Domain I of the 5′ non-translated genomic region in coxsackievirus B3 RNA is not required for productive replication

AbstractDomain I is a cloverleaf-like secondary structure at the 5′ termini of all enterovirus genomes, comprising part of a cis-acting replication element essential for efficient enteroviral replication. 5′ genomic terminal deletions up to as much as 55% of domain I can occur without lethality following coxsackie B virus infections. We report here that the entire CVB structural domain I can be deleted without lethality

Tailoring the magnetic properties of Fe asymmetric nanodots

Asymmetric dots as a function of their geometry have been investigated using three-dimensional (3D) object oriented micromagnetic framework (OOMMF) code. The effect of shape asymmetry of the disk on coercivity and remanence is studied. Angular dependence of the remanence and coercivity is also addressed. Asymmetric dots are found to reverse their magnetization by nucleation and propagation of a vortex, when the field is applied parallel to the direction of asymmetry. However, complex reversal modes appear when the angle at which the external field is applied is varied, leading to a non monotonic behavior of the coercivity and remanence.Comment: 5 pages, 7 figure

Single-neutron transfer from 11Be gs via the (p,d) reaction with a radioactive beam

The 11Be(p,d)10Be reaction has been performed in inverse kinematics with a radioactive 11Be beam of E/A = 35.3 MeV. Angular distributions for the 0+ ground state, the 2+, 3.37 MeV state and the multiplet of states around 6 MeV in 10Be were measured at angles up to 16 deg CM by detecting the 10Be in a dispersion-matched spectrometer and the coincident deuterons in a silicon array. Distorted wave and coupled-channels calculations have been performed to investigate the amount of 2+ core excitation in 11Be gs. The use of "realistic" 11Be wave functions is emphasised and bound state form factors have been obtained by solving the particle-vibration coupling equations. This calculation gives a dominant 2s component in the 11Be gs wave function with a 16% [2+ x 1d] core excitation admixture. Cross sections calculated with these form factors are in good agreement with the present data. The Separation Energy prescription for the bound state wave function also gives satisfactory fits to the data, but leads to a significantly larger [2 x 1d] component in 11Be gs.Comment: 39 pages, 12 figures. Accepted for publication in Nuclear Physics A. Added minor corrections made in proof to pages 26 and 3

The LABOCA survey of the extended Chandra Deep Field South : two modes of star formation in active galactic nucleus hosts?

We study the co-existence of star formation and active galactic nucleus (AGN) activity in Chandra X-ray-selected AGN by analyzing stacked 870 μm submillimeter emission from a deep and wide map of the Extended Chandra Deep Field South (ECDFS), obtained with the LABOCA instrument at the APEX telescope. The total X-ray sample of 895 sources with median redshift z ~ 1 drawn from the combined (E)CDFS X-ray catalogs is detected at >11σ significance at a mean submillimeter flux of 0.49 ± 0.04 mJy, corresponding to a typical star formation rate (SFR) around 30 M sun yr-1 for a T = 35 K, β = 1.5 graybody far-infrared spectral energy distribution. The good signal-to-noise ratio permits stacking analyses for major subgroups, splitting the sample by redshift, intrinsic luminosity, and AGN obscuration properties. We observe a trend of SFR increasing with redshift. An increase of SFR with AGN luminosity is indicated at the highest L 2-10 keV >~ 1044 erg s-1 luminosities only. Increasing trends with X-ray obscuration as expected in some AGN evolutionary scenarios are not observed for the bulk of the X-ray AGN sample but may be present for the highest intrinsic luminosity objects with L 2-10 keV >~ 1044 erg s-1. This behavior suggests a transition between two modes in the co-existence of AGN activity and star formation. For the bulk of the sample, the X-ray luminosity and obscuration of the AGN are not intimately linked to the global SFR of their hosts. The hosts are likely massive and forming stars secularly, at rates similar to the pervasive star formation seen in massive galaxies without an AGN at similar redshifts. In these systems, star formation is not linked to a specific state of the AGN and the period of moderately luminous AGN activity may not highlight a major evolutionary transition of the galaxy. The change indicated toward more intense star formation, and a more pronounced increase in SFRs between unobscured and obscured AGN reported in the literature at highest (L 2-10 keV >~ 1044 erg s-1) luminosities suggests that these luminous AGNs follow an evolutionary path on which obscured AGN activity and intense star formation are linked, possibly via merging. Comparison to local hard X-ray-selected AGN supports this interpretation. SFRs in the hosts of moderate luminosity AGN at z ~ 1 are an order of magnitude higher than at z ~ 0, following the increase in the non-AGN massive galaxy population. At high AGN luminosities, hosts on the evolutionary link/merger path emerge from this secular level of star formation

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

LDIP cooperates with SEIPIN and LDAP to facilitate lipid droplet biogenesis in Arabidopsis

Abstract Cytoplasmic lipid droplets (LDs) are evolutionarily conserved organelles that store neutral lipids and play critical roles in plant growth, development, and stress responses. However, the molecular mechanisms underlying their biogenesis at the endoplasmic reticulum (ER) remain obscure. Here we show that a recently identified protein termed LD-associated protein [LDAP]-interacting protein (LDIP) works together with both endoplasmic reticulum-localized SEIPIN and the LD-coat protein LDAP to facilitate LD formation in Arabidopsis thaliana. Heterologous expression in insect cells demonstrated that LDAP is required for the targeting of LDIP to the LD surface, and both proteins are required for the production of normal numbers and sizes of LDs in plant cells. LDIP also interacts with SEIPIN via a conserved hydrophobic helix in SEIPIN and LDIP functions together with SEIPIN to modulate LD numbers and sizes in plants. Further, the co-expression of both proteins is required to restore normal LD production in SEIPIN-deficient yeast cells. These data, combined with the analogous function of LDIP to a mammalian protein called LD Assembly Factor 1, are discussed in the context of a new model for LD biogenesis in plant cells with evolutionary connections to LD biogenesis in other eukaryotes