MONITORAMENTO DA QUALIDADE DA ?GUA DO RIO CUI?, JO?O PESSOA/PB

O crescimento populacional e a urbaniza??o contribuem com impactos significativos no meio ambiente, sobretudo nos recursos h?dricos. Em geral, o ecossistema l?tico ? a principal via de dep?sito de res?duos s?lidos, lan?amento de efluentes dom?sticos, bem como, na maioria das vezes, o uso e ocupa??o do solo inadequados em suas margens, o que corrobora com o desmatamento da mata ciliar e, consequentemente, o seu assoreamento. A ?gua apresenta um recurso natural finito e essencial para qualidade e exist?ncia de vida, logo a sua deteriora??o deve ser combatida, bem como seu desperd?cio. Este trabalho tem como objetivo monitorar e avaliar a qualidade da ?gua do rio Cui? dentro dos par?metros f?sicos, qu?micos e microbiol?gicos. Para tanto, foram demarcados 4 pontos em torno do rio Cui? a fim de coletar amostras, mas tamb?m um ponto especial na ETE de Mangabeira, visto que o rio ? o corpo h?drico receptor do efluente tratado desta ETE. Com isso, percebe-se v?rios pontos cr?ticos ao longo do rio Cui? comprometendo assim, a qualidade da ?gua, o que pode indicar que as atividades antr?picas como, cria??o de animais em pocilgas e lan?amento de esgotos dom?sticos est?o impactando significativamente este corpo h?drico. Os dados recomendam uma aten??o tanto para a implanta??o eficiente de um sistema de saneamento b?sico nas localidades pr?ximas, como tamb?m maior aten??o das autoridades p?blicas para a efici?ncia da esta??o de tratamento de efluentes

Academic stress and coping: Contributions to the adaptation of the MMC

Este estudo enquadra-se na investiga??o das estrat?gias de coping utilizadas perante dificuldades associadas ao quotidiano escolar. Utilizando entrevistas a 30 alunos, o estudo (1) identificou as principais situa??es geradoras de stress, reconhecendo a import?ncia relativa do stress acad?mico na vida dos alunos, e (2) analisou a validade cultural para o contexto portugu?s das situa??es stressantes usadas na escala Multidimensional Measure of Coping (MMC), avaliando as perce??es dos alunos quanto ao n?vel de stress induzido e controlo percebido relativamente a essas situa??es. Os resultados confirmaram a import?ncia da escola enquanto fonte significativa de stress, e a adequa??o da MMC ao contexto portugu?s.8C1E-AFB9-6BE1 | Maria Teresa Martins Gon?alvesN/

Effect of protective coatings on the water absorption and mechanical properties of 3D printed PLA

This work aims to study the influence of protective coatings on the water absorption and mechanical properties of 3D printed polyꖖlactic acid (PLA) parts. The PLA parts were fabricated with different levels of the 3D printing process parameters, aiming to define samples with distinct strength and ductility/toughness characteristics. Water absorption tests following the standard ASTM D570�98 were performed on uncoated and coated PLA specimens. The effectiveness of two protective coatings based on acrylic and polyurethane varnish on reducing water absorption was evaluated. Both protective coatings have shown being effective on preventing water absorption by the PLA, with polyurethane presenting the best performance reducing water absorption by 38%. Tensile tests were carried out to determine the ultimate tensile strength, elastic modulus, yield tensile strength, fracture strain and toughness of specimens, before and after the application of protective coatings. The polyurethane protective coating also benefits the tensile properties of PLA parts, increasing the strength and ductility/toughness characteristics of specimens up to 24%

Prenylated flavonoid-enriched fraction from maclura tinctoria shows biological activity against Staphylococcus aureus and protects galleria mellonella larvae from bacterial infection.

Background: The Atlantic Forest biome extends along the entire Brazilian coast and is home to approximately 20,000 plant species, many of which are endemic; it is considered one of the hotspot regions of the planet. Several of these species are sources of natural products with biological activities that are still unknown. In this study, we evaluated the antimicrobial activity of 90 extracts derived from native Atlantic Forest tree species against Staphylococcus aureus, an important human and veterinary pathogen. Methods: Extracts from native Atlantic Forest tree species were evaluated for their antimicrobial activity against S. aureus by in vitro standard methods. Phytochemical fractionation of the extract from Maclura tinctoria was performed by liquid-liquid partitioning. LC-DAD-ESI-MS was used for identification of constituents in the most active fraction. Damage of cells and alterations in the permeability of cell membrane were determined by atomic force microscopy (AFM) and crystal violet uptake assay, respectively. In vivo antimicrobial activity was evaluated using Galleria mellonella larvae infected with S. aureus with survival data collected using the Kaplan-Meier method. Results: Among the organic or aqueous extracts tested here, 26 showed biological activity. Eight species showed relevant results, with a minimum inhibitory concentration (MIC) below 1?mg/mL. Antibacterial activity was registered for three species for the first time. An organic extract from Maclura tinctoria leaves showed the lowest MIC (0.08?mg/mL). Fractionation of this extract by liquid-liquid partitioning led to obtaining fraction 11FO d with a MIC of 0.04?mg/mL. This fraction showed strong activity against veterinary S. aureus isolates and contributed to the increased survival of Galleria mellonella larvae infected with S. aureus ATCC 29213. The bacterial surface was not altered by the presence of 11FO d, and no cell membrane damage was detected. The LC-DAD-ESI/MS analyses identified prenylated flavonoids as the major constituents responsible for the antibacterial activity of this active extract. Conclusion: A fraction enriched in prenylated isoflavones and flavanones from M. tinctoria showed in vitro and in vivo efficacy as antistaphylococcal agents. These findings justify the need for further research to elucidate the mechanisms of action of these compounds

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

ATP signalling in epilepsy

This paper focuses on a role for ATP neurotransmission and gliotransmission in the pathophysiology of epileptic seizures. ATP along with gap junctions propagates the glial calcium wave, which is an extraneuronal signalling pathway in the central nervous system. Recently astrocyte intercellular calcium waves have been shown to underlie seizures, and conventional antiepileptic drugs have been shown to attenuate these calcium waves. Blocking ATP-mediated gliotransmission, therefore, represents a potential target for antiepileptic drugs. Furthermore, while knowledge of an antiepileptic role for adenosine is not new, a recent study showed that adenosine accumulates from the hydrolysis of accumulated ATP released by astrocytes and is believed to inhibit distant synapses by acting on adenosine receptors. Such a mechanism is consistent with a surround-inhibitory mechanism whose failure would predispose to seizures. Other potential roles for ATP signalling in the initiation and spread of epileptiform discharges may involve synaptic plasticity and coordination of synaptic networks. We conclude by making speculations about future developments

Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector

Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030