In vivo characterization of hippocampal electrophysiological processes in the heterozygous Pten knockout model of autism

While cognitive deficits have been described in the heterozygous Pten (+/-) KO mouse model of autism, little work has been done to demonstrate how corresponding in vitro physiological alterations in this model may underpin these cognitive deficits in vivo. As Pten KO (+/-) is known to alter electrophysiological characteristics of neurons in vitro, this study measures the in vivo electrophysiological characteristics of CA1 interneurons, pyramidal cells, and place cells which may underlie the spatial cognitive deficits seen in the model. Four transgenic conditional heterozygous Pten+/loxPloxP;Gfap-cre mice (HetPten) and four homozygous Pten littermate control mice were used in this study. This transgene drives cre expression and excision of the Pten gene in hippocampal granule cells of the dentate gyrus, and neurons in CA2 and CA1, but not astrocytes. In vivo local field potentials and single cell recordings were made in CA1 of each mouse during an open field foraging task in two distinct arenas. HetPten mice were found to have increased interneuron and pyramidal cell firing rates. In addition, place cells demonstrated abnormal properties including increased out-of-field firing rates, an increased number of fields, and trends towards larger field sizes that were less stable in comparison to controls. HetPten mice had slower CA1 fast gamma oscillations and more variable speed/theta oscillation correlations. Behaviorally, there were weak trends towards decreased motor output compared to controls. These data suggest that the electrophysiological alterations due to Pten KO (+/-) in mouse hippocampal neurons lead to hyperactivation of CA1 interneurons, pyramidal cells, and place cells

Una propuesta de clasificación sobre el amplio espectro de la Propiedad Intelectual

Fil: Spinella, Liliana. Universidad de Buenos Aires; CONICET. Centro de Investigaciones Filosóficas

Naturalized Metaphysics and Scientific Constraint: A Model-Building Approach

A problem with recent work about the relationship between metaphysics and science, especially in the theorizing of those who identify as “naturalized metaphysicians”, is the spotty, metaphorical characterization of what it means for science to “constrain” metaphysics. The most robust account of scientific constraint on metaphysical theorizing is advanced by James Ladyman and Don Ross in their 2007 book Every Thing Must Go. Ladyman & Ross claim that the only legitimate metaphysical hypotheses are those that unify two previously disparate scientific explanations. I will critique Ladyman & Ross’ account of naturalized metaphysics (and, by extension, their view of science’s constraint on metaphysics), and offer an alternative view of naturalized metaphysics as a practice of constructing physically possible models of reality. This account yields a different view of science’s constraint on metaphysics, specifically, that models must be physically possible in order to be of methodological and heuristic use to scientists

Properties of high-density matter in neutron stars

This short review aims at giving a brief overview of various states of matter that have been suggested to exist in the ultra-dense centers of neutron stars. Particular emphasis is put on the role of quark deconfinement in neutron stars and on the possible existence of compact stars made of absolutely stable strange quark matter (strange stars). Astrophysical phenomena, which distinguish neutron stars from quark stars, are discussed and the question of whether or not quark deconfinement may occur in neutron stars is investigated. Combined with observed astrophysical data, such studies are invaluable to delineate the complex structure of compressed baryonic matter and to put firm constraints on the largely unknown equation of state of such matter.Fil: Weber, Fridolin. San Diego State University; Estados Unidos. University of California; Estados UnidosFil: Contrera, Gustavo Aníbal Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Área Física Teórica; Argentina. San Diego State University; Estados UnidosFil: Orsaria, Milva Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Área Física Teórica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. San Diego State University; Estados UnidosFil: Spinella, William. San Diego State University. Computational Sciences Research Center; Estados UnidosFil: Zubairi, Omair. San Diego State University. Computational Sciences Research Center; Estados Unido