Zróżnicowanie poziomu płac w Polsce w układzie przestrzennym

Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 zostało dofinansowane ze środków MNiSW w ramach działalności upowszechniającej nauk

Identification of a Conserved Anti-Apoptotic Protein That Modulates the Mitochondrial Apoptosis Pathway

Here we identified an evolutionarily highly conserved and ubiquitously expressed protein (C9orf82) that shows structural similarities to the death effector domain of apoptosis-related proteins. RNAi knockdown of C9orf82 induced apoptosis in A-549 and MCF7/casp3-10b lung and breast carcinoma cells, respectively, but not in cells lacking caspase-3, caspase-10 or both. Apoptosis was associated with activated caspases-3, -8, -9 and -10, and inactivation of caspases 10 or 3 was sufficient to block apoptosis in this pathway. Apoptosis upon knockdown of C9orf82 was associated with increased caspase-10 expression and activation, which was required for the generation of an 11 kDa tBid fragment and activation of Caspase-9. These data suggest that C9orf82 functions as an anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. We designate this ubiquitously expressed and evolutionarily conserved anti-apoptotic protein Conserved Anti-Apoptotic Protein (CAAP). We also demonstrated that treatment of MCF7/casp3-10b cells with staurosporine and etoposides induced apoptosis and knockdown of CAAP expression. This implies that the CAAP protein could be a target for chemotherapeutic agents

Saving lives: Evidence from a conditional food supplementation program

Many governments in developing countries implement programs that aim to address nutrional failures in early childhood, yet evidence on the effectiveness of these interventions is scant. This paper evaluates the impact of a conditional food supplementation program on child mortality in Ecuador. The Programa de Alimentación y Nutrición Nacional (PANN) 2000 was implemented by regular staff at local public health posts and consisted of offering a free micronutrient-fortied food, Mi Papilla, for children aged 6 to 24 months in exchange for routine health check-ups for the children. Our regression discontinuity design exploits the fact that at its inception, the PANN 2000 was running for about 8 months only in the poorest communities (parroquias) of certain provinces. Our main result is that the presence of the program reduced child mortality in cohorts with 8 months of differential exposure from a level of about 2.5 percent by 1 to 1.5 percentag

Saving lives: Evidence from a conditional food supplementation program

© 2014 by the Board of Regents of the University of Wisconsin System. This paper evaluates the impact of a conditional food supplementation program on child mortality in Ecuador. The program (PANN 2000) was implemented by regular staffat local public health posts and consisted of offering free micronutrient-fortified food for children aged 6-24 months in exchange for routine health checkups. Our regression discontinuity design exploits the fact that the program was initially running only in the poorest communities of certain provinces. We find that its presence reduced child mortality in cohorts with eight months of differential exposure from a level of about 2.5 percent by 1 to 1.5 percentage points.Litschig acknowledges financial support from the Spanish Ministry of Economy and Competitiveness, through the Severo Ochoa Programme for Centres of Excellence in R&D (SEV-2011-0075)Peer Reviewe