Cluster-randomized, crossover trial of head positioning in acute stroke

The role of supine positioning after acute stroke in improving cerebral blood flow and the countervailing risk of aspiration pneumonia have led to variation in head positioning in clinical practice. We wanted to determine whether outcomes in patients with acute ischemic stroke could be improved by positioning the patient to be lying flat (i.e., fully supine with the back horizontal and the face upwards) during treatment to increase cerebral perfusion. METHODS In a pragmatic, cluster-randomized, crossover trial conducted in nine countries, we assigned 11,093 patients with acute stroke (85% of the strokes were ischemic) to receive care in either a lying-flat position or a sitting-up position with the head elevated to at least 30 degrees, according to the randomization assignment of the hospital to which they were admitted; the designated position was initiated soon after hospital admission and was maintained for 24 hours. The primary outcome was degree of disability at 90 days, as assessed with the use of the modified Rankin scale (scores range from 0 to 6, with higher scores indicating greater disability and a score of 6 indicating death). RESULTS The median interval between the onset of stroke symptoms and the initiation of the assigned position was 14 hours (interquartile range, 5 to 35). Patients in the lying-flat group were less likely than patients in the sitting-up group to maintain the position for 24 hours (87% vs. 95%, P\u3c0.001). In a proportional-odds model, there was no significant shift in the distribution of 90-day disability outcomes on the global modified Rankin scale between patients in the lying-flat group and patients in the sitting-up group (unadjusted odds ratio for a difference in the distribution of scores on the modified Rankin scale in the lying-flat group, 1.01; 95% confidence interval, 0.92 to 1.10; P = 0.84). Mortality within 90 days was 7.3% among the patients in the lying-flat group and 7.4% among the patients in the sitting-up group (P = 0.83). There were no significant betweengroup differences in the rates of serious adverse events, including pneumonia. CONCLUSIONS Disability outcomes after acute stroke did not differ significantly between patients assigned to a lying-flat position for 24 hours and patients assigned to a sitting-up position with the head elevated to at least 30 degrees for 24 hours

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Navigating the new normal: A study on Indonesian travelers\u27 willingness to pay more post-pandemic using the theory of planned behavior

One of the industries that have been most negatively impacted by the COVID-19 pandemic is the tourism industry, which has seen a major drop in international travel, an increase in domestic travel, and changes in consumer behavior. This study aims to study the intention of people to travel and the willingness of people to pay more for safety and precautions when traveling. These studies have addressed the matter of the lack of research on changes in the behavior and patterns of travelers.  A total of 239 valid questionnaires were collected using an online survey with a purposive sampling technique. The PLS-SEM is employed to test the model. The theory of planned behavior (TPB) as a conceptual framework. Perceived risk influences the attitude of Indonesian Tourists in post-pandemic but has no influence on perceived behavior control. Attitude has a positive and significant direct influence on intention to travel and willingness to pay more. Perceived behavior control influences on intention to travel but no influence on willingness to pay more. Lastly, the intention to pay more does not influence willingness to pay more. The empirical findings have the potential to enhance the implementation of safety precautions in tourism services and the formulation of efficient strategies to revive tourism. This study substantially contributes to the body of knowledge because presented empirical proof of travel behavior patterns in Indonesia in the post-pandemic

Association of Self-reported High-Risk Allergy History With Allergy Symptoms After COVID-19 Vaccination

Allergic history in individuals with confirmed anaphylaxis to a messenger RNA (mRNA) COVID-19 vaccine is common. However, the risk factors for allergy symptoms after receiving the vaccine are unknown

The healthiness of food and beverages on price promotion at promotional displays: A cross-sectional audit of australian supermarkets

Supermarket environments can strongly influence purchasing decisions. Price promotions are recognised as a particularly persuasive tactic, but the healthiness of price promotions in prominent in-store locations is understudied. This study compared the prevalence and magnitude of price promotions on healthy and unhealthy food and beverages (foods) displayed at prominent in-store locations within Australian supermarkets, including analyses by supermarket group and area-level socio-economic position. A cross-sectional in-store audit of price promotions on foods at key display areas was undertaken in 104 randomly selected stores from major Australian supermarket groups (Woolworths, Coles, Aldi and independents) in Victoria, Australia. Of the display space dedicated to foods with price promotions, three of the four supermarket groups had a greater proportion of display space devoted to unhealthy (compared to healthy) foods at each promotional location measured (end of aisles: 66%; island bins: 53%; checkouts: 88%). Aldi offered very few price promotions. Few measures varied by area-level socio-economic position. This study demonstrated that price promotions at prominent in-store locations in Australian supermarkets favoured unhealthy foods. Marketing of this nature is likely to encourage the purchase of unhealthy foods, highlighting the need for retailers and policy-makers to consider addressing in-store pricing and placement strategies to encourage healthier food environments

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing

The Student Movement Volume 106 Issue 17: Just Your Normal Weekly Student Movement Issue: No Clickbait

HUMANS Department of Biology Hires Renowned Woodchuck Specialist Charles Lignum, Interviewed by: Scott Moncrieff Silly Little Hats Mandate, Qualyn Robinson, Alyssa Henriquez ARTS & ENTERTAINMENT Kim Kardashian\u27s History at AU, Solana Campbell with Megan Napod and Alyssa Henriquez Love is Blind Beta Tests a Season in Berrien Springs, Alyssa Henriquez NEWS I\u27m So Sorry: A Heartfelt Goodbye, Chris Ngugi Introducing... Cardfield!, Abigail Lee The Cardinalito: The New Student Craze Over the Saucy Dish, Nathan Mathieu IDEAS A Student Movement Towards a Southern Location, Nathan Mathieu Why Meier Must be Renovated Immediately PULSE Andrews University Dating App: AUlovelink, Wambui Karanja Sabbath Meatloaf Exposé, Alannah Tjhatra THE LAST WORD Don\u27t Make Me Laugh! Using Humor as Power, Lily Burkehttps://digitalcommons.andrews.edu/sm-106/1016/thumbnail.jp

Dear Young Feminist Me

We are a group of college students in a Feminist Rhetorics class, reaching out to share our stories and to tell you about some pretty cool feminists. We take up this work as an act of feminist rhetoric, guided by the feminist ideals of giving voice to fellow rhetoricians and challenging norms when sharing this work. Images shared here lead back to official websites or spaces for further information about feminist stars, and we hope you take some time to learn more about them all

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements