The Mighty Oak

I have a test I administer, in secret and in silence, to traveling companions along a stretch of road in southeast Nebraska. It is not a test of knowledge,or of character, but of timbre

The Mighty Oak

I have a test I administer, in secret and in silence, to traveling companions along a stretch of road in southeast Nebraska. It is not a test of knowledge,or of character, but of timbre

The delay-time distribution of type-Ia supernovae from Sloan II

We derive the delay-time distribution (DTD) of type-Ia supernovae (SNe Ia) using a sample of 132 SNe Ia, discovered by the Sloan Digital Sky Survey II (SDSS2) among 66,000 galaxies with spectral-based star-formation histories (SFHs). To recover the best-fit DTD, the SFH of every individual galaxy is compared, using Poisson statistics, to the number of SNe that it hosted (zero or one), based on the method introduced in Maoz et al. (2011). This SN sample differs from the SDSS2 SN Ia sample analyzed by Brandt et al. (2010), using a related, but different, DTD recovery method. Furthermore, we use a simulation-based SN detection-efficiency function, and we apply a number of important corrections to the galaxy SFHs and SN Ia visibility times. The DTD that we find has 4-sigma detections in all three of its time bins: prompt (t < 420 Myr), intermediate (0.4 2.4 Gyr), indicating a continuous DTD, and it is among the most accurate and precise among recent DTD reconstructions. The best-fit power-law form to the recovered DTD is t^(-1.12+/-0.08), consistent with generic ~t^-1 predictions of SN Ia progenitor models based on the gravitational-wave induced mergers of binary white dwarfs. The time integrated number of SNe Ia per formed stellar mass is N_SN/M = 0.00130 +/- 0.00015 Msun^-1, or about 4% of the stars formed with initial masses in the 3-8 Msun range. This is lower than, but largely consistent with, several recent DTD estimates based on SN rates in galaxy clusters and in local-volume galaxies, and is higher than, but consistent with N_SN/M estimated by comparing volumetric SN Ia rates to cosmic SFH.Comment: MNRAS, in pres

A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer

BACKGROUND: Overexpression of the HER2 proto-oncogene in human cancer cells has been associated with a poor prognosis, and survival improves with therapy targeting the HER2 gene. Animal studies and protein modeling suggest that the Ile655Val polymorphism located in the transmembrane domain of the HER2 protein might influence breast cancer development by altering the efficiency of homodimerization. METHODS: To investigate this genetic polymorphism, incident cases of invasive breast cancer (N = 1,094) and population controls of a similar age (N = 976) were interviewed during 2001 to 2003 regarding their risk factors for breast cancer. By using DNA collected from buccal samples mailed by the participants, the HER2 Ile655Val polymorphism was evaluated with the Applied Biosystems allelic discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated by logistic regression adjusted for numerous breast cancer risk factors. Analysis was restricted to women with self-reported European descent. RESULTS: Prevalence of the Val/Val genotype was 5.6% in cases and 7.1% in controls. In comparison with the Ile/Ile genotype, the Ile/Val genotype was not significantly associated with breast cancer risk (OR 0.97, 95% CI 0.79 to 1.18), whereas the Val/Val genotype was associated with a reduced risk (OR 0.63, 95% CI 0.42 to 0.92). This inverse association seemed strongest in older women (OR 0.51, 95% CI 0.29 to 0.89 for women aged more than 55 years), women without a family history of breast cancer (OR 0.54, 95% CI 0.35 to 0.84), postmenopausal women with greater body mass index (OR 0.43, 95% CI 0.20 to 0.91 for a body mass index of 25.3 kg/m(2 )or more), and cases diagnosed with non-localized breast cancer (OR 0.49, 95% CI 0.26 to 0.90). CONCLUSION: Although results from our population-based case-control study show an inverse association between the HER2 Ile655Val polymorphism and risk of invasive breast cancer, most other studies of this single-nucleotide polymorphism suggest an overall null association. Any further study of this polymorphism should involve sample populations with complete risk factor information and sufficient power to evaluate gene-environment interactions between the HER2 polymorphism and factors such as age and family history of breast cancer

Discovery of 90 Type Ia supernovae among 700,000 Sloan spectra: the Type-Ia supernova rate versus galaxy mass and star-formation rate at redshift ~0.1

Using a method to discover and classify supernovae (SNe) in galaxy spectra, we find 90 Type Ia SNe (SNe Ia) and 10 Type II SNe among the ~700,000 galaxy spectra in the Sloan Digital Sky Survey Data Release 7 that have VESPA-derived star-formation histories (SFHs). We use the SN Ia sample to measure SN Ia rates per unit stellar mass. We confirm, at the median redshift of the sample, z = 0.1, the inverse dependence on galaxy mass of the SN Ia rate per unit mass, previously reported by Li et al. (2011b) for a local sample. We further confirm, following Kistler et al. (2011), that this relation can be explained by the combination of galaxy "downsizing" and a power-law delay-time distribution (DTD; the distribution of times that elapse between a hypothetical burst of star formation and the subsequent SN Ia explosions) with an index of -1, inherent to the double-degenerate progenitor scenario. We use the method of Maoz et al. (2011) to recover the DTD by comparing the number of SNe Ia hosted by each galaxy in our sample with the VESPA-derived SFH of the stellar population within the spectral aperture. In this galaxy sample, which is dominated by old and massive galaxies, we recover a "delayed" component to the DTD of 4.5 +/- 0.6 (statistical) +0.3 -0.5 (systematic) X 10^-14 SNe Msun^-1 yr^-1 for delays in the range > 2.4 Gyr. The mass-normalized SN Ia rate, averaged over all masses and redshifts in our galaxy sample, is R(Ia,M,z=0.1) = 0.10 +/- 0.01 (statistical) +/- 0.01 (systematic) SNuM, and the volumetric rate is R(Ia,V,z=0.1) = 0.247 +0.029 -0.026 (statistical) +0.016 -0.031 (systematic) X 10^-4 SNe yr^-1 Mpc^-3. This rate is consistent with the rates and rate evolution from other recent SN Ia surveys, which together also indicate a ~t^-1 DTD.Comment: MNRAS accepted. 20 pages, 12 figures, 5 tables. Revised following referee report. A full version of figure 8 can be found at http://www.astro.tau.ac.il/~orgraur/Graur_SDSS_SNe_full.pd

Hubble Space Telescope studies of low-redshift Type Ia supernovae: Evolution with redshift and ultraviolet spectral trends

We present an analysis of the maximum light, near ultraviolet (NUV; 2900-5500 A) spectra of 32 low redshift (0.001<z<0.08) Type Ia supernovae (SNe Ia), obtained with the Hubble Space Telescope (HST). We combine this spectroscopic sample with high-quality gri light curves obtained with robotic telescopes to measure photometric parameters, such as stretch, optical colour, and brightness. By comparing our data to a comparable sample of SNe Ia at intermediate-z (0.4<z<0.9), we detect modest spectral evolution (3-sigma), in the sense that our mean low-z NUV spectrum has a depressed flux compared to its intermediate-z counterpart. We also see a strongly increased dispersion about the mean with decreasing wavelength, confirming the results of earlier surveys. These trends are consistent with changes in metallicity as predicted by contemporary SN Ia spectral models. We also examine the properties of various NUV spectral diagnostics in the individual spectra. We find a general correlation between stretch and the velocity (or position) of many NUV spectral features. In particular, we observe that higher stretch SNe have larger Ca II H&K velocities, that also correlate with host galaxy stellar mass. This latter trend is probably driven by the well-established correlation between stretch and stellar mass. We find no trends between UV spectral features and optical colour. Mean spectra constructed according to whether the SN has a positive or negative Hubble residual show very little difference at NUV wavelengths, indicating that the NUV evolution and variation we identify do not directly correlate with Hubble residuals. Our work confirms and strengthens earlier conclusions regarding the complex behaviour of SNe Ia in the NUV spectral region, but suggests the correlations we find are more useful in constraining progenitor models than improving the use of SNe Ia as cosmological probes.Comment: 22 pages, 14 figures, accepted in MNRAS with minor changes - Spectra are available on WISeREP, http://www.weizmann.ac.il/astrophysics/wiserep

Type Ia Supernova host galaxies as seen with IFU spectroscopy

(abridged) We used the wide-field IFU spectrograph PMAS/PPAK at the 3.5m telescope of Calar Alto Observatory to observe six nearby spiral galaxies that hosted SNe Ia. Spatially resolved 2D maps of the properties of the ionized gas and the stellar populations were derived. Five of the observed galaxies have an ongoing star formation rate of 1-5 M_sun/yr and mean stellar population ages ~5 Gyr. The sixth galaxy shows no star formation and has an about 12 Gyr old stellar population. All galaxies have stellar masses larger than 2E+10 M_sun and metallicities above solar. Four galaxies show negative radial metallicity gradients of the ionized gas up to -0.058 dex/kpc and one has nearly uniform metallicity with a possible shallow positive slope. The stellar components show shallower negative metallicity gradients up to -0.03 dex/kpc. We find no clear correlation between the properties of the galaxy and those of the supernovae, which may be because of the small ranges spanned by the galaxy parameters. However, we note that the Hubble residuals are on average positive while negative Hubble residuals are expected for SNe Ia in massive hosts such as the galaxies in our sample. In conclusion, IFU spectroscopy on 4-m telescopes is a viable technique for studying host galaxies of nearby SNe Ia. It allows one to correlate the supernova properties with the properties of their host galaxies at the projected positions of the supernovae. Our current sample of six galaxies is too small to draw conclusions about the SN Ia progenitors or correlations with the galaxy properties, but the ongoing CALIFA IFU survey will provide a solid basis to exploit this technique more and improve our understanding of SNe Ia as cosmological standard candles.Comment: accepted by A&A, final language-edited version, layout change

Methylglyoxal bis-guanylhydrazone in advanced bladder cancer

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28924/1/0000761.pd

Projected distances to host galaxy reduce SNIa dispersion

We use multiband imagery data from the Sloan digital sky survey to measure projected distances of 302 supernova Type Ia (SNIa) from the centre of their host galaxies, normalized to the galaxy's brightness scale length, with a Bayesian approach. We test the hypothesis that SNIae further away from the centre of their host galaxy are less subject to dust contamination (as the dust column density in their environment is smaller) and/or come from a more homogeneous environment. Using the Mann-Whitney U test, we find a statistically significant difference in the observed colour correction distribution between SNIae that are near and those that are far from the centre of their host. The local p-value is 3 7 10-3, which is significant at the 5 per cent level after look-elsewhere effect correction. We estimate the residual scatter of the two sub-groups to be 0.073 \ub1 0.018 for the far SNIae, compared to 0.114 \ub1 0.009 for the near SNIae - an improvement of 30 per cent, albeit with a low-statistical significance of 2\u3c3. This confirms the importance of host galaxy properties in correctly interpreting SNIa observations for cosmological inference

Corporate governance and strategic human resource management:four archetypes and proposals for a new approach to corporate sustainability

In this paper we develop a new typology connecting strategic human resource management (SHRM) to different models of firm-level corporate governance. By asking questions concerning ownership and control issues in the corporate governance literature and drawing on institutional logics, we build a typological framework that identifies four firm-level archetypes of corporate governance systems. Two archetypes represent dominant logic types (shareholder value, communitarian stakeholder), while the other two represent hybrid organizations (enlightened shareholder value, employee-ownership). Using these archetypes, we theorize the implications of different governance structures for SHRM and the challenges they pose. We conclude by discussing a novel solution to many of these challenges based on the corporate sustainability literature, and, in so doing, provide new directions for SHRM research to tackle key challenges facing organizations and the management of people