36 research outputs found
Flavour and Spin of the Proton and the Meson Cloud
We present a complete set of formulas for longitudinal momentum distribution
functions (splitting functions) of mesons in the nucleon. It can be applied in
the framework of convolution formalism to the deep-inelastic structure
functions (quark distributions) of the nucleon viewed as a system composed of
virtual 'mesons' and 'baryons'. Pseudoscalar and vector mesons as well as octet
and decuplet baryons are included. In contrast to many approaches in the
literature the present approach ensures charge and momentum conservation by the
construction. We present not only spin averaged splitting functions but also
helicity dependent ones, which can be used to study the spin content of the
nucleon. The cut-off parameters of the underlying form factors for different
vertices are determined from high-energy particle production data. This
information allows one to calculate the flavour and spin content of the
nucleon. The value of the Gottfried Sum Rule obtained from our model (S_G =
0.224) nicely agrees with that obtained by the NMC. In addition, we calculate
the x-dependence of the \bar d - \bar u asymmetry and get an impressive
agreement with a recent fit of Martin-Stirling-Roberts. The calculated axial
coupling constants for semileptonic decays of the octet baryons agree with the
experimental data already with SU(6) wave function for the bare nucleon.
Although we get improvements for the Ellis-Jaffe Sum Rules for the proton and
neutron in comparison to the naive quark model, the MCM is not sufficient to
reproduce the experimental data.Comment: written in ReVTex, 53 pages, 11 PS-figure
The luminosity function of field galaxies
Schmidt's method for construction of luminosity function of galaxies is
generalized by taking into account the dependence of density of galaxies from
the distance in the near Universe. The logarithmical luminosity function (LLF)
of field galaxies depending on morphological type is constructed. We show that
the LLF for all galaxies, and also separately for elliptical and lenticular
galaxies can be presented by Schechter function in narrow area of absolute
magnitudes. The LLF of spiral galaxies was presented by Schechter function for
enough wide area of absolute magnitudes: . Spiral galaxies differ slightly by
parameter . At transition from early spirals to the late spirals parameter in
Schechter function is reduced. The reduction of mean luminosity of galaxies is
observed at transition from elliptical galaxies to lenticular galaxies, to
early spiral galaxies, and further, to late spiral galaxies, in a bright end, .
The completeness and the average density of samples of galaxies of different
morphological types are estimated. In the range the mean number density of all
galaxies is equal 0.127 Mpc-3.Comment: 14 page, 8 figures, to appear in Astrophysic
Meson Cloud of the Nucleon in Polarized Semi-Inclusive Deep-Inelastic Scattering
We investigate the possibility of identifying an explicit pionic component of
the nucleon through measurements of polarized baryon fragments
produced in deep-inelastic leptoproduction off polarized protons, which may
help to identify the physical mechanism responsible for the breaking of the
Gottfried sum rule. The pion-exchange model predicts highly correlated
polarizations of the and target proton, in marked contrast with
the competing diquark fragmentation process. Measurement of asymmetries in
polarized production may also reveal the presence of a kaon cloud in
the nucleon.Comment: 23 pages REVTeX, 7 uuencoded figures, accepted for publication in
Zeit. Phys.
Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man
<p>Abstract</p> <p>Background</p> <p>Stem cell homing to the heart is mediated by the release of chemo-attractant cytokines. Stromal derived factor -1 alpha (SDF-1a) and monocyte chemotactic factor 1(MCP-1) are detectable in peripheral blood after myocardial infarction (MI). It remains unknown if they are produced by, and released from, the heart in order to attract stem cells to repair the damaged myocardium.</p> <p>Methods</p> <p>Murine hearts were studied for expression of MCP-1 and SDF-1a at day 3 and day 28 following myocardial infarction to determine whether production is increased following MI. In addition, we studied the coronary artery and coronary sinus (venous) blood from patients with normal coronary arteries, stable coronary artery disease (CAD), unstable angina and MI to determine whether these cytokines are released from the heart into the systemic circulation following MI.</p> <p>Results</p> <p>Both MCP-1 and SDF-1a are constitutively produced and released by the heart. MCP-1 mRNA is upregulated following murine experimental MI, but SDF-1a is suppressed. There is less release of SDF-1a into the systemic circulation in patients with all stages of CAD including MI, mimicking the animal model. However MCP-1 release from the human heart following MI is also suppressed, which is the exact opposite of the animal model.</p> <p>Conclusions</p> <p>SDF-1a and MCP-1 release from the human heart are suppressed following MI. In the case of SDF-1a, the animal model appropriately reflects the human situation. However, for MCP-1 the animal model is the exact opposite of the human condition. Human observational studies like this one are paramount in guiding translation from experimental studies to clinical trials.</p
Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV
The Lambda(b) differential production cross section and the cross section
ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum
pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7
TeV using data collected by the CMS experiment at the LHC. The measurements are
based on Lambda(b) decays reconstructed in the exclusive final state J/Psi
Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and
Lambda to proton pion, using a data sample corresponding to an integrated
luminosity of 1.9 inverse femtobarns. The product of the cross section times
the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls
faster than that of b mesons. The measured value of the cross section times the
branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06
+/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for
anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are
statistical and systematic, respectively.Comment: Submitted to Physics Letters
Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/1/aji12860_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/2/aji12860.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144634/3/aji12860-sup-0001-Supinfo.pd
An Integrated Disease/Pharmacokinetic/Pharmacodynamic Model Suggests Improved Interleukin-21 Regimens Validated Prospectively for Mouse Solid Cancers
Interleukin (IL)-21 is an attractive antitumor agent with potent immunomodulatory functions. Yet thus far, the cytokine has yielded only partial responses in solid cancer patients, and conditions for beneficial IL-21 immunotherapy remain elusive. The current work aims to identify clinically-relevant IL-21 regimens with enhanced efficacy, based on mathematical modeling of long-term antitumor responses. For this purpose, pharmacokinetic (PK) and pharmacodynamic (PD) data were acquired from a preclinical study applying systemic IL-21 therapy in murine solid cancers. We developed an integrated disease/PK/PD model for the IL-21 anticancer response, and calibrated it using selected “training” data. The accuracy of the model was verified retrospectively under diverse IL-21 treatment settings, by comparing its predictions to independent “validation” data in melanoma and renal cell carcinoma-challenged mice (R2>0.90). Simulations of the verified model surfaced important therapeutic insights: (1) Fractionating the standard daily regimen (50 µg/dose) into a twice daily schedule (25 µg/dose) is advantageous, yielding a significantly lower tumor mass (45% decrease); (2) A low-dose (12 µg/day) regimen exerts a response similar to that obtained under the 50 µg/day treatment, suggestive of an equally efficacious dose with potentially reduced toxicity. Subsequent experiments in melanoma-bearing mice corroborated both of these predictions with high precision (R2>0.89), thus validating the model also prospectively in vivo. Thus, the confirmed PK/PD model rationalizes IL-21 therapy, and pinpoints improved clinically-feasible treatment schedules. Our analysis demonstrates the value of employing mathematical modeling and in silico-guided design of solid tumor immunotherapy in the clinic