Open-access management research at a turning point: giving relevance to a stigmatized object

In this short piece, we start by briefly discussing why the model chosen by M@n@gement – free-to-submit, free-to-publish and free-to-read – remains a relevant template, indeed perhaps more relevant today than ever. Despite these assets, our model must compete with other open-access outlets, and contend with negative perceptions, on the part of academics and the general public, of the distance taken by research from its practical impact. We discuss this multidimensional stigma and consider how we, as a community of management researchers, can overcome these challenges to make open-access research sustainable and impactful

Making space for art: a spatial perspective of disruptive and defensive institutional work in Venezuela’s art world

The physical and material aspects of space, such as geographical distance or boundaries, have social and symbolic consequences that impact how people influence and are influenced by institutions. Social actors can however contest how space is conceived, perceived and lived, thus making space a crucial lever in the disruption and defense of institutions. However, we lack understanding of the spatial aspects of such institutional struggles. In exploring how space is leveraged in institutional work, our study foregrounds the socio-political nature of space, building on and expanding the theorization of Lefebvre. We draw on an in depth longitudinal analysis of the material, social and symbolic aspects of the spatial dimensions of disruptive and defensive institutional work over the past twenty years in Venezuela’s art world. Following the Bolivarian Revolution in the late 1990s, the incoming government transformed the organization of the national cultural landscape, resulting in a prolonged period of institutional disruption and defense. We demonstrate that actors use the material, social, and symbolic dimensions of space to challenge and maintain their key values and practices, and that those three dimensions are intertwined

Quantum-limited amplification and parametric instability in the reversed dissipation regime of cavity optomechanics.

Cavity optomechanical phenomena, such as cooling, amplification, or optomechanically induced transparency, emerge due to a strong imbalance in the dissipation rates of the parametrically coupled electromagnetic and mechanical resonators. Here we analyze the reversed dissipation regime where the mechanical energy relaxation rate exceeds the energy decay rate of the electromagnetic cavity. We demonstrate that this regime allows for mechanically induced amplification (or cooling) of the electromagnetic mode. Gain, bandwidth, and added noise of this electromagnetic amplifier are derived and compared to amplification in the normal dissipation regime. In addition, we analyze the parametric instability, i.e., optomechanical Brillouin lasing, and contrast it to conventional optomechanical phonon lasing. Finally, we propose an experimental scheme that realizes the reversed dissipation regime using parametric coupling and optomechanical cooling with a second electromagnetic mode enabling quantum-limited amplification. Recent advances in high-Q superconducting microwave resonators make the reversed dissipation regime experimentally realizable

Persistence of dissolved organic matter explained by molecular changes during its passage through soil

Dissolved organic matter affects fundamental biogeochemical processes in the soil such as nutrient cycling and organic matter storage. The current paradigm is that processing of dissolved organic matter converges to recalcitrant molecules (those that resist degradation) of low molecular mass and high molecular diversity through biotic and abiotic processes. Here we demonstrate that the molecular composition and properties of dissolved organic matter continuously change during soil passage and propose that this reflects a continual shifting of its sources. Using ultrahigh-resolution mass spectrometry and nuclear magnetic resonance spectroscopy, we studied the molecular changes of dissolved organic matter from the soil surface to 60 cm depth in 20 temperate grassland communities in soil type Eutric Fluvisol. Applying a semi-quantitative approach, we observed that plant-derived molecules were first broken down into molecules containing a large proportion of low-molecular-mass compounds. These low-molecular-mass compounds became less abundant during soil passage, whereas larger molecules, depleted in plant-related ligno-cellulosic structures, became more abundant. These findings indicate that the small plant-derived molecules were preferentially consumed by microorganisms and transformed into larger microbial-derived molecules. This suggests that dissolved organic matter is not intrinsically recalcitrant but instead persists in soil as a result of simultaneous consumption, transformation and formation

Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4 coreceptors on host cells. Individuals homozygous for the ccr5Δ32 polymorphism do not express CCR5 and are protected from infection by CCR5-tropic (R5) virus strains. As an approach to inactivating CCR5, we introduced CCR5-specific zinc-finger nucleases into human CD4+ T cells prior to adoptive transfer, but the need to protect cells from virus strains that use CXCR4 (X4) in place of or in addition to CCR5 (R5X4) remains. Here we describe engineering a pair of zinc finger nucleases that, when introduced into human T cells, efficiently disrupt cxcr4 by cleavage and error-prone non-homologous DNA end-joining. The resulting cells proliferated normally and were resistant to infection by X4-tropic HIV-1 strains. CXCR4 could also be inactivated in ccr5Δ32 CD4+ T cells, and we show that such cells were resistant to all strains of HIV-1 tested. Loss of CXCR4 also provided protection from X4 HIV-1 in a humanized mouse model, though this protection was lost over time due to the emergence of R5-tropic viral mutants. These data suggest that CXCR4-specific ZFNs may prove useful in establishing resistance to CXCR4-tropic HIV for autologous transplant in HIV-infected individuals

Gravitational Lensing in Astronomy

Deflection of light by gravity was predicted by General Relativity and observationaly confirmed in 1919. In the following decades various aspects of the gravitational lens effect were explored theoretically, among them the possibility of multiple or ring-like images of background sources, the use of lensing as a gravitational telescope on very faint and distant objects, and the possibility to determine Hubble's constant with lensing. Only relatively recently gravitational lensing became an observational science after the discovery of the first doubly imaged quasar in 1979. Today lensing is a booming part of astrophysics. In addition to multiply-imaged quasars, a number of other aspects of lensing have been discovered since, e.g. giant luminous arcs, quasar microlensing, Einstein rings, galactic microlensing events, arclets, or weak gravitational lensing. By now literally hundreds of individual gravitational lens phenomena are known. Although still in its childhood, lensing has established itself as a very useful astrophysical tool with some remarkable successes. It has contributed significant new results in areas as different as the cosmological distance scale, the large scale matter distribution in the universe, mass and mass distribution of galaxy clusters, physics of quasars, dark matter in galaxy halos, or galaxy structure.Comment: Review article for "Living Reviews in Relativity", see http://www.livingreviews.org . 41 pages, latex, 22 figures (partly in GIF format due to size constraints). High quality postscript files can be obtained electronically at http://www.aip.de:8080/~jkw/review_figures.htm

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

An event-system perspective on disruption: theorizing the pandemic and other discontinuities through historical and fictional accounts of the plague

Disruptions such as COVID-19 – and the subsequent flux they wreak on organizations and society – have become commonplace. In order to advance our understanding of (and adaptation to) future discontinuities and crises, we argue that we require a reconceptualization of how disruption occurs. To do so, we draw on Event Systems Theory (EST): in contrast to previous work viewing disruption as the outcome of a singular event, we focus on how disruption can occur from an event chain, i.e., a set of events that are temporally and causally connected. We abductively shape our conceptual arguments by drawing on narratives of past pandemics, reviewing two historical and two fictional texts that (re)create the experiences of those living through the Black Death and subsequent outbreaks of the bubonic plague. Rather than focusing on events themselves, we identify how certain characteristics among events in a chain lead to four micro-level experiences: stagnation, disorientation, polarization and repudiation. We then proceed to examine how these micro-level reactions culminate into macro-level transformations of economic, political and cultural norms. Our event-system perspective on disruption and crises thereby generates insight, not only into understanding the (post) pandemic world, but also into responses to future discontinuities