Ecos de la épica grecolatina en Juego de tronos, primera novela de la saga Canción de hielo y fuego de George R. R. Martin

La épica grecolatina ha sido fuente de inspiración durante toda la historia de la literatura. En este trabajo, observaremos la influencia de estos textos centrándonos en el género de la fantasía, concretamente en la fantasía heroica. Para ello, desglosaremos los subgéneros de literatura fantástica con ayuda de autores como Todorov y Neveleff y seleccionaremos algunas situaciones similares que podemos observar tanto en los poemas épicos como en Juego de tronos, primera novela de la saga Canción de hielo y fuego de George R. R. Martin, apoyándonos en la tesis de Roberto Cáceres Blanco «Narrativa de mundos imaginarios: poética para una épica moderna. De La serpiente de Uróboros a la Canción de Hielo y Fuego»

La vida es puro teatro

Mediante este Trabajo de Fin de Máster, se trata de dar cuenta de los aspectos más relevantes del curso 2018-2019 en el Máster en Profesorado de ESO y Bachillerato en la modalidad de Lengua Castellana y Literatura. Para ello, se incluyen reflexiones personales sobre las asignaturas cursadas y sobre la implementación en el aula durante los periodos de prácticas en el Colegio Escuelas Pías de Zaragoza de la Unidad Didáctica "La vida es puro teatro" y del Proyecto de Innovación Educativa sobre la aplicación de los signos de puntuación a través de la técnica del rompecabezas de Aronson. <br /

Estudio de pre-factibilidad para la creación de una pequeña empresa procesadora y distribuidora de bebida en polvo a base de maní y leche en el casco urbano de Managua durante 2020-2024

Realiza un estudio de pre-factibilidad para la creación de una pequeña empresa productora y distribuidora de bebida en polvo a base de maní y leche, determina a partir de un análisis de mercado, las variables mercadológicas que influyen en la aceptación del producto de parte de los consumidores del casco urbano, define la viabilidad técnica del proyecto teniendo en cuenta el tamaño de la planta, localización, proceso productivo requerido para la bebida, estructura organizacional y procedimientos legales que condicionan la operatividad de este, evalúa la rentabilidad del proyecto a través de un análisis financiero utilizando las técnicas del VPN y TIR

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014–2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Diseño de infraestructura para mejorar el servicio educativo de la I.E.I.P.S.M. N°16651 Petronila Abad Carrión, Bagua Grande, Utcubamba, Amazonas-2018

El presente estudio de investigación comprende DISEÑO SÍSMICO ESTRUCTURAL de la Institución Educativa N° 16651 “Petronila Abad Carrión”, bajo la estructura de expediente técnico de ingeniería civil, como posterior material académico de referencia y propuesta de ejecución. El documento de investigación está enfocado bajo la metodología no experimental – mixta; la cual comprende los objetivos específicos de Identificar el estado situacional de la infraestructura, elaborar los estudios básicos de ingeniería, diseño la infraestructura a través de su memoria de cálculo, planos de diseño, metrados, costos, presupuesto y programación de obras y la propuesta de plan de operación y mantenimiento de la infraestructura. La infraestructura de proyecto a nivel primaria y secundaria comprende su diseño de siete edificaciones, con un máximo de dos pisos de altura; dispuestas con áreas de uso compartido de ambientes administrativos, especiales, ambientes complementarios y losa de uso múltiple techada; y a nivel inicial, la construcción de tres edificaciones, los que en conjunto cubrirán las necesidades de bienestar y confort para sus ocupantes. Su presupuesto total de inversión es de S/. 9´534,584.00 soles, en un tiempo de ejecución de 9 meses

Allende vive 30 años

El Seminario Internacional 30 Años Allende Vive, convocado por la Revista América Libre, el Centro de Educación Popular, CEPIS, de Brasil, el Centro Martín Luther King de Cuba y el ICAL, en un momento en que las luchas populares retoman la iniciativa, se planteó rescatar la memoria del proceso de la Unidad Popular y del ejemplo de Salvador Allende y proyectarla a las búsquedas que los movimientos populares realizan para construir alternativas al neoliberalismo, la emergencia de nuevos gobiernos populares, los caminos de creación de poder popular, la perspectiva socialista como proyecto y como opción. La publicación del seminario 30 Años Allende Vive constituye un aporte para la reflexión de la izquierda latinoamericana, y una importante fuente de consulta tanto para referencias históricas como para los muy actuales debates sobre la construcción de alternativas de cambio con perspectiva socialista.Presentación; Discurso de Inauguración del Seminario Internacional 30 Años, Allende Vive; Inauguración del Seminario 30 Años, Allende Vive; Saludos; Transformaciones de Estructura y Redistribución del Ingreso; La educación y la cultura en el Gobierno Popular; Reforma Agraria y Soberanía Alimentaria; Los logros de la Unidad Popular y las perspectivas en diferentes sectores sociales; Soberanía sobre los Recursos Naturales. El Cobre; El programa de gobierno de Salvador Allende; La Verdad sobre la Unidad Popular y el Golpe de Estado; Unidad Popular, Impacto y Solidaridad Internacional; Presentación del libro Salvador Allende, Textos Escogidos; La política imperialista. El ALCA y la militarización del mundo. El Plan Colombia; La unidad de los pueblos contra la estrategia imperialista, guerrerista, desestabilizadora y golpista de Estados Unidos; Ponencia de las Fuerzas Armadas Revolucionarias de Colombia Ejército del Pueblo (FARC-EP); Los cristianos en la lucha por el socialismo; Fuerzas Armadas, Democracia y Soberanía Nacional; Situación del movimiento sindical antes y después del golpe; Derechos Humanos antes y después del golpe de estado; Movimientos GLBTT y Procesos Revolucionarios en América Latina. Construyendo el nuevo sujeto histórico; Políticas de Género de la Izquierda Latinoamericana; Panel sobre Medios de comunicación; Gobernar la revolución. Por una gobernabilidad revolucionaria para la revolución bolivariana; La integración latinoamericana y el sueño bolivariano; Las alternativas populares en América Latina ayer y hoy. Izquierda e Institucionalidad, Reforma y Revolución; Los movimientos sociales y los partidos políticos en la construcción de las alternativas populares. Sujeto histórico, alianzas, programas, estrategias; La perspectiva socialista en la construcción de las alternativas populare

Formin Homology 2 Domain Containing 3 (FHOD3) Is a Genetic Basis for Hypertrophic Cardiomyopathy.

The genetic cause of hypertrophic cardiomyopathy remains unexplained in a substantial proportion of cases. Formin homology 2 domain containing 3 (FHOD3) may have a role in the pathogenesis of cardiac hypertrophy but has not been implicated in hypertrophic cardiomyopathy. This study sought to investigate the relation between FHOD3 mutations and the development of hypertrophic cardiomyopathy. FHOD3 was sequenced by massive parallel sequencing in 3,189 hypertrophic cardiomyopathy unrelated probands and 2,777 patients with no evidence of cardiomyopathy (disease control subjects). The authors evaluated protein-altering candidate variants in FHOD3 for cosegregation, clinical characteristics, and outcomes. The authors identified 94 candidate variants in 132 probands. The variants' frequencies were significantly higher in patients with hypertrophic cardiomyopathy (74 of 3,189 [2.32%]) than in disease control subjects (18 of 2,777 [0.65%]; p  FHOD3 is a novel disease gene in hypertrophic cardiomyopathy, accounting for approximately 1% to 2% of cases. The phenotype and the rate of cardiovascular events are similar to those reported in unselected cohorts. The FHOD3 gene should be routinely included in hypertrophic cardiomyopathy genetic testing panels