A New Model For Vela Jr. Supernova Remnant

We consider Vela Jr. as being the old Supernova Remnant (SNR) at the beginning of the transition from adiabatic to radiative stage of evolution. According to our model, Vela Jr. is situated outside Vela SNR at the distance of 600 pc and its age is 17500 yr. We model the high energy fluxes from Vela Jr. and its broadband spectrum. We find our results compatible with experimental data in radio waves, X- and gamma-rays. Our hydrodynamical model of Vela Jr. explains the observed TeV gamma-ray flux by hadronic mechanism. The proposed model does not contradict to the low density environment of the SNR and does not need extreme fraction of the explosion energy to be transferred to Cosmic Rays.Comment: Accepted for publication in Astroparticle Physic

Manganese Superoxide Dismutase: Guardian of the Powerhouse

The mitochondrion is vital for many metabolic pathways in the cell, contributing all or important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the urea cycle, the citric acid cycle, and ATP synthesis. The mitochondrion is also a major site of reactive oxygen species (ROS) production in the cell. Aberrant production of mitochondrial ROS can have dramatic effects on cellular function, in part, due to oxidative modification of key metabolic proteins localized in the mitochondrion. The cell is equipped with myriad antioxidant enzyme systems to combat deleterious ROS production in mitochondria, with the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) acting as the chief ROS scavenging enzyme in the cell. Factors that affect the expression and/or the activity of MnSOD, resulting in diminished antioxidant capacity of the cell, can have extraordinary consequences on the overall health of the cell by altering mitochondrial metabolic function, leading to the development and progression of numerous diseases. A better understanding of the mechanisms by which MnSOD protects cells from the harmful effects of overproduction of ROS, in particular, the effects of ROS on mitochondrial metabolic enzymes, may contribute to the development of novel treatments for various diseases in which ROS are an important component