Cross sections for the excitation of isovector charge-exchange resonances in 208Tl

The Glauber approximation for the treatment of heavy-ion scattering, has already been shown to give reliable predictions for the reaction cross section in the particular case of intermediate energy charge-exchange processes. In the present work, we couple a Glauber-type model to microscopic Random Phase Approximation calculations of the charge-exchange excitations of $^{208}$Pb. The aim is to solve the longstanding question whether the very elusive charge-exchange isovector monopole has been really identified in the past experiments, or other multipoles were prevalent in the observed spectra.Comment: text + 4 figures; accepted for publication in Phys. Rev.

Three-body decay of the d* dibaryon

Under certain circumstances, a three-body decay width can be approximated by an integral involving a product of two off-shell two-body decay widths. This ``angle-average'' approximation is used to calculate the $\pi NN$ decay width of the $d^*(J^\pi=3^+, T=0)$ dibaryon in a simple $\Delta^2$ model for the most important Feynman diagrams describing pion emissions with baryon-baryon recoil and meson retardation. The decay width is found to be about 0.006 (0.07, 0.5) MeV at the $d^*$ mass of 2065 (2100, 2150) MeV for input dynamics derived from the Full Bonn potential. The smallness of this width is qualitatively understood as the result of the three-body decay being ``third forbidden''. The concept of $\ell$ forbiddenness and the threshold behavior of a three-body decay are further studied in connection with the $\pi NN$ decay of the dibaryon $d'(J^\pi=0^-, T=0 or 2)$ where the idea of unfavorness has to be introduced. The implications of these results are briefly discussed.Comment: 15 pages, RevTeX, two-column journal style, six figure

Percolation of Color Sources and the determination of the Equation of State of the Quark-Gluon Plasma (QGP) produced in central Au-Au collisions at \sqrt S_{NN}= 200 GeV

The Color String Percolation Model (CSPM) is used to determine the equation of state (EOS) of the QGP produced in central Au-Au collisions at $\sqrt{s_{NN}}$ = 200 A GeV using STAR data at RHIC. When the initial density of interacting colored strings exceeds the 2D percolation threshold a cluster is formed, which defines the onset of color deconfinement. These interactions also produce fluctuations in the string tension which transforms the Schwinger particle (gluon) production mechanism into a maximum entropy thermal distribution. The single string tension is determined by identifying the known value of the universal hadron limiting temperature $T_{c}$ = 167.7 $\pm$ 2.6 MeV with the CSPM percolation temperature at the critical threshold $\xi_{c}$ =1.2. At mid-rapidity the initial Bjorken energy density and the initial temperature determine the number of degrees of freedom consistent with the formation of a $\sim$ 2+1 flavor QGP. An analytic expression for the equation of state, the sound velocity $C_{s}^{2}(\xi)$ is obtained in CSPM. The CSPM $C_{s}^{2}(\xi)$ and the bulk thermodynamic values $\varepsilon /T^{4}$ and $s /T^{3}$ are in excellent agreement in the phase transition region with recent lattice QCD simulations (LQCD) by the HotQCD Collaboration.Comment: 4 pages, 3 figure

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r =-0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r =-0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation

Spinodal decomposition in multicomponent fluid mixtures: A molecular dynamics study

We have investigated the effect of the number p of components on the dynamics of phase separation in two-dimensional symmetric multicomponent fluids. In contrast to concentrated two-dimensional binary fluids, where the growth dynamics is controlled by the coupling of the velocity held to the order parameter, leading to large growth-exponent values, the dynamics in multicomponent fluids (p = 3, 4) is found to follow a t(1/3) growth law, where t is time, which we relate to a long-wavelength evaporation-condensation process. These findings, which are proposed to be consequences of the compact domain structure persisting in multicomponent fluids, imply that hydrodynamic modes do not affect the dynamics of the phase separation in these systems

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy