231 research outputs found
The Sigma 13 (10-14) twin in alpha-Al2O3: A model for a general grain boundary
The atomistic structure and energetics of the Sigma 13 (10-14)[1-210]
symmetrical tilt grain boundary in alpha-Al2O3 are studied by first-principles
calculations based on the local-density-functional theory with a mixed-basis
pseudopotential method. Three configurations, stable with respect to
intergranular cleavage, are identified: one Al-terminated glide-mirror twin
boundary, and two O-terminated twin boundaries, with glide-mirror and two-fold
screw-rotation symmetries, respectively. Their relative energetics as a
function of axial grain separation are described, and the local electronic
structure and bonding are analysed. The Al-terminated variant is predicted to
be the most stable one, confirming previous empirical calculations, but in
contrast with high-resolution transmission electron microscopy observations on
high-purity diffusion-bonded bicrystals, which resulted in an O-terminated
structure.
An explanation of this discrepancy is proposed, based on the different
relative energetics of the internal interfaces with respect to the free
surfaces
Non-detection of a statistically anisotropic power spectrum in large-scale structure
We search a sample of photometric luminous red galaxies (LRGs) measured by
the Sloan Digital Sky Survey (SDSS) for a quadrupolar anisotropy in the
primordial power spectrum, in which P(\vec{k}) is an isotropic power spectrum
P(k) multiplied by a quadrupolar modulation pattern. We first place limits on
the 5 coefficients of a general quadrupole anisotropy. We also consider
axisymmetric quadrupoles of the form P(\vec{k}) = P(k){1 +
g_*[(\hat{k}\cdot\hat{n})^2-1/3]} where \hat{n} is the axis of the anisotropy.
When we force the symmetry axis \hat{n} to be in the direction (l,b)=(94
degrees,26 degrees) identified in the recent Groeneboom et al. analysis of the
cosmic microwave background, we find g_*=0.006+/-0.036 (1 sigma). With uniform
priors on \hat{n} and g_* we find that -0.41<g_*<+0.38 with 95% probability,
with the wide range due mainly to the large uncertainty of asymmetries aligned
with the Galactic Plane. In none of these three analyses do we detect evidence
for quadrupolar power anisotropy in large scale structure.Comment: 23 pages; 10 figures; 3 tables; replaced with version published in
JCAP (added discussion of scale-varying quadrupolar anisotropy
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in âs = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fbâ1 of protonâproton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC
Measurements of inclusive jet suppression in heavy ion collisions at the LHC
provide direct sensitivity to the physics of jet quenching. In a sample of
lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated
luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with
a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the
transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the
anti-kt algorithm with values for the distance parameter that determines the
nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of
the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp.
Jet production is found to be suppressed by approximately a factor of two in
the 10% most central collisions relative to peripheral collisions. Rcp varies
smoothly with centrality as characterized by the number of participating
nucleons. The observed suppression is only weakly dependent on jet radius and
transverse momentum. These results provide the first direct measurement of
inclusive jet suppression in heavy ion collisions and complement previous
measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables,
submitted to Physics Letters B. All figures including auxiliary figures are
available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02
The Unitary Gas and its Symmetry Properties
The physics of atomic quantum gases is currently taking advantage of a
powerful tool, the possibility to fully adjust the interaction strength between
atoms using a magnetically controlled Feshbach resonance. For fermions with two
internal states, formally two opposite spin states, this allows to prepare long
lived strongly interacting three-dimensional gases and to study the BEC-BCS
crossover. Of particular interest along the BEC-BCS crossover is the so-called
unitary gas, where the atomic interaction potential between the opposite spin
states has virtually an infinite scattering length and a zero range. This
unitary gas is the main subject of the present chapter: It has fascinating
symmetry properties, from a simple scaling invariance, to a more subtle
dynamical symmetry in an isotropic harmonic trap, which is linked to a
separability of the N-body problem in hyperspherical coordinates. Other
analytical results, valid over the whole BEC-BCS crossover, are presented,
establishing a connection between three recently measured quantities, the tail
of the momentum distribution, the short range part of the pair distribution
function and the mean number of closed channel molecules.Comment: 63 pages, 8 figures. Contribution to the Springer Lecture Notes in
Physics "BEC-BCS Crossover and the Unitary Fermi gas" edited by Wilhelm
Zwerger. Revised version correcting a few typo
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity
The genetic architecture of the human cerebral cortex
INTRODUCTION
The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure.
RATIONALE
To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations.
RESULTS
We identified 306 nominally genome-wide significant loci (P < 5 Ă 10â8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 Ă 10â10; 187 influencing surface area and 12 influencing thickness).
Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = â0.32, SE = 0.05, P = 6.5 Ă 10â12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness.
To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity.
We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinsonâs disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism.
CONCLUSION
This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function
Search for the Standard Model Higgs boson decaying into bbÂŻ produced in association with top quarks decaying hadronically in pp collisions at âs = 8 TeV with the ATLAS detector
A search for Higgs boson production in association with a pair of top quarks (ttÂŻ H) is performed, where the Higgs boson decays to bbÂŻ, and both top quarks decay hadronically. The data used correspond to an integrated luminosity of 20.3 fbâ1 of pp collisions at âs = 8 TeV collected with the ATLAS detector at the Large Hadron Collider. The search selects events with at least six energetic jets and uses a boosted decision tree algorithm to discriminate between signal and Standard Model background. The dominant multijet background is estimated using a dedicated data-driven technique. For a Higgs boson mass of 125 GeV, an upper limit of 6.4 (5.4) times the Standard Model cross section is observed (expected) at 95% confidence level. The best-fit value for the signal strength is ÎŒ = 1.6 ± 2.6 times the Standard Model expectation for mH = 125 GeV. Combining all ttÂŻ H searches carried out by ATLAS at âs = 8 and 7 TeV, an observed (expected) upper limit of 3.1 (1.4) times the Standard Model expectation is obtained at 95% confidence level, with a signal strength ÎŒ = 1.7 ± 0.8
Macrofauna edĂĄfica em estĂĄdios sucessionais de Floresta Estacional Semidecidual e pastagem mista em Pinheiral (RJ): Rio de Janeiro State
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