18 research outputs found
Overproduction of cosmic superstrings
We show that the naive application of the Kibble mechanism seriously
underestimates the initial density of cosmic superstrings that can be formed
during the annihilation of D-branes in the early universe, as in models of
brane-antibrane inflation. We study the formation of defects in effective field
theories of the string theory tachyon both analytically, by solving the
equation of motion of the tachyon field near the core of the defect, and
numerically, by evolving the tachyon field on a lattice. We find that defects
generically form with correlation lengths of order M_s^{-1} rather than H^{-1}.
Hence, defects localized in extra dimensions may be formed at the end of
inflation. This implies that brane-antibrane inflation models where inflation
is driven by branes which wrap the compact manifold may have problems with
overclosure by cosmological relics, such as domain walls and monopoles.Comment: 31 pages, 16 figures, JHEP style; References added; Improved
discussion of initial condition
Torsion Constraints in the Randall--Sundrum Scenario
Torsion appears due to fermions coupled to gravity and leads to the strongest
particle physics bounds on flat extra dimensions. In this work, we consider
torsion constraints in the case of a warped extra dimension with brane and bulk
fermions. From current data we obtain a 3-sigma bound on the TeV--brane mass
scale scale \Lambda_\pi > 2.2 (10) TeV for the AdS curvature k=1 (0.01) in
(reduced) Planck units. If Dirac or light sterile neutrinos reside on the
brane, the bound increases to 17 (78) TeV.Comment: typos corrected, matches the Phys. Rev. D versio
Adiabatic perturbation theory: from Landau-Zener problem to quenching through a quantum critical point
We discuss the application of the adiabatic perturbation theory to analyze
the dynamics in various systems in the limit of slow parametric changes of the
Hamiltonian. We first consider a two-level system and give an elementary
derivation of the asymptotics of the transition probability when the tuning
parameter slowly changes in the finite range. Then we apply this perturbation
theory to many-particle systems with low energy spectrum characterized by
quasiparticle excitations. Within this approach we derive the scaling of
various quantities such as the density of generated defects, entropy and
energy. We discuss the applications of this approach to a specific situation
where the system crosses a quantum critical point. We also show the connection
between adiabatic and sudden quenches near a quantum phase transitions and
discuss the effects of quasiparticle statistics on slow and sudden quenches at
finite temperatures.Comment: 20 pages, 3 figures, contribution to "Quantum Quenching, Annealing
and Computation", Eds. A. Das, A. Chandra and B. K. Chakrabarti, Lect. Notes
in Phys., Springer, Heidelberg (2009, to be published), reference correcte
Big bounce from spin and torsion
The Einstein-Cartan-Sciama-Kibble theory of gravity naturally extends general
relativity to account for the intrinsic spin of matter. Spacetime torsion,
generated by spin of Dirac fields, induces gravitational repulsion in fermionic
matter at extremely high densities and prevents the formation of singularities.
Accordingly, the big bang is replaced by a bounce that occurred when the energy
density was on the order of (in
natural units), where is the fermion number density and is
the number of thermal degrees of freedom. If the early Universe contained only
the known standard-model particles (), then the energy density at
the big bounce was about 15 times larger than the Planck energy. The minimum
scale factor of the Universe (at the bounce) was about times smaller
than its present value, giving \approx 50 \mum. If more fermions existed in
the early Universe, then the spin-torsion coupling causes a bounce at a lower
energy and larger scale factor. Recent observations of high-energy photons from
gamma-ray bursts indicate that spacetime may behave classically even at scales
below the Planck length, supporting the classical spin-torsion mechanism of the
big bounce. Such a classical bounce prevents the matter in the contracting
Universe from reaching the conditions at which a quantum bounce could possibly
occur.Comment: 6 pages; published versio
Four-fermion interaction from torsion as dark energy
The observed small, positive cosmological constant may originate from a
four-fermion interaction generated by the spin-torsion coupling in the
Einstein-Cartan-Sciama-Kibble gravity if the fermions are condensing. In
particular, such a condensation occurs for quark fields during the
quark-gluon/hadron phase transition in the early Universe. We study how the
torsion-induced four-fermion interaction is affected by adding two terms to the
Dirac Lagrangian density: the parity-violating pseudoscalar density dual to the
curvature tensor and a spinor-bilinear scalar density which measures the
nonminimal coupling of fermions to torsion.Comment: 6 pages; published versio
Deriving the mass of particles from Extended Theories of Gravity in LHC era
We derive a geometrical approach to produce the mass of particles that could
be suitably tested at LHC. Starting from a 5D unification scheme, we show that
all the known interactions could be suitably deduced as an induced symmetry
breaking of the non-unitary GL(4)-group of diffeomorphisms. The deformations
inducing such a breaking act as vector bosons that, depending on the
gravitational mass states, can assume the role of interaction bosons like
gluons, electroweak bosons or photon. The further gravitational degrees of
freedom, emerging from the reduction mechanism in 4D, eliminate the hierarchy
problem since generate a cut-off comparable with electroweak one at TeV scales.
In this "economic" scheme, gravity should induce the other interactions in a
non-perturbative way.Comment: 30 pages, 1 figur
Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major
Background
The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic microorganisms. It has previously been demonstrated that small-molecule compounds designed to target Mip from the Gram-negative bacterium Burkholderia pseudomallei bind at the site of enzymatic activity of the protein, inhibiting the in vitro activity of Mip.
Objectives
In this study, co-crystallography experiments with recombinant B. pseudomallei Mip (BpMip) protein and Mip inhibitors, biochemical analysis and computational modelling were used to predict the efficacy of lead compounds for broad-spectrum activity against other pathogens.
Methods
Binding activity of three lead compounds targeting BpMip was verified using surface plasmon resonance spectroscopy. The determination of crystal structures of BpMip in complex with these compounds, together with molecular modelling and in vitro assays, was used to determine whether the compounds have broad-spectrum antimicrobial activity against pathogens.
Results
Of the three lead small-molecule compounds, two were effective in inhibiting the PPIase activity of Mip proteins from Neisseria meningitidis, Klebsiella pneumoniae and Leishmania major. The compounds also reduced the intracellular burden of these pathogens using in vitro cell infection assays.
Conclusions
These results indicate that Mip is a novel antivirulence target that can be inhibited using small-molecule compounds that prove to be promising broad-spectrum drug candidates in vitro. Further optimization of compounds is required for in vivo evaluation and future clinical applications
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
Fiducial and differential cross sections of Higgs boson production measured in the four-lepton decay channel in pp collisions at âs = 8 TeV with the ATLAS detector
Measurements of fiducial and differential cross sections of Higgs boson production in the HâZZâ â 4â decay channel are presented. The cross sections are determined within a fiducial phase space and corrected for detection efficiency and resolution effects. They are based on 20.3 fbâÂč of pp collision data, produced at âs = 8 TeV centre-of-mass energy at the LHC and recorded by the ATLAS detector. The differential measurements are performed in bins of transverse momentum and rapidity of the four-lepton system, the invariant mass of the subleading lepton pair and the decay angle of the leading lepton pair with respect to the beam line in the four-lepton rest frame, as well as the number of jets and the transverse momentum of the leading jet. The measured cross sections are compared to selected theoretical calculations of the Standard Model expectations. No significant deviation from any of the tested predictions is found
Measurements of production cross sections of polarized same-sign W boson pairs in association with two jets in proton-proton collisions at s=13 TeV
The first measurements of production cross sections of polarized same-sign W±W±boson pairs in proton-proton collisions are reported. The measurements are based on a data sample collected with the CMS detector at the LHC at a center-of-mass energy of 13TeV, corresponding to an integrated luminosity of 137fbâ1. Events are selected by requiring exactly two same-sign leptons, electrons or muons, moderate missing transverse momentum, and two jets with a large rapidity separation and a large dijet mass to enhance the contribution of same-sign W±W±scattering events. An observed (expected) 95% confidence level upper limit of 1.17 (0.88)fbis set on the production cross section for longitudinally polarized same-sign W±W±boson pairs. The electroweak production of same-sign W±W±boson pairs with at least one of the Wbosons longitudinally polarized is measured with an observed (expected) significance of 2.3 (3.1) standard deviations.SCOAP