Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

A comparative study of Virtual Communities in Bangladesh and the USA

The objective of this study is to compare the differences between Virtual Communities in Bangladesh and the USA in terms of website usability, marketing, languages and norms. The two countries were compared because the USA is a more advanced country compared to Bangladesh. Studying their differences would identify possible gaps which can be bridged to improve Virtual Communities of Bangladesh and perhaps other developing countries. Thirty-three Virtual Communities sites from both countries were randomly selected and evaluated based on a set of criteria relating to the above aspects. The data were analyzed using statistical tests to determine any significant difference between Virtual Communities of the two countries. The study found significant differences in the website usability aspects i.e. the use of multimedia; in marketing aspects i.e. the use of electronic catalogs and Web advertisements; and in languages and norms i.e. the inclusion of language options and the use of religious, collectivistic, and structured messages. As a conclusion, useful recommendations were given to Web developers, marketers, and Bangladeshi government to improve Web usability, marketing, and cultural environment of Bangladeshi Virtual Communities. Future studies can be conducted by replicating the study to other developing countries such as China and India

User acceptance of ATM and transit applications embedded in Malaysia's national identity smartcard

The research investigates the user acceptance Of automated teller machine (ATM) and transit applications embedded in. Malaysia's national identity smartcard named as MyKad. A research framework was developed based oil the Unified Theory of Acceptance and Use of Technology (UTAUT). A questionnaire survey was conducted oil 100 MyKod holders residing in Multimedia Super Corridor and descriptive statistics were used to analyze the survey data. The results show that Malaysians are unsure of their intention to use the two applications. They lack in understanding about their usefulness and the effort needed to use them. Consequently, there is 170 social support in their usage, and the applications have no credibility and would cause anxiety when used. Besides, it is perceived that there are insufficient facilitating conditions to use the applications. Recommendations are given to improve acceptability. The study is useful for those countries interested in increasing the acceptability of their multipurpose national identity smartcard applications

Cost effectiveness of ergonomic redesign of electronic motherboard

A case study to illustrate the cost effectiveness of ergonomic redesign of electronic motherboard was presented. The factory was running at a loss due to the high costs of rejects and poor quality and productivity. Subjective assessments and direct observations were made on the factory. Investigation revealed that due to motherboard design errors, the machine had difficulty in placing integrated circuits onto the pads, the operators had much difficulty in manual soldering certain components and much unproductive manual cleaning (MC) was required. Consequently, there were high rejects and occupational health and safety (OHS) problems, such as, boredom and work discomfort. Also, much labour and machine costs were spent on repairs. The motherboard was redesigned to correct the design errors, to allow more components to be machine soldered and to reduce MC. This eliminated rejects, reduced repairs, saved US $581,495/year and improved operators' OHS. The customer also saved US$142,105/year on loss of business. (C) 2003 Elsevier Ltd. All rights reserved

Quality, productivity, occupational health and safety and cost effectiveness of ergonomic improvements in the test workstations of an electronic factory

An ergonomic study was conducted to improve the workstations for electrical tests in a printed circuit assembly (PCA) factory in an industrially developing country (IDC). Subjective assessment and direct observation methods were used on the operators to discover the problems in their workstations. The problems found were: (i) poor workstation design, (ii) mix-up of tested and untested boards, (iii) missing or incorrect test steps, and (iv) unclear pass/fail colour inspection criteria. Ergonomic interventions implemented were: (i) an improved workstation with space for resting arms and the oscilloscope and computer keyboards within easy reach of the operators; (ii) clear segregation of tested and untested boards to prevent mix-up; (iii) retraining of operators by more qualified trainers; and (iv) reference colour samples for more effective recognition of different colours in the projection screen. The results were average savings in yearly rejection cost (of US$574,560), reduction in rejection rate, increase in monthly revenue, improvements in productivity, quality, operators' working conditions and occupational health and safety (OHS) and enhancement in customers' satisfaction. The cost of the interventions was less than US$1100. The interventions implemented were simple and inexpensive but resulted in many benefits

A technology acceptance study of online banking service in Malaysia

Online banking service (OBS) is new in Malaysia (introduced about 6 years ago). The study is the first research in Malaysia that investigates user acceptance of OBS based on Unified Theory of Acceptance and Use of Technology model (Venkatesh, Morris, Davis and Davis, 2003). Two hundred and eighty questionnaires were distributed and collected from two major cities, Kuala Lumpur and Melaka. Since this is a preliminary study, only descriptive statistics was used to analyse the data. The results show that Malaysians have intentions of using OBS (mean rating of close to 4.00). Moreover, Malaysians recognize the benefits of OBS by giving a high mean rating (close to 4.00) to performance expectancy. However, they give relative low mean ratings (close to 3.00) on other indicators of Behavioural Intention to Use OBS such as effort expectancy, social influence, facilitating conditions and perceived credibility. Recommendations were given to promote a safe, efficient and conducive environment for user adoption of online banking

Ergonomic improvements of workstations for visual inspection and electrical tests in a multimedia product factory

Workstations for Visual Inspections (WVIs) and also for Electrical Tests (WETs) of a multimedia product factory were studied from Ergonomic viewpoints. The problems, identified by subjective assessments and direct observations, were related to poor designs of workstations, work processes and improper tools, causing high (12.2 ± 4.1 %) product returns. In some WVIs, operators were having visual fatigue due to excessive magnifying glass usage, glare from inspection templates and too many components to check within a very short period. Some WETs were not organised to reduce hands and body motions, and to eliminate confusing criteria for passing or failing of the tests. They also had poor visual projection tests due to too bright ambient illumination on the screen. The Ergonomic improvements were: the reduced usage of magnifying glass, the use of no-glare templates, visual inspection of only the electrically non-tested components, the re-design of WETs for economy of motion, the improvement on pass or fail criteria, dark space for effective visual projection tests, etc. These ergonomic interventions improved the company's productivity and operators' health, reduced the product returns and saved USD 70,900 per month