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a randomized, open, multicenter phase III trial of lenalidomide/dexamethasone versus lenalidomide/dexamethasone plus subsequent autologous stem cell transplantation and lenalidomide maintenance in patients with relapsed multiple myeloma

Background Despite novel therapeutic agents, most multiple myeloma (MM) patients eventually relapse. Two large phase III trials have shown significantly improved response rates (RR) of lenalidomide/dexamethasone compared with placebo/dexamethasone in relapsed MM (RMM) patients. These results have led to the approval of lenalidomide for RMM patients and lenalidomide/dexamethasone has since become a widely accepted second-line treatment. Furthermore, in RMM patients consolidation with high-dose chemotherapy plus autologous stem cell transplantation has been shown to significantly increase progression free survival (PFS) as compared to cyclophosphamide in a phase III trial. The randomized prospective ReLApsE trial is designed to evaluate PFS after lenalidomide/dexamethasone induction, high-dose chemotherapy consolidation plus autologous stem cell transplantation and lenalidomide maintenance compared with the well-established lenalidomide/dexamethasone regimen in RMM patients. Methods/Design ReLApsE is a randomized, open, multicenter phase III trial in a planned study population of 282 RMM patients. All patients receive three lenalidomide/dexamethasone cycles and - in absence of available stem cells from earlier harvesting - undergo peripheral blood stem cell mobilization and harvesting. Subsequently, patients in arm A continue on consecutive lenalidomide/dexamethasone cycles, patients in arm B undergo high dose chemotherapy plus autologous stem cell transplantation followed by lenalidomide maintenance until discontinuation criteria are met. Therapeutic response is evaluated after the 3rd (arm A + B) and the 5th lenalidomide/dexamethasone cycle (arm A) or 2 months after autologous stem cell transplantation (arm B) and every 3 months thereafter (arm A + B). After finishing the study treatment, patients are followed up for survival and subsequent myeloma therapies. The expected trial duration is 6.25 years from first patient in to last patient out. The primary endpoint is PFS, secondary endpoints include overall survival (OS), RR, time to best response and the influence of early versus late salvage high dose chemotherapy plus autologous stem cell transplantation on OS. Discussion This phase III trial is designed to evaluate whether high dose chemotherapy plus autologous stem cell transplantation and lenalidomide maintenance after lenalidomide/dexamethasone induction improves PFS compared with the well-established continued lenalidomide/dexamethasone regimen in RMM patients. Trial registration: ISRCTN16345835 (date of registration 2010-08-24)

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Measurements of branching fraction ratios and CP-asymmetries in suppressed B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^- decays

Author: Aaltonen T.
Abbiendi G.
Abbrescia M.
Abdulsalam A.
Ahmad W. Haj
Ahuja S.
Albergo S.
Almenar C. Cuenca
Alvarez Gonzalez B.
Amerio S.
Amidei D.
Anastassov A.
Anderson M.
Annovi A.
Antos J.
Apollinari G.
Appel J. A.
Appelt E.
Apresyan A.
Aranyi A.
Arenton M. W.
Arfaei H.
Arisawa T.
Artikov A.
Asaadi J.
Ashmanskas W.
Auerbach B.
Aurisano A.
Autermann C.
Azfar F.
Aziz T.
Bachtis M.
Badgett W.
Bakhshiansohi H.
Balazs M.
Banerjee S.
Banerjee S.
Barbagli G.
Barbaro-Galtieri A.
Barbone L.
Barnes V. E.
Barnett B. A.
Barria P.
Barth C.
Bartos P.
Bauce M.
Bauer G.
Bedeschi F.
Beecher D.
Behari S.
Behr J.
Behrenhoff W.
Behrens U.
Belknap D.
Bellettini G.
Bellinger J.
Bellinger J. N.
Benaglia A.
Bencze G.
Beni N.
Benjamin D.
Benussi L.
Benvenuti A. C.
Beretvas A.
Berger J.
Bergholz M.
Beri S. B.
Bernardini J.
Bethani A.
Bhatnagar V.
Bhattacharya S.
Bhatti A.
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Binkley M.
Bisello D.
Bizjak I.
Bland K. R.
Blobel V.
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Bobrovskyi S.
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Boudreau J.
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Boveia A.
Braibant-Giacomelli S.
Brigliadori L.
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Campanelli M.
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Canelli F.
Capiluppi P.
Cappello G.
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Carlsmith D.
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Carron S.
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Castro E.
Catastini P.
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Cavaliere V.
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Cipriano P. M. Ribeiro
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da Costa J. Guimaraes
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de Barbaro P.
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Publication venue: 'American Physical Society (APS)'
Publication date: 01/01/2011
Field of study

We report the first reconstruction in hadron collisions of the suppressed decays B^- -> D(-> K^+ pi^-)K^- and B^- -> D(-> K^+ pi^-)pi^-, sensitive to the CKM phase gamma, using data from 7 fb^-1 of integrated luminosity collected by the CDF II detector at the Tevatron collider. We reconstruct a signal for the B^- -> D(-> K^+ pi^-)K^- suppressed mode with a significance of 3.2 standard deviations, and measure the ratios of the suppressed to favored branching fractions R(K) = [22.0 \pm 8.6(stat)\pm 2.6(syst)]\times 10^-3, R^+(K) = [42.6\pm 13.7(stat)\pm 2.8(syst)]\times 10^-3, R^-(K)= [3.8\pm 10.3(stat)\pm 2.7(syst]\times 10^-3, as well as the direct CP-violating asymmetry A(K) = -0.82\pm 0.44(stat)\pm 0.09(syst) of this mode. Corresponding quantities for B^- -> D(-> K^+ pi^-)pi^- decay are also reported.Comment: 8 pages, 1 figure, accepted by Phys.Rev.D Rapid Communications for Publicatio

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Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

Author: Abbaneo D
Abbiendi G
Abbrescia M
Abdullin S
Acosta D
Acosta JG
Acosta MV
Adair A
Adam N
Adam W
Adams MR
Adams T
Adiguzel A
Adler V
Adzic P
Agostino L
Agram JL
Aguilar-Benitez M
Aguilo E
Ahmad M
Ahmad WH
Ahuja S
Akchurin N
Akgun B
Akgun U
Akin IV
Alagoz E
Albajar C
Albayrak EA
Albergo S
Albrow M
Alda Junior WL
Alexander J
Aliev T
Almeida N
Alver B
Alverson G
Alves GA
Amapane N
Amsler C
Anagnostou G
Anastassov A
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Zatserklyaniy A
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Zheng Y
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Ziebarth EB
Ziegler J
Zielinski M
Zito G
Zoeller MH
Zotto P
Zou W
Zumerle G
Zuranski A
Publication venue: 'IOP Publishing'
Publication date: 01/01/2012
Field of study

The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO

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Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

Author: Abbaneo D
Abbiendi G
Abbrescia M
Abdullin S
Acosta D
Acosta JG
Acosta MV
Adair A
Adam N
Adam W
Adams MR
Adams T
Adiguzel A
Adler V
Adzic P
Agostino L
Agram JL
Aguilar-Benitez M
Aguilo E
Ahmad M
Ahmad WH
Ahuja S
Akchurin N
Akgun B
Akgun U
Akin IV
Alagoz E
Albajar C
Albayrak EA
Albergo S
Albrow M
Alda Junior WL
Alexander J
Aliev T
Almeida N
Alver B
Alverson G
Alves GA
Amapane N
Amsler C
Anagnostou G
Anastassov A
Anderson J
Anderson M
Andrea J
Andreev V
Andreev V
Andreev Y
Andrews W
Anghel IM
Anjos TS
Antonelli L
Antunes JR
Antunovic Z
Apanasevich L
Apollinari G
Appelt E
Apresyan A
Aranyi A
Arce P
Arcidiacono R
Arenton MW
Arfaei H
Argiro S
Arisaka K
Arneodo M
Arora S
Asawatangtrakuldee C
Asghar MI
Askew A
Assran Y
Ata M
Atac M
Atramentov O
Attikis A
Auffray E
Autermann C
Auzinger G
Avdeeva E
Avery P
Avetisyan A
Azarkin M
Azhgirey I
Aziz T
Azzi P
Azzolini V
Azzurri P
Baarmand MM
Babb J
Bacchetta N
Bachtis M
Baden A
Baeni L
Baesso P
Baffioni S
Bagliesi G
Bai Y
Baillon P
Bainbridge R
Bakhshiansohi H
Bakirci MN
Bakken JA
Balazs M
Ball AH
Ball G
Ban Y
Banerjee S
Banerjee S
Bansal S
Banzuzi K
Barbagli G
Barberis E
Barbone L
Bardak C
Barfuss AF
Bargassa P
Barge D
Baringer P
Barker A
Barnes VE
Barnett BA
Barney D
Barone L
Barrett M
Bartalini P
Barth C
Basegmez S
Basso L
Battilana C
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Bauer G
Bauerdick LAT
Baumgartel D
Baur U
Bayshev I
Bazterra VE
Bean A
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Beaudette F
Beaupere N
Bedjidian M
Beernaert K
Behrenhoff W
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Bell KW
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Belotelov I
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Bose S
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Chao Y
Charaf O
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Cho Y
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Colino N
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Colling D
Conetti S
Contardo D
Conte E
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Correa Martins Junior M
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Covarelli R
Cox B
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Regenerative economics at the service of islands: Assessing the socio-economic metabolism of Samothraki in Greece

Author: de Jong Martin
Fath Brian D.
Fiscus Dan
Goerner Sally
Noll Dominik
Shraven Dan
Singh Simron Jit
Ulanowicz Robert E.
Webster Ken
Zisopoulos Filippos K.
Publication venue: Journal of Cleaner Production
Publication date: 17/04/2023
Field of study

For many islands, the answer to the question “why a locally, self-sustaining, and regenerative economy is needed?” is clear. The struggle often lies in the “how”. Here, we argue that tools from regenerative economics, which follow an island economy-as-an-organism analogy, offer valuable and complementary insights to socio-metabolic research. Indicators from flow-based and information-based ecological network analysis can quantify proper- ties of an island’s socio-economic metabolism (SEM) which are related to cycling, resilience, and degree of mutualism, among others. To illustrate the applicability of these methods, we select Samothraki in Greece as a case study. Results show that over the years the island became very efficient in streamlining imported resources, experiencing physical growth as indicated by a substantial increase in its total material throughput. This growth was attributed to a high degree of order (i.e., network efficiency) endowed by the constraining (ordered) part of the linear structure of the island’s SEM. The disordered part of its SEM which is related to resilience, played a much smaller role which became progressively more important over the years, albeit to a limited degree. While the island exhibits an increasing trend in its robustness, its value over the years studied was well below what is typically observed for healthy natural ecosystems, and its current SEM has a very low ability to generate internal flow activity and cycling of resources per unit input. This limited robustness is due to the island’s dependency on imports but also due to its linear SEM which had a very small number of feedback loops in its network. A scenario analysis showed that a reticulated network structure would theoretically endow the island with increased resilience, and hence robustness, by allowing for more internal resource flow activity to be circulated as regen- erative re-investment. This article highlights that methods from regenerative economics can be used as diagnostic tools to assess and monitor the impact of strategies related to circular economy interventions on network properties, and to illuminate their effect on the regenerative potential of islands

Repositório Científico da Universidade de Évora