80 research outputs found
Search for the standard model Higgs boson at LEP
- Author
- Abbaneo D
- Abbaneo D
- Abbiendi G
- Abbiendi G
- Abdallah J
- Abreu P
- Achard P
- Adam W
- Adriani O
- Adzic P
- Affholderbach K
- Aguilar-Benitez M
- Ainsley C
- Akesson PF
- Albrecht T
- Alcaraz J
- Alderweireld T
- Alemanni G
- Alemany-Fernandez R
- Alexander G
- Allaby J
- Allison J
- Allmendinger T
- Allport PP
- Aloisio A
- Alviggi MG
- Amaldi U
- Amapane N
- Amaral P
- Amato S
- Anagnostou G
- Anashkin E
- Anderhub H
- Anderson KJ
- Andreazza A
- Andreev VP
- Andringa S
- Anjos N
- Anselmo F
- Antilogus P
- Antonelli A
- Antonelli M
- Apel WD
- Arcelli S
- Arefiev A
- Armstrong SR
- Arnoud Y
- Asai S
- Ask S
- Asman B
- Augustin JE
- Augustinus A
- Awunor O
- Axen D
- Azemoon T
- Aziz T
- Azuelos G
- Azzurri P
- Baarmand M
- Badaud F
- Bagliesi G
- Bagnaia P
- Bailey I
- Baillon P
- Bajo A
- Baksay G
- Baksay L
- Baldew SV
- Ballestrero A
- Bambade P
- Banerjee S
- Banerjee S
- Barate R
- Barate R
- Barberio E
- Barbier R
- Barczyk A
- Bardin D
- Barillere R
- Barker G
- Barklow T
- Barlow RJ
- Baroncelli A
- Bartalini P
- Basile M
- Batalova N
- Batley RJ
- Battaglia M
- Battiston R
- Baubillier M
- Bay A
- Becattini F
- Bechtle P
- Becker U
- Becks KH
- Begalli M
- Behner F
- Behnke T
- Behrmann A
- Bell KW
- Bell PJ
- Bella G
- Bellerive A
- Bellucci L
- Ben-Haim E
- Bencivenni G
- Benekos N
- Benelli G
- Benvenuti A
- Berat C
- Berbeco R
- Berdugo J
- Berges P
- Berggren M
- Berkelman K
- Berntzon L
- Bertrand D
- Bertucci B
- Besancon M
- Besson N
- Betev BL
- Bethke S
- Beuselinck R
- Biasini M
- Biebell O
- Biglietti M
- Biland A
- Binnie DM
- Blair GA
- Blaising JJ
- Bloch D
- Bloch-Devaux B
- Blom M
- Blondel A
- Bloodworth IJ
- Bluj M
- Blumenschein U
- Blyth SC
- Bobbink GJ
- Boccali T
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- Boeriun O
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- Boldizsar L
- Bologna G
- Bonacorsi D
- Bonesini M
- Bonissent A
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- Bouhova-Thacker E
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- Braibant S
- Brandt S
- Branson JG
- Bravo S
- Brenner R
- Brient JC
- Brigliadori L
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- Brodet E
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- Bruckman P
- Bruneliere R
- Brunet JM
- Buchmuller O
- Buesser K
- Bugge L
- Buijs A
- Burckhart HJ
- Burger JD
- Burger WJ
- Buschmann P
- Cai XD
- Callot O
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- Cameron W
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- Camporesi T
- Canale V
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- Capon G
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- Cavallari F
- Cavallo F
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- Cavanaugh R
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- Cerutti F
- Chamizo M
- Chang CY
- Chang YH
- Chapkin M
- Charlton DG
- Charpentier P
- Checchia P
- Chemarin M
- Chen A
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- Chung SU
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- Cowan G
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- Crespo JM
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- Cuevas J
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- Da Silva W
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- Dallavalle GM
- Dallison S
- Dalmau J
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- Davier M
- Davies G
- De Angelis A
- de Asmundis R
- De Boer W
- De Bonis I
- De Clercq C
- De Filippis N
- de Guevara PL
- de Jong R
- de la Cruz B
- De Lotto B
- De Maria N
- De Min A
- de Palma M
- de Paula L
- De Roeck A
- De Salvo A
- De Vivie de Regie JB
- De Wolf EA
- Debreczeni J
- Decamp D
- Deglon P
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- Deiters K
- Della Ricca G
- della Volpe D
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- Desch K
- Dessagne S
- Dhamotharan S
- Di Ciaccio L
- Di Simone A
- Diemoz M
- Dienes B
- Dierckxsens M
- Dietl H
- Dionisi C
- Dissertori G
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- Doria A
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- Drees J
- Drevermann H
- Dris M
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- Duerdoth IP
- Duflot L
- Duinker P
- Ealet A
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- Edgecock TR
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- Ekelof T
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- Eppling FJ
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- Extermann P
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- Falagan MA
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- Fassouliotis D
- Favara A
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- Fayolle D
- Fedin O
- Feindt M
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- Ferguson DPS
- Ferguson T
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- Fernandez J
- Fernandez-Bosman M
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- Fesefeldt H
- Fiandrini E
- Fiedler F
- Field JH
- Filthaut F
- Finch AJ
- Fisher PH
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- Goncalves P
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- Greening TC
- Grenier G
- Grimm O
- Grivaz JF
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- Gruenewald MW
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- Grupen C
- Gruwe M
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- Guida M
- Gunther PO
- Gupta A
- Gupta VK
- Gurtu A
- Gutay LJ
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- Haas D
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- Kouznetsov O
- Kowalewski RV
- Kraber M
- Kraemer RW
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- Krumstein Z
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- Kuhn D
- Kunin A
- Kupper M
- Kyriakis A
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- Lamsa J
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- Landi G
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- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 17/07/2003
- Field of study
Carnosine:can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?
- Author
- A Almeida
- A Baguet
- A Bierhaus
- A Boldyrev
- A Boldyrev
- A Ertel
- A Herrero-Mendez
- A Mai
- A Negre-Salvayre
- A Scozzafava
- A Vincent
- AA Boldyrev
- AA Boldyrev
- AA Boldyrev
- AB Bonner
- Alan R Hipkiss
- AP Herbert
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- AR Hipkiss
- C Corona
- C Granchi
- C Renner
- C Renner
- CD Logsdon
- Clare Bromley
- CV Dang
- D Ikeda
- DC Wallace
- DO Son
- E Kida
- E Lionaki
- E Villa-Cuesta
- EJ Baran
- F Bellia
- F Gaunitz
- G Aldini
- G Aldini
- G Munch
- G Vistoli
- GA McFarland
- GC Scheper
- H Abe
- I Aviles-Olmos
- I Everaert
- I Pilecka
- J Kamei
- J Kim
- J Liu
- J Pietkiewicz
- JE Preston
- JH Kang
- JM Funes
- K Bauer
- K Kulebyakin
- K Mikami
- K Natter
- K Shimizu
- KD Salway
- KM Desai
- KN Chengappa
- L Garfinkel
- L Grinio
- M Agathocleous
- M Dunnett
- M Fontana
- M Ohsawa
- MA Babizhayev
- MJ Eberhardt
- MK Fasseas
- ML Wahlqvist
- MS Alhamdani
- MS Alhamdani
- MS Pognetto
- MV Zakharchenko
- N Chondrogianni
- N Dehvari
- N Rabbani
- O Warburg
- OE Nekrasova
- P Rodriguez-Rodriguez
- P Yellen
- PA Kumar
- PA Maher
- PQ Trombley
- Q Fu
- R Abe
- R Holliday
- R Kohen
- R Moreno-Sanchez
- Roslyn M Bill
- S De Marchis
- SP Cartwright
- Stephane R Gross
- Stephanie P Cartwright
- T Ikeda
- T Ohkawara
- T Uchiki
- V Licker
- W Derave
- Y Deng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/02/2013
- Field of study
The dipeptide carnosine (β-alanyl-L-histidine) has contrasting but beneficial effects on cellular activity. It delays cellular senescence and rejuvenates cultured senescent mammalian cells. However, it also inhibits the growth of cultured tumour cells. Based on studies in several organisms, we speculate that carnosine exerts these apparently opposing actions by affecting energy metabolism and/or protein homeostasis (proteostasis). Specific effects on energy metabolism include the dipeptide's influence on cellular ATP concentrations. Carnosine's ability to reduce the formation of altered proteins (typically adducts of methylglyoxal) and enhance proteolysis of aberrant polypeptides is indicative of its influence on proteostasis. Furthermore these dual actions might provide a rationale for the use of carnosine in the treatment or prevention of diverse age-related conditions where energy metabolism or proteostasis are compromised. These include cancer, Alzheimer's disease, Parkinson's disease and the complications of type-2 diabetes (nephropathy, cataracts, stroke and pain), which might all benefit from knowledge of carnosine's mode of action on human cells. © 2013 Hipkiss et al.; licensee Chemistry Central Ltd
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
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- Youssef H
- Youssif JH
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- Zalabia MF
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- Zani A
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- Zapata Ponze De Leon M
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- Zardab A
- Zegarra S
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- Zerihun AB
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- Zuber M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
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- Díaz PV
- Dünser MW
- E Silva ZC
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- Ebeling G
- Echeverri JE
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- Ediboglu O
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- Egea-Guerero JJ
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- Egi M
- El Adawy AS
- El Hamid MA
- El Hossainy R
- El Sayed E
- El Sayed F
- El Sayed I
- El-Hamamsy M
- El-Keraie A
- Eladawy S
- Elbers PW
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- Eliet J
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- Emmerich M
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- ENVIN-HELICS Study Group
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- Estagnasie P
- Esteban A
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- Evelein-Brugman S
- Facchin F
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- Fang M
- Fanzaghi P
- Farias P
- Faulds MC
- Fave G
- Feehan A
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- Feliot E
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- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
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- Fileković S
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- Jardim JJ
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- Jareño A
- Javadpour S
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- Jo YH
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- Kokkini S
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- Moerer O
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- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
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- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
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- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
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- Adham W
- Adhitama N
- Adil M
- Adisa AO
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- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
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- Agbedinu K
- Agius M
- Aglan A
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- Aguilera M
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- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
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- Ahmed LAM
- Ahmed S
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- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
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- Al-Hameedi HII
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- Al-khatib A
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- Alaael-Dein S
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- Alhammali T
- Alhassan B
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- Alherz M
- Ali A
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- Ali A
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- Ali FM
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- Ali THA
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- Alihonou T
- Alimi Q
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- Alkaaki A
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- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
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- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
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- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
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- Ambrozeviciute V
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- Amer MA
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- Amin J
- Amjad M
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- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
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- Andreotti D
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- Ang YL
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- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
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- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
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- Arevalo Azmitia JR
- Arias Pacheco RD
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- Arshad MM
- Arslan E
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- Asele FA
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- Atiyeh A
- Atkins ET
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- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
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- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
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- Badr A
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- Baldacchino M
- Balducci G
- Balila RMH
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- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
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- Bassem M
- Bassit KA
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- Beamon M
- Beasley W
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- Bedada AG
- Bediako-Bowan A
- Behar N
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- Bekhet AH
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- Belli A
- Bello B
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- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
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- Bertuello I
- Beuran M
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- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
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- Bjorklund I
- Blacker S
- Blackwell J
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- Blencowe N
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- Bottini C
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- Breslin R
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- Burns H
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- Camilleri-Brennan J
- Camilleri-Brennan J
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- Camilo Correa J
- Campagnaro T
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- Cecilia T
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- Cengiz Y
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- Chachulski W
- Chai C-A
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- Chambers A
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- Chan E
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- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
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- Chen CY
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- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
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- Dar M
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- del Pilar Paucar A
- Delforge X
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- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
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- Dick L
- Dickfos M
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- Dijan E
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- Din F
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- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
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- Driscoll A
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- Du Plessis D
- du Plooy F
- Du Toit F
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- Duhoranenayo D
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- Ebrahim OS
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- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
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- Elshaer M
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- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
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- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
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- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
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- Falco N
- Falzon M
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- Farag S
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- Faraz A
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- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
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- Firwana A
- Fitsum A
- Fitzgerald JE
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- Florez Farfan ES
- Foco M
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- Foo CC
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- Forno W
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- Fowler AJ
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- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
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- Gad MO
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- Gadhvi V
- Gado A
- Gaignard E
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- Gaizauskas V
- Gala T
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- Galiqi G
- Galleano R
- Gallo G
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- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
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- Garland A
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- Gemenetzis G
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- George R
- Germanos S
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- Gerosa A
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- Geuoshy A
- Ghaben A
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- Gkiokas G
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- Glover TE
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- Goh W
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- Goldin E
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- Gomaa A
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- Gonzales Montejo MS
- Gonzales Stuva JP
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- Griffiths M
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- Grisin E
- Grizhja B
- Grobler DC
- Grosos C
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- Gubeli A
- Gudal A
- Gudal A
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- Guevara Torres S
- Guevara R
- Guglielmo V
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- Gul E
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- Gulcicek OB
- Gulielmi A
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- Gunawan R
- Guner A
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- Gustafsson U
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- Gyamfi FE
- Gyanchandani N
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- Hache-Marliere M
- Haddad N
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- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
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- Hamarshi A
- Hamasaki Hamaguchi JL
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- Hasanah A
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- Hashim A
- Hashish A
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- Haslegrave A
- Hassaan A
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- Hassan I
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- Hassanein AB
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- Herrera Puma CM
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- Zapata Ponze De Leon M
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- Zardab A
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- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
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- Zilinskas J
- Zilinskas J
- Zilinskiene R
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- Ziubryte G
- Zohair A
- Zorrilla CD
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- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Search for standard model production of four top quarks in the lepton + jets channel in pp collisions at √s = 8 TeV
- Author
- A. A. Ocampo Rios
- A. Abdulsalam
- A. Adair
- A. Adiguzel
- A. Agapitos
- A. Ahmad
- A. Aleksandrov
- A. Apresyan
- A. Apyan
- A. Askew
- A. Attikis
- A. Aubin
- A. Avetisyan
- A. B. Meyer
- A. Baden
- A. Barker
- A. Bean
- A. Belloni
- A. Belyaev
- A. Belyaev
- A. Benaglia
- A. Beretvas
- A. Bethani
- A. Bhardwaj
- A. Bocci
- A. Bodek
- A. Bonato
- A. Bornheim
- A. Branca
- A. Brinkerhoff
- A. Burgmeier
- A. C. Benvenuti
- A. C. Marini
- A. C. Mignerey
- A. Cakir
- A. Calamba
- A. Calderon
- A. Campbell
- A. Castaneda Hernandez
- A. Castro
- A. Caudron
- A. Chatterjee
- A. Cimmino
- A. Colaleo
- A. Custódio
- A. D. R. Vargas Trevino
- A. Dabrowski
- A. David
- A. De Cosa
- A. De Roeck
- A. Degano
- A. Delgado Peris
- A. Dermenev
- A. Descroix
- A. Dierlamm
- A. Dimitrov
- A. Dishaw
- A. Dominguez
- A. Drozdetskiy
- A. Elliott-Peisert
- A. Ellithi Kamel
- A. Ershov
- A. Escalante Del Valle
- A. F. Barfuss
- A. Fagot
- A. Fahim
- A. Fanfani
- A. Ferapontov
- A. Florent
- A. G. Delannoy
- A. Garabedian
- A. Garcia-Bellido
- A. Gaz
- A. Geiser
- A. Ghezzi
- A. Giammanco
- A. Giassi
- A. Gilbert
- A. Givernaud
- A. Godshalk
- A. Gozzelino
- A. Graziano
- A. Grebenyuk
- A. Gude
- A. Gurrola
- A. Gurtu
- A. Güth
- A. H. Ball
- A. Harel
- A. Heister
- A. Hernandez-Almada
- A. Hervé
- A. Hinzmann
- A. Holzner
- A. Hunt
- A. Ivanov
- A. J. Bell
- A. J. Zsigmond
- A. Jafari
- A. Juodagalvis
- A. K. Kalsi
- A. K. Mohanty
- A. Kalinin
- A. Kalinowski
- A. Kalogeropoulos
- A. Kamenev
- A. Kasmi
- A. Kayis Topaksu
- A. Khan
- A. Kharchilava
- A. Khukhunaishvili
- A. Knutsson
- A. Kornmayer
- A. Korytov
- A. Kropivnitskaya
- A. Kubik
- A. Kumar
- A. Kumar
- A. Kyriakis
- A. Künsken
- A. Lanaro
- A. Lanev
- A. Lath
- A. Ledovskoy
- A. Leonidov
- A. Levin
- A. Levine
- A. Lobanov
- A. Lopez Virto
- A. Luthra
- A. Léonard
- A. M. Rossi
- A. M. Sirunyan
- A. Malakhov
- A. Marinov
- A. Markou
- A. Martelli
- A. Massironi
- A. Melo
- A. Messineo
- A. Mestvirishvili
- A. Meyer
- A. Modak
- A. Moeller
- A. Mohammadi
- A. Mohapatra
- A. Montanari
- A. Morelos Pineda
- A. Mott
- A. Mussgiller
- A. Nayak
- A. Nikitenko
- A. Nowack
- A. Nürnberg
- A. O. M. Iorio
- A. Olbrechts
- A. Ostapchuk
- A. P. R. Gay
- A. Panagiotou
- A. Pashenkov
- A. Penzo
- A. Perieanu
- A. Perloff
- A. Perrotta
- A. Petrilli
- A. Pfeiffer
- A. Pin
- A. Polatoz
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- A. Pompili
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- A. Pozdnyakov
- A. Psallidas
- A. Pérez-Calero Yzquierdo
- A. Quintario Olmeda
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- A. Savoy-Navarro
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- A. Shrinivas
- A. Singovsky
- A. Skuja
- A. Sobol
- A. Soha
- A. Solano
- A. Spiezia
- A. Spiridonov
- A. Stahl
- A. Staiano
- A. Starodumov
- A. Svyatkovskiy
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- A. T. Meneguzzo
- A. T. Serban
- A. Tapper
- A. Tatarinov
- A. Taurok
- A. Thea
- A. Tiko
- A. Topkar
- A. Toropin
- A. Tricomi
- A. Tropiano
- A. Tsirou
- A. Tumasyan
- A. Uzunian
- A. V. Gritsan
- A. Van Spilbeeck
- A. Vanhoefer
- A. Vartak
- A. Venturi
- A. Vilela Pereira
- A. Vinogradov
- A. Volkov
- A. Vorobyev
- A. Whitbeck
- A. Woodard
- A. Y. Rodríguez-Marrero
- A. Yagil
- A. York
- A. Zabi
- A. Zanetti
- A. Zarubin
- A. Zhokin
- A. Zucchetta
- A. Zuranski
- A.-C. Le Bihan
- A.-M. Magnan
- AL Read
- An. Vorobyev
- Arun Kumar
- Ashok Kumar
- B Fuks
- B. A. Barnett
- B. Akgun
- B. Asavapibhop
- B. Betchart
- B. Bilin
- B. Bilki
- B. Blumenfeld
- B. Boimska
- B. Bylsma
- B. C. Choudhary
- B. C. Radburn-Smith
- B. Calvert
- B. Carlson
- B. Casal
- B. Clerbaux
- B. Cox
- B. Dahmes
- B. De La Cruz
- B. Diamond
- B. Fabbro
- B. Francis
- B. Gobbo
- B. Gomber
- B. Gomez Moreno
- B. Hong
- B. Hooberman
- B. Ille
- B. Isildak
- B. Kargoll
- B. Kilminster
- B. Klima
- B. Kreis
- B. L. Winer
- B. Lee
- B. Lutz
- B. Mangano
- B. Marzocchi
- B. Mathias
- B. Michlin
- B. Millan Mejias
- B. P. Padley
- B. Parida
- B. Pavlov
- B. Pollack
- B. Rahbaran
- B. Roland
- B. Safarzadeh
- B. Snook
- B. Stieger
- B. Tali
- B. Ujvari
- B. Wittmer
- B. Wyslouch
- C. A. Bernardes
- C. A. Carrillo Montoya
- C. Albajar
- C. Amsler
- C. Asawatangtrakuldee
- C. Autermann
- C. Avila
- C. Barth
- C. Battilana
- C. Baus
- C. Beirão Da Cruz E Silva
- C. Beluffi
- C. Bernet
- C. Biino
- C. Botta
- C. Brew
- C. Bruner
- C. Böser
- C. Caillol
- C. Calabria
- C. Campagnari
- C. Charlot
- C. Civinini
- C. Clarke
- C. Collard
- C. Contreras-Campana
- C. Cowden
- C. De Oliveira Martins
- C. Delaere
- C. Dietz
- C. Diez Pardos
- C. Dozen
- C. Dragoiu
- C. E. Gerber
- C. Fabjan
- C. Fantasia
- C. Farrell
- C. Favaro
- C. Fernandez Bedoya
- C. Ferro
- C. Florez
- C. Foudas
- C. George
- C. Goetzmann
- C. Grab
- C. Grandi
- C. H. Jiang
- C. H. Shepherd-Themistocleous
- C. Hajdu
- C. Hartl
- C. Heidemann
- C. Henderson
- C. Hill
- C. Jessop
- C. Jorda
- C. Justus
- C. Kleinwort
- C. Kottachchi Kankanamge Don
- C. La Licata
- C. Lange
- C. Lazaridis
- C. Lin
- C. Lourenço
- C. Lucas
- C. M. Kuo
- C. Maguire
- C. Mariotti
- C. Markou
- C. Martin
- C. Martinez Rivero
- C. Mesropian
- C. Mironov
- C. Mora Herrera
- C. Neu
- C. Newman-Holmes
- C. Nicolaou
- C. Nuttens
- C. Nägeli
- C. Ochando
- C. O’Brien
- C. Palmer
- C. Paus
- C. Pena
- C. Riccardi
- C. Richardson
- C. Rogan
- C. Roland
- C. Rovelli
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- Y. Iiyama
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- Y. J. Lei
- Y. J. Lu
- Y. K. Choi
- Y. Kim
- Y. Kubota
- Y. Kuessel
- Y. Lu
- Y. M. Tzeng
- Y. Mao
- Y. Mao
- Y. Maravin
- Y. Musienko
- Y. Onel
- Y. Pakhotin
- Y. Roh
- Y. S. Lai
- Y. Sirois
- Y. Takahashi
- Y. Tu
- Y. W. Chang
- Y. Weng
- Y. Yang
- Y. Yilmaz
- Y. Zheng
- Y.-J. Lee
- Yu. Andreev
- Z. Antunovic
- Z. Demiragli
- Z. Hu
- Z. L. Trocsanyi
- Z. Meng
- Z. Szillasi
- Z. Tsamalaidze
- Z. Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Open Access, Copyright CERN, for the benefit of the CMS Collaboration. Article funded by SCOAP3.Abstract: A search is presented for standard model (SM) production of four top quarks (Formula presented.) in pp collisions in the lepton + jets channel. The data correspond to an integrated luminosity of 19.6 fb−1 recorded at a centre-of-mass energy of 8 TeV with the CMS detector at the CERN LHC. The expected cross section for SM (Formula presented.) production is (Formula presented.). A combination of kinematic reconstruction and multivariate techniques is used to distinguish between the small signal and large background. The data are consistent with expectations of the SM, and an upper limit of 32 fb is set at a 95% confidence level on the cross section for producing four top quarks in the SM, where a limit of 32 ± 17 fb is expected
Nuclear effects on the transverse momentum spectra of charged particles in pPb collisions at √SNN = 5.02 TeV
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- A. A. Ocampo Rios
- A. Abdulsalam
- A. Adair
- A. Adiguzel
- A. Agapitos
- A. Ahmad
- A. Aleksandrov
- A. Apresyan
- A. Apyan
- A. Askew
- A. Attikis
- A. Aubin
- A. Avetisyan
- A. B. Meyer
- A. Baden
- A. Barker
- A. Bean
- A. Belloni
- A. Belyaev
- A. Belyaev
- A. Benaglia
- A. Beretvas
- A. Bethani
- A. Bhardwaj
- A. Bocci
- A. Bodek
- A. Bonato
- A. Bornheim
- A. Branca
- A. Brinkerhoff
- A. Burgmeier
- A. C. Benvenuti
- A. C. Marini
- A. C. Mignerey
- A. Cabrera
- A. Cakir
- A. Calamba
- A. Calderon
- A. Campbell
- A. Castaneda Hernandez
- A. Castro
- A. Caudron
- A. Chatterjee
- A. Cimmino
- A. Colaleo
- A. Custódio
- A. D. R. Vargas Trevino
- A. Dabrowski
- A. David
- A. De Cosa
- A. De Roeck
- A. Degano
- A. Delgado Peris
- A. Demiyanov
- A. Dermenev
- A. Descroix
- A. Dierlamm
- A. Dimitrov
- A. Dishaw
- A. Dominguez
- A. Drozdetskiy
- A. Elliott-Peisert
- A. Ellithi Kamel
- A. Ershov
- A. Escalante Del Valle
- A. Fagot
- A. Fahim
- A. Fanfani
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- A. Zarubin
- A. Zhokin
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- T. Khurshid
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- T. Speer
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- T. Tuuva
- T. Umer
- T. Virdee
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- T. Williams
- T. Y. Ling
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- Th. Müller
- U. Behrens
- U. Bhawandeep
- U. E. Surat
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- U. Grundler
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- V. A. Giakoumopoulou
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- V. Zhukova
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- W. D. Teo
- W. D. Zeuner
- W. De Boer
- W. Dominik
- W. Erdmann
- W. Ferguson
- W. Flanagan
- W. Funk
- W. H. Smith
- W. Haj Ahmad
- W. J. Spalding
- W. J. Womersley
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- W. Kiesenhofer
- W. Ko
- W. L. Aldá Júnior
- W. L. Prado Da Silva
- W. Lange
- W. Li
- W. Lin
- W. Lohmann
- W. Luo
- W. Lustermann
- W. Sun
- W. T. Ford
- W. To
- W. Treberer-Treberspurg
- W. Van Doninck
- W. Waltenberger
- W. Wolszczak
- W. Xie
- W. Zou
- W.-S. Hou
- X-N Wang
- X. Aslanoglou
- X. Janssen
- X. Quan
- X. Shi
- Y. Assran
- Y. Ban
- Y. Chao
- Y. Chen
- Y. Choi
- Y. D. Oh
- Y. Erdogan
- Y. Eshaq
- Y. F. Liu
- Y. Gao
- Y. Gershtein
- Y. H. Chang
- Y. Iiyama
- Y. Ivanov
- Y. J. Lu
- Y. K. Choi
- Y. Kim
- Y. Kubota
- Y. Kuessel
- Y. Lu
- Y. M. Tzeng
- Y. Mao
- Y. Mao
- Y. Maravin
- Y. Musienko
- Y. Onel
- Y. Pakhotin
- Y. Roh
- Y. S. Lai
- Y. Sirois
- Y. Takahashi
- Y. Tu
- Y. W. Chang
- Y. Weng
- Y. Yang
- Y. Yilmaz
- Y.-J. Lee
- Yu. Andreev
- Z. Antunovic
- Z. Demiragli
- Z. Hu
- Z. L. Trocsanyi
- Z. Meng
- Z. Szillasi
- Z. Tsamalaidze
- Z. Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Transverse momentum spectra of charged particles are measured by the CMS experiment at the CERN LHC in pPb collisions at [Formula: see text][Formula: see text], in the range [Formula: see text][Formula: see text] and pseudorapidity [Formula: see text] in the proton-nucleon center-of-mass frame. For [Formula: see text][Formula: see text], the charged-particle production is asymmetric about [Formula: see text], with smaller yield observed in the direction of the proton beam, qualitatively consistent with expectations from shadowing in nuclear parton distribution functions (nPDF). A pp reference spectrum at [Formula: see text][Formula: see text] is obtained by interpolation from previous measurements at higher and lower center-of-mass energies. The [Formula: see text] distribution measured in pPb collisions shows an enhancement of charged particles with [Formula: see text][Formula: see text] compared to expectations from the pp reference. The enhancement is larger than predicted by perturbative quantum chromodynamics calculations that include antishadowing modifications of nPDFs
Insights into APC/C: from cellular function to diseases and therapeutics
- Author
- A Almeida
- A Ballabeni
- A Budina-Kolomets
- A Herrero-Mendez
- A Kelly
- A Lasorella
- A Mocciaro
- A Musacchio
- A Peschiaroli
- A Takahashi
- A Varshavsky
- A Williamson
- AC Burrows
- AC Klarer
- AH Kim
- AK Fu
- AL Chabes
- Anil A. Shah
- BH Choi
- BH Choi
- BO Petersen
- C Behrends
- C Kraft
- C Kuang
- C Lindon
- C Michaelis
- C Penas
- CM Pickart
- D Adhikari
- D Engelbert
- D Gao
- D Izawa
- D Komander
- D Komander
- D Ostapenko
- D Zhang
- DD Mao
- DJ Baker
- DJ Baker
- E Manchado
- E Voets
- ER Kramer
- F Bassermann
- F Bassermann
- F Dotiwala
- F Ikeda
- F Ikeda
- F Stegmeier
- FY Teng
- GJ Gutierrez
- H Yu
- HC Huang
- HC Jeong
- HJ Cho
- HJ Park
- HR de Boer
- HS Kim
- I Garcia-Cao
- I Garcia-Higuera
- IO Estevez-Garcia
- J Huang
- J Laoukili
- J Pines
- J Sajman
- J Stegmuller
- J Sun
- J Zhang
- JA Pesin
- JJ Frye
- JJ Miller
- JK Ahlskog
- JL Bandura
- JM Peters
- JM Peters
- JN Huang
- JR Skaar
- JR Skaar
- JS Han
- K Haglund
- K Jeganathan
- K Masuda
- K Yuan
- KL Sackton
- KV Prasad
- L Bedford
- L Busino
- L Chang
- L Chang
- L Jin
- L Lafranchi
- L Li
- L Ning
- L Song
- L Wan
- L Wiebusch
- L Zhang
- LE Littlepage
- LS Michel
- M Boekhout
- M Donzelli
- M Eguren
- M Li
- M Li
- M Min
- M Rape
- M Yamaguchi
- MB Metzger
- MC Maiuri
- MC Rodrigo-Brenni
- ME Harley
- ME Tanenbaum
- Mingjing He
- ML Matsumoto
- N Derive
- NB Cronin
- NG Brown
- NG Brown
- NJ Huang
- NL Lehman
- O Bar-On
- P D’Arcy
- P Garcia-Nogales
- P Kalitsis
- P Rodriguez-Rodriguez
- P van Roessel
- Q Wang
- Q Xie
- R Sotillo
- R Visintin
- RC Russell
- RH Costa
- RJ Deshaies
- S Badodi
- S Bao
- S Giovinazzi
- S Kobayashi
- S Miniowitz-Shemtov
- S Morais da Silva
- S Pauklin
- S Shoji
- S Sivakumar
- S Stewart
- S Stewart
- SB Lee
- SL Carter
- SL Colombo
- SM Nijman
- SS Lee
- T Bashir
- T Fujita
- T Fujita
- T Kato
- T Ueno
- TJ McGarry
- V Amador
- V D’Angiolella
- V Oakes
- VS Yang
- W Wang
- WJ Wu
- X Huang
- X Zeng
- X Zeng
- XM Cotto-Rios
- Y Johmura
- Y Konishi
- Y Wang
- Y Yang
- Y Yang
- Yong Wan
- Z Lin
- Z Yang
- Z Zhang
- Z Zhou
- Zhuan Zhou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/07/2016
- Field of study
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome stability, energy metabolism, cell death, autophagy as well as carcinogenesis. Activity of APC/C is principally governed by two WD-40 domain proteins, Cdc20 and Cdh1, in and beyond cell cycle. In the past decade, the results based on numerous biochemical, 3D structural, mouse genetic and small molecule inhibitor studies have largely attracted our attention into the emerging role of APC/C and its regulation in biological function, human diseases and potential therapeutics. This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics
Insights into the emission of the blazar 1ES 1011+496 through unprecedented broadband observations during 2011 and 2012
- Author
- Aleksic J
- Ansoldi S
- Antonelli LA
- Antoranz P
- Arcaro C
- Babic A
- Bangale P
- Barres de Almeida U
- Barrio JA
- Becerra Gonzalez J
- Bednarek W
- Bernardini E
- Biasuzzi B
- Biland A
- Blanch O
- Bonnefoy S
- Bonnoli G
- Borracci F
- Bretz T
- Buson S
- Carmona E
- Carosi A
- Colin P
- Colombo E
- Contreras JL
- Cortina J
- Covino S
- D'Ammando F
- Da Vela P
- Dazzi F
- De Angelis A
- De Caneva G
- De Lotto B
- de Ona Wilhelmi E
- Delgado Mendez C
- Di Pierro F
- Dominis Prester D
- Dorner D
- Doro M
- Einecke S
- Eisenacher D
- Elsaesser D
- Fernandez-Barral A
- Fidalgo D
- Fonseca MV
- Font L
- Frantzen K
- Fruck C
- Galindo D
- Garcia Lopez RJ
- Garczarczyk M
- Garrido Terrats D
- Gaug M
- Godinovic N
- Gonzalez Munoz A
- Gozzini SR
- Hadasch D
- Hanabata Y
- Hayashida M
- Herrera J
- Hose J
- Hovatta T
- Hrupec D
- Idec W
- Kadenius V
- Kellermann H
- Knoetig ML
- Kodani K
- Konno Y
- Kovalev YY
- Krause J
- Kubo H
- Kushida J
- La Barbera A
- Lateenmaki A
- Lelas D
- Lewandowska N
- Lindfors E
- Lister ML
- Lombardi S
- Longo F
- Lopez M
- Lopez-Coto R
- Lopez-Oramas A
- Lorenz E
- Lozano I
- Makariev M
- Mallot K
- Maneva G
- Mannheim K
- Maraschi L
- Marcote B
- Mariotti M
- Martinez M
- Max-Moerbeck W
- Mazin D
- Menzel U
- Miranda JM
- Mirzoyan R
- Moralejo A
- Moroni PGP
- Munar-Adrover P
- Mundell C
- Nakajima D
- Neustroev V
- Niedzwiecki A
- Nievas Rosillo M
- Nilsson K
- Nishijima K
- Noda K
- Orito R
- Overkemping A
- Paiano S
- Palatiello M
- Paneque D
- Paoletti R
- Paredes JM
- Paredes-Fortuny X
- Persic M
- Poutanen J
- Prandini E
- Puljak I
- Pushkarev AB
- Rastorgueva-Foi E
- Readhead ACS
- Reinthal R
- Rhode W
- Ribo M
- Richards JL
- Rico J
- Rodriguez Garcia J
- Saito K
- Saito T
- Sanchez DA
- Satalecka K
- Savolainen T
- Scalzotto V
- Scapin V
- Schweizer T
- Shore SN
- Sillanpaa A
- Sitarek J
- Snidaric I
- Sobczynska D
- Stamerra A
- Steele IA
- Steinbring T
- Strzys M
- Takalo L
- Takami H
- Tammi J
- Tavecchio F
- Temnikov P
- Terzic T
- Tescaro D
- Teshima M
- Thaele J
- Tornikoski M
- Torres DF
- Toyama T
- Treves A
- Vogler P
- Will M
- Zanin R
- Publication venue
- 'EDP Sciences'
- Publication date
- Field of study
Context. 1ES 1011+496 (z = 0.212) was discovered in very high-energy (VHE, E> 100 GeV) γ rays with MAGIC in 2007. The absence of simultaneous data at lower energies led to an incomplete characterization of the broadband spectral energy distribution (SED).
Aims. We study the source properties and the emission mechanisms, probing whether a simple one-zone synchrotron self-Compton (SSC) scenario is able to explain the observed broadband spectrum.
Methods. We analyzed data in the range from VHE to radio data from 2011 and 2012 collected by MAGIC, Fermi-LAT, Swift, KVA, OVRO, and Metsähovi in addition to optical polarimetry data and radio maps from the Liverpool Telescope and MOJAVE.
Results. The VHE spectrum was fit with a simple power law with a photon index of 3.69 ± 0.22 and a flux above 150 GeV of (1.46 ± 0.16) × 10-11 ph cm-2 s-1. The source 1ES 1011+496 was found to be in a generally quiescent state at all observed wavelengths, showing only moderate variability from radio to X-rays. A low degree of polarization of less than 10% was measured in optical, while some bright features polarized up to 60% were observed in the radio jet. A similar trend in the rotation of the electric vector position angle was found in optical and radio. The radio maps indicated a superluminal motion of 1.8 ± 0.4 c, which is the highest speed statistically significant measured so far in a high-frequency-peaked BL Lac.
Conclusions. For the first time, the high-energy bump in the broadband SED of 1ES 1011+496 could be fully characterized from 0.1 GeV to 1 TeV, which permitted a more reliable interpretation within the one-zone SSC scenario. The polarimetry data suggest that at least part of the optical emission has its origin in some of the bright radio features, while the low polarization in optical might be due to the contribution of parts of the radio jet with different orientations of the magnetic field with respect to the optical emission
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