571 research outputs found
Study of Bc+ decays to the K+K−π+ final state and evidence for the decay Bc+→χc0π+
- Author
- Aaij R
- Adeva B
- Adinolfi M
- Ajaltouni Z
- Akar S
- Albrecht J
- Alessio F
- Alexander M
- Ali S
- Alkhazov G
- Altarelli M Pepe
- Amato S
- Amerio S
- Amhis Y
- An L
- Anderlini L
- Andreassi G
- Andreotti M
- Andrews JE
- Appleby RB
- Archilli F
- Artamonov A
- Artuso M
- Aslanides E
- Auriemma G
- Baalouch M
- Babuschkin I
- Bachmann S
- Back JJ
- Badalov A
- Baesso C
- Baldini W
- Barlow RJ
- Barschel C
- Barsuk S
- Barter W
- Baszczyk M
- Batozskaya V
- Batsukh B
- Battista V
- Bay A
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- Beddow J
- Bedeschi F
- Bediaga I
- Bel LJ
- Bellee V
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- Belous K
- Belyaev I
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- Bencivenni G
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- Boettcher T
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- Bowcock TJV
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- Cazon BR Gruberg
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- Cheung S-F
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- Cid Vidal X
- Ciezarek G
- Clarke PEL
- Clemencic M
- Cliff HV
- Closier J
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- Collaboration Lhcb
- Collaboration LHCb
- Collazuol G
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- Contu A
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- Wimberley J
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- Wislicki W
- Witek M
- Wormser G
- Wotton SA
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- Wright S
- Wyllie K
- Xie Y
- Xing Z
- Xu Z
- Yang Z
- Yin H
- Yu J
- Yuan X
- Yushchenko O
- Zangoli M
- Zarebski KA
- Zavertyaev M
- Zhang L
- Zhang Y
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- Zhelezov A
- Zheng Y
- Zhokhov A
- Zhu X
- Zhukov V
- Zucchelli S
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2016
- Field of study
A study of Bc+→K+K−π+ decays is performed for the first time
using data corresponding to an integrated luminosity of 3.0 fb−1
collected by the LHCb experiment in pp collisions at centre-of-mass energies
of 7 and 8 TeV. Evidence for the decay Bc+→χc0(→K+K−)π+
is reported with a significance of 4.0 standard deviations, resulting in the
measurement of
σ(B+)σ(Bc+)×B(Bc+→χc0π+) to
be (9.8−3.0+3.4(stat)±0.8(syst))×10−6.
Here B denotes a branching fraction while σ(Bc+) and
σ(B+) are the production cross-sections for Bc+ and B+ mesons.
An indication of bˉc weak annihilation is found for the region
m(K−π+)<1.834GeV/c2, with a significance of
2.4 standard deviations.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-022.html,
link to supplemental material inserted in the reference
Precise measurement of the W-boson mass with the CDF II detector
- Author
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- Zhou C.
- Zucchelli S..
- Zucchelli S..ng S
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
We have measured the W-boson mass MW using data corresponding to 2.2/fb of
integrated luminosity collected in proton-antiproton collisions at 1.96 TeV
with the CDF II detector at the Fermilab Tevatron collider. Samples consisting
of 470126 W->enu candidates and 624708 W->munu candidates yield the measurement
MW = 80387 +- 12 (stat) +- 15 (syst) = 80387 +- 19 MeV. This is the most
precise measurement of the W-boson mass to date and significantly exceeds the
precision of all previous measurements combined
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Expected Performance of the ATLAS Experiment - Detector, Trigger and Physics
- Author
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- \uc5sman B
- Aad G
- Abat E
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- Abdallah J
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- Zhemchugov A
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- Zitoun R
- Zivkovic L
- Zmouchko V V
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zychacek V
- Publication venue
- Publication date
- 01/01/2008
- Field of study
A detailed study is presented of the expected performance of the ATLAS
detector. The reconstruction of tracks, leptons, photons, missing energy and
jets is investigated, together with the performance of b-tagging and the
trigger. The physics potential for a variety of interesting physics processes,
within the Standard Model and beyond, is examined. The study comprises a series
of notes based on simulations of the detector and physics processes, with
particular emphasis given to the data expected from the first years of
operation of the LHC at CERN
X-ray emission from the Sombrero galaxy: discrete sources
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
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- Clement E
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- Cline D
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- Cremaldi LM
- Cripps N
- Cuevas J
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- Cure B
- Cushman P
- Cussans D
- Cutajar M
- Cutts D
- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
- Da Silva WLP
- Dahmes B
- Dahms T
- Dallavalle GM
- Damgov J
- Damiao DD
- Dammann D
- Danielson T
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- Das S
- Daskalakis G
- Dasu S
- Daubie E
- David A
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- Davies G
- De Araujo FTD
- de Barbaro P
- De Benedetti A
- De Boer W
- de Cassagnac RG
- De Cosa A
- de Fatis TT
- De Filippis N
- De Gruttola M
- De Guio F
- De Jeneret JD
- De La Cruz B
- De Lentdecker G
- De Mattia M
- de Monchenault GH
- De Palma M
- De Roeck A
- De Souza SF
- de Troconiz JF
- De Visscher S
- De Wolf EA
- Debreczeni G
- Deisher A
- Deiters K
- Dejardin M
- del Arbol PMR
- Del Re D
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- Dell'Orso R
- Della Negra M
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- Dero V
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- Di Guida S
- Di Marco E
- Di Matteo L
- Diamond B
- Dias FA
- Dias MAF
- Diemoz M
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- Dominik W
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- Draeger J
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- Dremin I
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- Duda M
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- Duggan D
- Dumanoglu I
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- Eugster J
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- Wilkinson R
- Williams G
- Willmott C
- Wimpenny S
- Winn D
- Winstrom L
- Wissing C
- Wittich P
- Wittmer B
- Wohri HK
- Wolf R
- Womersley WJ
- Won S
- Wood D
- Wood JS
- Worm SD
- Wright D
- Wrochna G
- Wu JH
- Wu W
- Wulz CE
- Wurthwein F
- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yan M
- Yang F
- Yang M
- Yang M
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- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang L
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zoeller MH
- Zorbilmez C
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
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- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
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- Akchurin N
- Akgun B
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- Aliev T
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- Altenhofer G
- Altsybeev I
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- Andelin D
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- Zachariadou A
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- Zeuner WD
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Symptoms of depression and quality of life of people living with HIV/AIDS
- Author
- Barroso J
- Beck AT
- Berlim MT
- Canini SRMS
- Chandra PS
- Ciesla JA
- Claudia Benedita dos Santos
- Corso AN
- Cruess DG
- Cruz LN
- Elucir Gir
- Evans DL
- Evans DL
- Galvão MTG
- Gorenstein C
- Jia H
- Li L
- Malbergier A
- Marli Teresinha Gimenez Galvão
- Mello VA
- O’Connel K
- Patterson K
- Penzak SR
- Perez IR
- Renata Karina Reis
- Saldanha AAW
- Schimitt JHL
- Sheila Araujo Teles
- Soárez PC
- Stumpf BP
- Teng CT
- Trépanier LL
- Vanderley José Haas
- Willians P
- Zimpel RR
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Is the meiofauna a good indicator for climate change and anthropogenic impacts?
- Author
- A Ahnert
- A Borja
- A Carpentier
- A Forchino
- A Guerrini
- A Mazzola
- A McIntyre-Wressnig
- A Piot
- A Pusceddu
- A Pusceddu
- A Pusceddu
- A Pusceddu
- A Rose
- AA Cook
- AD Kennedy
- AH Parulekar
- AJ Gooday
- AJ Gooday
- AJ Gooday
- AJ Gooday
- AJ Gooday
- AJ Radwell
- Alexandre Arvigo
- Andrew J. Gooday
- Ann Vanreusel
- Antoine Rio-Cabello
- AP Covich
- AR Thurber
- AW Decho
- AWG Wurff van der
- B Buchardt
- B Freedman
- B Górska
- B Lebreton
- BC Coull
- BC Coull
- BD Wigham
- BE Hopper
- BK Sen Gupta
- BR Kuipers
- BS Ingole
- BS Ingole
- BT Hentschel
- C Alsterberg
- C Bussau
- C Bussau
- C Colen Van
- C Fontanier
- C Heip
- C Lizhe
- C Mora
- C Neira
- C Neira
- C Schmidt
- C Vinagre
- C Woulds
- CD Levings
- CE Richmond
- Christophe Fontanier
- CM Duarte
- CM Jessup
- CR Smith
- CT Schafer
- D Danovaro
- D Gwyther
- D Leduc
- D Leduc
- D Thistle
- D Thistle
- D Thistle
- D Thistle
- D Zeppilli
- D Zeppilli
- Daniel Leduc
- Daniela Zeppilli
- David Fernandes
- Dendy Mahabror
- DG Raffaelli
- Diego Fontaneto
- DK Alexeev
- DL Angel
- DM Miljutin
- DOB Jones
- DP Edwards
- DT Rudnick
- DU Hooper
- E Alve
- E Alve
- E Armynot du Châtelet
- E Baldrighi
- E Buffan-Dubau
- E Gontikaki
- E Mahmoudi
- E Olafsson
- E Piña-Ochoa
- E Piña-Ochoa
- EJ Barron
- EJ O’Gorman
- ER Ricketts
- Etienne Pouplard
- F Pranovi
- F Riemann
- F Ruiz
- F Ruiz
- FB Phleger
- Fenchel
- FJ Jorissen
- FJA Nascimento
- FJA Nascimento
- G Pergent
- G Tita
- G Veit-Köhler
- G Vranken
- G Vranken
- G Woodward
- GAP Santos Dos
- GI Shapiro
- GM Sheills
- Gwendoline Traisnel
- H Beyrem
- H Ek
- H Hinz
- H Kurihara
- H Modig
- H Nomaki
- H Nomaki
- H Nomaki
- H Nomaki
- H Nomaki
- H Nomaki
- H Thiel
- H Thiel
- H Tomimatsu
- H Torres-Pratts
- HK Talge
- HM Bik
- HM Bik
- I Boldina
- I Mesel De
- IAEA (International Atomic Energy Agency)
- IPCC
- IPCC
- J Grzymski
- J Gutt
- J Gwyther
- J Ingels
- J Ingels
- J Ingels
- J Mallon
- J Pawlowski
- J Renaud-Mornant
- J Schönfeld
- J Turner
- J Vanaverbeke
- J Veillette
- J Veillette
- J Vidović
- JBC Jackson
- JG Baguley
- JJ Helly
- JJ Lee
- JM Bernhard
- JM Bernhard
- JM Bernhard
- JM Bernhard
- JM Gee
- JM Guinotte
- JM Wȩsławski
- Jozée Sarrazin
- JP Barry
- JP Barry
- JS Bradshaw
- Julien Thébault
- Justine Castrec
- JW Fleeger
- JW Fleeger
- JW Murray
- K Grzelak
- K Vopel
- K Vopel
- K Worsaae
- KA Koho
- Kevin Urvoy
- KR Carman
- L Ferraro
- L Stramma
- L Stramma
- L Teuber
- L Würzberg
- LA Hack
- LA Levin
- LA Levin
- Laura Raimondeau
- LD Guidi-Guilvard
- LJ Snider
- LL Perez-Cruz
- Ludovic Hermabessiere
- M Armenteros
- M Balsamo
- M Bampton
- M Collins
- M Curini-Galletti
- M Edwards
- M Gallitelli
- M Grego
- M Grego
- M Jochum
- M Kramer
- M Loreau
- M Mojtahid
- M Raes
- M Schratzberger
- M Schratzberger
- M Schratzberger
- M Schratzberger
- M Schratzberger
- M Schratzberger
- M Troch De
- M Woombs
- M Woombs
- M Yasuhara
- M Yasuhara
- M Yasuhara
- MA Green
- MA Mateo
- MA Miljutina
- MA Miljutina
- MA Rex
- MA Rudd
- MA Wetzel
- MA Wetzel
- Marc Long
- Mariam Weyand
- Marianna Mea
- Martin V. Sørensen
- MC Austen
- MC Murrell
- Michael Pantalos
- MJ Kaiser
- ML Mahaut
- Morgan Danielo
- MV Sørensen
- N Glock
- N Lampadariou
- N Risgaard-Petersen
- N Villano
- NG Sergeeva
- NK Revkov
- NL Bindoff
- NN Rabalais
- NN Rabalais
- Noémie Allio
- O Giere
- O Giere
- O Hoegh-Guldberg
- P Durack
- P Frenzel
- P Hallock
- P Jensen
- P Riera
- P Vassallo
- PA Montagna
- PE Renaud
- Pedro Martinez Arbizu
- PF Kingston
- PJ Somerfield
- PJD Lambshead
- PJD Lambshead
- Quentin Morel
- R Carriço
- R Coma
- R Danovaro
- R Danovaro
- R Danovaro
- R Danovaro
- R Engler
- R Garcia
- R Gingold
- R Hale
- R Harvey
- R Howell
- R Huys
- R Riera
- R Riera
- R Sandulli
- R Singh
- Raphaelle Fumeron
- RC Aller
- Reinhardt Møbjerg Kristensen
- RIE Newell
- RJ Matear
- RL Diaz
- RM Warwick
- RM Warwick
- RM Warwick
- RM Warwick
- RM Warwick
- RM Warwick
- RN Arieli
- Roxanne Langonne-Augen
- RR Hessler
- S Amjad
- S Bonaglia
- S Gollasch
- S Gollasch
- S Jennings
- S Laakmann
- S Mirto
- S Mirto
- S Oron
- S Somot
- S Wang
- S Widdicombe
- SA Gerlach
- SA Gerlach
- SA Gerlach
- SA Netto
- Sarah Seite
- SC Doney
- SC Doney
- SG Bolam
- SI Rogers
- SJ Forster
- SL Dashfield
- SM Burton
- SR Ernst
- T Bongers
- T Irizuki
- T Kang
- T Mascart
- T Mascart
- T Moens
- T Radziejewska
- T Radziejewska
- T Wernberg
- T Yamanaka
- TA Scambos
- Tangi Le Bot
- TF Sutherland
- Thomas Andro
- Thomas Van Der Stegen
- TK Gyedu-Ababio
- TK Gyedu-Ababio
- TK Pinto
- Tristan James
- U Braeckman
- V Bouchet
- V Cadre Le
- Valentin Foulon
- VB Pogrebov
- VG Fonseca
- Viatcheslav N. Ivanenko
- Vivien Hulot
- VMP Bouchet
- VV Galtsova
- WP Sijp
- WS Liu
- WS Liu
- X Sun
- XQ Ngo
- ZA Ansari
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Our planet is changing, and one of the most pressing challenges facing the scientific community revolves around understanding how ecological communities respond to global changes. From coastal to deep-sea ecosystems, ecologists are exploring new areas of research to find model organisms that help predict the future of life on our planet. Among the different categories of organisms, meiofauna offer several advantages for the study of marine benthic ecosystems. This paper reviews the advances in the study of meiofauna with regard to climate change and anthropogenic impacts. Four taxonomic groups are valuable for predicting global changes: foraminifers (especially calcareous forms), nematodes, copepods and ostracods. Environmental variables are fundamental in the interpretation of meiofaunal patterns and multistressor experiments are more informative than single stressor ones, revealing complex ecological and biological interactions. Global change has a general negative effect on meiofauna, with important consequences on benthic food webs. However, some meiofaunal species can be favoured by the extreme conditions induced by global change, as they can exhibit remarkable physiological adaptations. This review highlights the need to incorporate studies on taxonomy, genetics and function of meiofaunal taxa into global change impact research
Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study
- Author
- Abduljalal M
- Abdullaev AA
- Abdullaeva GJ
- Abifadel M
- Acevedo Rivera KJ
- Adamidis P-S
- Aguilar HG
- Aguilar-Salinas CA
- Al-Khateeb A
- Al-Rasadi K
- Al-Sarraf A
- Al-Sayed N
- Alammari D
- Alareedh M
- Alcala HG
- Alfil S
- Alhabib K
- Alieva RB
- Alkhnifsawi M
- Almahmeed W
- Almeida AF
- Alnouri F
- Alonso R
- Alrowaily NL
- Alsahari A
- Alvarado RM
- Alvarez JA
- Alves AC
- Amezcua Martinez JC
- Anagnostis P
- Anastasiou G
- Antonio-Villa NE
- Antza C
- Aouchiche K
- Aparicio BPN
- Arca M
- Arjona Villica~na RD
- Arriaga Cazares HE
- Ashavaid TF
- Ates S
- Attilakos A
- Averna M
- Ayoub C
- Balligand J-L
- Banach M
- Barrera Bustillo MDLR
- Bartkova I
- Batool H
- Battelino T
- Baumgartner-Kaut M
- Bañares V
- Bendary A
- Benn M
- Benso A
- Berteotti M
- Bertolini S
- Bielecka-Dąbrowa A
- Bilhoto C
- Binder C
- Biolo GB
- Bizjan BJ
- Blom D
- Boccara F
- Bogsrud MP
- Bonanni L
- Borghi C
- Borowiec-Wolna J
- Bossi AC
- Bourbon M
- Branchi A
- Brandts JM
- Bruckert E
- Brunham L
- Buganova I
- Buonuomo PS
- Buresova K
- Béliard S
- Calabrò P
- Calandra S
- Capra ME
- Cariou B
- Carrera RA
- Carrié A
- Casula M
- Catapano AL
- Cavallaro R
- Cefalù AB
- Cepova J
- Chacon RC
- Charrières S
- Chlebus I
- Chlebus K
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- Cipollone F
- Citroni N
- Coelho R
- Cohen H
- Cooremans ER
- Corral P
- Correia S
- Cottin Y
- Cruz D
- Cuevas A
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- De Andrés R
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- Debreova M
- Del Ben M
- Deltas C
- Demeure F
- Descamps OS
- Dharmayat KI
- Di Filippo M
- Dieplinger H
- Do D-L
- Dominguez GJ
- Doumas M
- Dourmap C
- Drogari E
- Durlach V
- Durst R
- Dvorakova J
- Dwiputra B
- Díaz-Díaz JL
- Elbahry A
- Elias-Lopez D
- Encinas BR
- Ezhov MV
- Fabryova L
- Farnier M
- Federici M
- Ferreira P
- Ferreira-Hermosillo A
- Ferri C
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- Georgiou A
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- Giorgino F
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- Guzman BG
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- Holguin Almada JR
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- Hovingh GK
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- Ioannou A
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- Viigimaa M
- Virtuoso MJ
- Vohnout B
- Vrablik M
- Vázquez Cárdenas A
- Wang L
- Wasąg B
- Watts GF
- Weigman A
- Werba JP
- Wojtecka A
- Yamashita S
- Yelnik C
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- Zacharis E
- Zakirova DV
- Zambon A
- Zazueta AR
- Zdrojewski T
- Zenti MG
- Zepeda Carrillo EA
- Zubieta VM
- Šaligova J
- Żarczyńska-Buchowiecka M
- Publication venue
- Elsevier
- Publication date
- 29/08/2023
- Field of study
Background Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8–13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05–6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50–75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life. Funding Pfizer, Amgen, Merck Sharp & Dohme, Sanofi–Aventis, Daiichi Sankyo, and Regeneron
Measurement of the B0s →J/ψη lifetime
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- Zucchelli S
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Using a data set corresponding to an integrated luminosity of 3 fb−1, collected by the LHCb experiment in pp collisions at centre-of-mass energies of 7 and 8 TeV, the effective lifetime in the Bs0→J/ψη decay mode, τeff, is measured to be
τeff=1.479±0.034 (stat)±0.011 (syst) ps. Assuming CP conservation, τeff corresponds to the lifetime of the light Bs0 mass eigenstate. This is the first measurement of the effective lifetime in this decay mode
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