Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries(1,2). However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world(3) and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health(4,5). However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular riskchanged from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.Peer reviewe

Prevalence and Factors Associated with Food Insecurity in the Context of the Economic Crisis in Brazil

BACKGROUND: The Brazilian economy has been officially in recession since 2014. Since then, there has been an increase in the unemployment rate, cost of food, and cuts in the budgets of social programs, among other situations that may interfere with the food security of the population. OBJECTIVES: The aims of this study were to identify the prevalence of and factors associated with food insecurity (FI) in Alagoas, one of the poorest states in Brazil, and to discuss the results in the context of the national economic crisis. METHODS: This was a cross-sectional study in a probabilistic sample of 3366 families. FI was identified on the basis of the Brazilian Food Insecurity Measurement. The associations with independent variables that achieved P < 0.2 (by chi-square test) in the crude analysis were submitted to multivariable analysis. RESULTS: The observed prevalence of FI was 58.3% (33.1%, 17.9%, and 7.3% for mild, moderate, and severe FI, respectively), which is considerably higher than the 34.6% found in 2013 by the Brazilian Institute of Geography and Statistics before the worsening of the economic crisis. The factors independently associated with FI in this study included the following: female head of household, head of the family having no income, female head of household being overweight, ≥4 family members, ≤4 rooms in the house, household income less than the minimum wage, family belonging to the lower economic classes (D or E), using the Bolsa Família program, residing in a nonmasonry house, or not residing in their own house. CONCLUSIONS: The prevalence of FI in Alagoas is very high, and considering previous studies, there was a marked increase in FI during the Brazilian economic crisis. All associated factors are related to the greater social vulnerability of the family. The present data point to the need to strengthen public policies for health promotion, education, employment, and income and to ensure the human right to adequate food, with the aim of reducing social vulnerability within the family in a sustainable way. In addition, this study contributes to the understanding of how national conditions can influence household-level FI

The use of protein hydrolysate improves the protein intestinal absorption in undernourished mice infected with Schistosoma mansoni

Patients residing in endemic areas for schistosomiasis in Brazil are usually undernourished and when they develop the hepatosplenic clinical form of the disease should usually receive hospital care, many of them being in need of nutritional rehabilitation before specific treatment can be undertaken. In the mouse model, investigations carried out in our laboratory detected a reduced aminoacid uptake in undernourished animals which is aggravated by a superimposed infection with Schistosoma mansoni. However, in well-nourished infected mice no dysfunction occurs. In this study, we tried to improve the absorptive intestinal performance of undernourished mice infected with S. mansoni by feeding them with hydrolysed casein instead of whole casein. The values obtained for the coefficient of protein intestinal absorption (cpia) among well-nourished mice were above 90% (either hydrolysed or whole protein). In undernourished infected mice, however, the cpia improved significantly after feeding them with hydrolysed casein, animals reaching values close to those obtained in well-nourished infected mice

High Blood Pressure among Students in Public and Private Schools in Maceió, Brazil

<div><p>The prevalence of hypertension in childhood is increasing, and investigation of its distribution is important for planning timely interventions. This study assessed the prevalence of high blood pressure (HBP) and associated factors in students between 9 and 11 years of age enrolled in public and private schools in Maceió, Brazil. A cross-sectional study was performed in a probabilistic sample of students (10.3 ± 0.5 years). The students were selected from a systematic sampling of 80 schools (40 public and 40 private). To maintain similar proportions of students existing in public and private schools in Maceió, 21 and 14 students were randomly selected from each public and private school, respectively. The prevalence ratio (PR) was estimated using Poisson regression. A total of 1,338 students were evaluated (800 from public schools and 538 from private schools). No differences were observed between school types in terms of student age and gender (<i>p</i> > 0.05). The prevalence of obesity (19.9% vs. 9.0%; PR = 2.2; 95% CI = 1.67–2.92) and hypertension (21.2% vs. 11.4%; PR = 1.86; 95% CI = 1.45–2.40) were higher in private schools. The association between high blood pressure and type of school (public or private) remained statistically significant even after adjustment for obesity (PR = 1.53; 95% CI = 1.19–1.97). In conclusion: (a) students from private schools have higher socioeconomic status, BMI, and HBP prevalence compared to those of public school; (b) among the evaluated students, the prevalence of obesity only partially explained the higher prevalence of high blood pressure among students from private schools. Other factors related to lifestyle of children from private schools may explain the higher prevalence of HBP. This results show the need to implement measures to promote healthy lifestyles in the school environment, since children with HBP are more likely to become hypertensive adults. Therefore, early detection and intervention in children with HBP is an important action for the prevention of hypertension in adulthood.</p></div

Socioeconomic, demographic, nutritional, and health characteristics of elementary school children according to type of school.

<p>χ²: chi-square test; BMI-for-age >2 SD: Body Mass Index-for-age > 2 standard deviation</p><p>Maceió (Alagoas), Brazil, 2013.</p