and defensive help. Particularly, the analysis of combined performance indicators disclosed relevant information on attack effectiveness, suggesting players to adopt a dynamic attitude in the weak side before getting the ball, while their teammates are developing individual and collective actions to create free space and enhance inside game options and effectiveness. Current findings shed some light on specific knowledge concerning tactical behaviours in NBA basketball, contributing in the design of specific programmes to increase inside game options and players’ decision- making according to specific game constraints

Inside Game Effectiveness in Nba Basketball: Analysis of Collective Interactions

The inside game constitutes an essential aspect of modern basketball, particularly in the National Basketball Association (NBA), in where the best players of the world compete. The purpose of this study was to identify players’ dynamics that increase game performance when using inside pass in the NBA, considering game contextual effects. The sample included 808 inside passes from 25 randomly selected matches of the 2011 NBA Playoffs series. A series of logistic regression analyses were used to analyse passers and receivers’ actions and their effectiveness during inside passes, both isolated and combined. Main results revealed that the interactions combining passer’s previous actions (dribbling or faking) with receiver’s cuts towards the basket achieved the highest offensive effectiveness. Performing screens in favour to the receiver was an effective alternative to increase inside passing options since it reduces the defensive pressure. Furthermore, player’s actions prior to passing the ball were even more successful if combined and synchronized with the receivers’ displacements, especially cutting to the basket. This information allows a better understanding of basketball collective strategies, contributing to the design of precise practice tasks and so improving the training process

Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder and the most frequent cause of dementia. To date, there are only a few approved drugs for AD, which show little or no effect on disease progression. Impaired intracellular calcium homeostasis is believed to occur early in the cascade of events leading to AD. Here, we examined the possibility of normalizing the disrupted calcium homeostasis in the endoplasmic reticulum (ER) store as an innovative approach for AD drug discovery. High-throughput screening of a small-molecule compound library led to the identification of tetrahydrocarbazoles, a novel multifactorial class of compounds that can normalize the impaired ER calcium homeostasis. We found that the tetrahydrocarbazole lead structure, first, dampens the enhanced calcium release from ER in HEK293 cells expressing familial Alzheimer's disease (FAD)-linked presenilin 1 mutations. Second, the lead structure also improves mitochondrial function, measured by increased mitochondrial membrane potential. Third, the same lead structure also attenuates the production of amyloid-beta (A beta) peptides by decreasing the cleavage of amyloid precursor protein (APP) by beta-secretase, without notably affecting alpha- and gamma-secretase cleavage activities. Considering the beneficial effects of tetrahydrocarbazoles addressing three key pathological aspects of AD, these compounds hold promise for the development of potentially effective AD drug candidates

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta