515 research outputs found
"I know that you know that I know": neural substrates associated with social cognition deficits in DM1 patients
- Author
- A Modoni
- A Orsini
- A Sistiaga
- A Zalesky
- AM D'Mello
- Antonio Petrucci
- Barbara Spanò
- Carlo Caltagirone
- CD Frith
- CD Frith
- D Büsch
- D Wechsler
- E Bullmore
- Elisabetta Bucci
- ER Johnson
- F Van Overwalle
- FG Happé
- G Meola
- Gabriella Silvestri
- Giovanni Antonini
- Giovanni Meola
- J Mathieu
- JD Brook
- JR Wozniak
- L Carluer
- L Serra
- L Serra
- Laura Serra
- Lisa Cipolotti
- Loretta Licchelli
- M Kobayakawa
- M Minnerop
- M Prior
- M Rubinov
- M Serafin
- M Xia
- Manlio Giacanelli
- Mara Cercignani
- Marco Bozzali
- Matteo Mancini
- MF Folstein
- Michela Bruschini
- ML Phillips
- MP van den Heuvel
- O Mothersill
- RA Mar
- Ruben Artero
- S Baron-Cohen
- S Baron-Cohen
- S Baron-Cohen
- S Baron-Cohen
- S Cheng
- S Whitfield-Gabrieli
- S Winblad
- SG Shamay-Tsoory
- SG Shamay-Tsoory
- SJ Carrington
- SM Schaafsma
- Z Dai
- ZT Yeh
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2016
- Field of study
Myotonic dystrophy type-1 (DM1) is a genetic multi-systemic disorder involving several organs including the brain. Despite the heterogeneity of this condition, some patients with non-congenital DM1 can present with minimal cognitive impairment on formal testing but with severe difficulties in daily-living activities including social interactions. One explanation for this paradoxical mismatch can be found in patients' dysfunctional social cognition, which can be assessed in the framework of the Theory of Mind (ToM). We hypothesize here that specific disease driven abnormalities in DM1 brains may result in ToM impairments. We recruited 20 DM1 patients who underwent the "Reading the Mind in the Eyes" and the ToM-story tests. These patients, together with 18 healthy controls, also underwent resting-state functional MRI. A composite Theory of Mind score was computed for all recruited patients and correlated with their brain functional connectivity. This analysis provided the patients' "Theory of Mind-network", which was compared, for its topological properties, with that of healthy controls. We found that DM1 patients showed deficits in both tests assessing ToM. These deficits were associated with specific patterns of abnormal connectivity between the left inferior temporal and fronto-cerebellar nodes in DM1 brains. The results confirm the previous suggestions of ToM dysfunctions in patients with DM1 and support the hypothesis that difficulties in social interactions and personal relationships are a direct consequence of brain abnormalities, and not a reaction symptom. This is relevant not only for a better pathophysiological comprehension of DM1, but also for non-pharmacological interventions to improve clinical aspects and impact on patients' success in life
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
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- Winer BL
- Winn D
- Winstrom L
- Wissing C
- Wittich P
- Wittmer B
- Woehri HK
- Wolf M
- Wolf R
- Womersley WJ
- Won S
- Wood D
- Wood J
- Wood JS
- Worm SD
- Wright D
- Wrochna G
- Wu W
- Wuerthwein F
- Wulz C-E
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Transcriptome profiling of chemosensory appendages in the malaria vector Anopheles gambiae reveals tissue- and sex-specific signatures of odor coding
- Author
- A Blackwell
- A della Torre
- A Mortazavi
- AF Carey
- AL Tichy
- AN Clements
- AN Fox
- Antonis Rokas
- C Costantini
- C Gillot
- C Pennetier
- CA Hill
- CT Hittinger
- D Schymura
- David C Rinker
- DS Hekmat-Scafe
- E Warr
- EA Hallem
- G Gibson
- G Wang
- HM Robertson
- HW Kwon
- IA Ismail
- J Bohbot
- J Chandrashekar
- J Kim
- J Li
- JD Charlwood
- JE Crawford
- JF Sutcliffe
- JG Gibbons
- JY Kwon
- K Sato
- K Touhara
- KE Kaissling
- KP Siju
- L Abuin
- L Bai
- L Bai
- L Sarov-Blat
- LA Baton
- Laurence J Zwiebel
- LJ Zwiebel
- M Bonizzoni
- M de Bruyne
- M Maibeche-Coisne
- M Neira-Oviedo
- MD Robinson
- ME Rogers
- MH Lee
- MS Kim
- N Durand
- N Durand
- NO Verhulst
- O Marinotti
- O Marinotti
- P Cayirlioglu
- PA t Hoen
- Patrick L Jones
- PE Cook
- PI Howell
- PJ Balwierz
- PJ Clyne
- PX Xu
- R Aguilar
- R Aguilar
- R Benton
- R Jason Pitts
- RD Finn
- RE Gary
- RG Vogt
- RJ Pitts
- RJ Pitts
- RK Ayer Jr
- RK Ayer Jr
- RW Justice
- S Das
- SB McIver
- SB McIver
- SB McIver
- SM Meola
- SM Meola
- SW Kruse
- T Lu
- V Croset
- W Guo
- W Takken
- Y Xia
- YT Qiu
- Z Gong
- Z Wang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Chemosensory signal transduction guides the behavior of many insects, including <it>Anopheles gambiae</it>, the major vector for human malaria in sub-Saharan Africa. To better understand the molecular basis of mosquito chemosensation we have used whole transcriptome RNA sequencing (RNA-seq) to compare transcript expression profiles between the two major chemosensory tissues, the antennae and maxillary palps, of adult female and male <it>An. gambiae</it>.</p> <p>Results</p> <p>We compared chemosensory tissue transcriptomes to whole body transcriptomes of each sex to identify chemosensory enhanced genes. In the six data sets analyzed, we detected expression of nearly all known chemosensory genes and found them to be highly enriched in both olfactory tissues of males and females. While the maxillary palps of both sexes demonstrated strict chemosensory gene expression overlap, we observed acute differences in sensory specialization between male and female antennae. The relatively high expression levels of chemosensory genes in the female antennae reveal its role as an organ predominately assigned to chemosensation. Remarkably, the expression of these genes was highly conserved in the male antennae, but at much lower relative levels. Alternatively, consistent with a role in mating, the male antennae displayed significant enhancement of genes involved in audition, while the female enhancement of these genes was observed, but to a lesser degree.</p> <p>Conclusions</p> <p>These findings suggest that the chemoreceptive spectrum, as defined by gene expression profiles, is largely similar in female and male <it>An. gambiae</it>. However, assuming sensory receptor expression levels are correlated with sensitivity in each case, we posit that male and female antennae are perceptive to the same stimuli, but possess inverse receptive prioritizations and sensitivities. Here we have demonstrated the use of RNA-seq to characterize the sensory specializations of an important disease vector and grounded future studies investigating chemosensory processes.</p
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
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- Yi K
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- Yilmaz Y
- Yohay R
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- Yun JC
- Zabel J
- Zabi A
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- Zakaria M
- Zalewski P
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- Zeyrek M
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- Zheng Y
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- Zhu B
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- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
A search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Compressed representation of a partially defined integer function over multiple arguments
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta MV
- Adair A
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agram J-L
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alderweireldt S
- Alexander J
- Aliev T
- Alimena J
- Almeida N
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Androsov K
- Antonelli L
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arneodo M
- Arora S
- Asavapibhop B
- Asawatangtrakuldee C
- Asghar MI
- Asin I
- Askew A
- Aslanoglou X
- Assran Y
- Ata M
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachmair F
- Bachtis M
- Baden A
- Baeni L
- Baffioni S
- Bagliesi G
- Bahtiyar H
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Ball AH
- Ban Y
- Banerjee S
- Banerjee S
- Bansal M
- Bansal S
- Barbagli G
- Barberis E
- Barbone L
- Barfuss AF
- Bargassa P
- Barge D
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Measurement of jet fragmentation into charged particles in pp and PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Zhang Z
- Zheng Y
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- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Jet fragmentation in pp and PbPb collisions at a centre-of-mass energy of
2.76 TeV per nucleon pair was studied using data collected with the CMS
detector at the LHC. Fragmentation functions are constructed using
charged-particle tracks with transverse momenta pt > 4 GeV for dijet events
with a leading jet of pt > 100 GeV. The fragmentation functions in PbPb events
are compared to those in pp data as a function of collision centrality, as well
as dijet-pt imbalance. Special emphasis is placed on the most central PbPb
events including dijets with unbalanced momentum, indicative of energy loss of
the hard scattered parent partons. The fragmentation patterns for both the
leading and subleading jets in PbPb collisions agree with those seen in pp data
at 2.76 TeV. The results provide evidence that, despite the large parton energy
loss observed in PbPb collisions, the partition of the remaining momentum
within the jet cone into high-pt particles is not strongly modified in
comparison to that observed for jets in vacuum.Comment: Submitted to the Journal of High Energy Physic
Inducing Cross-Clade Neutralizing Antibodies against HIV-1 by Immunofocusing
- Author
- A Meola
- A Schreiber
- AB Riemer
- AJ Conley
- AJ McMichael
- AW Zuercher
- B Li
- BD Walker
- BF Haynes
- C Königs
- C Prezzi
- CA Derdeyn
- CC Huang
- CE Hioe
- D Davis
- D Enshell-Seijffers
- DA Calarese
- Derya Unutmaz
- DR Burton
- E Coeffier
- EF Pettersen
- EM Bublil
- EM Bublil
- EO Saphire
- EO Saphire
- F Felici
- F Ferrantelli
- F Ferrantelli
- F Ferrantelli
- Fabian M. P. Kaiser
- G Galfre
- G Scala
- GB McGaughey
- GP Smith
- Helena Ong
- I Mayrose
- J Huang
- J Sticht
- JM Binley
- JR Mascola
- JR Mascola
- M Humbert
- M Humbert
- M Kitabwalla
- M Sharon
- MB Zwick
- MB Zwick
- Michael Humbert
- MK Gorny
- MK Gorny
- MR Posner
- NB Siddappa
- O Rosen
- PD Kwong
- PM Keller
- PW Parren
- R Hofmann-Lehmann
- R Pantophlet
- R Roccasecca
- R Wyatt
- R Wyatt
- RA Rasmussen
- RJ Song
- Robert A. Rasmussen
- RS Veazey
- Ruth M. Ruprecht
- S Rowland-Jones
- S Zolla-Pazner
- S Zolla-Pazner
- Shiu-Lok Hu
- SM Cleveland
- T Zhou
- TW Baba
- V Holl
- V Moreau
- VG Kramer
- W Xu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
Background: Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We sought to test whether HIV-1 Env mimics may serve as immunogens. Methodology/Principal Findings: Using random peptide phage display libraries, we identified the epitopes recognized by polyclonal antibodies of a rhesus monkey that had developed high-titer, broadly reactive nAbs after infection with a simianhuman immunodeficiency virus (SHIV) encoding env of a recently transmitted HIV-1 clade C (HIV-C). Phage peptide inserts were analyzed for conformational and linear homology using computational analysis; some peptides mimicked various domains of the original HIV-C Env, such as conformational V3 loop epitopes and the conserved linear region of the gp120 C-terminus. Next, we devised a novel prime/boost strategy to test the immunogenicity of such phage-displayed peptides and primed mice only once with HIV-C gp160 DNA followed by boosting with mixtures of recombinant phages. Conclusions/Significance: This strategy, which was designed to focus the immune system on a few Env epitopes (immunofocusing), not only induced HIV-C gp160 binding antibodies and cross-clade nAbs, but also linked a conserved HIV Env region for the first time to the induction of nAbs: the C-terminus of gp120. The identification of conserved antige
Search for Dark Matter and Supersymmetry with a Compressed Mass Spectrum in the Vector Boson Fusion Topology in Proton-Proton Collisions at root s=8 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
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- Adams JR
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- Adzic P
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- Ahmad A
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- Albergo S
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
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- Aldá Júnior WL
- Aleksandrov A
- Alexander J
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- Alunni Solestizi L
- Alverson G
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- Calderon A
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- Carvalho W
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- Castaldi R
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- Castiñeiras De Saa JR
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- Civinini C
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- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Observation of the diphoton decay of the Higgs boson and measurement of its properties
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams MR
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
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- Acosta JG
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- Weber HA
- Weber M
- Weiler T
- Weinberg M
- Welke C
- Wendland L
- Weng Y
- Werner JS
- West C
- Wetzel J
- Whitbeck A
- Whitmore J
- Wickramage N
- Wilbur S
- Wilken R
- Wilkinson R
- Williams T
- Wimpenny S
- Winer BL
- Winn D
- Winstrom L
- Wissing C
- Wittich P
- Wittmer B
- Wolf M
- Wolf R
- Wolfe E
- Wolfe H
- Wollny H
- Womersley WJ
- Won S
- Wood D
- Wood J
- Wood JS
- Woodard A
- Woods N
- Worm SD
- Wright D
- Wu Z
- Wulsin HW
- Wulz CE
- Wyslouch B
- Wöhri HK
- Würthwein F
- Xiao H
- Xiao M
- Xie S
- Xie W
- Xu L
- Xu Z
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yzquierdo AP
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zeinali M
- Zenoni F
- Zenz SC
- Zeuner WD
- Zevi Della Porta G
- Zeyrek M
- Zhang F
- Zhang J
- Zhang L
- Zhokin A
- Zhu RY
- Zhukov V
- Zhukova V
- Zorbilmez C
- Zotto P
- Zou W
- Zsigmond AJ
- Zucchetta A
- Zumerle G
- Zuranski A
- Zvada M
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
- …