238 research outputs found

    To What Extent Can Vegetation Mitigate Greenhouse Warming? A Modeling Approach

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    Climate models participating in the IPCC Fourth Assessment Report indicate that under a 2xCO2 environment, runoff would increase faster than precipitation overland. However, observations over large U.S watersheds indicate otherwise. This inconsistency suggests that there may be important feedbacks between climate and land surface unaccounted for in the present generation of models. We postulate that the increase in precipitation associated with the increase in CO2 is also increasing vegetation density, which may already be feeding back onto climate. Including this feedback in a climate model simulation resulted in precipitation and runoff trends consistent with observations and reduced the warming by 0.6OC overland. This unaccounted for missing water may be linked to about 10% of the missing land carbon sink. A recent compilation of outputs from 19 coupled atmosphere-ocean general circulation models used in the IPCC Fourth Assessment Report (AR4) shows projected increases in air temperature, precipitation and river discharge for 24 major rivers in the world in response to doubling CO2 by the end of the century (1). The ensemble mean from these models also indicates that, compared to their respective baselines overland, the global mean of the runoff change would increase faster (8.9% per year) than that of the precipitation (5% per year). We analyze century-scale observed annual runoff time-series (1901-2002) over 9 hydrological units covering large regions of the Eastern United States (Fig.1) compiled by the United States Geological Survey (USGS)(2). These regions were selected because they are the most forested; the least water-limited and are not under extensive irrigation. We compare these time-series to similar time-series of observed annual precipitation anomalies spanning the period 1900-1995 (3). Both time-series exhibit a positive longterm trend (Fig. 2); however, in contrast to the analysis of (I), these historic data records show that the rate of precipitation increase is 5.5 % per year, roughly double the rate of runoff increase of 3.1 % per year

    Abstracting modelling languages: A reutilization approach

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    The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-31095-9_9Proceedings of 24th International Conference, CAiSE 2012, Gdansk, Poland, June 25-29, 2012Model-Driven Engineering automates the development of information systems. This approach is based on the use of Domain-Specific Modelling Languages (DSMLs) for the description of the relevant aspects of the systems to be built. The increasing complexity of the target systems has raised the need for abstraction techniques able to produce simpler versions of the models, but retaining certain properties of interest. However, developing such abstractions for each DSML from scratch is a time and resource consuming activity. Our solution to this situation is a number of techniques to build reusable abstractions that are defined once and can be reused over families of modelling languages sharing certain requirements. As a proof of concept, we present a catalogue of reusable abstractions, together with an implementation in the MetaDepth multi-level meta-modelling tool.Work funded by the Spanish Ministry of Economy and Competitivity (TIN2011-24139), and the R&D programme of Madrid Region (S2009/TIC-1650)

    Psychosis risk candidate ZNF804A localizes to synapses and regulates neurite formation and dendritic spine structure

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    BackgroundVariation in the gene encoding zinc finger binding protein 804A (ZNF804A) is associated with schizophrenia (SCZ) and bipolar disorder (BP). Evidence suggests that ZNF804A is a regulator of gene transcription and is present in nuclear and extranuclear compartments. However, a detailed examination of ZNF804A distribution and its neuronal functions has yet to be performed.MethodsThe localization of ZNF804A protein was examined in neurons derived from human neural progenitor cells (hNPCs), human induced pluripotent stem cells (hiPSCs) or in primary rat cortical neurons. Additionally, siRNA-mediated knockdown of ZNF804A was conducted to determine its role in neurite formation, maintenance of dendritic spine morphology and responses to activity-dependent stimulations.ResultsEndogenous ZNF804A protein localized to somato-dendritic compartments and co-localized with the putative synaptic markers in young neurons derived from hNPCs and hiPSCs. In mature rat neurons, Zfp804A, the homolog of ZNF804A, was present in a subset of dendritic spines and co-localized with synaptic proteins in specific nanodomains, as determined by superresolution microscopy. Interestingly, knockdown of ZNF804A attenuated neurite outgrowth in young neurons, an effect potentially mediated by reduced neuroligin-4 (NLGN4) expression. Furthermore, knockdown of ZNF804A in mature neurons resulted in the loss of dendritic spine density, and impaired responses to activity-dependent stimulation.ConclusionsThese data reveal a novel subcellular distribution for ZNF804A within somato-dendritic compartments and a nanoscopic organisation at excitatory synapses. Moreover, our results suggest that ZNF804A plays an active role in neurite formation, maintenance of dendritic spines and activity-dependent structural plasticity

    To wet or not to wet: that is the question

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    Wetting transitions have been predicted and observed to occur for various combinations of fluids and surfaces. This paper describes the origin of such transitions, for liquid films on solid surfaces, in terms of the gas-surface interaction potentials V(r), which depend on the specific adsorption system. The transitions of light inert gases and H2 molecules on alkali metal surfaces have been explored extensively and are relatively well understood in terms of the least attractive adsorption interactions in nature. Much less thoroughly investigated are wetting transitions of Hg, water, heavy inert gases and other molecular films. The basic idea is that nonwetting occurs, for energetic reasons, if the adsorption potential's well-depth D is smaller than, or comparable to, the well-depth of the adsorbate-adsorbate mutual interaction. At the wetting temperature, Tw, the transition to wetting occurs, for entropic reasons, when the liquid's surface tension is sufficiently small that the free energy cost in forming a thick film is sufficiently compensated by the fluid- surface interaction energy. Guidelines useful for exploring wetting transitions of other systems are analyzed, in terms of generic criteria involving the "simple model", which yields results in terms of gas-surface interaction parameters and thermodynamic properties of the bulk adsorbate.Comment: Article accepted for publication in J. Low Temp. Phy

    Scale issues in soil moisture modelling: problems and prospects

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    Soil moisture storage is an important component of the hydrological cycle and plays a key role in land-surface-atmosphere interaction. The soil-moisture storage equation in this study considers precipitation as an input and soil moisture as a residual term for runoff and evapotranspiration. A number of models have been developed to estimate soil moisture storage and the components of the soil-moisture storage equation. A detailed discussion of the impli cation of the scale of application of these models reports that it is not possible to extrapolate processes and their estimates from the small to the large scale. It is also noted that physically based models for small-scale applications are sufficiently detailed to reproduce land-surface- atmosphere interactions. On the other hand, models for large-scale applications oversimplify the processes. Recently developed physically based models for large-scale applications can only be applied to limited uses because of data restrictions and the problems associated with land surface characterization. It is reported that remote sensing can play an important role in over coming the problems related to the unavailability of data and the land surface characterization of large-scale applications of these physically based models when estimating soil moisture storage.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

    A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007

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    We present the results of the first search for gravitational wave bursts associated with high energy neutrinos. Together, these messengers could reveal new, hidden sources that are not observed by conventional photon astronomy, particularly at high energy. Our search uses neutrinos detected by the underwater neutrino telescope ANTARES in its 5 line configuration during the period January - September 2007, which coincided with the fifth and first science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed for candidate gravitational-wave signals coincident in time and direction with the neutrino events. No significant coincident events were observed. We place limits on the density of joint high energy neutrino - gravitational wave emission events in the local universe, and compare them with densities of merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access area to figures, tables at https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000

    Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

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    A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
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