489 research outputs found
Deciphering the roadmap of in vivo reprogramming toward pluripotency
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Differentiated cells can be converted into pluripotent stem cells by expressing the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) in a process known as reprogramming. Here, using single-cell RNA sequencing of pancreas undergoing reprogramming, we identify markers along the trajectory from acinar cell identity to pluripotency. These markers allow direct in situ visualization of cells undergoing dedifferentiation and acquiring features of early and advanced intermediate reprogramming. We also find that a fraction of cells do not dedifferentiate upon OSKM expression and are characterized by stress markers of the REG3 and AP-1 families. Importantly, most markers of intermediate reprogramming in the pancreas are also observed in stomach, colon, and cultured fibroblasts expressing OSKM. Among them is LY6A, a protein characteristic of progenitor cells and generally upregulated during tissue repair. Our roadmap defines intermediate reprogramming states that could be functionally relevant for tissue regeneration and rejuvenation.Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved
A Systems Biology Approach to Drug Targets in Pseudomonas aeruginosa Biofilm
- Author
- Almut Heinken
- AM Feist
- AM Feist
- B Palsson
- B Palsson
- C Pommerenke
- CK Stover
- D Perumal
- D Perumal
- DB Kell
- DD Sriramulu
- DS Lee
- DS Wishart
- G Borriello
- GP Bodey
- GR Zimmermann
- Gunnar Sigurdsson
- I Thiele
- I Thiele
- Ines Thiele
- J Schellenberger
- JA Driscoll
- JD Orth
- JL del Pozo
- K Fang
- L Hall-Stoodley
- LL Silver
- M Musken
- MA Jacobs
- MA Oberhardt
- MA Oberhardt
- MA Oberhardt
- MI Sigurdsson
- N Jamshidi
- NC Duarte
- ND Price
- ND Price
- O Gonzalez
- P Bielecki
- Ping Xu
- PS Stewart
- RM Fleming
- RM Fleming
- Ronan M. T. Fleming
- S Lewenza
- S Moreau-Marquis
- S Obrzut
- S Selvarasu
- SA Becker
- Y Carmeli
- Y Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Antibiotic resistance is an increasing problem in the health care system and we are in a constant race with evolving bacteria. Biofilm-associated growth is thought to play a key role in bacterial adaptability and antibiotic resistance. We employed a systems biology approach to identify candidate drug targets for biofilm-associated bacteria by imitating specific microenvironments found in microbial communities associated with biofilm formation. A previously reconstructed metabolic model of Pseudomonas aeruginosa (PA) was used to study the effect of gene deletion on bacterial growth in planktonic and biofilm-like environmental conditions. A set of 26 genes essential in both conditions was identified. Moreover, these genes have no homology with any human gene. While none of these genes were essential in only one of the conditions, we found condition-dependent genes, which could be used to slow growth specifically in biofilm-associated PA. Furthermore, we performed a double gene deletion study and obtained 17 combinations consisting of 21 different genes, which were conditionally essential. While most of the difference in double essential gene sets could be explained by different medium composition found in biofilm-like and planktonic conditions, we observed a clear effect of changes in oxygen availability on the growth performance. Eight gene pairs were found to be synthetic lethal in oxygen-limited conditions. These gene sets may serve as novel metabolic drug targets to combat particularly biofilm-associated PA. Taken together, this study demonstrates that metabolic modeling of human pathogens can be used to identify oxygen-sensitive drug targets and thus, that this systems biology approach represents a powerful tool to identify novel candidate antibiotic targets
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
- Aasvang GM
- Abajobir AA
- Abate KH
- Abbafati C
- Abbas KM
- Abd-Allah F
- Abdulle AM
- Abera SF
- Abraham B
- Abu-Raddad LJ
- Abyu GY
- Adebiyi AO
- Adedeji IA
- Ademi Z
- Adou AK
- Adsuar JC
- Afshin A
- Agardh EE
- Agarwal A
- Agrawal A
- Ajala ON
- Akinyemiju TF
- Al-Aly Z
- Alam K
- Alam NKM
- Aldhahri SF
- Aldridge RW
- Alemu ZA
- Alexander LT
- Ali R
- Alkerwi A
- Alla F
- Allebeck P
- Alsharif U
- Altirkawi KA
- Alvarez Martin E
- Alves Silveira DG
- Alvis-Guzman N
- Amare AT
- Amberbir A
- Amegah AK
- Amini H
- Ammar W
- Amrock SM
- Andersen HH
- Anderson BO
- Anderson HR
- Antonio CAT
- Anwar P
- Aquino Faraon EJ
- Arnlov J
- Artaman A
- Asayesh H
- Asghar RJ
- Assadi R
- Atique S
- Avokpaho EFGA
- Awasthi A
- Azzopardi P
- Bacha U
- Badawi A
- Baernighausen T
- Bahit MC
- Balakrishnan K
- Bans C
- Barac A
- Barber RM
- Barker-Collo SL
- Barquera S
- Barregard L
- Barrero LH
- Basu S
- Bazargan-Hejazi S
- Beardsley J
- Beatriz Heredia-Pi I
- Beatriz Lawrynowicz AE
- Bedi N
- Beghi E
- Bell ML
- Bello AK
- Bennett DA
- Bensenor IM
- Berhane A
- Bernabe E
- Betsu BD
- Beyene AS
- Bhala N
- Bhansali A
- Bhatt S
- Bhutta ZA
- Biadgilign S
- Bicer BK
- Bikbov B
- Biryukov S
- Bisanzio D
- Bjertness E
- Blore JD
- Borschmann R
- Boufous S
- Bourne RRA
- Brainin M
- Brauer M
- Brazinova A
- Breitborde NJK
- Brenner H
- Broday DM
- Brugha TS
- Brunekreef B
- Burnett R
- Butt ZA
- Cahill LE
- Caicedo AJP
- Calabria B
- Cardenas R
- Carmen Gomez-Cabrera M
- Carpenter D
- Casey DC
- Castaneda-Oquela CA
- Castillo Rivas J
- Catala-Lopez F
- Cercy K
- Chang J-C
- Charlson FJ
- Chiang PP-C
- Chibalabala M
- Chimed-Ochir O
- Chisumpa VH
- Chitheer AA
- Choi J-YJ
- Christensen H
- Christopher DJ
- Ciobanu LG
- Coates MM
- Cohen AJ
- Colquhoun SM
- Cooper LT
- Cooperrider K
- Cornaby L
- Cortinovis M
- Crump JA
- Cuevas-Nasu L
- Damasceno A
- Dandona L
- Dandona R
- Darby SC
- Dargan PI
- das Neves J
- Davis AC
- Davletov K
- De la Cruz-Gongora V
- De Leo D
- Defo BK
- Degenhardt L
- Del Gobbo LC
- del Pozo-Cruz B
- Dellavalle RP
- Deribew A
- Des Jarlais DC
- Dharmaratne SD
- Dhillon PK
- Diaz-Tome C
- Dicker D
- Dimbuene ZT
- Ding EL
- Dolores Sanchez-Nino M
- Dorsey ER
- Doyle KE
- Driscoll TR
- Duan L
- Dubey M
- Duncan BB
- Elyazar I
- Endries AY
- Ermakov SP
- Erskine HE
- Eshrati B
- Estanislao Castro R
- Esteghamati A
- Estep K
- Factors GBDR
- Fahimi S
- Farid TA
- Faro A
- Farvid MS
- Farzadfar F
- Feigin VL
- Fereshtehnejad S-M
- Fernandes JG
- Ferrari AJ
- Filipa de Castro E
- Fischer F
- Fitchett JRA
- Fleming T
- Foigt N
- Foreman K
- Forouzanfar MH
- Fowkes FGR
- Francisco Hernandez-Llanes N
- Franklin RC
- Frostad JJ
- Fuerst T
- Fullman N
- Futran ND
- Gakidou E
- Garcia-Basteiro AL
- Gebrehiwot TT
- Gebremedhin AT
- Geleijnse JM
- Gessner BD
- Gething PW
- Giref AZ
- Giroud M
- Gishu MD
- Godwin WW
- Goenka S
- Gomez-Dantes H
- Gona P
- Goodridge A
- Gopalani SV
- Gotay CC
- Goto A
- Gouda HN
- Griswold M
- Gugnani HC
- Guillemin F
- Guo Y
- Gupta R
- Gupta R
- Gutierrez RA
- Haagsma JA
- Hafezi-Nejad N
- Haile D
- Hailu GB
- Halasa YA
- Hamadeh RR
- Hamidi S
- Handal AJ
- Hankey GJ
- Hao Y
- Harb HL
- Harikrishnan S
- Hassanvand MS
- Hassen TA
- Havmoeller R
- Heydarpour P
- Hoek HW
- Hoffman HJ
- Horino M
- Horita N
- Hosgood HD
- Hoy DG
- Hsairi M
- Htet AS
- Hu G
- Huang JJ
- Husseini A
- Hutchings SJ
- Huybrechts I
- Iburg KM
- Idrisov BT
- Ileanu BV
- Inoue M
- Jacobs TA
- Jacobsen KH
- Jahanmehr N
- Jakovljevic MB
- Jansen HAFM
- Jassal SK
- Javanbakht M
- Jayatilleke AU
- Jee SH
- Jeemon P
- Jha V
- Jiang Y
- Jibat T
- Jin Y
- Johnson CO
- Jonas JB
- Kabir Z
- Kalkonde Y
- Kamal R
- Kan H
- Karch A
- Karema CK
- Karimkhani C
- Kasaeian A
- Kaul A
- Kawakami N
- Kazi DS
- Keiyoro PN
- Kemp AH
- Kengne AP
- Keren A
- Kesavachandran CN
- Khader YS
- Khan AR
- Khan EA
- Khan G
- Khang Y-H
- Khatibzadeh S
- Khera S
- Khoja TAM
- Khubchandani J
- Kiadaliri AA
- Kieling C
- Kim C-I
- Kim D
- Kimokoti RW
- Kinfu Y
- Kissoon N
- Kivipelto M
- Knibbs LD
- Kokubo Y
- Kopec JA
- Koul PA
- Koyanagi A
- Kravchenko M
- Kromhout H
- Krueger H
- Ku T
- Kuchenbecker RS
- Kuipers EJ
- Kumar GA
- Kwan GF
- Kyu HH
- Lal DK
- Lalloo R
- Lallukka T
- Lan Q
- Landon N
- Larson HJ
- Larsson A
- Latif AA
- Leasher JL
- Leigh J
- Leung J
- Levi M
- Levy TS
- Li X
- Li Y
- Liang J
- Liang X
- Lim SS
- Liu PY
- Liu S
- Lloyd BK
- Logroscino G
- Lopez AD
- Lotufo PA
- Lozano R
- Lunevicius R
- Maclntyre M
- Mahdavi M
- Mahesh PA
- Majdan M
- Majeed A
- Malekzadeh R
- Malta DC
- Manamo WAA
- Mapoma CC
- Marcenes W
- Marczak L
- Maria Haro J
- Martin RV
- Martinez-Raga J
- Masiye F
- Matsushita K
- Matzopoulos R
- Mayosi BM
- McGrath JJ
- McKee M
- Meaney PA
- Medina C
- Mehari A
- Mekonnen AB
- Melaku YA
- Memish ZA
- Mena-Rodriguez F
- Mendoza W
- Mensah GA
- Mensink GBM
- Meretoja A
- Meretoja TJ
- Mesfin YM
- Mhimbira FA
- Miller TR
- Mills EJ
- Mirarefin M
- Misganaw A
- Mock CN
- Mohammadi A
- Mohammed S
- Mokdad AH
- Mola GLD
- Monasta L
- Montanez Hernandez JC
- Montico M
- Moradi-Lakeh M
- Morawska L
- Mori R
- Mozaffarian D
- Mueller UO
- Mullany E
- Mumford JE
- Murray CJL
- Murthy GVS
- Nachega JB
- Naghavi M
- Naheed A
- Nangia V
- Nassiri N
- Neal B
- Newton JN
- Ng M
- Nguyen QL
- Nisar MI
- Norheim OF
- Norman RE
- Norrving B
- Nyakarahuka L
- Obermeyer CM
- Ogbo FA
- Oh I-H
- Oladimeji O
- Olivares PR
- Olsen H
- Olusanya BO
- Olusanya JO
- Opio JN
- Oren E
- Orozco R
- Ortiz A
- Ota E
- Pana A
- Park E-K
- Parry CD
- Parsaeian M
- Patel T
- Patil ST
- Patten SB
- Patton GC
- Pearce N
- Pereira DM
- Perico N
- Pesudovs K
- Pete PMN
- Petzold M
- Phillips MR
- Piel FB
- Pillay JD
- Plass D
- Polinder S
- Pond CD
- Pope CA
- Pope D
- Popova S
- Poulton RG
- Pourmalek F
- Prasad NM
- Qorbani M
- Quintanilla BPA
- Rabiee RHS
- Radfar A
- Rafay A
- Rahimi-Movaghar V
- Rahman M
- Rahman MHU
- Rahman SU
- Rai RK
- Rajsic S
- Raju M
- Ram U
- Rana SM
- Ranganathan K
- Rao P
- Razo Garcia CA
- Refaat AH
- Rehm CD
- Rehm J
- Reinig N
- Reitsma MB
- Remuzzi G
- Resnikoff S
- Ribeiro AL
- Ricardo Campos-Nonato I
- Rivera JA
- Rodriguez A
- Rodriguez-Ramirez S
- Rojas-Rueda D
- Rolm HS
- Roman Y
- Ronfani L
- Roshandel G
- Roth GA
- Rothenbacher D
- Roy A
- Saleh MM
- Salomon JA
- Sanabria JR
- Sanchez-Pimienta TG
- Sandar L
- Santomauro DF
- Santos IS
- Sarmiento-Suarez R
- Sartorius B
- Satpathy M
- Savic M
- Sawhney M
- Schmidhuber J
- Schmidt MI
- Schneider IJC
- Schoettker B
- Schutte AE
- Schwebel DC
- Scott JG
- Seedat S
- Sepanlou SG
- Servan-Mori EE
- Shaheen A
- Shahraz S
- Shaikh MA
- Sharma R
- She J
- Sheikhbahaei S
- Shen J
- Sheth KN
- Shi P
- Shibuya K
- Shigematsu M
- Shin M-J
- Shiri R
- Shishani K
- Shiue I
- Shrime MG
- Sigfusdottir ID
- Silva DAS
- Silverberg JI
- Simard EP
- Sindi S
- Singh A
- Singh JA
- Singh PK
- Slepak EL
- Sofia E Sa Farinha C
- Soljak M
- Soneji S
- Sorensen RJD
- Sposato LA
- Sreeramareddy CT
- Stathopoulou V
- Steckling N
- Steel N
- Stein DJ
- Stein MB
- Stockl H
- Stranges S
- Stroumpoulis K
- Sunguya BF
- Sur PJ
- Swaminathan S
- Sykes BL
- Szoeke CEI
- Tabares-Seisdedos R
- Takahashi K
- Talongwa RT
- Tanne D
- Tavakkoli M
- Taye BW
- Taylor HR
- Tedla BA
- Tefera WM
- Tegegne TK
- Tekle DY
- Terkawi AS
- Thakur JS
- Thomas BA
- Thomas ML
- Thomson AJ
- Thorne-Lyman AL
- Thrift AG
- Thurston GD
- Tillmann T
- Tobe-Gai R
- Tobollik M
- Topor-Madry R
- Topouzis F
- Towbin JA
- Tran BX
- Tsilimparis N
- Tura AK
- Tuzcu EM
- Tyrovolas S
- Ukwaja KN
- Undurraga EA
- Uneke CJ
- Uthman OA
- van Donkelaar A
- van Os J
- Varakin YY
- Vasankari T
- Veerman JL
- Venketasubramanian N
- Violante FS
- Vollset SE
- Vos T
- Wagner GR
- Wagner JA
- Waller SG
- Wang H
- Wang J
- Wang L
- Wang Y
- Weichenthal S
- Weiderpass E
- Weintraub RG
- Werdecker A
- Westerman R
- Whiteford HA
- Wijeratne T
- Wiysonge CS
- Wolfe CDA
- Won S
- Woolf AD
- Wubshet M
- Xavier D
- Xu G
- Yadav AK
- Yakob B
- Yalew AZ
- Yano Y
- Yaseri M
- Ye P
- Yip P
- Yonemoto N
- Yoon S-J
- Younis MZ
- Yu C
- Zaidi Z
- Zaki MES
- Zhao Y
- Zhou M
- Zhu J
- Zipkin B
- Zodpey S
- Zuhlke LJ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation
High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency
- Author
- A Kimura
- AL Price
- Annette T. Lee
- Björn R. Ludviksson
- C Tian
- CA Alper
- Concepción Núñez
- David E. Goldgar
- EG De La Concha
- EG De la Concha
- EJ Yunis
- Elena Urcelay
- F Cucca
- FM Schaffer
- Gudmundur Jorgensen
- Gumersindo Fontán
- H Erlich
- H Sekine
- HK Machulla
- HW Schroeder Jr
- J Klein
- J Klein
- J Kralovicova
- J Marchini
- J Mohammadi
- J Mohammadi
- JA Todd
- JD Rioux
- JE Volanakis
- Katri Haimila
- L Hammarstrom
- L Hammarstrom
- Lennart Hammarström
- Leonid Padyukov
- M Ambrus
- M Fiore
- M Stephens
- M Thomsen
- ME Conley
- Miguel Fernández-Arquero
- Nd Pozo
- Ning Wang
- O Olerup
- O Olerup
- O Olerup
- PD Burrows
- Peter K. Gregersen
- PI de Bakker
- Qiang Pan-Hammarström
- R Horton
- R Horton
- RC Ferreira
- Ricardo C. Ferreira
- Robert R. Graham
- S Leslie
- S Nejentsev
- S Purcell
- S Saghafi
- Sinikka Koskinen
- TA Aly
- Timothy W. Behrens
- TJ Cobain
- Ward Ortmann
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Selective IgA deficiency (IgAD; serum IgA<0.07 g/l) is the most common form of human primary immune deficiency, affecting approximately 1∶600 individuals in populations of Northern European ancestry. The polygenic nature of IgAD is underscored by the recent identification of several new risk genes in a genome-wide association study. Among the characterized susceptibility loci, the association with specific HLA haplotypes represents the major genetic risk factor for IgAD. Despite the robust association, the nature and location of the causal variants in the HLA region remains unknown. To better characterize the association signal in this region, we performed a high-density SNP mapping of the HLA locus and imputed the genotypes of common HLA-B, -DRB1, and -DQB1 alleles in a combined sample of 772 IgAD patients and 1,976 matched controls from 3 independent European populations. We confirmed the complex nature of the association with the HLA locus, which is the result of multiple effects spanning the entire HLA region. The primary association signal mapped to the HLA-DQB1*02 allele in the HLA Class II region (combined P = 7.69×10−57; OR = 2.80) resulting from the combined independent effects of the HLA-B*0801-DRB1*0301-DQB1*02 and -DRB1*0701-DQB1*02 haplotypes, while additional secondary signals were associated with the DRB1*0102 (combined P = 5.86×10−17; OR = 4.28) and the DRB1*1501 (combined P = 2.24×10−35; OR = 0.13) alleles. Despite the strong population-specific frequencies of HLA alleles, we found a remarkable conservation of these effects regardless of the ethnic background, which supports the use of large multi-ethnic populations to characterize shared genetic association signals in the HLA region. We also provide evidence for the location of association signals within the specific extended haplotypes, which will guide future sequencing studies aimed at characterizing the precise functional variants contributing to disease pathogenesis
Performance of missing transverse momentum reconstruction with the ATLAS detector using proton–proton collisions at √s = 13 TeV
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Arabidze G
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Atkin RJ
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Avramidou R
- Ayoub MK
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The performance of the missing transverse momentum (EmissT) reconstruction with the ATLAS detector is evaluated using data collected in proton–proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015. To reconstruct EmissT, fully calibrated electrons, muons, photons, hadronically decaying τ -leptons, and jets reconstructed from calorimeter energy deposits and charged-particle tracks are used. These are combined with the soft hadronic activity measured by reconstructed charged-particle tracks not associated with the hard objects. Possible double counting of contributions from reconstructed charged-particle tracks from the inner detector, energy deposits in the calorimeter, and reconstructed muons from the muon spectrometer is avoided by applying a signal ambiguity resolution procedure which rejects already used signals when combining the various EmissT contributions. The individual terms as well as the overall reconstructed EmissT are evaluated with various performance metrics for scale (linearity), resolution, and sensitivity to the data-taking conditions. The method developed to determine the systematic uncertainties of the EmissT scale and resolution is discussed. Results are shown based on the full 2015 data sample corresponding to an integrated luminosity of 3.2 fb−1
Combined measurement of differential and total cross sections in the H → γγ and the H → ZZ* → 4ℓ decay channels at s=13 TeV with the ATLAS detector
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- Zhemchugov A
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- Zhu CG
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- Zhulanov V
- Zibell A
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- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fb−1 of 13 TeV proton–proton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured H→γγ and H→ZZ*(→4ℓ event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0−5.9 +6.0 (stat.) −3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
Measurement of the t¯tZ and t¯tW cross sections in proton-proton collisions at √s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
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- Abreu H
- Abulaiti Y
- Acharya BS
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- Zhemchugov A
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- Zobernig G
- Zoccoli A
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- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
A measurement of the associated production of a top-quark pair (t¯t) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb−1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The t¯tZ and t¯tW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σt¯tZ=0.95±0.08stat±0.10syst pb and σt¯tW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the t¯tZ cross section is used to set constraints on effective field theory operators which modify the t¯tZ vertex
Anatomy of the sign-problem in heavy-dense QCD
- Author
- Adam E Romero
- Aranda C Padilla
- Arjanovic MM
- Armadans R Caminal
- Astigarraga ME Pozo
- Barajas CA Chavez
- Bechtle P
- Beck HP
- Becker K
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- Yen AL
- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshida R
- Yoshihara K
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- Youssef S
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- Yuen SPY
- Yusuff I
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- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
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- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
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- Zhang G
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- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
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- Zhou L
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
QCD at finite densities of heavy quarks is investigated
using the density-of-states method. The phase factor
expectation value of the quark determinant is calculated to
unprecedented precision as a function of the chemical potential.
Results are validated using those from a reweighting
approach where the latter can produce a significant signalto-noise
ratio. We confirm the particle–hole symmetry at low
temperatures, find a strong sign problem at intermediate values
of the chemical potential, and an inverse Silver Blaze
feature for chemical potentials close to the onset value: here,
the phase-quenched theory underestimates the density of the
full theory
Operation and performance of the ATLAS Tile Calorimeter in Run 1
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouelfadl 
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez 
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor 
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Arce ATH
- Ardell RE
- Arduh FA
- Argos FC
- Arguin J-
- Argyropoulos S
- Armadans R
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME
- Atkin RJ
- Atkinson M
- Atlay NB
- Auerbach B
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- Åkesson TPA
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- Bachacou H
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- Bahilo JJL
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- Bannoura AAE
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- Baroncelli A
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- Buzatu A
- Buzykaev AR
- Bührer F
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- Cabrera Urbán S
- Caforio D
- Cai H
- Cairo VMM
- Cakir I
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvente Lopez S
- Calvet D
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- Camarda S
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- Caminal 
- Camincher C
- Campana S
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- Camplani A
- Campoverde A
- Canale V
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- Cantero J
- Cao T
- Cao Y
- Capeans Garrido MDM
- Caprini I
- Caprini M
- Capua M
- Carbone RM
- Cardarelli R
- Cardillo FC
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carrá S
- Carrillo-Montoya GD
- Casadei D
- Casado MP
- Casha AF
- Casolino M
- Casper DW
- Castelijn R
- Castillo Gimenez V
- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
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- Cavasinni V
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- Cetin SA
- Chafaq A
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- Chau CC
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- Chekulaev SV
- Chelkov GA
- Chelstowska MA
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- De Benedetti A
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- De Cecco S
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- De Moura 
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- Zur 
- Zwalinski L
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The Tile Calorimeter is the hadron calorimeter covering the central region of the ATLAS experiment at the Large Hadron Collider. Approximately 10,000 photomultipliers collect light from scintillating tiles acting as the active material sandwiched between slabs of steel absorber. This paper gives an overview of the calorimeter’s performance during the years 2008–2012 using cosmic-ray muon events and proton–proton collision data at centre-of-mass energies of 7 and 8TeV with a total integrated luminosity of nearly 30 fb−1. The signal reconstruction methods, calibration systems as well as the detector operation status are presented. The energy and time calibration methods performed excellently, resulting in good stability of the calorimeter response under varying conditions during the LHC Run 1. Finally, the Tile Calorimeter response to isolated muons and hadrons as well as to jets from proton–proton collisions is presented. The results demonstrate excellent performance in accord with specifications mentioned in the Technical Design Report
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
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