Oxidation of Native and Modified Hemoglobin and Myoglobin by Sodium Nitrate. Effect of Inositol Hexaphosphate

Native and modified hemoglobin, myoglobin and a and phemoglobin subunits were oxidized by sodium nitrite at pH 6. The experiments were carried out under oxy and deoxy conditions with and without inositol hexaphosphate (IHP). It is shown (a) that under oxy condition low concentration of IHP inhibits the oxidation of native hemoglobin only. However, high concentration of IHP inhibits the oxidation of both myoglobin and modified hemoglobin (digested or 0-93-SH groups blocked). This inhibition is partially counteracted by high oxygen pressure, (b) Under deoxy condition the oxidation rates of all hemeproteins studied are significantly faster than that of native hemoglobin. IHP inhibits the oxidation of all except the myoglobin and hemoglobin subunits. It is concluded that although the IHP inhibitory effect on hemoglobin oxidation by nitrite can be explained by the shift of the R↔T conformational equilibrium towards T conformation, some other structural changes such as alteration in molecular surface charges must occur to account for the effect of IHP on the oxidation of hemeproteins devoid of heme-heme interaction

Reduction of the Two Body Problem in N=2 Chern Simons Supergravity

By an extension of the methods used for the reduction of the two body problem in 2+1 dimensional gravity, we show that the two body problem in N=2 Chern Simons supergravity can be reduced exactly to an equivalent on body formalism. We give exact expressions for the invariants of the reduced one body problem.Comment: 9 pages, LaTe

Materials Handling Vehicles : Policy Framework for an Emerging Fuel Cell Market

© 2012 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of Canadian Hydrogen and Fuel Cell Association. Open access under CC BY-NC-ND licenseThere are several challenges to wide-spread commercialisation of the technology hydrogen fuel-cell technology; including reliability and cost implications, infrastructure requirements, and safety aspects of the upcoming technology. Targeted policy initiatives are required to address two significant bottlenecks; reliability and cost constraints. Such policy measures and financial mechanisms providing incentives for manufacturers and end-users of the novel technology create an initial impetus for the introduction of the forthcoming technology into the market place. The current approach, policy mechanisms and their impacts are reviewed in the context of demonstration projects, deploying material handling equipment, involving public-private initiatives.Final Published versio