15 research outputs found
Physical activity attenuates the influence of FTO variants on obesity risk : a meta-analysis of 218,166 adults and 19,268 children
BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) = 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.Peer reviewe
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Peer reviewe
On the Wiener criterion and quasilinear obstacle problems
SIGLETIB Hannover: RO 5389(6) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman
Immunotherapy against drug resistance as a therapy compliment increasing the duration of the effective use of art
Quantitative 31P NMR analysis of solid wood offers an insight into the acetylation of its components
Recommended from our members
Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: the Food4Me study
Objective: To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults.
Methods: Of 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet.
Results: FTO genotype was associated with a higher body weight [b: 1.09 kg per risk allele, (95% CI:0.14-2.04),
P=0.024], BMI [b: 0.54 kg m-2, (0.23-0.83), P<0.0001], and WC [b: 1.07 cm, (0.24-1.90),P=0.011]. Moderate-equivalent PA attenuated the effect of FTO on BMI (P[interaction]=0.020). Among inactive individuals, FTO increased BMI by 1.06 kg m-2 per allele (P=0.024), whereas the increase in BMI was substantially attenuated among active individuals (0.16 kg m-2, P=0.388). We observed similar effects for WC (P[interaction]=0.005): the FTO risk allele increased WC by 2.72 cm per allele among inactive individuals but by only 0.49 cm in active individuals.
Conclusions: PA attenuates the effect of FTO genotype on BMI and WC. This may have important public health implications because genetic susceptibility to obesity in the presence of FTO variants may be reduced by adopting a physically active lifestyle