79 research outputs found
Kinetic models for estimating occupancy from single-scan PET displacement studies
- Author
- Publication venue
- Publication date
- 01/09/2023
- Field of study
The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an alternative design in which the drug is administered during an on-going scan (i.e., a displacement study). This approach results both in lower radiation exposure and lower costs. Existing kinetic models assume steady state. This condition is not present during a drug displacement and consequently, our aim here was to develop kinetic models for analysing PET displacement data. We modified existing compartment models to accommodate a time-variant increase in occupancy following the pharmacological in-scan intervention. Since this implies the use of differential equations that cannot be solved analytically, we developed instead one approximate and one numerical solution. Through simulations, we show that if the occupancy is relatively high, it can be estimated without bias and with good accuracy. The models were applied to PET data from six pigs where [11C]UCB-J was displaced by intravenous brivaracetam. The dose-occupancy relationship estimated from these scans showed good agreement with occupancies calculated with Lassen plot applied to baseline-block scans of two pigs. In summary, the proposed models provide a framework to determine target occupancy from a single displacement scan.</p
Multimessenger Search for Sources of Gravitational Waves and High-Energy Neutrinos: Results for Initial LIGO-Virgo and IceCube
- Author
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- Son E. J.
- Sorazu B.
- Souradeep T.
- Spiczak G. M.
- Spiering C.
- Staley A.
- Stamatikos M.
- Stanev T.
- Stanisha N. A.
- Stasik A.
- Stebbins J.
- Steinke M.
- Steinlechner J.
- Steinlechner S.
- Stephens B. C.
- Steplewski S.
- Stevenson S.
- Stezelberger T.
- Stokstad R. G.
- Stone R.
- Stops D.
- Strahler E. A.
- Strain K. A.
- Straniero N.
- Strigin S.
- Strotjohann N. L.
- Ström R.
- Sturani R.
- Stuver A. L.
- Stößl A.
- Sullivan G. W.
- Summerscales T. Z.
- Susmithan S.
- Sutton P. J.
- Swinkels B.
- Taavola H.
- Taboada I.
- Tacca M.
- Talukder D.
- Tamburro A.
- Tanner D. B.
- Tao J.
- Tarabrin S. P.
- Taylor R.
- Tellez G.
- Tepe A.
- Ter-Antonyan S.
- Terliuk A.
- Tešić G.
- The IceCube Collaboration
- The LIGO Scientific Collaboration
- The Virgo Collaboration
- Thirugnanasambandam M. P.
- Thomas M.
- Thomas P.
- Thorne K. A.
- Thorne K. S.
- Thrane E.
- Tilav S.
- Tiwari V.
- Tjus J. Becker
- Toale P. A.
- Tobin M. N.
- Tokmakov K. V.
- Tomlinson C.
- Tonelli M.
- Torres C. V.
- Torrie C. I.
- Tosi D.
- Travasso F.
- Traylor G.
- Tse M.
- Tselengidou M.
- Tshilumba D.
- Tuennermann H.
- Ugolini D.
- Unger E.
- Unnikrishnan C. S.
- Urban A. L.
- Usman S. A.
- Usner M.
- Vahlbruch H.
- Vajente G.
- Valdes G.
- Vallecorsa S.
- Vallisneri M.
- van Beuzekom M.
- van der Sluys M. V.
- van Eijndhoven N.
- van Heijningen J.
- van Santen J.
- van Veggel A. A.
- Vandenbroucke J.
- Vass S.
- Vasúth M.
- Vaulin R.
- Vecchio A.
- Vedovato G.
- Vehring M.
- Veitch J.
- Veitch P. J.
- Venkateswara K.
- Verkindt D.
- Vetrano F.
- Viceré A.
- Vincent-Finley R.
- Vinet J. -Y.
- Vitale S.
- Vo T.
- Vocca H.
- Voge M.
- Vorvick C.
- Vousden W. D.
- Vraeghe M.
- Vyachanin S. P.
- Wade A. R.
- Wade L.
- Wade M.
- Walck C.
- Walker M.
- Wallace L.
- Wallraff M.
- Walsh S.
- Wang M.
- Wang X.
- Ward R. L.
- Was M.
- Weaver B.
- Weaver Ch.
- Wei L. -W.
- Weinert M.
- Weinstein A. J.
- Weiss R.
- Welborn T.
- Wellons M.
- Wen L.
- Wendt C.
- Wessels P.
- West M.
- Westerhoff S.
- Westphal T.
- Wette K.
- Whelan B. J.
- Whelan J. T.
- White D. J.
- Whitehorn N.
- Whiting B. F.
- Wichary C.
- Wiebe K.
- Wiebusch C. H.
- Wiesner K.
- Wilkinson C.
- Williams D. R.
- Williams K.
- Williams L.
- Williams R.
- Williams T. D.
- Williamson A. R.
- Willis J. L.
- Willke B.
- Wimmer M.
- Winkler W.
- Wipf C. C.
- Wiseman A. G.
- Wissing H.
- Wittel H.
- Woan G.
- Wolf M.
- Wolovick N.
- Wood T. R.
- Worden J.
- Woschnagg K.
- Wu Y.
- Xu D. L.
- Xu X. W.
- Yablon J.
- Yakushin I.
- Yam W.
- Yamamoto H.
- Yancey C. C.
- Yanez J. P.
- Yang H.
- Yodh G.
- Yoshida S.
- Yoshida S.
- Yvert M.
- Zadrożny A.
- Zanolin M.
- Zarzhitsky P.
- Zendri J. -P.
- Zhang Fan
- Zhang L.
- Zhao C.
- Zhu H.
- Zhu X. J.
- Ziemann J.
- Zierke S.
- Zucker M. E.
- Zuraw S.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2014
- Field of study
We report the results of a multimessenger search for coincident signals from
the LIGO and Virgo gravitational-wave observatories and the partially completed
IceCube high-energy neutrino detector, including periods of joint operation
between 2007-2010. These include parts of the 2005-2007 run and the 2009-2010
run for LIGO-Virgo, and IceCube's observation periods with 22, 59 and 79
strings. We find no significant coincident events, and use the search results
to derive upper limits on the rate of joint sources for a range of source
emission parameters. For the optimistic assumption of gravitational-wave
emission energy of 10−2\,M⊙c2 at ∼150\,Hz with ∼60\,ms duration, and high-energy neutrino emission of 1051\,erg
comparable to the isotropic gamma-ray energy of gamma-ray bursts, we limit the
source rate below 1.6×10−2\,Mpc−3yr−1. We also examine
how combining information from gravitational waves and neutrinos will aid
discovery in the advanced gravitational-wave detector era
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
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- Adams C
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- Adams SM
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- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
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- Anderson WG
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- Angner EO
- Angus CR
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- Anupama GC
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- Arceo R
- Ardid M
- Areeda JS
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- Array MWA Murchison Widefield
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- Clearwater P
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Abbas Rezaianzadeh
- Abdonas Tamosiunas
- Abdul Basit
- Abdul Hamid Zargar
- Abdullah Alkandari
- Abdullatif Husseini
- Abhijit Sen
- Abla M Sibai
- Abu Am Hanif
- Adela Chirita-Emandi
- Adelheid Weber
- Adetoyeje Y Oyeyemi
- Adewale L Oyeyemi
- Adolfo Rubinstein
- Adoubi Kassi Anicet
- Adroaldo Cesar Araujo Gaya
- Afshin Ostovar
- Agnes L Kadvan
- Agneta Sjöberg
- Agneta Yngve
- Agnès Le Port
- Agustinus Soemantri
- Agustín Perez-Londoño
- Ahmad A Zainuddin
- Ahmad Faudzi Yusoff
- Ahmad Reza Dorosty
- Ahmed A Madar
- Aida Pilav
- Aïcha Soumaré
- Akaninyene Otu
- Akihiro Yoshihara
- Akkumis Salhanova
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Alanna G da Silva
- Albertino Damasceno
- Alberto Barceló
- Alberto Palloni
- Albina A Fakhretdinova
- Alejandro Diaz
- Aleksander Giwercman
- Aleksandra Gomula
- Aleksandra Piwonska
- Alessandro Gialluisi
- Aletta E Schutte
- Alexander D Deev
- Alexandra M Cucu
- Alexandre C Pereira
- Alfonso Siani
- Alfonso Sousa-Poza
- Ali Ahmadi
- Ali Akbar Shayesteh
- Ali Esmaeili
- Ali Ghanbari
- Ali Reza Safarpour
- Alice Bonilla-Vargas
- Alicia Matijasevich
- Alina G Platonova
- Alina Kerimkulova
- Aline Meirhaeghe
- Aline P Batista
- Alireza Ansari-Moghaddam
- Alireza Khosravi
- Alireza Moslem
- Alireza Sadjadi
- Alisha N Wade
- Alison J Hayes
- Alison J Price
- Allan G Hill
- Allan Linneberg
- Almaz Sharman
- Altan Onat
- Aluisio Jd Barros
- Alun Evans
- Amalia De Curtis
- Amanda G Thrift
- Amanda J Cross
- Amaneh Shayanrad
- Ambady Ramachandran
- Amelia C Crampin
- Amina Barkat
- Amir Houshang Mehrparvar
- Amirabbas Momenan
- Ana Azevedo
- Ana B Crujeiras
- Ana Barradas-Pires
- Ana Carolina Mgn de Sá
- Ana D González-Alvarez
- Ana Henriques
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- Ana Jelaković
- Ana Maria B Menezes
- Ana P Ortiz
- Ana Paula C Cândido
- Anabela Mota-Pinto
- Anar Dushpanova
- Anastasia Markaki
- Anders Grøntved
- Andre L Guimaraes
- Andre P Kengne
- Andrea Gazzinelli
- Andrea Gualtieri
- Andrea Rodriguez-Martinez
- Andrea Rvr Horimoto
- Andrea Schneider
- Andrea Y Rodríguez
- Andrea Zentai
- Andreas Stang
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- Andrzej Pająk
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- Victoria Farrugia Sant'Angelo
- Vijaya Lingam
- Viktoria Anna Kovacs
- Viktoriya Furdela
- Vilma E Irazola
- Vilma Kriaucioniene
- Vilmundur Gudnason
- Vilnis Dzerve
- Vinay B Nangia
- Vincent Jr DeGennaro
- Vincenzo Capuano
- Vincenzo Solfrizzi
- Violeta Iotova
- Virginija Dulskiene
- Virgílio V Ramires
- Visnja Djordjic
- Viswanathan Mohan
- Viviana Guajardo
- Viviane C Cardoso
- Vladimir Kutsenko
- Wafaie W Fawzi
- Wan Mohamad Wan Bebakar
- Wan Nazaimoon Wan Mohamud
- Wei Zheng
- Wei-Cheng Lo
- Wei-Yen Lim
- Weili Yan
- Wen-Harn Pan
- Wenbin Wei
- Wendy Van Lippevelde
- Wenhua Zhao
- Wichai Aekplakorn
- Willem A Hanekom
- William A Neal
- William R Tebar
- Wilma M Hopman
- Winsome R Parnell
- Wm Monique Verschuren
- Wojciech Drygas
- Wojciech Rusek
- Wolfgang Ahrens
- Wolfgang Kratzer
- Xenophon Theodoridis
- Xiangjun Wang
- Xiaoguang Yang
- Xiaotian Liu
- Ximena Berrios Carrasola
- Xinyi Gwee
- Xiu-Hua Guo
- Xu Lin
- Xu Ma
- Xueling Sim
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yajaira Briceño
- Yang Yang
- Yanhui Dong
- Yanina Zocalo
- Yanitsa V Zhecheva
- Yannis Manios
- Yanping Li
- Yemane Berhane
- Yeunsook Rho
- Yeva Movsesyan
- Yi Song
- Yi Zeng
- Yih Chung Tham
- Yiling J Cheng
- Yin Guo
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Yosef Farzi
- Yoto Yotov
- Youcef Laid
- Young-Ho Khang
- Yousef Saleh Khader
- Yu-Ling Yu
- Yuan He
- Yufang Bi
- Yuki Fujita
- Yulia Balanova
- Yuliya V Solovieva
- Yuna He
- Yunjiang Yu
- Yury P Nikitin
- Yves Kameli
- Yves Martin-Prevel
- Yvonne T van der Schouw
- Zahra Mohammadi
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zengchang Pang
- Zhamilya Battakova
- Zhamyila Usupova
- Zhanna Kalmatayeva
- Zhen-Yu Zhang
- Zhengming Chen
- Ziad A Abdeen
- Zivka Dika
- Zlatko Fras
- Zulfiqar A Bhutta
- Zulfiya Abdurrahmonova
- Zumin Shi
- Łukasz Kryst
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We
estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from
1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods We used data from 3663 population-based studies with 222 million participants that measured height and
weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate
trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children
and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the
individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference)
and obesity (BMI >2 SD above the median).
Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in
11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed
changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and
140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of
underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and
countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior
probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse
was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of
thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a
posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%)
with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and
obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for
both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such
as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged
children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls
in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and
42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents,
the increases in double burden were driven by increases in obesity, and decreases in double burden by declining
underweight or thinness.
Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an
increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy
nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of
underweight while curbing and reversing the increase in obesit
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abdurehman Ame Mehadi
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- Abeldaño Zuñiga Roberto Ariel
- Abhilash E S
- Abiodun Olugbenga Olusola
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Abreu Lucas Guimarães
- Abrha Woldu Aberhe
- Abrigo Michael R M
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Aburuz Salahdein
- Acuna Juan Manuel
- Adair Tim
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adegboye Oyelola A
- Adekanmbi Victor
- Aden Bashir
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adeyeoluwa Temitayo Esther
- Adeyomoye Olorunsola Israel
- Adha Rishan
- Adibi Amin
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Abel
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afyouni Shadi
- Afzal Saira
- Agasthi Pradyumna
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmadzade Mohadese
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akinosoglou Karolina
- Akkala Sreelatha
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al Homsi Ammar
- Al Qadire Mohammad
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Eyadhy Ayman
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Jumaily Adel
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Ala Moein
- Aladelusi Timothy Olukunle
- Alalalmeh Samer O
- Alam Khurshid
- Alam Manjurul
- Alam Zufishan
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldridge Robert W
- Alemi Sharifullah
- Alhabib Khalid F
- Alhalaiqa Fadwa Alhalaiqa Naji
- Ali Abid
- Ali Akhtar
- Ali Beriwan Abdulqadir
- Ali Hassam
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Zahid
- Alian Samakkhah Shohreh
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aligol Mohammad
- Alimi Rasoul
- Aliyi Ahmednur Adem
- Aljunid Syed Mohamed
- Almahmeed Wael
- Almazan Joseph Uy
- Almidani Omar
- Alomari Mahmoud A
- Alonso Nivaldo
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Altaf Awais
- Altirkawi Khalid A
- Alvi Farrukh Jawad
- Alwafi Hassan
- Aly Hany
- Alzoubi Karem H
- Amare Azmeraw T
- Ameyaw Edward Kwabena
- Amhare Abebe Feyissa
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Aminian Dehkordi Javad
- Amiri Sohrab
- Amu Hubert
- Amugsi Dickson A
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Angappan Dhanalakshmi
- Anil Abhishek
- Anjum Afifa
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Iyadunni Adesola
- Anwar Sumadi Lukman
- Anyasodor Anayochukwu Edward
- Appiah Seth Christopher Yaw
- Aqeel Muhammad
- Arab-Zozani Morteza
- Arabloo Jalal
- Arabzadeh Bahri Razman
- Arafat Mosab
- Araújo Ana Margarida
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- Aremu Abdulfatai
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- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Arulappan Judie
- Aruleba Idowu Thomas
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Asaad Malke
- Asgary Saeed
- Ashemo Mubarek Yesse
- Ashraf Muhammad
- Asika Marvellous O
- Athari Seyyed Shamsadin
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
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- Awotidebe Adedapo Wasiu
- Ayala Quintanilla Beatriz Paulina
- Ayanore Martin Amogre
- Ayele Getnet Melaku
- Ayuso-Mateos Jose L
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
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- Babashahi Mina
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- Barchitta Martina
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- Barqawi Hiba Jawdat
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- Basharat Zarrin
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- Belgaumi Uzma Iqbal
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- Bisulli Francesca
- Biswas Atanu
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- Bitaraf Saeid
- Bjørge Tone
- Bleyer Archie
- Boampong Mary Sefa
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bolarinwa Obasanjo Afolabi
- Bonakdar Hashemi Milad
- Bonny Aime
- Bora Basara Berrak
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- Borschmann Rohan
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- Chahine Yaacoub
- Chakraborty Chiranjib
- Chan Jeffrey Shi Kai
- Chang Chin-Kuo
- Charalampous Periklis
- Charan Jaykaran
- Chattu Vijay Kumar
- Chatzimavridou-Grigoriadou Victoria
- Chavula Malizgani Paul
- Cheema Huzaifa Ahmad
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- Chen Haowei
- Chen Lingxiao
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- Chi Gerald
- Chirinos-Caceres Jesus Lorenzo
- Chitheer Abdulaal
- Cho So Mi Jemma
- Cho William C S
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- Chu Dinh-Toi
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- Chung Eric
- Chung Eunice
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- Clark Cain C T
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- Columbus Alyssa
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- Costa Vera Marisa
- Cousin Ewerton
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- Culbreth Garland T
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- D'Amico Emanuele
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- Dadana Sriharsha
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- Damiani Giovanni
- Daneshvar Sara
- Darwesh Aso Mohammad
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- Dashti Mohsen
- Davis Weaver Nicole
- Davletov Kairat
- Dávila-Cervantes Claudio Alberto
- De Leo Diego
- Debele Aklilu Tamire
- Degenhardt Louisa
- Dehbandi Reza
- Deitesfeld Lee
- Delgado-Enciso Ivan
- Delgado-Ortiz Laura
- Demant Daniel
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- Devanbu Vinoth Gnana Chellaiyan
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- Dhimal Mandira Lamichhane
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- Dias da Silva Diana
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- Dirac M Ashworth
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- Do Thanh Chi
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- Dokova Klara Georgieva
- Dolecek Christiane
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- Ebenezer Oluwakemi
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- Echieh Chidiebere Peter
- Ed-Dra Abdelaziz
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- Edvardsson David
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- Eghdami Shayan
- Eikemo Terje Andreas
- Eini Ebrahim
- Ekholuenetale Michael
- Ekpor Emmanuel
- Ekundayo Temitope Cyrus
- El Arab Rabie Adel
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- Fagbamigbe Adeniyi Francis
- Fahimi Saman
- Falzone Luca
- Farinha Carla Sofia e Sá
- Faris MoezAlIslam Ezzat Mahmoud
- Farjoud Kouhanjani Mohsen
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- Fekadu Ginenus
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- Gandhi Aravind P
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- Ghajar Alireza
- Ghanbarnia Mohammad Javad
- Ghasemi MohammadReza
- Ghasemzadeh Afsaneh
- Ghassemi Fariba
- Ghazy Ramy Mohamed
- Ghimire Sailaja
- Gholamian Asadollah
- Gholamrezanezhad Ali
- Ghorbani Vajargah Pooyan
- Ghozali Ghozali
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- Guarducci Giovanni
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- Gudeta Mesay Dechasa
- Guha Avirup
- Guicciardi Stefano
- Gunawardane Damitha Asanga
- Gunturu Sasidhar
- Guo Cui
- Gupta Anish Kumar
- Gupta Bhawna
- Gupta Indarchand Ratanlal
- Gupta Rajat Das
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vijai Kumar
- Gupta Vivek Kumar
- Gutiérrez Reyna Alma
- Habibzadeh Farrokh
- Habibzadeh Parham
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- Hasaballah Ahmed I
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- Hosseinzadeh Mehdi
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- Hostiuc Sorin
- Hsairi Mohamed
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- Yesodharan Renjulal
- Yesuf Subah Abderehim
- Yiğit Arzu
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- Zahedi Mohammad
- Zahid Muhammad Nauman
- Zahir Mazyar
- Zakham Fathiah
- Zaki Nazar
- Zakzuk Josefina
- Zamagni Giulia
- Zaman Burhan Abdullah
- Zaman Sojib Bin
- Zamora Nelson
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- Zandi Milad
- Zandieh Ghazal G Z
- Zanghì Aurora
- Zare Iman
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zeng Youjie
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Hongwei
- Zhang Yunquan
- Zhang Zhaofeng
- Zhang Zhenyu
- Zhao Hanqing
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Zhaohua
- Ziaeefar Pardis
- Zielińska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
Search for High-energy Neutrinos from Binary Neutron Star Merger GW170817 with ANTARES, IceCube, and the Pierre Auger Observatory
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- Publication venue
- IOP Publishing
- Publication date
- 21/08/2018
- Field of study
- …