Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry

Elliptic flow of charged particles in Pb-Pb collisions at 2.76 TeV

We report the first measurement of charged particle elliptic flow in Pb-Pb collisions at 2.76 TeV with the ALICE detector at the CERN Large Hadron Collider. The measurement is performed in the central pseudorapidity region (|$\eta$|<0.8) and transverse momentum range 0.2< $p_{\rm T}$< 5.0 GeV/$c$. The elliptic flow signal v$_2$, measured using the 4-particle correlation method, averaged over transverse momentum and pseudorapidity is 0.087 $\pm$ 0.002 (stat) $\pm$ 0.004 (syst) in the 40-50% centrality class. The differential elliptic flow v$_2(p_{\rm T})$ reaches a maximum of 0.2 near $p_{\rm T}$ = 3 GeV/$c$. Compared to RHIC Au-Au collisions at 200 GeV, the elliptic flow increases by about 30%. Some hydrodynamic model predictions which include viscous corrections are in agreement with the observed increase.Comment: 10 pages, 4 captioned figures, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/389

Two-pion Bose-Einstein correlations in central Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76 TeV

The first measurement of two-pion Bose-Einstein correlations in central Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV at the Large Hadron Collider is presented. We observe a growing trend with energy now not only for the longitudinal and the outward but also for the sideward pion source radius. The pion homogeneity volume and the decoupling time are significantly larger than those measured at RHIC.Comment: 17 pages, 5 captioned figures, 1 table, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/388

Suppression of charged particle production at large transverse momentum in central Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}} = 2.76 TeV

Inclusive transverse momentum spectra of primary charged particles in Pb-Pb collisions at $\sqrt{s_{_{\rm NN}}}$ = 2.76 TeV have been measured by the ALICE Collaboration at the LHC. The data are presented for central and peripheral collisions, corresponding to 0-5% and 70-80% of the hadronic Pb-Pb cross section. The measured charged particle spectra in $|\eta|<0.8$ and $0.3 < p_T < 20$ GeV/$c$ are compared to the expectation in pp collisions at the same $\sqrt{s_{\rm NN}}$, scaled by the number of underlying nucleon-nucleon collisions. The comparison is expressed in terms of the nuclear modification factor $R_{\rm AA}$. The result indicates only weak medium effects ($R_{\rm AA} \approx$ 0.7) in peripheral collisions. In central collisions, $R_{\rm AA}$ reaches a minimum of about 0.14 at $p_{\rm T}=6$-7GeV/$c$ and increases significantly at larger $p_{\rm T}$. The measured suppression of high-$p_{\rm T}$ particles is stronger than that observed at lower collision energies, indicating that a very dense medium is formed in central Pb-Pb collisions at the LHC.Comment: 15 pages, 5 captioned figures, 3 tables, authors from page 10, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/98

Higher harmonic anisotropic flow measurements of charged particles in Pb-Pb collisions at 2.76 TeV

We report on the first measurement of the triangular $v_3$, quadrangular $v_4$, and pentagonal $v_5$ charged particle flow in Pb-Pb collisions at 2.76 TeV measured with the ALICE detector at the CERN Large Hadron Collider. We show that the triangular flow can be described in terms of the initial spatial anisotropy and its fluctuations, which provides strong constraints on its origin. In the most central events, where the elliptic flow $v_2$ and $v_3$ have similar magnitude, a double peaked structure in the two-particle azimuthal correlations is observed, which is often interpreted as a Mach cone response to fast partons. We show that this structure can be naturally explained from the measured anisotropic flow Fourier coefficients.Comment: 10 pages, 4 figures, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/387

An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Measurement of the anomalous precession frequency of the muon in the Fermilab Muon g-2 Experiment

The Muon g-2 Experiment at Fermi National Accelerator Laboratory (FNAL) has measured the muon anomalous precession frequency $\omega_a$ to an uncertainty of 434 parts per billion (ppb), statistical, and 56 ppb, systematic, with data collected in four storage ring configurations during its first physics run in 2018. When combined with a precision measurement of the magnetic field of the experiment's muon storage ring, the precession frequency measurement determines a muon magnetic anomaly of $a_{\mu}({\rm FNAL}) = 116\,592\,040(54) \times 10^{-11}$ (0.46 ppm). This article describes the multiple techniques employed in the reconstruction, analysis and fitting of the data to measure the precession frequency. It also presents the averaging of the results from the eleven separate determinations of \omega_a, and the systematic uncertainties on the result.Comment: 29 pages, 19 figures. Published in Physical Review

Performance of missing transverse momentum reconstruction in proton-proton collisions at root s=13 TeV using the CMS detector

The performance of missing transverse momentum ((p) over right arrow (miss)(T)) reconstruction algorithms for the CMS experiment is presented, using proton-proton collisions at a center-of-mass energy of 13 TeV, collected at the CERN LHC in 2016. The data sample corresponds to an integrated luminosity of 35.9 fb(-1). The results include measurements of the scale and resolution of (p) over right arrow (miss)(T), and detailed studies of events identified with anomalous (p) over right arrow (miss)(T). The performance is presented of a (p) over right arrow (miss)(T) reconstruction algorithm that mitigates the effects of multiple proton-proton interactions, using the "pileup per particle identification" method. The performance is shown of an algorithm used to estimate the compatibility of the reconstructed (p) over right arrow (miss)(T) with the hypothesis that it originates from resolution effects.Peer reviewe

Soil desiccation for Loess soils on natural and regrown areas

In the Loess Plateau, soil desiccation has become a serious problem for forest and grass vegetation. Soil desiccation leads to the formation of a dried soil layer (DSL). This paper presents the results of research carried out in the central part of the Loess Plateau. The objective of the research was to produce a statistically supported set of indicators for evaluating soil desiccation of forestlands, to present a heuristic idea for soil desiccation and to supply scientific support for replacing farmland with forest or grass in the Loess Plateau and other regions of China. Here, we suggest that more attention should be paid to soil desiccation and its effects on the ecosystem of the region in the future. The results showed that natural Quercus liaotungensis forestlands (NQF) retained more water content than regrown Robinnia pseudoscacia forestlands (RRF). Significant DSLs were formed in the RRF but not in the NQF. A possible reason for no formation of DSL in NQF could be due to the presence of an arbor-shrub-herb stand structure and large humus and litter accumulation, which increased the natural forest's (NF) adaptability to the environmental conditions. Soil water content in the north-facing slope was significantly larger than in the south-facing slope. DSLs formed in the 0-500 cm layer of the south-facing slope. When slope gradient was greater than 25 degrees, soil water content deceased sharply and showed significant difference compared with 9 degrees, 15 degrees and 20 degrees (P &lt; 0.05). So, we conclude that plant species, aspect and slope angle could be the predicators for the formation of DSLs. The analysis on soil physical properties of 0-60 cm layer indicated that plant species, aspect and slope angle also have significant effects on bulk density, porosity, plant-available capacity, and hydraulic conductivity, especially in the 0-20 and 20-40 cm layers. In the NQF and RRF with north-facing slope, soil physical properties were improved. (C) 2008 Elsevier B.V. All rights reserved

Paleo-megalake termination in the Quaternary: Paleomagnetic andwater-level evidence from south Bohai Sea, China

Asian marginal seas play an important role in moderating material and energy flux linkages between Asia and the Northwest Pacific, and thus have profound climatic and environmental effects. In this study, by combining paleomagnetic study with sediment grain-size analysis on the Lz908 borehole sedimentary sequence from the southern Bohai Sea, new insights into regional geomorphological process since the late early Pleistocene are obtained. The main results are as follows. (1) Paleomagnetic findings suggest that the sequence recorded the Brunhes normal chron and the late Matuyama reverse chron, including the Jaramillo normal subchron. (2) The sedimentary processes in the study area since 1327 ka show a three-stage pattern, with depositional rates of 4.3, 17 and 107 cm/ka during 1327–260 ka (later part of the early and middle Pleistocene), 260–10 ka (late middle and late Pleistocene), and the Holocene, respectively. (3) The sedimentary basin was a part of the Bohai Paleolakes (BHPL) prior to 260 ka, whose water levels were consistently higher than 3 m above the present-day level. After 260 ka, seawater entered the Bohai basin, and relative sea level cyclically fluctuated with global sea-level changes. We therefore infer that the Miaodao Islands, which were the natural barrier of the BHPL blocking seawater entry, had partially subsided before 260 ka, only allowing seawater to enter the basin during a global sea-level maximum. The BHPL terminated around 260 ka, and the “barrier” subsided completely around ~ 130 ka, causing the Bohai basin to become an inner shelf sea