304 research outputs found
In vivo gene transfer to the brain cortex using a single injection of HSV-1 vector into the medial septum
- Publication venue
- 'Salvia Medical Sciences Ltd'
- Publication date
- 20/09/2005
- Field of study
This study shows that an ICP4-replication-deficient herpes simplex virus containing
the Moloney murine leukaemia virus LTR fused with the coding sequence
for the beta-galactosidase gene can be used as a very effective vector for
delivering the beta-galactosidase reporter gene into the rat brain septum. F344
rats received bilateral stereotaxic injections into the nucleus of the diagonal
band and into the medial septum. The X-gal stain was used to detect the
activity of the expressed beta-galactosidase enzyme. The delivered reporter gene
was expressed successfully not only in the neuronal cells of the injected areas
but also in cells that project to the injection area such as cortex cells about
6 mm away from the injection sites. Expression was visible at 1, 3 and 9 weeks
following injection. We conclude that this vector can effectively deliver genes
into different regions of the mature mammalian brain and also to areas distant
from the injection site
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
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- Formica A
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- Zhang J
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- Zhemchugov A
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- Zibell A
- Zieminska D
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- Zimmermann C
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- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
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- Zhemchugov A
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- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV
- Author
- Aad G
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- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Phencyclidine (PCP)-Induced Disruption in Cognitive Performance is Gender-Specific and Associated with a Reduction in Brain-Derived Neurotrophic Factor (BDNF) in Specific Regions of the Female Rat Brain
- Author
- A Egerton
- AE West
- B Grayson
- B Grayson
- B Henry
- BE Sumner
- BK Lipska
- Brian Henry
- C Wetmore
- CS Weickert
- DC Choi
- DJ Pulford
- EA Berg
- F Fumagalli
- FM Benes
- G Paxinos
- Gaurav K. Shemar
- GP Reynolds
- H Nawa
- HH Hansen
- HS Phillips
- J Semba
- JA Gorski
- JD Jentsch
- Joanna C. Neill
- JS Rodefer
- JS Sutcliffe
- JY Koh
- K Hashimoto
- Leonie Cruise
- M Birrell
- M Takahashi
- M Takahashi
- MB Spina
- ME Shenton
- MK Harte
- Mohammed Shahid
- MR Stefani
- N Durany
- NF Idris
- O Guillion
- P Vanhoutte
- PJ Harrison
- S Begliuomini
- S Snigdha
- Samantha L. McLean
- SF Altschul
- Shikha Snigdha
- SL McLean
- SM Cochran
- SR Shelnutt
- ST Bland
- T Matsumoto
- TB Franklin
- TD Corso
- V Trajkovska
- Y Xia
- YL Ma
- Z Abdul-Monim
- Z Abdul-Monim
- Publication venue
- Humana Press Inc
- Publication date
- 01/01/2010
- Field of study
Phencyclidine (PCP), used to mimic certain aspects of schizophrenia, induces sexually dimorphic, cognitive deficits in rats. In this study, the effects of sub-chronic PCP on expression of brain-derived neurotrophic factor (BDNF), a neurotrophic factor implicated in the pathogenesis of schizophrenia, have been evaluated in male and female rats. Male and female hooded-Lister rats received vehicle or PCP (n = 8 per group; 2 mg/kg i.p. twice daily for 7 days) and were tested in the attentional set shifting task prior to being sacrificed (6 weeks post-treatment). Levels of BDNF mRNA were measured in specific brain regions using in situ hybridisation. Male rats were less sensitive to PCP-induced deficits in the extra-dimensional shift stage of the attentional set shifting task compared to female rats. Quantitative analysis of brain regions demonstrated reduced BDNF levels in the medial prefrontal cortex (p < 0.05), motor cortex (p < 0.01), orbital cortex (p < 0.01), olfactory bulb (p < 0.05), retrosplenial cortex (p < 0.001), frontal cortex (p < 0.01), parietal cortex (p < 0.01), CA1 (p < 0.05) and polymorphic layer of dentate gyrus (p < 0.05) of the hippocampus and the central (p < 0.01), lateral (p < 0.05) and basolateral (p < 0.05) regions of the amygdaloid nucleus in female PCP-treated rats compared with controls. In contrast, BDNF was significantly reduced only in the orbital cortex and central amygdaloid region of male rats (p < 0.05). Results suggest that blockade of NMDA receptors by sub-chronic PCP administration has a long-lasting down-regulatory effect on BDNF mRNA expression in the female rat brain which may underlie some of the behavioural deficits observed post PCP administration
Exploring the Solar Wind from Its Source on the Corona into the Inner Heliosphere during the First Solar Orbiter-Parker Solar Probe Quadrature
- Author
- Andretta V
- Antonucci E
- Auchere F
- Bale SD
- Bemporad A
- Bruno R
- Capobianco G
- Capuano GE
- Case AW
- Casini C
- Casti M
- Chioetto P
- Corso AJ
- Da Deppo V
- De Leo Y
- de Wit TD
- Fineschi S
- Frassati F
- Frassetto F
- Giordano S
- Goetz K
- Guglielmino SL
- Habbal S
- Harvey PR
- Heinzel P
- Jerse G
- Kasper JC
- Korreck KE
- Landini F
- Larson D
- Liberatore A
- Livi R
- MacDowall RJ
- Magli E
- Malaspina DM
- Massone G
- Messerotti M
- Moses JD
- Naletto G
- Nicolini G
- Nistico G
- Panasenco O
- Pancrazzi M
- Pelizzo MG
- Perrone D
- Pinto RF
- Pulupa M
- Reale F
- Romano P
- Romoli M
- Sasso C
- Schuehle U
- Sorriso-Valvo L
- Spadaro D
- Stangalini M
- Stevens ML
- Strachan L
- Straus T
- Susino R
- Telloni D
- Teriaca L
- Uslenghi M
- Velli M
- Verscharen D
- Volpicelli CA
- Whittlesey P
- Woodham LD
- Zangrilli L
- Zank GP
- Zimbardo G
- Zuppella P
- Publication venue
- IOP Publishing Ltd
- Publication date
- 01/01/2021
- Field of study
This Letter addresses the first Solar Orbiter (SO)–Parker Solar Probe (PSP) quadrature, occurring on 2021 January 18 to investigate the evolution of solar wind from the extended corona to the inner heliosphere. Assuming ballistic propagation, the same plasma volume observed remotely in the corona at altitudes between 3.5 and 6.3 solar radii above the solar limb with the Metis coronagraph on SO can be tracked to PSP, orbiting at 0.1 au, thus allowing the local properties of the solar wind to be linked to the coronal source region from where it originated. Thanks to the close approach of PSP to the Sun and the simultaneous Metis observation of the solar corona, the flow-aligned magnetic field and the bulk kinetic energy flux density can be empirically inferred along the coronal current sheet with an unprecedented accuracy, allowing in particular estimation of the Alfvén radius at 8.7 solar radii during the time of this event. This is thus the very first study of the same solar wind plasma as it expands from the sub-Alfvénic solar corona to just above the Alfvén surface
Effects of a pulmonary rehabilitation program on physical capacity, peripheral muscle function and inflammatory markers in asthmatic children and adolescents: study protocol for a randomized controlled trial
- Author
- A Fanelli
- A Moreira
- Aline Santos Meneses
- AW Sousa
- C Escala La
- Dirceu Solé
- ERS Task Force
- EZ Moraes
- F Pitta
- F Villa
- FA Mendes
- Fabiano Politti
- Fernanda Cordoba Lanza
- FP Counil
- GA Borg
- Gustavo Falbo Wandalsen
- HJ Hermens
- I Matsumoto
- I Vogiatzis
- IB Wicher
- JA Neder
- Jessyca Pachi Rodrigues Selman
- JM Hänggi
- JS Wang
- K Corder
- K Meer de
- Kátia De Angelis
- L Lochte
- L Lochte
- L Welsh
- LB Andrade
- M Thomas
- MA Spruit
- Mariana Mazzuca Reimberg
- MJ Buchfuhrer
- MR Miller
- Márcia Carvalho Mallozi
- OS Levin
- PA Eichenberger
- PD Wagner
- Rejane Agnelo Silva Castro
- S Basaran
- S Godfrey
- S Mathur
- SB Ahmaidi
- Simone Dal Corso
- SJ Singh
- Sociedade Brasileira de Pneumologia
- T Ringbaek
- TD Howard
- V Areias
- VH Wanrooij
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: a worldwide collaborative project.
- Author
- Å
- Abdenur Je
- Abdulrahman M
- Adair O
- Al Nuaimi SA
- Allen Jj
- Antonozzi I
- Archer S
- Au S
- Auray Blais C
- Baker M
- Bamforth F
- Beckmann K
- Berberich Sl
- Bermejo Ms
- Binard R
- Boemer F
- Bonham J
- Breen Nn
- Bryant Sc
- Bryant Sc
- Caggana M
- Caggana M
- Caldwell Sg
- Caldwell Sg
- Cameron Ca
- Camilot M
- Camilot M
- Campbell C
- Campbell C
- Carducci C
- Carducci C
- Cariappa R
- Carlisle C
- Caruso U
- Cassanello M
- Castilla Am
- Chakraborty P
- Chandrasekar R
- Cheillan D
- Chien Yh
- Childs Ta
- Chrastina P
- Colandre Me
- Corso G
- Currier R
- Cyr D
- Czuczy N
- D&apos
- Davis T
- de Juan JA
- de Sain Van der Velden MG
- Delgado Pecellin C
- Di Gangi IM
- Di Stefano CM
- Domingos Mt
- Dotsikas Y
- Downing M
- Downs Sm
- Dy B
- Dymerski M
- Eaton R
- Eckerd Bm
- El Mougy F
- Elvers B
- Eroh S
- Espada M
- Espinoza Vc
- Evans C
- Fawbush S
- Fijolek Kf
- Fisher L
- Franzson L
- Frazier Dm
- Garcí
- Garcia Lr
- Gavrilov D
- Gerace R
- Giordano G
- Greed Lc
- Greenberg Cr
- Grier R
- Grycki E
- Gu X
- Gulamali Majid F
- Hadachi Sm
- Hagar Af
- Han L
- Hannon Wh
- Haslip C
- Hassan Fa
- He M
- Hietala A
- Himstedt L
- Hoffman Gl
- Hoffman W
- Hoggatt P
- Hopkins Pv
- Hougaard Dm
- Hughes K
- Hunt Pr
- Hwu Wl
- Hynes J
- Ibarra Gonzá
- Ingham Ca
- Irazabal Yg
- Ivanova M
- Jó
- Jacox Wb
- John C
- Johnson Jp
- Jones Al
- Juan Fita MJ
- Karg E
- Kasper D
- Katakouzinos D
- Khneisser I
- Klopper B
- Knoll D
- Kobayashi H
- Kohlmueller D
- Koneski R
- Kouapei R
- Kozich V
- Kremensky I
- La Marca Giancarlo
- Lavochkin M
- Lee Sy
- Lehotay Dc
- Lemes A
- Lepage J
- Lesko B
- Lewis B
- Lim C
- Linard S
- Lindner M
- Lloyd Puryear MA
- Lorey F
- Loukas Yl
- Luedtke J
- Maffitt N
- Magee Jf
- Manning A
- Manos S
- Marie S
- Marquardt G
- Martin Sj
- Matern D
- Mayfield Gibson SK
- Mayne P
- McCallister Td
- McCann M
- McClure J
- McGill Jj
- McHugh Dm
- McKeever Cd
- McNeilly B
- Mellado Jm
- Morrissey Ma
- Moutsatsou P
- Mulcahy Ea
- Nikoloudis D
- Norgaard Pedersen B
- Oglesbee D
- Ojodu J
- Oltarzewski M
- Ombrone D
- Papakonstantinou V
- Park Hd
- Pasquali M
- Pasquini E
- Pass Ka
- Patel P
- Peterson C
- Pettersen Rd
- Pino Gb
- Pitt Jj
- Poh S
- Pollak A
- Porter C
- Poston Pa
- Price Rw
- Queijo C
- Quesada J
- Ramos Ac
- Ramos De
- Randell E
- Ranieri E
- Raymond K
- Reddic Je
- Reoyo Sp
- Reuben A
- Ricciardi C
- Rinaldo P
- Rivera Jd
- Roberts A
- Rocha H
- Roche G
- Rueda I
- Ruiz C
- Ruoppolo M
- Rutledge Sl
- Ryu E
- Saban C
- Sahai I
- Santiago Borrero P
- Schenone A
- Schoos R
- Schweitzer B
- Scott P
- Seashore Mr
- Seeterlin Ma
- Sesser De
- Sevier Dw
- Shone Sm
- Sica Yc
- Sinclair G
- Skrinska Va
- Stanley El
- Strovel Et
- Sunny S
- Takats Z
- Tanyalcin T
- Teofoli F
- Thompson Jr
- Tomashitis K
- Torres J
- Torres R
- Tortorelli S
- Turi S
- Turner K
- Tzanakos N
- Valiente Ag
- Vallance H
- Vela Amieva M
- Vilarinho L
- Vincent Mf
- von Dö
- Vorster Bc
- Watson Ms
- Webster D
- Weiss S
- Wilcken B
- Wiley V
- Williams Sk
- Willis Sa
- Woontner M
- Wright K
- Yahyaoui R
- Yamaguchi S
- Yssel M
- Zakowicz W. M.
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbasi-Kangevari M
- Abd-Rabu R
- Abdelmasseh M
- Abdoli A
- Abolhassani H
- Abu-Gharbieh E
- Accrombessi MMK
- Adnani QES
- Afzal MS
- Agarwal G
- Agrawaal KK
- Agudelo-Botero M
- Ahinkorah BO
- Ahmad S
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi S
- Ahmed Salih Y
- Ahmed A
- Akande-Sholabi W
- Akram T
- Al Hamad H
- Al-Aly Z
- Al-Raddadi RM
- Alcalde-Rabanal JE
- Alipour V
- Aljunid SM
- Alvis-Guzman N
- Amini S
- Ancuceanu R
- Andrei CL
- Andrei T
- Anjana RM
- Ansar A
- Antonazzo IC
- Antony B
- Anyasodor AE
- Arabloo J
- Arizmendi D
- Armocida B
- Artamonov AA
- Arulappan J
- Aryan Z
- Asgari S
- Ashraf T
- Astell-Burt T
- Atorkey P
- Atout MMW
- Ayanore MA
- Badiye AD
- Baig AA
- Bairwa M
- Baker JL
- Baltatu OC
- Banik PC
- Barnett A
- Barone MTU
- Barone-Adesi F
- Barrow A
- Bedi N
- Belete R
- Belgaumi UI
- Bell AW
- Bennett DA
- Bensenor IM
- Beran D
- Bhagavathula AS
- Bhaskar S
- Bhattacharyya K
- Bhojaraja VS
- Bijani A
- Bikbov B
- Birara S
- Bodolica V
- Bonny A
- Brenner H
- Briko NI
- Butt ZA
- Caetano dos Santos FL
- Campos-Nonato IR
- Cao C
- Cao Y
- Cerin E
- Chakraborty PA
- Chandan JS
- Chattu VK
- Chen S
- Choi J-YJ
- Choudhari SG
- Chowdhury EK
- Chu D-T
- Corso B
- Cousin E
- Cámera LA
- Dadras O
- Dai X
- Damasceno AAM
- Dandona L
- Dandona R
- De Neve J-W
- Denova-Gutiérrez E
- Dhamnetiya D
- Diaz D
- Duncan BB
- Dávila-Cervantes CA
- Ebtehaj S
- Edinur HA
- Eftekharzadeh S
- El Sayed I
- Elgendy IY
- Elhadi M
- Elmonem MA
- Faisaluddin M
- Farooque U
- Feng X
- Fernandes E
- Fischer F
- Flood D
- Freitas M
- Gaal PA
- Gad MM
- Gaewkhiew P
- Getacher L
- Ghafourifard M
- Ghanei Gheshlagh R
- Ghashghaee A
- Ghith N
- Ghozali G
- Gill PS
- Ginawi IA
- Glushkova EV
- Golechha M
- Gopalani SV
- Guimarães RA
- Gupta R
- Gupta RD
- Gupta S
- Gupta VB
- Gupta VK
- Habtewold TD
- Hafezi-Nejad N
- Halwani R
- Hanif A
- Hankey GJ
- Haque S
- Hasaballah AI
- Hasan SS
- Hashi A
- Hassanipour S
- Hay SI
- Hayat K
- Heidari M
- Hossain MBH
- Hossain S
- Hosseini M
- Hoveidamanesh S
- Huang J
- Humayun A
- Hussain R
- Hwang B-F
- Ibitoye SE
- Ikuta KS
- Inbaraj LR
- Iqbal U
- Islam MS
- Islam RM
- Islam SMS
- Ismail NE
- Isola G
- Itumalla R
- Iwagami M
- Iyamu IO
- Jahani MA
- Jakovljevic M
- Jayawardena R
- Jha RP
- John O
- Jonas JB
- Joo T
- Kabir A
- Kalhor R
- Kamath A
- Kanchan T
- Kandel H
- Kapoor N
- Kayode GA
- Kebede SA
- Keshavarz P
- Keykhaei M
- Khader YS
- Khajuria H
- Khan M
- Khan MAB
- Khan MN
- Khater AM
- Khoja TAM
- Khubchandani J
- Kim MS
- Kim YJ
- Kimokoti RW
- Kisa A
- Kisa S
- Kivimäki M
- Korshunov VA
- Korzh O
- Koyanagi A
- Krishan K
- Kuate Defo B
- Kumar GA
- Kumar N
- Kusuma D
- La Vecchia C
- Lacey B
- Larsson AO
- Lasrado S
- Lee CB
- Lee PH
- Lee SWH
- Lee W-C
- Li M-C
- Lim L-L
- Lim SS
- Lucchetti G
- Majeed A
- Malik AA
- Mansouri B
- Mantovani LG
- Martini S
- Mathur P
- McAlinden C
- Mehedi N
- Mekonnen T
- Menezes RG
- Mersha AG
- Miao Jonasson J
- Miazgowski T
- Michalek IM
- Mirica A
- Mirrakhimov EM
- Mirza AZ
- Mithra P
- Mohammadian-Hafshejani A
- Mohammadpourhodki R
- Mohammed A
- Mokdad AH
- Molokhia M
- Monasta L
- Moni MA
- Moradpour F
- Moradzadeh R
- Mostafavi E
- Mueller UO
- Murray CJL
- Mustafa A
- Nagel G
- Naghavi M
- Nangia V
- Naqvi AA
- Nayak BP
- Nazari J
- Ndejjo R
- Negoi RI
- Neupane Kandel S
- Nguyen CT
- Nguyen HLT
- Noubiap JJ
- Nowak C
- Oancea B
- Odukoya OO
- Oguntade AS
- Ojo TT
- Olagunju AT
- Ong KL
- Onwujekwe OE
- Ortiz A
- Owolabi MO
- Palladino R
- Panda-Jonas S
- Pandi-Perumal SR
- Pardhan S
- Parekh T
- Parvizi M
- Pepito VCF
- Perianayagam A
- Petcu I-R
- Pilania M
- Podder V
- Polibin RV
- Postma MJ
- Prashant A
- Rabiee M
- Rabiee N
- Rahimi-Movaghar V
- Rahman M
- Rahman MA
- Rahman MM
- Rahmawaty S
- Rajai N
- Ram P
- Rana J
- Ranabhat K
- Ranasinghe P
- Rao CR
- Rao S
- Rawaf DL
- Rawaf S
- Rawal L
- Renzaho AMN
- Rezaei N
- Rezapour A
- Riahi SM
- Ribeiro D
- Rodriguez JAB
- Roever L
- Rohloff P
- Rwegerera GM
- Ryan PM
- Saber-Ayad MM
- Sabour S
- Saddik B
- Saeedi Moghaddam S
- Sahebkar A
- Sahoo H
- Saif-Ur-Rahman KM
- Salimzadeh H
- Samaei M
- Sanabria J
- Santric-Milicevic MM
- Sathian B
- Sathish T
- Schlaich MP
- Schmidt MI
- Seidu A-A
- Senthil Kumar N
- Seylani A
- Shaikh MA
- Shamshad H
- Shawon MSR
- Sheikhbahaei S
- Shetty JK
- Shiri R
- Shivakumar KM
- Shuval K
- Singh A
- Singh JA
- Skryabin VY
- Skryabina AA
- Sofi-Mahmudi A
- Soheili A
- Stein C
- Sun J
- Szerencsés V
- Szócska M
- Tabarés-Seisdedos R
- Tadbiri H
- Tadesse EG
- Tariqujjaman M
- Thankappan KR
- Thapar R
- Thomas N
- Timalsina B
- Tobe-Gai R
- Tonelli M
- Tovani-Palone MR
- Tran BX
- Tripathy JP
- Tudor Car L
- Tusa BS
- Uddin R
- Upadhyay E
- Valadan Tahbaz S
- Valdez PR
- Vasankari TJ
- Verma M
- Villalobos-Daniel VE
- Vladimirov SK
- Vo B
- Vos T
- Vu GT
- Vukovic R
- Waheed Y
- Wamai RG
- Werdecker A
- Wickramasinghe ND
- Winkler AS
- Wubishet BL
- Xu S
- Xu X
- Yahyazadeh Jabbari SH
- Yatsuya H
- Yaya S
- Yazie TSY
- Yi S
- Yonemoto N
- Yunusa I
- Zadey S
- Zaman SB
- Zamanian M
- Zamora N
- Zastrozhin MS
- Zastrozhina A
- Zhang Z-J
- Zhong C
- Zmaili M
- Zumla A
- Šekerija M
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r2=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (−28·4 to −2·9) for all diabetes, and by 21·0% (–33·0 to −5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (−13·6% [–28·4 to 3·4]) and for type 1 diabetes (−13·6% [–29·3 to 8·9]). Interpretation Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations.publishedVersio
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